LOCUS       NM_006372               2754 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens synaptotagmin binding cytoplasmic RNA interacting
            protein (SYNCRIP), transcript variant 1, mRNA.
ACCESSION   NM_006372
VERSION     NM_006372.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Ishtayeh,H., Galves,M., Barnatan,T.T., Berdichevsky,Y.,
            Amer-Sarsour,F., Pasmanik-Chor,M., Braverman,I., Blumen,S.C. and
            Ashkenazi,A.
  TITLE     Oculopharyngeal muscular dystrophy mutations link the RNA-binding
            protein HNRNPQ to autophagosome biogenesis
  JOURNAL   Aging Cell 22 (10), e13949 (2023)
   PUBMED   37559347
  REMARK    GeneRIF: Oculopharyngeal muscular dystrophy mutations link the
            RNA-binding protein HNRNPQ to autophagosome biogenesis.
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Semino,F., Schroter,J., Willemsen,M.H., Bast,T., Biskup,S.,
            Beck-Woedl,S., Brennenstuhl,H., Schaaf,C.P., Kolker,S.,
            Hoffmann,G.F., Haack,T.B. and Syrbe,S.
  TITLE     Further evidence for de novo variants in SYNCRIP as the cause of a
            neurodevelopmental disorder
  JOURNAL   Hum Mutat 42 (9), 1094-1100 (2021)
   PUBMED   34157790
  REMARK    GeneRIF: Further evidence for de novo variants in SYNCRIP as the
            cause of a neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Mourelatos,Z., Abel,L., Yong,J., Kataoka,N. and Dreyfuss,G.
  TITLE     SMN interacts with a novel family of hnRNP and spliceosomal
            proteins
  JOURNAL   EMBO J 20 (19), 5443-5452 (2001)
   PUBMED   11574476
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Lau,P.P., Chang,B.H. and Chan,L.
  TITLE     Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a
            component of apobec-1 editosome
  JOURNAL   Biochem Biophys Res Commun 282 (4), 977-983 (2001)
   PUBMED   11352648
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Grosset,C., Chen,C.Y., Xu,N., Sonenberg,N., Jacquemin-Sablon,H. and
            Shyu,A.B.
  TITLE     A mechanism for translationally coupled mRNA turnover: interaction
            between the poly(A) tail and a c-fos RNA coding determinant via a
            protein complex
  JOURNAL   Cell 103 (1), 29-40 (2000)
   PUBMED   11051545
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   Harris,C.E., Boden,R.A. and Astell,C.R.
  TITLE     A novel heterogeneous nuclear ribonucleoprotein-like protein
            interacts with NS1 of the minute virus of mice
  JOURNAL   J Virol 73 (1), 72-80 (1999)
   PUBMED   9847309
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF037448.1, AL136082.22,
            DA117533.1 and DB160837.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006372.4.
            
            Summary: This gene encodes a member of the cellular heterogeneous
            nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding
            proteins that complex with heterogeneous nuclear RNA (hnRNA) and
            regulate alternative splicing, polyadenylation, and other aspects
            of mRNA metabolism and transport. The encoded protein plays a role
            in multiple aspects of mRNA maturation and is associated with
            several multiprotein complexes including the apoB RNA
            editing-complex and survival of motor neurons (SMN) complex.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene, and a pseudogene of this
            gene is located on the short arm of chromosome 20. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF037448.1, AK222776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369622.8/ ENSP00000358635.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-959               AF037448.1         424-1382
            960-961             AL136082.22        38033-38034         c
            962-2509            AF037448.1         1385-2932
            2510-2625           DA117533.1         458-573
            2626-2754           DB160837.1         456-584
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.3"
     gene            1..2754
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="synaptotagmin binding cytoplasmic RNA interacting
                     protein"
                     /db_xref="GeneID:10492"
                     /db_xref="HGNC:HGNC:16918"
                     /db_xref="MIM:616686"
     exon            1..90
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            91..250
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1974
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NS1-associated protein 1; heterogeneous nuclear
                     ribonucleoprotein Q; glycine- and tyrosine-rich
                     RNA-binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein Q
                     isoform 1"
                     /protein_id="NP_006363.4"
                     /db_xref="CCDS:CCDS5005.1"
                     /db_xref="GeneID:10492"
                     /db_xref="HGNC:HGNC:16918"
                     /db_xref="MIM:616686"
                     /translation="MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLD
                     EIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTY
                     RQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSV
                     GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQE
                     AVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILY
                     HQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVM
                     AKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMN
                     GKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG
                     RGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAP
                     SRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRK
                     ADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK"
     exon            251..369
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            370..477
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            478..591
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            592..768
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            769..904
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1110
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1260
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1382
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..2754
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="hexamer: AATAAA"
     polyA_site      2197
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="hexamer: AATAAA"
     polyA_site      2528
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="major polyA site"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="hexamer: ATTAAA"
     polyA_site      2624
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="SYNCRIP"
                     /gene_synonym="GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1;
                     NSAP1; PP68"
ORIGIN      
        1 actcgcgccg gacacaggga gcagcgagca cgcgtttccc gcaacccgat accatcggac
       61 aggatttctc cgcctcagcc caacggggag atctctggaa acatggctac agaacatgtt
      121 aatggaaatg gtactgaaga gcccatggat actacttctg cagttatcca ttcagaaaat
      181 tttcagacat tgcttgatgc tggtttacca cagaaagttg ctgaaaaact agatgaaatt
      241 tacgttgcag ggctagttgc acatagtgat ttagatgaaa gagctattga agctttaaaa
      301 gaattcaatg aagacggtgc attggcagtt cttcaacagt ttaaagacag tgatctctct
      361 catgttcaga acaaaagtgc ctttttatgt ggagtcatga agacttacag gcagagagaa
      421 aaacaaggga ccaaagtagc agattctagt aaaggaccag atgaggcaaa aattaaggca
      481 ctcttggaaa gaacaggcta cacacttgat gtgaccactg gacagaggaa gtatggagga
      541 ccacctccag attccgttta ttcaggtcag cagccttctg ttggcactga gatatttgtg
      601 ggaaagatcc caagagatct atttgaggat gaacttgttc cattatttga gaaagctgga
      661 cctatatggg atcttcgtct aatgatggat ccactcactg gtctcaatag aggttatgcg
      721 tttgtcactt tttgtacaaa agaagcagct caggaggctg ttaaactgta taataatcat
      781 gaaattcgtt ctggaaaaca tattggtgtc tgcatctcag ttgccaacaa taggcttttt
      841 gtgggctcta ttcctaagag taaaaccaag gaacagattc ttgaagaatt tagcaaagta
      901 acagagggtc ttacagacgt cattttatac caccaaccgg atgacaagaa aaaaaacaga
      961 ggcttttgct ttcttgaata tgaagatcac aaaacagctg cccaggcaag gcgtaggtta
     1021 atgagtggta aagtcaaggt ctgggggaat gttggaactg ttgaatgggc tgatcctata
     1081 gaagatcctg atcctgaggt tatggcaaag gtaaaagtgc tgtttgtacg caaccttgcc
     1141 aatactgtaa cagaagagat tttagaaaag gcatttagtc agtttgggaa actggaacga
     1201 gtgaagaagt taaaagatta tgcgttcatt cattttgatg agcgagatgg tgctgtcaag
     1261 gctatggaag aaatgaatgg caaagacttg gagggagaaa atattgaaat tgtttttgcc
     1321 aagccaccag atcagaaaag gaaagaaaga aaagctcaga ggcaagcagc aaaaaatcaa
     1381 atgtatgacg attactacta ttatggtcca cctcatatgc cccctccaac aagaggtcga
     1441 gggcgtggag gtagaggtgg ttatggatat cctccagatt attatggata tgaagattat
     1501 tatgattatt atggttatga ttaccataac tatcgtggtg gatatgaaga tccatactat
     1561 ggttatgaag attttcaagt tggagctaga ggaaggggtg gtagaggagc aaggggtgct
     1621 gctccatcca gaggtcgtgg ggctgctcct ccccgcggta gagccggtta ttcacagaga
     1681 ggaggtcctg gatcagcaag aggcgttcga ggtgcgagag gaggtgccca acaacaaaga
     1741 ggccgcgggg tacgtggtgc gaggggtggc cgcggtggaa atgtaggagg aaagcgcaaa
     1801 gctgatgggt acaaccagcc agattccaag cggcgccaga ccaataatca gaactggggc
     1861 tcccaaccca ttgctcagca accgctccaa ggtggtgatc attctggtaa ctatggttac
     1921 aaatctgaaa accaggagtt ttatcaggat acttttgggc aacagtggaa gtagaaacag
     1981 tagggcctct gtaaaattgg agactgatag gttgatcaga aactcaccct aaatctgaac
     2041 gggtgccgct ataatttgtg acatctggca agatttccct ttatgtatat attttaacaa
     2101 tccgcttgga cacgaacaaa gccacacttc taactgcttc tggcgaactg attttatttt
     2161 taattttttt caataaagat attcttagat actgaaagaa atagttaatg agtttgcatt
     2221 tgtgcttgag aaaatttggc tcaagtccat ttggctgtag tgtcaacgat gtttccagta
     2281 gtgtttagat ttggtgtctt caaaggtagt tgattaaaac caagtgtgtc tttaatatct
     2341 tgtatcagaa taactttgta tgttaccaac ttaaattgct agaataaggt aaattgatac
     2401 acaactgcta tttttaattt agaactttga cctaatttgg gttttcaaaa ccattttggc
     2461 tacttgtatt ctttatgctg ttgtttattt caataaaaaa ttcacaccta aatgtatact
     2521 tactaaaatt gtgtttacaa ttcgtttttc acaaaatttc ctgcaaattt ggttcaaatt
     2581 gtatagcatg tcaaggccaa ttaaagggtt ttgtgccttg ttaattcttg tgtggaatat
     2641 gtctgcacat tacacaacac tgatttattg cagttttctg cttctggttt aaagtgctat
     2701 tttacaacag acttcatgtt cccatcaaaa ataaaaagat aatacatgta gtaa
//
