LOCUS       XM_005252147            5119 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens spleen associated tyrosine kinase (SYK),
            transcript variant X1, mRNA.
ACCESSION   XM_005252147
VERSION     XM_005252147.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005252147.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..5119
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /note="spleen associated tyrosine kinase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 49 ESTs, 1088 long SRA reads, 11 Proteins,
                     and 97% coverage of the annotated genomic feature by
                     RNAseq alignments, including 89 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:HGNC:11491"
                     /db_xref="MIM:600085"
     CDS             263..2170
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /codon_start=1
                     /product="tyrosine-protein kinase SYK isoform X1"
                     /protein_id="XP_005252204.1"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:HGNC:11491"
                     /db_xref="MIM:600085"
                     /translation="MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQS
                     RNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCL
                     LKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIAT
                     TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRI
                     DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL
                     PGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADK
                     GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM
                     KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEM
                     AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA
                     KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF
                     SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL
                     RLRNYYYDVVN"
ORIGIN      
        1 accccggcgg cggctggaga gcgaggagga gcgggtggcc ccgcgctgcg cccgccctcg
       61 cctcacctgg cgcaggtagg tgtggccgcg tcccctaccc ggccgggact ttctggtaag
      121 gagaggaggt tacggggaac gacgcgctgc tttcatgccc tttcttgttc taccttcatc
      181 ggccgaggta aaagtgctga aaccatgtga ataaaataca ggtggacacc tgcgcaggtg
      241 tgtgccctcc ggcccctgaa gcatggccag cagcggcatg gctgacagcg ccaaccacct
      301 gcccttcttt ttcggcaaca tcacccggga ggaggcagaa gattacctgg tccagggggg
      361 catgagtgat gggctttatt tgctgcgcca gagccgcaac tacctgggtg gcttcgccct
      421 gtccgtggcc cacgggagga aggcacacca ctacaccatc gagcgggagc tgaatggcac
      481 ctacgccatc gccggtggca ggacccatgc cagccccgcc gacctctgcc actaccactc
      541 ccaggagtct gatggcctgg tctgcctcct caagaagccc ttcaaccggc cccaaggggt
      601 gcagcccaag actgggccct ttgaggattt gaaggaaaac ctcatcaggg aatatgtgaa
      661 gcagacatgg aacctgcagg gtcaggctct ggagcaggcc atcatcagtc agaagcctca
      721 gctggagaag ctgatcgcta ccacagccca tgaaaaaatg ccttggttcc atggaaaaat
      781 ctctcgggaa gaatctgagc aaattgtcct gataggatca aagacaaatg gaaagttcct
      841 gatccgagcc agagacaaca acggctccta cgccctgtgc ctgctgcacg aagggaaggt
      901 gctgcactat cgcatcgaca aagacaagac agggaagctc tccatccccg agggaaagaa
      961 gttcgacacg ctctggcagc tagtcgagca ttattcttat aaagcagatg gtttgttaag
     1021 agttcttact gtcccatgtc aaaaaatcgg cacacaggga aatgttaatt ttggaggccg
     1081 tccacaactt ccaggttccc atcctgcgac ttggtcagcg ggtggaataa tctcaagaat
     1141 caaatcatac tccttcccaa agcctggcca cagaaagtcc tcccctgccc aagggaaccg
     1201 gcaagagagt actgtgtcat tcaatccgta tgagccagaa cttgcaccct gggctgcaga
     1261 caaaggcccc cagagagaag ccctacccat ggacacagag gtgtacgaga gcccctacgc
     1321 ggaccccgag gagatcaggc ccaaggaggt ttacctggac cgaaagctgc tgacgctgga
     1381 agacaaagaa ctgggctctg gtaattttgg aactgtgaaa aagggctact accaaatgaa
     1441 aaaagttgtg aaaaccgtgg ctgtgaaaat actgaaaaac gaggccaatg accccgctct
     1501 taaagatgag ttattagcag aagcaaatgt catgcagcag ctggacaacc cgtacatcgt
     1561 gcggatgatc gggatatgcg aggccgagtc ctggatgctg gttatggaga tggcagaact
     1621 tggtcccctc aataagtatt tgcagcagaa cagacatgtc aaggataaga acatcataga
     1681 actggttcat caggtttcca tgggcatgaa gtacttggag gagagcaatt ttgtgcacag
     1741 agatctggct gcaagaaatg tgttgctagt tacccaacat tacgccaaga tcagtgattt
     1801 cggactttcc aaagcactgc gtgctgatga aaactactac aaggcccaga cccatggaaa
     1861 gtggcctgtc aagtggtacg ctccggaatg catcaactac tacaagttct ccagcaaaag
     1921 cgatgtctgg agctttggag tgttgatgtg ggaagcattc tcctatgggc agaagccata
     1981 tcgagggatg aaaggaagtg aagtcaccgc tatgttagag aaaggagagc ggatggggtg
     2041 ccctgcaggg tgtccaagag agatgtacga tctcatgaat ctgtgctgga catacgatgt
     2101 ggaaaacagg cccggattcg cagcagtgga actgcggctg cgcaattact actatgacgt
     2161 ggtgaactaa ccgctcccgc acctgtcggt ggctgccttt gatcacagga gcaatcacag
     2221 gaaaatgtat ccagaggaat tgattgtcag ccacctccct ctgccagtcg ggagagccag
     2281 gcttggatgg aacatgccca caacttgtca cccaaagcct gtcccaggac tcaccctcca
     2341 caaagcaaag gcagtcccgg gagaaaagac ggatggcagg atccaagggg ctagctggat
     2401 ttgtttgttt tcttgtctgt gtgattttca tacaggttat ttttacgatc tgtttccaaa
     2461 tccctttcat gtctttccac ttctctgggt cccggggtgc atttgttact catcgggccc
     2521 agggacattg cagagtggcc tagagcactc tcaccccaag cggccttttc caaatgccca
     2581 aggatgcctt agcatgtgac tcctgaaggg aaggcaaagg cagaggaatt tggctgcttc
     2641 tacggccatg agactgatcc ctggccactg aaaagctttc ctgacaataa aaatgttttg
     2701 aggctttaaa aagaaaatca agtttgacca gtgcagtttc taagcatgta gccagttaag
     2761 gaaagaaaga aagaaaaaaa aaaaaggcct ggatactgct tttgctgtct ctgttatgag
     2821 atggaagact tacatgtttg tgataaaagg ggaccatgag aatgaattgg cttggcttac
     2881 tttccccctg aaatcctctc tcctgcagac tgtcttgaag acctggtgac tggtaaataa
     2941 agccctgcat ggaggctgca cagcaggggc aagaggccca tcccccagca tctcactgag
     3001 gacagcttca ggctgccttc ctctgaacgt ggtccacacc ttcctctcct ccacagagag
     3061 ggtgccgcca gaatcccctg tcgctttctg tgtctgcaat ggggggcagc acagggatca
     3121 aagccatcta aagagtttcc aaagaaagta ttaattcaga acaagccaaa gaccctgagc
     3181 ctcaccacaa acaggccttt tggagtgtga atttgagttg aagatacaag atcggagaat
     3241 gattttctgg tcttaactaa tcctcatctt catgtttgat ctttaagaag tcatcaccca
     3301 ttgatttcag ttttgctgta cctcttgaaa gttaaagaga catctcagca ctttaggagg
     3361 ccgaggcggg tggatcactt gaggtaagga gtttgagact agcctggcca atatggtaaa
     3421 accccatctc tactaaaaat acaaaaatta gccgggcatg gtggcatgtg tctgtagtcc
     3481 cagctactcg ggaggctgag gcaggagaat cgcttgaacc caggaaacgg aggtcgcagt
     3541 gagccaagat catgccactg cactccagct tgggcatcac agcgagactc tgtcaaaaca
     3601 aacaaacaaa aaaacaactt aaagaggtaa tttagccatc attcttatgc cagcagatat
     3661 aaataaactt ggacccatct ggtcttcagc taaacctgag acattttaaa gtgcatggac
     3721 agccatggac agcaggccct cctctaacag gggatgcaag gcatggagaa agacaatcag
     3781 tacccaagct cagccacaga agacaggagt cactcatata acttgtgttt agaagttttt
     3841 ggtagccacg cacactttct gaaatcacac tatctggtgg tttaatcata tttttaaaga
     3901 cagaatccct gagtgctgag cagattctca aaacacattt agaatccctg aaattagaaa
     3961 gatcaatgac aaaatatctg tcagccaggc cacaaacagg tgtaaaatta tgaaaggagt
     4021 ggttggatgt gccaagtttg gtaaagtggt gactgcatct gagaaagagg ctgtgaggct
     4081 gaactcttgg tggcttcctt ctgtaacttc cagagggagt cttcaacaca ggccccgtgc
     4141 tcgtaggaat acggtagcac ctatgtagga agtgcgtgga gttttctgtc ttctttctgt
     4201 gtgatttttg gcctttttat cagcacttct cccctcccag gagcctgggg atgccaaaca
     4261 tccagaatgt gatgggacaa gatgggggca ggggcctcac ctccctgcag aggtccggcc
     4321 aggtctcctt gtccctggac aatctcctga gcctctctgc ttggtggagc aggcacctgt
     4381 gtgcagaatt cccactgtgg ccagcacgag gaagtctttt ctagtgaaaa tgtgtcttgt
     4441 ggtcaggaat aattatcctt tcccctgtag ccaccaagga gggcaaatag agaaaggtaa
     4501 cctaattgaa ggattggtca tgtgaaaagg gctacatttg ggaagctggg aaaggcctcc
     4561 aggcttctag agcagctagc ttgggctgga ttctcatacc caggctgccc cttggattgt
     4621 tctacccaag cttttccctg gggtctgggc tcactccata aggtaaggtg ccttttacct
     4681 tatggtcctt ctttagcagg taacaaagga gcatcagggg caggctgccc tggtggcatc
     4741 acactggcta gtgaggccgt gaatatcttg tcccccagca gggccgacag tttctatcac
     4801 agaaaacagt gtgttcagtg gtgaaaatcg ttgcatgcat gttttcatct gagcgtgtcc
     4861 ttctcccata ctccctatca gccagccctg cctgtagctg ctgtatggtg attgcacttg
     4921 gacatcagtc caatgactgc aagtcggcct ggattttcac ttgcagaggc tacagctgca
     4981 ttgtcaggtc tcccagccct gcagagagct ccctccactg gttagcagtg tgttgtgttt
     5041 tccattcatt tcagaagagc tacattgtgt cactggacat ttttaaaaac tgtgattttt
     5101 aataaaaatt taaaatttg
//
