LOCUS       NM_024893               2092 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens synapse differentiation inducing 1 (SYNDIG1),
            transcript variant 1, mRNA.
ACCESSION   NM_024893
VERSION     NM_024893.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Kalashnikova,E., Lorca,R.A., Kaur,I., Barisone,G.A., Li,B.,
            Ishimaru,T., Trimmer,J.S., Mohapatra,D.P. and Diaz,E.
  TITLE     SynDIG1: an activity-regulated, AMPA- receptor-interacting
            transmembrane protein that regulates excitatory synapse development
  JOURNAL   Neuron 65 (1), 80-93 (2010)
   PUBMED   20152115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024282.1 and DB306704.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024893.2.
            
            Summary: This gene encodes a protein that belongs to the
            interferon-induced transmembrane family of proteins. A similar
            protein in rat is thought to regulate the development of excitatory
            synapses. [provided by RefSeq, Jul 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.437021.1,
                                           SRR3476690.1162973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376862.4/ ENSP00000366058.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2007              AK024282.1         431-2437
            2008-2092           DB306704.1         2-86                c
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..2092
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /note="synapse differentiation inducing 1"
                     /db_xref="GeneID:79953"
                     /db_xref="HGNC:HGNC:15885"
                     /db_xref="MIM:614311"
     exon            1..125
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /inference="alignment:Splign:2.1.0"
     exon            126..683
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..980
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /note="synapse differentiation induced gene 1;
                     transmembrane protein 90B; interferon induced
                     transmembrane protein domain containing 5; dispanin
                     subfamily C member 2"
                     /codon_start=1
                     /product="synapse differentiation-inducing gene protein 1"
                     /protein_id="NP_079169.1"
                     /db_xref="CCDS:CCDS13164.1"
                     /db_xref="GeneID:79953"
                     /db_xref="HGNC:HGNC:15885"
                     /db_xref="MIM:614311"
                     /translation="MDGIIEQKSMLVHSKISDAGKRNGLINTRNLMAESRDGLVSVYP
                     APQYQSHRVGASTVPASLDSSRSEPMQQLLDPNTLQQSVESRYRPNIILYSEGVLRSW
                     GDGVAADCCETTFIEDRSPTKDSLEYPDGKFIDLSADDIKIHTLSYDVEEEEEFQELE
                     SDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHETNKAVAKGDLHQ
                     ASTSSRRALFLAVLSITIGTGVYVGVAVALIAYLSKNNHL"
     exon            684..821
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /inference="alignment:Splign:2.1.0"
     exon            822..2092
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /note="hexamer: AATAAG"
     polyA_site      2008
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /note="major polyA site"
     regulatory      2041..2046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
                     /note="hexamer: AACAAA"
     polyA_site      2073
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
     polyA_site      2092
                     /gene="SYNDIG1"
                     /gene_synonym="C20orf39; DSPC2; IFITMD5; TMEM90B"
ORIGIN      
        1 agaggaggag agagcctggc agcggaggag cagaggcggg cgccgcaccg ccccgcacgc
       61 tcgctcgctc gggagagtcg cgggcggccg cttgggcgca cttgccgggt caccttgtcc
      121 cggaggagaa atggcttccc tgaggcaagt gtaacctaca ttcccagccc accagcctga
      181 cgcccagcca gggagagagt accatggatg gcatcattga acagaagagc atgctggtgc
      241 acagtaaaat cagtgatgct ggcaagagga atggtttaat taacaccaga aacttgatgg
      301 ccgagagcag agatggtctg gtgtctgttt acccagcgcc ccagtaccag agccaccggg
      361 tgggggccag cacagtgccg gccagcctgg acagcagcag gagtgagccg atgcagcagc
      421 tgctggaccc caacaccctg cagcagtcag tggagtcccg ctaccggccc aacatcatcc
      481 tctattcaga gggcgtgctg cgctcctggg gggacggtgt ggccgccgac tgctgcgaga
      541 ccaccttcat cgaggaccgg tcgcccacca aagacagcct cgagtacccg gatgggaagt
      601 tcattgacct ctcagctgat gacataaaaa tccacaccct gtcctacgat gtggaggagg
      661 aggaggagtt ccaggagctg gagagcgact actcaagcga cacagagagt gaggacaatt
      721 tcctcatgat gcccccgcgg gaccacctgg gcctcagtgt cttctccatg ctctgctgct
      781 tctggcctct gggcatcgca gccttctact tgtcccatga gaccaacaaa gccgtggcca
      841 agggggactt gcaccaggcc agcaccagct cccggcgggc cctattcctg gcagtgctgt
      901 ccatcaccat tgggactggc gtctatgtgg gcgtggccgt ggccctcatc gcctacctct
      961 ccaagaacaa ccacctgtga gcttcctgcg aatggagggg gagcacccgg ggccaggtct
     1021 gtgtggacgt ggaggaagca ggcataccgc atgatgctgt acagtacaaa tgattgccaa
     1081 atgatgccac gaagccctgg gatttcctac ccatggattt attttgtttt tatcctttaa
     1141 tttcatgttc acagcactgt gtagagcacc agacagacgg gcactgctaa tccttccaaa
     1201 ggaaagctcc aaagatccca gcccgcaagg ctgtctctgg atggattctg gtggatgaat
     1261 ggcaacgcgg ctctctgcag cctgccagtg cccagagtgc caccgcatta gcaatataca
     1321 aacagtccaa aaaagtgttt attttttatg gaatacggtg caataggcag aggacaaggg
     1381 acacatcact cttctgtctg tggccctgct ggagtccttt gtgccccccg gagtccacac
     1441 gccttccctg caagacgaga atggggctgg gaagaaagag gcaacaccac ggctggcagg
     1501 agccccgctg cactgctctg cagacccatt ggcctgaccc tgagaagcag agccagcaaa
     1561 gcccgggacc tgcccctctt tctttccctt cacaccaccc cagcctcagg atgtcaagcc
     1621 acctccggaa cgtgtctaca ctccacagct accccgcagc aatacgcact cttgggacct
     1681 cgctgatcta ggatggggag gcaggccacc gcccctccca agactcctca agaaagagcc
     1741 ccgcggttgc tccggaaact cgaggcactg cagctatggg cactgcctca gcctaaagac
     1801 acaggggcgc ctcccaatca ccgcgctggc ggatgctcac cccgtcataa gcagaaacta
     1861 gtgatcctgg aaatgagatg ggccttactc tgtcgactaa atgaatagct attttcttgt
     1921 cattttttaa agtgcaactc ttgcttcatg ctgcttaagt taccagatga atgctgagaa
     1981 ataagtaatc acagacattt taataccatt tcattgctgt tttacgagtg ttcattactt
     2041 aacaaaaaat tatcttttag ctttttcgct taagactttt ctttctgatg aa
//
