LOCUS       NM_006772               6015 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1),
            transcript variant 1, mRNA.
ACCESSION   NM_006772
VERSION     NM_006772.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6015)
  AUTHORS   Bednarczuk,N., Housby,H., Lee,I.O., Consortium,I., Skuse,D. and
            Wolstencroft,J.
  TITLE     Behavioural and neurodevelopmental characteristics of SYNGAP1
  JOURNAL   J Neurodev Disord 16 (1), 46 (2024)
   PUBMED   39148034
  REMARK    GeneRIF: Behavioural and neurodevelopmental characteristics of
            SYNGAP1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6015)
  AUTHORS   Kim,H.J., Kim,M., Jang,S., Cho,J.S., Kim,S.Y., Cho,A., Kim,H.,
            Lim,B.C., Chae,J.H., Choi,J., Kim,K.J. and Kim,W.
  TITLE     SYNGAP1-related developmental and epileptic encephalopathy:
            Genotypic and phenotypic characteristics and longitudinal insights
  JOURNAL   Am J Med Genet A 194 (8), e63606 (2024)
   PUBMED   38563110
  REMARK    GeneRIF: SYNGAP1-related developmental and epileptic
            encephalopathy: Genotypic and phenotypic characteristics and
            longitudinal insights.
REFERENCE   3  (bases 1 to 6015)
  AUTHORS   Wright,D., Kenny,A., Eley,S., McKechanie,A.G. and Stanfield,A.C.
  TITLE     Visual social attention in SYNGAP1-related intellectual disability
  JOURNAL   Autism Res 17 (6), 1083-1093 (2024)
   PUBMED   38698724
  REMARK    GeneRIF: Visual social attention in SYNGAP1-related intellectual
            disability.
REFERENCE   4  (bases 1 to 6015)
  AUTHORS   Wright,D., Kenny,A., Mizen,L.A.M., McKechanie,A.G. and
            Stanfield,A.C.
  TITLE     The Behavioral Profile of SYNGAP1-Related Intellectual Disability
  JOURNAL   Am J Intellect Dev Disabil 129 (3), 199-214 (2024)
   PUBMED   38657965
  REMARK    GeneRIF: The Behavioral Profile of SYNGAP1-Related Intellectual
            Disability.
REFERENCE   5  (bases 1 to 6015)
  AUTHORS   Carvill,G.L., Heavin,S.B., Yendle,S.C., McMahon,J.M., O'Roak,B.J.,
            Cook,J., Khan,A., Dorschner,M.O., Weaver,M., Calvert,S., Malone,S.,
            Wallace,G., Stanley,T., Bye,A.M., Bleasel,A., Howell,K.B.,
            Kivity,S., Mackay,M.T., Rodriguez-Casero,V., Webster,R.,
            Korczyn,A., Afawi,Z., Zelnick,N., Lerman-Sagie,T., Lev,D.,
            Moller,R.S., Gill,D., Andrade,D.M., Freeman,J.L., Sadleir,L.G.,
            Shendure,J., Berkovic,S.F., Scheffer,I.E. and Mefford,H.C.
  TITLE     Targeted resequencing in epileptic encephalopathies identifies de
            novo mutations in CHD2 and SYNGAP1
  JOURNAL   Nat Genet 45 (7), 825-830 (2013)
   PUBMED   23708187
  REMARK    GeneRIF: De novo CHD2 and SYNGAP1 mutations are new causes of
            epileptic encephalopathies, accounting for 1.2% and 1% of cases,
            respectively.
REFERENCE   6  (bases 1 to 6015)
  AUTHORS   Berryer,M.H., Hamdan,F.F., Klitten,L.L., Moller,R.S., Carmant,L.,
            Schwartzentruber,J., Patry,L., Dobrzeniecka,S., Rochefort,D.,
            Neugnot-Cerioli,M., Lacaille,J.C., Niu,Z., Eng,C.M., Yang,Y.,
            Palardy,S., Belhumeur,C., Rouleau,G.A., Tommerup,N., Immken,L.,
            Beauchamp,M.H., Patel,G.S., Majewski,J., Tarnopolsky,M.A.,
            Scheffzek,K., Hjalgrim,H., Michaud,J.L. and Di Cristo,G.
  TITLE     Mutations in SYNGAP1 cause intellectual disability, autism, and a
            specific form of epilepsy by inducing haploinsufficiency
  JOURNAL   Hum Mutat 34 (2), 385-394 (2013)
   PUBMED   23161826
  REMARK    GeneRIF: De novo missense mutations, p.R579X, and possibly all the
            other truncating mutations in SYNGAP1 result in a loss of its
            function, causing intellectual disability, autism, and a specific
            form of epilepsy.
REFERENCE   7  (bases 1 to 6015)
  AUTHORS   Kim,J.H., Liao,D., Lau,L.F. and Huganir,R.L.
  TITLE     SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90
            protein family
  JOURNAL   Neuron 20 (4), 683-691 (1998)
   PUBMED   9581761
REFERENCE   8  (bases 1 to 6015)
  AUTHORS   Kroll,J. and Waltenberger,J.
  TITLE     The vascular endothelial growth factor receptor KDR activates
            multiple signal transduction pathways in porcine aortic endothelial
            cells
  JOURNAL   J Biol Chem 272 (51), 32521-32527 (1997)
   PUBMED   9405464
REFERENCE   9  (bases 1 to 6015)
  AUTHORS   Holder,J.L. Jr., Hamdan,F.F. and Michaud,J.L.
  TITLE     SYNGAP1-Related Intellectual Disability
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   30789692
REFERENCE   10 (bases 1 to 6015)
  AUTHORS   Fantl,W.J., Escobedo,J.A., Martin,G.A., Turck,C.W., del Rosario,M.,
            McCormick,F. and Williams,L.T.
  TITLE     Distinct phosphotyrosines on a growth factor receptor bind to
            specific molecules that mediate different signaling pathways
  JOURNAL   Cell 69 (3), 413-423 (1992)
   PUBMED   1374684
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662799.16, DA057307.1,
            AK307888.1, AK094225.1, AL713634.1, BX282051.1 and AK124666.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 16, 2019 this sequence version replaced NM_006772.2.
            
            Summary: This gene encodes a Ras GTPase activating protein that is
            a member of the N-methyl-D-aspartate receptor complex. The
            N-terminal domain of the protein contains a Ras-GAP domain, a
            pleckstrin homology domain, and a C2 domain that may be involved in
            binding of calcium and phospholipids. The C-terminal domain
            consists of a ten histidine repeat region, serine and tyrosine
            phosphorylation sites, and a T/SXV motif required for postsynaptic
            scaffold protein interaction. The encoded protein negatively
            regulates Ras, Rap and
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
            trafficking to the postsynaptic membrane to regulate synaptic
            plasticity and neuronal homeostasis. Allelic variants of this gene
            are associated with intellectual disability and autism spectrum
            disorder. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646630.1/ ENSP00000496007.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL662799.16        72434-72438
            6-190               DA057307.1         1-185
            191-1037            AK307888.1         1-847
            1038-1038           AK094225.1         1033-1033
            1039-2494           AK307888.1         849-2304
            2495-3400           AL713634.1         1146-2051
            3401-3614           AK307888.1         3169-3382
            3615-4138           BX282051.1         1-524
            4139-5022           AL713634.1         2802-3685
            5023-5145           AK124666.1         921-1043
            5146-6015           AL713634.1         3809-4678
FEATURES             Location/Qualifiers
     source          1..6015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..6015
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /note="synaptic Ras GTPase activating protein 1"
                     /db_xref="GeneID:8831"
                     /db_xref="HGNC:HGNC:11497"
                     /db_xref="MIM:603384"
     exon            1..267
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..4232
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptic Ras GTPase activating protein, 135kDa; Ras
                     GTPase-activating protein SynGAP; neuronal RasGAP;
                     synaptic Ras GTPase activating protein 1 homolog; ras/Rap
                     GTPase-activating protein SynGAP; Ras/Rap
                     GTPase-activating protein 1"
                     /codon_start=1
                     /product="ras/Rap GTPase-activating protein SynGAP isoform
                     1"
                     /protein_id="NP_006763.2"
                     /db_xref="CCDS:CCDS34434.2"
                     /db_xref="GeneID:8831"
                     /db_xref="HGNC:HGNC:11497"
                     /db_xref="MIM:603384"
                     /translation="MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGW
                     NPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHL
                     GRSRRKSVPGGKQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQIL
                     PRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEF
                     CFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPP
                     KKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKK
                     RKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGK
                     GKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASA
                     LVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKD
                     AIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELK
                     EVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLT
                     LIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGY
                     IDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSER
                     PRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPP
                     PGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLN
                     SSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTD
                     GVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPP
                     GDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQH
                     MLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSS
                     GNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNP
                     TMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHS
                     LKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSI
                     IGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAP
                     PAPPPPPRLQITENGEFRNTADH"
     exon            268..389
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            390..495
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            496..587
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            588..709
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            710..863
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            864..962
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1586
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1731
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1876
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2113
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2315
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2494
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2536
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..3608
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3782
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3994
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..4085
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..6015
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5993..5998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /note="hexamer: AATAAA"
     polyA_site      6015
                     /gene="SYNGAP1"
                     /gene_synonym="MRD5; RASA1; RASA5; SYNGAP"
                     /note="major polyA site"
ORIGIN      
        1 ctctctctcg gctgccgctg ctgccgttgg ctcttattct cctcctcctc ctcctctctc
       61 ctcctctctg cttctctctg ctcctctctc ctcctctctc ctcctcctcc tcctccacct
      121 cctcctcctt ctccccctct ttctccccct ctttctctct tctttctccc ccgtcccccc
      181 gccccctccc cccaggcctg atgagcaggt ctcgagcctc catccatcgg gggagcatcc
      241 ccgcgatgtc ctatgccccc ttcagagatg tacggggacc ctctatgcac cgaacccaat
      301 acgttcattc cccgtatgat cgtcctggtt ggaaccctcg gttctgcatc atctcgggga
      361 accagctgct catgctggat gaggatgaga tacaccccct actgatccgg gaccggagga
      421 gcgagtccag tcgcaacaaa ctgctgagac gcacagtctc cgtgccggtg gaggggcggc
      481 cccacggcga gcatgaatac cacttgggtc gctcgaggag gaagagtgtc ccagggggga
      541 agcagtacag catggagggt gcccctgctg cgcccttccg gccctcgcaa ggcttcctga
      601 gccgacggct aaaaagctcc atcaaacgaa cgaagtcaca acccaaactt gaccggacca
      661 gcagctttcg ccagatcctg cctcgcttcc gaagtgctga ccatgaccgg gcccggctga
      721 tgcaaagctt taaggagtca cactctcatg agtccttgct gagtcctagc agtgcagctg
      781 aggcattgga gctcaacttg gatgaagatt ccattatcaa gccagtgcac agctccatcc
      841 tgggccagga gttctgtttt gaggtaacaa cttcatcagg aacaaaatgc tttgcctgtc
      901 ggtctgcggc cgaaagagac aaatggattg agaatctgca gcgggcagta aagcccaaca
      961 aggacaacag ccgccgggta gacaatgtgc taaagctgtg gatcatagag gcccgggagc
     1021 tgccccccaa gaagcggtac tactgtgagc tctgcctgga tgacatgctg tatgcacgca
     1081 ccacctccaa gccccgctct gcctctgggg acaccgtctt ctggggcgag cacttcgagt
     1141 ttaacaacct gccggctgtc cgtgccctgc ggctgcatct gtaccgtgac tcagacaaaa
     1201 agcgcaagaa ggacaaggca ggctatgtcg gcctggtgac tgtgccagtg gccaccctgg
     1261 ctgggcgcca cttcacagag cagtggtacc ctgtaaccct gccaacaggc agtgggggat
     1321 ctgggggcat gggttcggga gggggagggg gctcgggggg tggctcaggg ggcaagggca
     1381 aaggaggttg cccggctgtg cggctgaaag cacgttacca gacaatgagc atcttgccca
     1441 tggagctata taaagagttt gcagagtatg tcaccaacca ttatcggatg ctgtgtgcag
     1501 tcttggagcc cgccctgaat gtcaaaggca aggaggaggt tgccagtgca ctagttcaca
     1561 tcctgcagag tacaggcaag gccaaggact tcctttcaga catggccatg tctgaggtag
     1621 accggttcat ggaacgggag cacctcatat tccgcgagaa cacgcttgcc actaaagcca
     1681 tagaagagta tatgagactg attggtcaga aatacctcaa ggatgccatt ggagaattca
     1741 tccgtgctct gtatgaatct gaggaaaact gcgaggtaga ccctatcaag tgcacagcat
     1801 ccagtttggc agagcaccag gccaacctgc gaatgtgctg tgagttggcc ctgtgcaagg
     1861 tggtcaactc ccactgcgtg ttcccgaggg agctgaagga ggtgtttgct tcgtggcggc
     1921 tgcgctgcgc agagcgaggc cgggaggaca tcgcagacag gcttatcagc gcctcactct
     1981 tcctgcgctt cctctgccca gcgattatgt cgcccagtct ctttgggctt atgcaggagt
     2041 acccagatga gcagacctca cgaaccctca ccctcattgc caaggtcatc cagaacctgg
     2101 ccaacttttc caagtttacc tcaaaggagg actttctggg cttcatgaat gagtttctgg
     2161 agctggaatg gggttccatg cagcagtttt tgtatgagat ctccaatctg gacacgctaa
     2221 ccaacagcag tagctttgag ggttacatcg acttgggccg agagctctcc acactgcatg
     2281 ccctactctg ggaggtgctg ccccagctca gcaaggaagc cctcctgaag ctgggtccac
     2341 tgccccggct cctcaacgac atcagcacag ctctgaggaa ccccaacatc caaaggcagc
     2401 caagccgcca gagtgagcgg ccccggcctc agcctgtggt actgcggggg ccatcggctg
     2461 agatgcaggg ctacatgatg cgggacctca acagctccat cgaccttcag tccttcatgg
     2521 ctcgaggcct caacagctct atggacatgg ctcgcctccc ctccccaacc aaggaaaagc
     2581 cacccccacc accgcctggt ggtggtaaag acctgttcta tgtaagccgt ccacccctgg
     2641 cccgttcctc accagcatac tgcacgagca gctcggacat cacagagcca gagcagaaga
     2701 tgctgagtgt caacaagagt gtgtccatgc tggacttaca gggtgatggg cctggtggcc
     2761 gcctcaacag cagcagtgtt tcgaacctgg cggccgtagg ggacctgctg cactcaagcc
     2821 aggcctcgct gacagcagcc ttggggctac ggcctgcgcc tgccggacgc ctctcccagg
     2881 ggagtggctc atccatcacg gcggctggca tgcgcctcag ccagatgggt gtcaccacag
     2941 acggtgtccc tgcccagcaa ctgcgaatcc ccctctcctt ccagaaccct ctcttccaca
     3001 tggctgctga tgggccaggt cccccaggcg gccatggagg gggcggtggc catggcccac
     3061 cttcctccca tcaccaccac caccaccatc accaccaccg aggtggagag ccccctgggg
     3121 acacctttgc cccattccat ggctatagca agagtgagga cctctcttcc ggggtcccca
     3181 agccccctgc tgcctccatc cttcatagcc acagctacag tgatgagttt ggaccctctg
     3241 gcactgactt cacccgtcgg cagctttcac tccaggacaa cctgcagcac atgctgtccc
     3301 ctccccagat caccattggt ccccagaggc cagccccctc agggcctgga ggtgggagcg
     3361 gtgggggcag cggtgggggt ggcgggggcc agccgcctcc attgcagagg ggcaagtctc
     3421 agcagttgac agtcagcgca gcccagaaac cccggccatc cagcgggaat ctattgcagt
     3481 ccccagagcc aagttatggc cccgcccgtc cacggcaaca gagcctcagc aaggagggca
     3541 gcattggggg cagcgggggc agcggtggcg gagggggtgg ggggctgaag ccctccatca
     3601 ccaagcagca ttctcagaca ccatccacat tgaaccccac aatgccagcc tctgagcgga
     3661 cagtggcctg ggtctccaac atgcctcacc tgtcggctga catcgagagt gcccacatcg
     3721 agcgggaaga gtacaagctc aaggagtact caaaatcgat ggatgagagc cggctggata
     3781 gggtgaagga gtacgaggag gagattcact cactgaaaga gcggctgcac atgtccaacc
     3841 ggaagctgga agagtatgag cggaggctgc tgtcccagga agaacaaacc agcaaaatcc
     3901 tgatgcagta tcaggcccga ctggagcaga gtgagaagag gctaaggcag cagcaggcag
     3961 agaaggattc ccagatcaag agcatcattg gcaggctgat gctggtggag gaggagctgc
     4021 gccgggacca ccccgccatg gctgagccgc tgccagaacc caagaagagg ctgctcgacg
     4081 ctcaggagag gcagcttccc cccttgggtc caacaaaccc gcgtgtgacg ctggccccac
     4141 cgtggaatgg cctggccccc ccagccccac cacccccacc ccggctgcag attacggaga
     4201 acggcgagtt ccgaaacacc gcagaccact agcccaccca gcatcagaga ccttctcttc
     4261 ctttcctgtg caccccaccc tgtaacagca ccaaccacca ggattggaca tcaccgagga
     4321 acagcgggat tgcctccccg aatgcctccc tgggaggcac actgattgcc cacccccacc
     4381 actgcaccat ttccaggagg gagagtgggg accctcagcc gccccctttt ccttcccatt
     4441 ggggtgctgc cctctctttg acccccaggg acccttgccc caggacaccg cctaccccgt
     4501 acagacccct tcactccggg gtgctatccc catcctctgc ctcatcgttc ccctgagcac
     4561 tgggggacag accctcaccc ccaccctggg ggtgtggcac ctccaaactt tcaacttcag
     4621 ggtgattttt ttagcagtaa ccagagctga caatctaact cccctccacc gccccatttt
     4681 ggcctcccct gccccccttg ttatggggag gggaccccgg gtgagggggc cctattaccc
     4741 cttgatttct caggagcgtc tgggggggct cagcacgcac aaactccttc tccttctacc
     4801 actcttaaat ttactccctc cccacccaga acccagatgg ggtggagggg gccaccgggg
     4861 cagggagggg gcggcaaggg gggaatggga gttgtctccc cttctcccca cacctgatct
     4921 gctctcggct ggtcccagag cggggtgagg gggcttatgc ccccccctcc cccagtgtgt
     4981 tgggtggggt ggaattgagg ttagggtgag gggtcagggt ttaggagggt gtgtatgttg
     5041 ggaggacagg ctagttgatc tgtcctactc tgacacacag tcccctctgc cccttccttc
     5101 tctcttcttg gtctctactc ccagggggag gggggaactt actctaggaa aagccatgtc
     5161 tctctccccc agggtggggg gacctgtgtt ggaggagggg tgttgggggg cccccttcca
     5221 tgactctgtc ccctggggga ggtaggacag ggctgggctt ccctctcatc ctccccctcc
     5281 caatctcctt ccacctccct ccctcccgcc agctccacga tttttcggtg tttctctgta
     5341 catagttttc tggcgggata ggggaggtag gatggatggg gtttggggtg ggtaggccat
     5401 gggaggggag aagcccctcc ttggcacccc ctcttccctg actgctgtcc cctacccagc
     5461 cttgccccct tcatcctttt gcgtttggta ttgagactct cctagactct actcctcttt
     5521 cttttgtatg gacagttccc cttcagtccc atccccctac acatacaccc agccggggcc
     5581 aaatttatac ttatataaaa gttgtaaata tgtgaaattt tatccctgtg ccctttcccc
     5641 acctcaggcc ctacccctgg accctcccca accttccttc tctcttcttt ggctgttgta
     5701 attatctggg gtttgtactg tacatatccg gggtgtgtgt gtgtgggctg ggggcaaccc
     5761 ttctgtacag agcttcctgg ccccctcccc ccccgcccct ctgcttccct ccccacccac
     5821 cacctcaagg gtagggagtt gctcttccta cctgttttat tttgttttct cgttctccct
     5881 ccccacccca ctcccagcct tatctatccc ccctcactgt ccccttttct ccactcccag
     5941 ccccatttcc tttttttctg gagtgtgtgg tgaaacagaa aaaaacatgt ttaataaacg
     6001 gagattgttc tttta
//
