LOCUS       NM_004710               1495 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens synaptogyrin 2 (SYNGR2), transcript variant 1, mRNA.
ACCESSION   NM_004710
VERSION     NM_004710.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Liu,C., Qu,Z., Zhao,H., Wang,P., Zhan,C. and Zhang,Y.
  TITLE     Pan-cancer analysis of SYNGR2 with a focus on clinical implications
            and immune landscape in liver hepatocellular carcinoma
  JOURNAL   BMC Bioinformatics 24 (1), 192 (2023)
   PUBMED   37170221
  REMARK    GeneRIF: Pan-cancer analysis of SYNGR2 with a focus on clinical
            implications and immune landscape in liver hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1495)
  AUTHORS   Sun,Q., Qi,X., Zhang,Y., Wu,X., Liang,M., Li,C., Li,D.,
            Cardona,C.J. and Xing,Z.
  TITLE     Synaptogyrin-2 Promotes Replication of a Novel Tick-borne
            Bunyavirus through Interacting with Viral Nonstructural Protein NSs
  JOURNAL   J Biol Chem 291 (31), 16138-16149 (2016)
   PUBMED   27226560
  REMARK    GeneRIF: synaptogyrin-2 is essential to promoting the formation of
            the IBs to become virus factories for viral RNA replication through
            its interaction with NSs. These findings unveil the function of
            synaptogyrin-2 as an enhancer in viral infection.
REFERENCE   3  (bases 1 to 1495)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1495)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 1495)
  AUTHORS   Kedra,D., Pan,H.Q., Seroussi,E., Fransson,I., Guilbaud,C.,
            Collins,J.E., Dunham,I., Blennow,E., Roe,B.A., Piehl,F. and
            Dumanski,J.P.
  TITLE     Characterization of the human synaptogyrin gene family
  JOURNAL   Hum Genet 103 (2), 131-141 (1998)
   PUBMED   9760194
REFERENCE   6  (bases 1 to 1495)
  AUTHORS   Janz,R. and Sudhof,T.C.
  TITLE     Cellugyrin, a novel ubiquitous form of synaptogyrin that is
            phosphorylated by pp60c-src
  JOURNAL   J Biol Chem 273 (5), 2851-2857 (1998)
   PUBMED   9446595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021593.15.
            
            On Nov 30, 2019 this sequence version replaced NM_004710.6.
            
            Summary: This gene encodes an integral membrane protein containing
            four transmembrane regions and a C-terminal cytoplasmic tail that
            is tyrosine phosphorylated. The exact function of this protein is
            unclear, but studies of a similar rat protein suggest that it may
            play a role in regulating membrane traffic in non-neuronal cells.
            The gene belongs to the synaptogyrin gene family. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029755.1, AY358916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225777.8/ ENSP00000225777.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC021593.15        17894-18028         c
            136-373             AC021593.15        15555-15792         c
            374-513             AC021593.15        14960-15099         c
            514-1495            AC021593.15        13889-14870         c
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1495
                     /gene="SYNGR2"
                     /note="synaptogyrin 2"
                     /db_xref="GeneID:9144"
                     /db_xref="HGNC:HGNC:11499"
                     /db_xref="MIM:603926"
     exon            1..135
                     /gene="SYNGR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..711
                     /gene="SYNGR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cellugyrin"
                     /codon_start=1
                     /product="synaptogyrin-2 isoform 1"
                     /protein_id="NP_004701.1"
                     /db_xref="CCDS:CCDS11753.1"
                     /db_xref="GeneID:9144"
                     /db_xref="HGNC:HGNC:11499"
                     /db_xref="MIM:603926"
                     /translation="MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIY
                     GEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRK
                     YLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWG
                     VLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGY
                     QPPPVY"
     exon            136..373
                     /gene="SYNGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..513
                     /gene="SYNGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1495
                     /gene="SYNGR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNGR2"
                     /note="hexamer: AATAAA"
     polyA_site      1495
                     /gene="SYNGR2"
                     /note="major polyA site"
ORIGIN      
        1 gcgttccgcg gcggcggcag cggcggcgac ggcgacatgg agagcggggc ctacggcgcg
       61 gccaaggcgg gcggctcctt cgacctgcgg cgcttcctga cgcagccgca ggtggtggcg
      121 cgcgccgtgt gcttggtctt cgccttgatc gtgttctcct gcatctatgg tgagggctac
      181 agcaatgccc acgagtctaa gcagatgtac tgcgtgttca accgcaacga ggatgcctgc
      241 cgctatggca gtgccatcgg ggtgctggcc ttcctggcct cggccttctt cttggtggtc
      301 gacgcgtatt tcccccagat cagcaacgcc actgaccgca agtacctggt cattggtgac
      361 ctgctcttct cagctctctg gaccttcctg tggtttgttg gtttctgctt cctcaccaac
      421 cagtgggcag tcaccaaccc gaaggacgtg ctggtggggg ccgactctgt gagggcagcc
      481 atcaccttca gcttcttttc catcttctcc tggggtgtgc tggcctccct ggcctaccag
      541 cgctacaagg ctggcgtgga cgacttcatc cagaattacg ttgaccccac tccggacccc
      601 aacactgcct acgcctccta cccaggtgca tctgtggaca actaccaaca gccacccttc
      661 acccagaacg cggagaccac cgagggctac cagccgcccc ctgtgtactg agcggcggtt
      721 agcgtgggaa gggggacaga gagggccctc ccctctgccc tggactttcc catgagcctc
      781 ctggaactgc cagcccctct ctttcacctg ttccatcctg tgcagctgac acacagctaa
      841 ggagcctcat agcctggcgg gggctggcag agccacaccc caagtgcctg tgcccagagg
      901 gcttcagtca gccgctcact cctccagggc acttttagga aagggttttt agctagtgtt
      961 tttcctcgct tttaatgacc tcagccccgc ctgcagtggc tagaagccag caggtgccca
     1021 tgtgctactg acaagtgcct cagcttcccc ccggcccggg tcaggccgtg ggagccgcta
     1081 ttatctgcgt tctctgccaa agactcgtgg gggccatcac acctgccctg tgcagcggag
     1141 ccggaccagg ctcttgtgtc ctcactcagg tttgcttccc ctgtgcccac tgctgtatga
     1201 tctgggggcc accaccctgt gccggtggcc tctgggctgc ctcccgtggt gtgagggcgg
     1261 ggctggtgct catggcactt cctccttgct cccacccctg gcagcaggga agggctttgc
     1321 ctgacaacac ccagctttat gtaaatattc tgcagttgtt acttaggaag cctggggagg
     1381 gcaggggtgc cccatggctc ccagactctg tctgtgccga gtgtattata aaatcgtggg
     1441 ggagatgccc ggcctgggat gctgtttgga gacggaataa atgttttctc attca
//
