LOCUS       NM_004209               2026 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens synaptogyrin 3 (SYNGR3), mRNA.
ACCESSION   NM_004209
VERSION     NM_004209.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2026)
  AUTHORS   Ho,P.W., Li,L., Liu,H.F., Choi,Z.Y., Chang,E.E.S., Pang,S.Y.,
            Malki,Y., Leung,C.T., Kung,M.H., Ramsden,D.B. and Ho,S.L.
  TITLE     In vivo overexpression of synaptogyrin-3 promotes striatal synaptic
            dopamine uptake in LRRK2R1441G mutant mouse model of Parkinson's
            disease
  JOURNAL   Brain Behav 13 (2), e2886 (2023)
   PUBMED   36624932
  REMARK    GeneRIF: In vivo overexpression of synaptogyrin-3 promotes striatal
            synaptic dopamine uptake in LRRK2[R1441G] mutant mouse model of
            Parkinson's disease.
REFERENCE   2  (bases 1 to 2026)
  AUTHORS   Murphy,R.M., Tasoulas,J., Porrello,A., Carper,M.B., Tsai,Y.H.,
            Coffey,A.R., Kumar,S., Zeng,P.Y., Schrank,T.P., Midkiff,B.R.,
            Cohen,S., Salazar,A.H., Hayward,M.C., Hayes,D.N., Olshan,A.,
            Gupta,G.P., Nichols,A.C., Yarbrough,W.G., Pecot,C.V. and
            Amelio,A.L.
  TITLE     Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and
            Prognostic Biomarker in Head and Neck Cancer
  JOURNAL   Cancer Res Commun 2 (9), 987-1004 (2022)
   PUBMED   36148399
  REMARK    GeneRIF: Tumor Cell Extrinsic Synaptogyrin 3 Expression as a
            Diagnostic and Prognostic Biomarker in Head and Neck Cancer.
REFERENCE   3  (bases 1 to 2026)
  AUTHORS   Li,L., Ho,P.W., Liu,H., Pang,S.Y., Chang,E.E., Choi,Z.Y., Malki,Y.,
            Kung,M.H., Ramsden,D.B. and Ho,S.L.
  TITLE     Transcriptional Regulation of the Synaptic Vesicle Protein
            Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its
            Expression
  JOURNAL   Int J Mol Sci 23 (7), 3646 (2022)
   PUBMED   35409005
  REMARK    GeneRIF: Transcriptional Regulation of the Synaptic Vesicle Protein
            Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its
            Expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2026)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2026)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2026)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   7  (bases 1 to 2026)
  AUTHORS   Chang,H., Jeung,H.C., Jung,J.J., Kim,T.S., Rha,S.Y. and Chung,H.C.
  TITLE     Identification of genes associated with chemosensitivity to
            SAHA/taxane combination treatment in taxane-resistant breast cancer
            cells
  JOURNAL   Breast Cancer Res Treat 125 (1), 55-63 (2011)
   PUBMED   20224928
REFERENCE   8  (bases 1 to 2026)
  AUTHORS   Egana,L.A., Cuevas,R.A., Baust,T.B., Parra,L.A., Leak,R.K.,
            Hochendoner,S., Pena,K., Quiroz,M., Hong,W.C., Dorostkar,M.M.,
            Janz,R., Sitte,H.H. and Torres,G.E.
  TITLE     Physical and functional interaction between the dopamine
            transporter and the synaptic vesicle protein synaptogyrin-3
  JOURNAL   J Neurosci 29 (14), 4592-4604 (2009)
   PUBMED   19357284
  REMARK    GeneRIF: This study demonstrates the interaction of the mouse
            homolog, synaptogyrin 3, with the dopamine transporter (DAT).
REFERENCE   9  (bases 1 to 2026)
  AUTHORS   Belizaire,R., Komanduri,C., Wooten,K., Chen,M., Thaller,C. and
            Janz,R.
  TITLE     Characterization of synaptogyrin 3 as a new synaptic vesicle
            protein
  JOURNAL   J Comp Neurol 470 (3), 266-281 (2004)
   PUBMED   14755516
  REMARK    GeneRIF: This study identifies the mouse homolog, synaptogyrin 3,
            as a synaptic vesicle protein.
REFERENCE   10 (bases 1 to 2026)
  AUTHORS   Kedra,D., Pan,H.Q., Seroussi,E., Fransson,I., Guilbaud,C.,
            Collins,J.E., Dunham,I., Blennow,E., Roe,B.A., Piehl,F. and
            Dumanski,J.P.
  TITLE     Characterization of the human synaptogyrin gene family
  JOURNAL   Hum Genet 103 (2), 131-141 (1998)
   PUBMED   9760194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005606.3 and BC014087.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004209.5.
            
            Summary: This gene encodes an integral membrane protein. The exact
            function of this protein is unclear, but studies of a similar
            murine protein suggest that it is a synaptic vesicle protein that
            also interacts with the dopamine transporter. The gene product
            belongs to the synaptogyrin gene family. [provided by RefSeq, Dec
            2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014087.2, SRR1803611.203285.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248121.7/ ENSP00000248121.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC005606.3         49061-49115
            56-2026             BC014087.2         1-1971
FEATURES             Location/Qualifiers
     source          1..2026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2026
                     /gene="SYNGR3"
                     /note="synaptogyrin 3"
                     /db_xref="GeneID:9143"
                     /db_xref="HGNC:HGNC:11501"
                     /db_xref="MIM:603927"
     exon            1..232
                     /gene="SYNGR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..823
                     /gene="SYNGR3"
                     /codon_start=1
                     /product="synaptogyrin-3"
                     /protein_id="NP_004200.2"
                     /db_xref="CCDS:CCDS10456.1"
                     /db_xref="GeneID:9143"
                     /db_xref="HGNC:HGNC:11501"
                     /db_xref="MIM:603927"
                     /translation="MEGASFGAGRAGAALDPVSFARRPQTLLRVASWVFSIAVFGPIV
                     NEGYVNTDSGPELRCVFNGNAGACRFGVALGLGAFLACAAFLLLDVRFQQISSVRDRR
                     RAVLLDLGFSGLWSFLWFVGFCFLTNQWQRTAPGPATTQAGDAARAAIAFSFFSILSW
                     VALTVKALQRFRLGTDMSLFATEQLSTGASQAYPGYPVGSGVEGTETYQSPPFTETLD
                     TSPKGYQVPAY"
     exon            233..470
                     /gene="SYNGR3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..613
                     /gene="SYNGR3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..2026
                     /gene="SYNGR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNGR3"
                     /note="hexamer: AATAAA"
     polyA_site      2026
                     /gene="SYNGR3"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggcag cggctgcagc gttggtagca tcagcatcag catcagcggc agcggcagcg
       61 gcctcgggcg gggccggccg gacggacagg cggacagaag gcgccagggg cgcgcgtccc
      121 gcccgggccg gccatggagg gcgcctcctt cggcgcgggc cgcgcagggg ccgccctgga
      181 ccccgtgagc tttgcgcggc ggccccagac cctgctccgg gtcgcgtcct gggtgttctc
      241 catcgccgtc ttcgggccca tcgtcaacga gggctacgtg aacaccgaca gcggccccga
      301 gctgcgctgc gtgttcaacg ggaacgcggg cgcctgccgc ttcggcgtcg cgctgggcct
      361 cggagccttc ctcgcctgcg ccgccttcct gctgctcgat gtgcgcttcc agcaaatcag
      421 cagcgtccgc gaccgccggc gcgcggtgtt gctggacctg ggcttctcag gactctggtc
      481 cttcctgtgg ttcgtgggct tctgcttcct caccaatcag tggcagcgca cggcgccagg
      541 gccggccacg acgcaggcgg gggacgcggc gcgggccgcc atcgccttca gcttcttctc
      601 catcctcagc tgggtggcgc tcaccgtgaa ggccctgcag cggttccgcc tgggcaccga
      661 catgtcactc ttcgccaccg aacagctgag caccggggcg agccaggcct accccggcta
      721 tccggtgggc agcggcgtgg agggcaccga gacctaccag agcccgccct tcaccgagac
      781 cctggacacc agccccaaag ggtaccaggt gcccgcctac tagcggctgg caggcacaga
      841 ccagggctcc aaggccaccc caccaacgca ggccccaggg tctccgggac ctcccttggg
      901 tccttccagc tcagtgccgc ggacagagta ggtggccgct ttgcgccatc cggggccaag
      961 agggggtgga cccgcgtgtc tgggctgccc ctgccaagtt cccccagtcc ctcagcacct
     1021 ggccccagga ctgaggtcct gagaagggga tagcactgcc caggacgtgt gtccctagcc
     1081 tggaatggac tggcctgggg aaggctttcc cctcttgggc cacacctgct cactctgggg
     1141 ttgggggtcc agctgccctc tacgatcagg tgcaggggct gcccaggaca aagcgggggc
     1201 aggggaaaga caccaccctc gccccaagac tggggatcct ggccactgtt cccatcccat
     1261 gtccctgtgg gtagtgactg tctcgtttct gtcatggtgg tgcgtcccgt ccggagccac
     1321 tctccacttt ctctcacagg ctgctagaac agcccagccc tgtcagtgtt gtgatcatgg
     1381 tccagtcttc gggtttcacc tcctagtact ccacaagctg ctcctctctc tgtggccccg
     1441 gcccctgccc aggtgtgggt ggttctggcc aggaaggcac aaggtagctg tgggccaaga
     1501 caccagccct gtcctagccc ttcagtaaga ccttgccagg agaggagaag gatgcctggg
     1561 tgccaggcaa gacaagcccc tcagcaggag agaggcccag aggctccagc tggccaccgt
     1621 gccccacaag atggcccctg tgtggttccc tttaccttgg cttcctggcc cagtccctgc
     1681 ctctccacct gcaccctgct tcctggccca gtcccaggtt ggagtccctc tgcatagctg
     1741 actactcatg cattgctcaa agctggcttt tcacattaag tcaacaccaa acgtggttgc
     1801 cacatttcat cagacagaca cctccctctg gagatgcagt tgagtgacaa ccttgttaca
     1861 ttgtagccta gaccaattct gtgtggatat ttaagtgaac atgtttacaa tttttgtata
     1921 tatcactctc tccctctcct gaaagaccag agattgtgta ttttcagtgt cccatgttcc
     1981 gactgcacct tctttacaat aaagactgta actgagctga ctgtga
//
