LOCUS       NM_003490               7867 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens synapsin III (SYN3), transcript variant IIIa, mRNA.
ACCESSION   NM_003490 XM_011530406
VERSION     NM_003490.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7867)
  AUTHORS   Baris,R.O., Sahin,N., Bilgic,A.D., Ozdemir,C. and Edgunlu,T.G.
  TITLE     Molecular and in silico analyses of SYN III gene variants in autism
            spectrum disorder
  JOURNAL   Ir J Med Sci 192 (6), 2887-2895 (2023)
   PUBMED   37166614
  REMARK    GeneRIF: Molecular and in silico analyses of SYN III gene variants
            in autism spectrum disorder.
REFERENCE   2  (bases 1 to 7867)
  AUTHORS   Bolat,H., Unsel-Bolat,G., Ozgul,S., Pariltay,E., Tahillioglu,A.,
            Rohde,L.A., Akin,H. and Ercan,E.S.
  TITLE     Investigation of possible associations of the BDNF, SNAP-25 and SYN
            III genes with the neurocognitive measures: BDNF and SNAP-25 genes
            might be involved in attention domain, SYN III gene in executive
            function
  JOURNAL   Nord J Psychiatry 76 (8), 610-615 (2022)
   PUBMED   35077325
  REMARK    GeneRIF: Investigation of possible associations of the BDNF,
            SNAP-25 and SYN III genes with the neurocognitive measures: BDNF
            and SNAP-25 genes might be involved in attention domain, SYN III
            gene in executive function.
REFERENCE   3  (bases 1 to 7867)
  AUTHORS   Longhena,F., Faustini,G., Varanita,T., Zaltieri,M., Porrini,V.,
            Tessari,I., Poliani,P.L., Missale,C., Borroni,B., Padovani,A.,
            Bubacco,L., Pizzi,M., Spano,P. and Bellucci,A.
  TITLE     Synapsin III is a key component of alpha-synuclein fibrils in Lewy
            bodies of PD brains
  JOURNAL   Brain Pathol 28 (6), 875-888 (2018)
   PUBMED   29330884
  REMARK    GeneRIF: Synapsin III is a crucial alpha-synuclein interactant and
            a key component of Lewy bodies fibrils in the brain of patients
            affected by Parkinson's disease.
REFERENCE   4  (bases 1 to 7867)
  AUTHORS   Cruceanu,C., Kutsarova,E., Chen,E.S., Checknita,D.R., Nagy,C.,
            Lopez,J.P., Alda,M., Rouleau,G.A. and Turecki,G.
  TITLE     DNA hypomethylation of Synapsin II CpG islands associates with
            increased gene expression in bipolar disorder and major depression
  JOURNAL   BMC Psychiatry 16 (1), 286 (2016)
   PUBMED   27515700
  REMARK    GeneRIF: These findings contribute to previous work showing
            dysregulation of Synapsins, particularly SYN2, in mood disorders
            and improve our understanding of the regulatory mechanisms that
            precipitate these changes likely leading to the BD or MDD
            phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7867)
  AUTHORS   Xie,L., Dolai,S., Kang,Y., Liang,T., Xie,H., Qin,T., Yang,L.,
            Chen,L. and Gaisano,H.Y.
  TITLE     Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels
            in Insulin-Secreting INS-1 832/13 Cells
  JOURNAL   PLoS One 11 (2), e0147862 (2016)
   PUBMED   26848587
  REMARK    GeneRIF: Syn-3 may mimic Syn-1A in the ability to bind and modulate
            Cavs, but preferring Cav2.3 to perhaps participate in triggering
            fusion of newcomer insulin SGs during second-phase GSIS.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7867)
  AUTHORS   Porton,B., Ferreira,A., DeLisi,L.E. and Kao,H.T.
  TITLE     A rare polymorphism affects a mitogen-activated protein kinase site
            in synapsin III: possible relationship to schizophrenia
  JOURNAL   Biol Psychiatry 55 (2), 118-125 (2004)
   PUBMED   14732590
  REMARK    GeneRIF: A missense polymorphism, S470N, was identified in the
            synapsin III gene and appeared more frequently in individuals with
            schizophrenia. The site affected by the polymorphism, Ser470, was
            determined to be a substrate for mitogen-activated protein kinase.
REFERENCE   7  (bases 1 to 7867)
  AUTHORS   Tsai,M.T., Hung,C.C., Tsai,C.Y., Liu,M.Y., Su,Y.C., Chen,Y.H.,
            Hsiao,K.J. and Chen,C.H.
  TITLE     Mutation analysis of synapsin III gene in schizophrenia
  JOURNAL   Am J Med Genet 114 (1), 79-83 (2002)
   PUBMED   11840510
  REMARK    GeneRIF: Evidence is not in favor of a large effect of synapsin III
            gene in the pathogenesis of schizophrenia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7867)
  AUTHORS   Kao,H.T., Porton,B., Hilfiker,S., Stefani,G., Pieribone,V.A.,
            DeSalle,R. and Greengard,P.
  TITLE     Molecular evolution of the synapsin gene family
  JOURNAL   J Exp Zool 285 (4), 360-377 (1999)
   PUBMED   10578110
REFERENCE   9  (bases 1 to 7867)
  AUTHORS   Porton,B., Kao,H.T. and Greengard,P.
  TITLE     Characterization of transcripts from the synapsin III gene locus
  JOURNAL   J Neurochem 73 (6), 2266-2271 (1999)
   PUBMED   10582583
REFERENCE   10 (bases 1 to 7867)
  AUTHORS   Kao,H.T., Porton,B., Czernik,A.J., Feng,J., Yiu,G., Haring,M.,
            Benfenati,F. and Greengard,P.
  TITLE     A third member of the synapsin gene family
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4667-4672 (1998)
   PUBMED   9539796
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z83846.1, Z98256.1, Z82246.2,
            Z80902.2, Z82181.2 and Z71183.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 24, 2019 this sequence version replaced
            XM_011530406.3, NM_003490.3.
            
            Summary: This gene is a member of the synapsin gene family.
            Synapsins encode neuronal phosphoproteins which associate with the
            cytoplasmic surface of synaptic vesicles. Family members are
            characterized by common protein domains, and they are implicated in
            synaptogenesis and the modulation of neurotransmitter release,
            suggesting a potential role in several neuropsychiatric diseases.
            The protein encoded by this gene shares the synapsin family domain
            model, with domains A, C, and E exhibiting the highest degree of
            conservation. The protein contains a unique domain J, located
            between domains C and E. Based on this gene's localization to
            22q12.3, a possible schizophrenia susceptibility locus, and the
            established neurobiological roles of the synapsins, this family
            member may represent a candidate gene for schizophrenia. The TIMP3
            gene is located within an intron of this gene and is transcribed in
            the opposite direction. Alternative splicing of this gene results
            in multiple splice variants that encode different isoforms.
            [provided by RefSeq, Oct 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.158655.1,
                                           SRR1803611.24598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358763.7/ ENSP00000351614.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                Z83846.1           88341-88430         c
            91-563              Z83846.1           36400-36872         c
            564-621             Z83846.1           10693-10750         c
            622-713             Z98256.1           85238-85329         c
            714-873             Z98256.1           22816-22975         c
            874-963             Z98256.1           18765-18854         c
            964-1026            Z82246.2           13841-13903         c
            1027-1169           Z80902.2           9900-10042          c
            1170-1244           Z80902.2           6365-6439           c
            1245-1347           Z80902.2           2122-2224           c
            1348-1482           Z82181.2           11924-12058         c
            1483-1570           Z82181.2           10968-11055         c
            1571-1862           Z82181.2           1093-1384           c
            1863-7867           Z71183.2           19669-25673         c
FEATURES             Location/Qualifiers
     source          1..7867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..7867
                     /gene="SYN3"
                     /note="synapsin III"
                     /db_xref="GeneID:8224"
                     /db_xref="HGNC:HGNC:11496"
                     /db_xref="MIM:602705"
     exon            1..90
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            91..563
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1995
                     /gene="SYN3"
                     /note="isoform IIIa is encoded by transcript variant IIIa;
                     synapsin-3; cN28H9.2 (synapsin III)"
                     /codon_start=1
                     /product="synapsin-3 isoform IIIa"
                     /protein_id="NP_003481.3"
                     /db_xref="CCDS:CCDS13908.1"
                     /db_xref="GeneID:8224"
                     /db_xref="HGNC:HGNC:11496"
                     /db_xref="MIM:602705"
                     /translation="MNFLRRRLSDSSFMANLPNGYMTDLQRPDSSTSSPASPAMERRH
                     PQPLAASFSSPGSSLFSSLSSAMKQAPQATSGLMEPPGPSTPIVQRPRILLVIDDAHT
                     DWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSRSFKPD
                     FILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSL
                     GPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAM
                     AKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRL
                     WVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSK
                     MSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQPRPPPQGGPRQAQSPQP
                     QRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLAS
                     QPRPPVQGRSTSQQGEESKKPAPPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAET
                     IRNLRKSFASLFSD"
     exon            564..621
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            622..713
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..873
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            874..963
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1026
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1169
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1244
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1347
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1482
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1570
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1862
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..7867
                     /gene="SYN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYN3"
                     /note="hexamer: AAGAAA"
     polyA_site      3135
                     /gene="SYN3"
                     /note="major polyA site"
     regulatory      6938..6943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYN3"
                     /note="hexamer: AATAAA"
     polyA_site      6958
                     /gene="SYN3"
                     /note="major polyA site"
     regulatory      7211..7216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYN3"
                     /note="hexamer: ACTAAA"
     polyA_site      7230
                     /gene="SYN3"
                     /note="major polyA site"
ORIGIN      
        1 agaggctgag ctcccgggac ccggagcgga tcgactggcg ggcgccgcgc cgaggcacca
       61 ccgggcgccg agttcctggc ggctcgcacg caggtaaata aaggcagcta aagctgactg
      121 ctggttgcgc aaaatccccc tggctcttct ggctaaagtc ctaccactcc ctgtacctgg
      181 cagcagcctg tcttctgggc ctcacctaca cacgtctggg taggagccag tcatctccat
      241 ccatccacag ccatgaattt cctccggcga cgtctctctg acagcagctt catggccaac
      301 ctgcctaatg gctatatgac ggacctgcaa cgcccagata gctccaccag ctcacctgct
      361 tcccccgcca tggagaggag gcacccccag cccctggctg cctccttctc ctctccagga
      421 tccagccttt ttagctccct ctccagtgcc atgaagcagg cccctcaggc cacctcagga
      481 ctgatggagc ctccaggtcc ctccacgccc attgttcaaa gacccaggat cctgttggtg
      541 atcgatgatg cccatacaga ctggtcgaag tatttccatg ggaagaaggt gaatggagag
      601 attgagatcc gagtggagca ggctgaattc tcagagttga acctagctgc ctatgtgacc
      661 gggggctgca tggtggacat gcaggtcgtg agaaatggga ccaaagtggt gagcagatcc
      721 ttcaagccag acttcatcct ggtccgccag catgcctaca gcatggccct gggggaagac
      781 taccgcagcc tggtcatcgg cctgcagtat ggagggctgc ctgctgtcaa ctctctctac
      841 tccgtctaca acttctgcag caagccctgg gtgttctctc agctcattaa gatcttccat
      901 tccctgggtc ctgagaagtt cccgcttgtg gagcaaacat ttttccccaa ccataagcca
      961 atggtcacag ccccacactt cccggtggta gtcaagctgg gacatgccca cgctggaatg
     1021 ggaaagatca aagtggaaaa ccagcttgac ttccaggaca tcaccagcgt ggtcgccatg
     1081 gccaaaacct acgccaccac cgaggccttc atcgactcca agtacgacat ccgcatccag
     1141 aaaattggat ccaactacaa ggcttacatg agaacctcca tctctgggaa ctggaaggcc
     1201 aacacaggct ctgccatgct ggagcaggtg gccatgacag agaggtacag gctgtgggtg
     1261 gacagctgct cggaaatgtt tggcggcctg gacatctgtg ccgtcaaggc tgtccacagc
     1321 aaggatggca gagattacat catcgaggta atggacagct caatgccgct gattggagag
     1381 catgtggaag aggacagaca gctgatggcc gaccttgttg tctccaaaat gagccagctc
     1441 ccgatgccag gaggcacagc gccctccccc ctcagacctt gggctccaca gattaaatca
     1501 gcgaaatccc cagggcaagc ccagctgggg cctcagctag gccagcccca gccacgccca
     1561 cctccgcaag gaggccctcg ccaagctcag tctcctcagc cccagagatc tggaagcccc
     1621 tcccaacaga ggctctcccc acaaggccag cagcccctga gcccccagtc cggatctcca
     1681 cagcagcaaa ggtcaccagg ctctccgcag ctatcccggg catccagtgg cagctcccca
     1741 aaccaggcct ccaagccagg tgccaccctc gcctcacagc cccggccccc tgtgcagggc
     1801 cgtagtacct cccagcaggg tgaagagtcc aagaagccag caccacccca tccgcatctc
     1861 aacaaatctc agtccctgac taacagcctc agcacatccg acacctccca gcgtgggacc
     1921 ccaagtgaag acgaggccaa ggctgaaacc atccgcaacc tgaggaagtc ttttgccagc
     1981 ctgttctctg actaacgcca tccaggctgg gaggggaaga gtgctctgct acactcgtcc
     2041 ccctcctgcc tcatcttcct tctcagcctt ggttcctgat gggaacagaa tggagggcct
     2101 gagaacatac tttctaaatg cctttgaccc aggaaccgat tatctatatt tgttcccatt
     2161 ttccttcacc gtgacattcc agcattgtct gactgtgagg tgggcctttg agagcctcca
     2221 ggttcctcaa aacaggcctg agcgatgggc atcacaccct ctgcctaccc acgtgcctgc
     2281 ttacctgcca gataaccaag tgagatgtct gcgagtggct agttttcaca ttcttactag
     2341 tgtttggctc acctttgggc aaaggccccc tctaggcctt gccccacctc catcaaacgc
     2401 agacactgta gtcagacctc agcaatatag gaggcaataa tcttttaaca gtgttttgca
     2461 aacaaacaaa aagagaaaaa tcccagccag gggaactcgc cacctgccca cgctagttcc
     2521 atccacgctc aagacccgcc cttagaccag gcaggcaaag gcccccatca cactcggcca
     2581 ctagtggggt cctgaggcca agaaagaaac cagaccctgt atgacaagtg gggtctttca
     2641 gaacacgaca gaaacagggg ggcccttgta atgccactca tactcagagc attattctta
     2701 tttggacagc caagggcaga tcacaggtta ttgtaggaat aaagactagt ttacaaagga
     2761 gaaagaggcc ctggacttcc caaggaaagg gtcaggttag ggctcctgta cccattctgt
     2821 tccaccactg tttgatctct ctggcctccc accaggaatg ccgtttcctt tttatggatc
     2881 tgttgggaac cagagagaat caacagatca atgacatagg atccgaagtg caatgatagt
     2941 cacttctagt ttggcatttc acaaactctg tacagcaagg tattggtagg ttactcaatt
     3001 tcaaaagggc cccatggcca aatatgttta ggaaccgctg tttgtatttc tttttttgga
     3061 gacgcattgt atataatata tgtcaaaggc tttcggaatt cctgcaggaa agaaatcagc
     3121 tttgttaaat ccaaactgat gatttgactc aataagttag ttgcagagct ggaaaaagta
     3181 gtctaactcc cttcccagtg ctctttcccc tataccagtc tgcctctcat gcttagacag
     3241 cgttcagcgg tgatccaaat caccaagcac ctggtgctgg aaacattgta ggtgccagaa
     3301 gcagcctcct ggtcccaaag agagcccaag atattagaac atagccatgt tagccccttg
     3361 cctcccactt cgcaacatga gacatgtctt ccttttgctg tccacaggga agggagagag
     3421 ggaggtaaaa atggaagtgg ctttggcctg gagcagcttc tagttatgcc caagcaatgt
     3481 agattgtttg gtaatcagcc aagatccatc caggttccca ggagcataaa agcaatcatc
     3541 tcctttttgg tccttcaaaa ccaaactgga gtggtgacgt cagggccaga gaccctctcc
     3601 ttctgtgggc attggatcac ttagaactct caacctcaga aaagcctgcc ttcaagctgg
     3661 cttttgacgg gctattggct ggagactggg tcagtattga aagtgctagc tgtgcacctg
     3721 gctgccagaa agccacttgg cctttaggac agtcctcttc acattgccct cttccctcac
     3781 tcatgatcag gtctggattt aagagcaaga gaccccagga taattcagaa gtcctctctc
     3841 tcctcctgtt caagactctt ggtctgggat tcaataataa gtagcagacc tgacataaga
     3901 aagatcagat aggtccaatt gccagtgact attgggagcc ataatttggc agctggagac
     3961 tggtaggctc aggcctgatt aacactggct aggatcagca gcaaataaaa tagccattgt
     4021 gtgaggtgag aggtgaagag gtgaaggcct ggtactcttt ctagcgccca aaaagcccac
     4081 cacccttact ctgtctccat gctcggctga gttccatgtt ataggacagt ccctgcatgt
     4141 ctggcatgtc tggagctcac tctgcccagt aacacatctc ccttcttttt gctcagcctg
     4201 tgcaatgcaa cagaactagt ctggccagga gctggcagaa tcctatccag aggcagctga
     4261 gatgatgcag tgggcagtca gacacatgaa gctgctgctt tgcaggcatc attgtcgaca
     4321 cattcttcta gacccccaag gtgggtggag gtgggggtcc tggggtcaat atcccacagt
     4381 catgcttggg ggaggtcagg tgatggcaag gaatagatca gaccatttat aatccggtag
     4441 aactttgctt catcctcctg ctgctgctca cttaattctt tcaccactcc cttggaattt
     4501 ctgaagaaag ccaagtgggg catagggaaa agagacggga ggtgaaattc aaaatatcag
     4561 atgtgggtac cttttaaagt tattctgtta aaagaaatct aacagaagag agtataaata
     4621 ttgattaaca taaggtttga tgattagcca gtgattctag gagtcccctt acacacacac
     4681 acacacacac acacacacac acgcctggac aataacttgg aattgacaaa tgcacatcct
     4741 aaaatcctgt cacctcgcta tgagttcata gttctctgat aaccggcttc aagaggagaa
     4801 tggcttcccc acttgccccc aagaagatag ggatcactag tataagtcac acgatgaaag
     4861 aaccagaata ccagcctctc agactggaag gttcctgggc ccttccccct tctttcctga
     4921 caagggcagg tgaggttccc ccattagaag gatctggggc actgcttata agagcagcct
     4981 gttacaagat tcaagcacag agagctatag gagttgaagt ttggtttctt ccacttaaaa
     5041 aaatatatat ccaccctcct tactcagggg tagacctttc aaatattaat aaataatgct
     5101 gtgtgacatc ctgaataaac gggtaagaga aaacttgtag ggcagggtgt aaccatgagg
     5161 tcctcaagtt tcaggagatt aagaacacag gaaacccctg tggcaatcgt ccctcttcaa
     5221 caatctcacc cagttttcac ttagtaataa aagacagctc aaaacataca actgaatggt
     5281 aataggctgg acaaagtttc tcaacctgtg ggccacggcc atgggcagag ctagttacaa
     5341 aggcagatga agcttcatgt cggactaaag gagtccgaat ttctggtcac aggacccaga
     5401 acctgcatct ttgtcaatct ccccactttg aatgcacttt gatgtgagac cagcaaacct
     5461 gagctgggct ctgtgggaaa gccactgcat gagaaacagt actgctacgg gtgtgctgca
     5521 gtctccaacg cagctacgaa cccactcctt tagtgagtga aactagtggc cccgtgaaca
     5581 atgaccacat ggcctaaatt ctcccatatt cctatattct gtcctttggc ctcagacaca
     5641 cctcagcatc caaaggatat ctcccagata ctccagtatc tgtgtacaac agccgcagaa
     5701 cctccttcca agctccaaat caggccaggc atcctgattt ttataaccat actcatatat
     5761 ccagatccat gacataacac tagtttatag ccaacacatt taaataattt ccccactggg
     5821 gccaggcgca gtggctcaca tcagtaatcc cagcactttg ggaggccgag gtgggcggat
     5881 gactaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccat ctctactaaa
     5941 aatataaaaa attagccggg cgtggtagcg ggcgcctgta gtcccagcta ctagggaggc
     6001 tgaggcagga gaatggcgtg aacccgggag gcggagcttg cagtgagccg agatcgcacc
     6061 actgcactcc agcctgggca acagagtgag actctgtctc aaaataataa taataataat
     6121 aataatactt tccccattgg tctgtgtatg aacataggaa ccaaggacac ataggtctca
     6181 tggcgaccct aaaatagtct gttctgtcac atagactagt acctgttcct tccaaacatg
     6241 taacctttaa taattgtgac attttgaaat gggaaagggc aaaaaggagg gagaggggag
     6301 tcatgctgta tagactctaa aatgttatgt ttgttgtttt tcttgctttg tttcacaact
     6361 ttgagccaga gagaggctag cattttccct ccaagctgac tcggggaagc tgaaacacaa
     6421 caaagaccta tttgatttgt tcacaatgaa cagggattta aaaacgcagc cttagcggac
     6481 agctctacca gccacagaaa agttcttcca gatcttcctc ccgtcagcgc gataaaatgg
     6541 taccgtactt tggttaaatg taaaatcagc tttccaggaa cagtggcata tcctttctct
     6601 tccatcagtt ccctagattc tcttcattac tacattctct agcctaacat tccgtccctg
     6661 ctgaattaac taatattcag atacattcaa gatagaacta acactcaatt ctatctttcc
     6721 aaaatttaag gggatgatag gtcttcactc acatggtaac aaacacagca gcaaacccca
     6781 taaaactgaa catcaactgc cttctggaag ttctcatctg gcaagctagt gcaggtatct
     6841 tgtgcatggg tcaagagagt gaagctcaga gcacattgct tggcacccag caggtgttca
     6901 ggacatgttt tagctcagcc ctcctagaaa actatgaaat aaaatccaaa caaaagtatt
     6961 aagattgaag taaaaagatg tttttctaag agtatcaata tatggaagtc acttgcccag
     7021 gaacagaatc aaacaaacca aaacccagta aaatgagata gagaaaagaa gcggaagaag
     7081 atcaatggca ggttttcaac ctcaaaaaga cctcttccaa actgaatctg aagaggaatg
     7141 ggaggaggca gaatgagaac atgagacctc tccttggggc ccctttcatg cgcgtctgtg
     7201 tgaagagacc actaaacagg ctttgtgtga gcaacatggc tgtttatttc acctgggtgc
     7261 aggccggatg agtccgaaaa gagagtcagc aaagggagta gggatggggc cgttttatag
     7321 gatttgggaa ggtaatggaa aattacatgc aaagggggtt gttctctggt gggcaggggc
     7381 gggggtcaca aggtgctcag tgcgggagct tctgagccag aagaaggaaa tttacagggt
     7441 taatcactca gttaaggtgg ggcaggaaca aatcacaatg gtggaatgtc atcagttaag
     7501 gcggggcagg gccttttcac ttcttttgtg attcttcagt tacttcaggc catctgggcg
     7561 tatacgcgca agtcacaggg gatgcgatgg cttggcttgg gctcagaggc ctgacattcc
     7621 tgccttctta tattaataag aaaaataaaa caaaatagtg ttgaagtgtt ggggcgacga
     7681 aaatttttgg ggggtggtat ggagagagaa tgggcgatgt ttctcagggc tgcttcgagt
     7741 gggattaggg gcggcgtggg aacctagagt gggagagatt aagctgaagg gaggtctcgt
     7801 ggtaaggggt gatattgtgg ggatgttaga agaaacattt gttgtgtaga atgattggtg
     7861 acggcct
//
