LOCUS       NM_003177               4973 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens spleen associated tyrosine kinase (SYK), transcript
            variant 1, mRNA.
ACCESSION   NM_003177
VERSION     NM_003177.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4973)
  AUTHORS   Zhou,Q., Tu,X., Hou,X., Yu,J., Zhao,F., Huang,J., Kloeber,J.,
            Olson,A., Gao,M., Luo,K., Zhu,S., Wu,Z., Zhang,Y., Sun,C., Zeng,X.,
            Schoolmeester,K.J., Weroha,J.S., Hu,X., Jiang,Y., Wang,L.,
            Mutter,R.W. and Lou,Z.
  TITLE     Syk-dependent homologous recombination activation promotes cancer
            resistance to DNA targeted therapy
  JOURNAL   Drug Resist Updat 74, 101085 (2024)
   PUBMED   38636338
  REMARK    GeneRIF: Syk-dependent homologous recombination activation promotes
            cancer resistance to DNA targeted therapy.
REFERENCE   2  (bases 1 to 4973)
  AUTHORS   Geng,R., Zhao,Y., Xu,W., Ma,X., Jiang,Y., Han,X., Zhao,L. and Li,Y.
  TITLE     SIRPB1 regulates inflammatory factor expression in the glioma
            microenvironment via SYK: functional and bioinformatics insights
  JOURNAL   J Transl Med 22 (1), 338 (2024)
   PUBMED   38594692
  REMARK    GeneRIF: SIRPB1 regulates inflammatory factor expression in the
            glioma microenvironment via SYK: functional and bioinformatics
            insights.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4973)
  AUTHORS   Mansouri,M., ElHaddoumi,G., Kandoussi,I., Belyamani,L., Ibrahimi,A.
            and El Hafidi,N.
  TITLE     Syk protein inhibitors treatment for the allergic symptoms
            associated with hyper immunoglobulin E syndromes: A focused on a
            computational approach
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241282030 (2024)
   PUBMED   39241232
  REMARK    GeneRIF: Syk protein inhibitors treatment for the allergic symptoms
            associated with hyper immunoglobulin E syndromes: A focused on a
            computational approach.
REFERENCE   4  (bases 1 to 4973)
  AUTHORS   Hong,J., Yuan,Y., Wang,J., Liao,Y., Zou,R., Zhu,C., Li,B.,
            Liang,Y., Huang,P., Wang,Z., Lin,W., Zeng,Y., Dai,J.L. and
            Chung,R.T.
  TITLE     Expression of variant isoforms of the tyrosine kinase SYK
            determines the prognosis of hepatocellular carcinoma
  JOURNAL   Cancer Res 74 (6), 1845-1856 (2014)
   PUBMED   24477596
  REMARK    GeneRIF: SYK(L) downregulation or SYK(S) elevation are strong
            predictors of poor survival in patients with hepatocellular
            carcinoma.
REFERENCE   5  (bases 1 to 4973)
  AUTHORS   Prinos,P., Garneau,D., Lucier,J.F., Gendron,D., Couture,S.,
            Boivin,M., Brosseau,J.P., Lapointe,E., Thibault,P., Durand,M.,
            Tremblay,K., Gervais-Bird,J., Nwilati,H., Klinck,R., Chabot,B.,
            Perreault,J.P., Wellinger,R.J. and Elela,S.A.
  TITLE     Alternative splicing of SYK regulates mitosis and cell survival
  JOURNAL   Nat Struct Mol Biol 18 (6), 673-679 (2011)
   PUBMED   21552259
  REMARK    GeneRIF: Exposure of cancer cells to epithelial growth factor
            modulated the SYK splicing pattern to promote the pro-survival
            isoform that is associated with cancer tissues in vivo.
REFERENCE   6  (bases 1 to 4973)
  AUTHORS   Mocsai,A., Ruland,J. and Tybulewicz,V.L.
  TITLE     The SYK tyrosine kinase: a crucial player in diverse biological
            functions
  JOURNAL   Nat Rev Immunol 10 (6), 387-402 (2010)
   PUBMED   20467426
  REMARK    Review article
REFERENCE   7  (bases 1 to 4973)
  AUTHORS   Wang,L., Duke,L., Zhang,P.S., Arlinghaus,R.B., Symmans,W.F.,
            Sahin,A., Mendez,R. and Dai,J.L.
  TITLE     Alternative splicing disrupts a nuclear localization signal in
            spleen tyrosine kinase that is required for invasion suppression in
            breast cancer
  JOURNAL   Cancer Res 63 (15), 4724-4730 (2003)
   PUBMED   12907655
  REMARK    GeneRIF: Nuclear Syk possesses biological activities associated
            with tumor suppression in mammary epithelial cells.
            Erratum:[Cancer Res. 2003 Oct 15;63(20):7004]
REFERENCE   8  (bases 1 to 4973)
  AUTHORS   Muller,B., Cooper,L. and Terhorst,C.
  TITLE     Molecular cloning of the human homologue to the pig
            protein-tyrosine kinase syk
  JOURNAL   Immunogenetics 39 (5), 359-362 (1994)
   PUBMED   8168854
REFERENCE   9  (bases 1 to 4973)
  AUTHORS   Chan,A.C., Iwashima,M., Turck,C.W. and Weiss,A.
  TITLE     ZAP-70: a 70 kd protein-tyrosine kinase that associates with the
            TCR zeta chain
  JOURNAL   Cell 71 (4), 649-662 (1992)
   PUBMED   1423621
REFERENCE   10 (bases 1 to 4973)
  AUTHORS   Hutchcroft,J.E., Harrison,M.L. and Geahlen,R.L.
  TITLE     Association of the 72-kDa protein-tyrosine kinase PTK72 with the B
            cell antigen receptor
  JOURNAL   J Biol Chem 267 (12), 8613-8619 (1992)
   PUBMED   1569106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001645.2, L28824.1,
            AL354862.12 and W33104.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003177.6.
            
            Summary: This gene encodes a member of the family of non-receptor
            type Tyr protein kinases. This protein is widely expressed in
            hematopoietic cells and is involved in coupling activated
            immunoreceptors to downstream signaling events that mediate diverse
            cellular responses, including proliferation, differentiation, and
            phagocytosis. It is thought to be a modulator of epithelial cell
            growth and a potential tumour suppressor in human breast
            carcinomas. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (Syk(L)). Both variants 1
            and 3 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.153341.1,
                                           SRR1803615.5550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375754.9/ ENSP00000364907.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BC001645.2         32-120
            90-2463             L28824.1           121-2494
            2464-4848           AL354862.12        145120-147504
            4849-4973           W33104.1           18-142              c
FEATURES             Location/Qualifiers
     source          1..4973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.2"
     gene            1..4973
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /note="spleen associated tyrosine kinase"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:HGNC:11491"
                     /db_xref="MIM:600085"
     exon            1..75
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            76..533
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2024
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /EC_number="2.7.10.2"
                     /note="isoform Syk(L) is encoded by transcript variant 1;
                     tyrosine-protein kinase SYK; spleen tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase SYK isoform Syk(L)"
                     /protein_id="NP_003168.2"
                     /db_xref="CCDS:CCDS6688.1"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:HGNC:11491"
                     /db_xref="MIM:600085"
                     /translation="MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQS
                     RNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCL
                     LKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIAT
                     TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRI
                     DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL
                     PGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADK
                     GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM
                     KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEM
                     AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA
                     KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF
                     SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL
                     RLRNYYYDVVN"
     exon            534..694
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            695..833
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            834..912
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            913..962
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1031
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1119
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1297
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1507
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1697
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1838
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1951
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..4973
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2540..2545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /note="hexamer: AATAAA"
     polyA_site      2571
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
     regulatory      4955..4960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /note="hexamer: AATAAA"
     polyA_site      4973
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /note="major polyA site"
ORIGIN      
        1 accccggcgg cggctggaga gcgaggagga gcgggtggcc ccgcgctgcg cccgccctcg
       61 cctcacctgg cgcaggtgga cacctgcgca ggtgtgtgcc ctccggcccc tgaagcatgg
      121 ccagcagcgg catggctgac agcgccaacc acctgccctt ctttttcggc aacatcaccc
      181 gggaggaggc agaagattac ctggtccagg ggggcatgag tgatgggctt tatttgctgc
      241 gccagagccg caactacctg ggtggcttcg ccctgtccgt ggcccacggg aggaaggcac
      301 accactacac catcgagcgg gagctgaatg gcacctacgc catcgccggt ggcaggaccc
      361 atgccagccc cgccgacctc tgccactacc actcccagga gtctgatggc ctggtctgcc
      421 tcctcaagaa gcccttcaac cggccccaag gggtgcagcc caagactggg ccctttgagg
      481 atttgaagga aaacctcatc agggaatatg tgaagcagac atggaacctg cagggtcagg
      541 ctctggagca ggccatcatc agtcagaagc ctcagctgga gaagctgatc gctaccacag
      601 cccatgaaaa aatgccttgg ttccatggaa aaatctctcg ggaagaatct gagcaaattg
      661 tcctgatagg atcaaagaca aatggaaagt tcctgatccg agccagagac aacaacggct
      721 cctacgccct gtgcctgctg cacgaaggga aggtgctgca ctatcgcatc gacaaagaca
      781 agacagggaa gctctccatc cccgagggaa agaagttcga cacgctctgg cagctagtcg
      841 agcattattc ttataaagca gatggtttgt taagagttct tactgtccca tgtcaaaaaa
      901 tcggcacaca gggaaatgtt aattttggag gccgtccaca acttccaggt tcccatcctg
      961 cgacttggtc agcgggtgga ataatctcaa gaatcaaatc atactccttc ccaaagcctg
     1021 gccacagaaa gtcctcccct gcccaaggga accggcaaga gagtactgtg tcattcaatc
     1081 cgtatgagcc agaacttgca ccctgggctg cagacaaagg cccccagaga gaagccctac
     1141 ccatggacac agaggtgtac gagagcccct acgcggaccc cgaggagatc aggcccaagg
     1201 aggtttacct ggaccgaaag ctgctgacgc tggaagacaa agaactgggc tctggtaatt
     1261 ttggaactgt gaaaaagggc tactaccaaa tgaaaaaagt tgtgaaaacc gtggctgtga
     1321 aaatactgaa aaacgaggcc aatgaccccg ctcttaaaga tgagttatta gcagaagcaa
     1381 atgtcatgca gcagctggac aacccgtaca tcgtgcggat gatcgggata tgcgaggccg
     1441 agtcctggat gctggttatg gagatggcag aacttggtcc cctcaataag tatttgcagc
     1501 agaacagaca tgtcaaggat aagaacatca tagaactggt tcatcaggtt tccatgggca
     1561 tgaagtactt ggaggagagc aattttgtgc acagagatct ggctgcaaga aatgtgttgc
     1621 tagttaccca acattacgcc aagatcagtg atttcggact ttccaaagca ctgcgtgctg
     1681 atgaaaacta ctacaaggcc cagacccatg gaaagtggcc tgtcaagtgg tacgctccgg
     1741 aatgcatcaa ctactacaag ttctccagca aaagcgatgt ctggagcttt ggagtgttga
     1801 tgtgggaagc attctcctat gggcagaagc catatcgagg gatgaaagga agtgaagtca
     1861 ccgctatgtt agagaaagga gagcggatgg ggtgccctgc agggtgtcca agagagatgt
     1921 acgatctcat gaatctgtgc tggacatacg atgtggaaaa caggcccgga ttcgcagcag
     1981 tggaactgcg gctgcgcaat tactactatg acgtggtgaa ctaaccgctc ccgcacctgt
     2041 cggtggctgc ctttgatcac aggagcaatc acaggaaaat gtatccagag gaattgattg
     2101 tcagccacct ccctctgcca gtcgggagag ccaggcttgg atggaacatg cccacaactt
     2161 gtcacccaaa gcctgtccca ggactcaccc tccacaaagc aaaggcagtc ccgggagaaa
     2221 agacggatgg caggatccaa ggggctagct ggatttgttt gttttcttgt ctgtgtgatt
     2281 ttcatacagg ttatttttac gatctgtttc caaatccctt tcatgtcttt ccacttctct
     2341 gggtcccggg gtgcatttgt tactcatcgg gcccagggac attgcagagt ggcctagagc
     2401 actctcaccc caagcggcct tttccaaatg cccaaggatg ccttagcatg tgactcctga
     2461 agggaaggca aaggcagagg aatttggctg cttctacggc catgagactg atccctggcc
     2521 actgaaaagc tttcctgaca ataaaaatgt tttgaggctt taaaaagaaa atcaagtttg
     2581 accagtgcag tttctaagca tgtagccagt taaggaaaga aagaaagaaa aaaaaaaaag
     2641 gcctggatac tgcttttgct gtctctgtta tgagatggaa gacttacatg tttgtgataa
     2701 aaggggacca tgagaatgaa ttggcttggc ttactttccc cctgaaatcc tctctcctgc
     2761 agactgtctt gaagacctgg tgactggtaa ataaagccct gcatggaggc tgcacagcag
     2821 gggcaagagg cccatccccc agcatctcac tgaggacagc ttcaggctgc cttcctctga
     2881 acgtggtcca caccttcctc tcctccacag agagggtgcc gccagaatcc cctgtcgctt
     2941 tctgtgtctg caatgggggg cagcacaggg atcaaagcca tctaaagagt ttccaaagaa
     3001 agtattaatt cagaacaagc caaagaccct gagcctcacc acaaacaggc cttttggagt
     3061 gtgaatttga gttgaagata caagatcgga gaatgatttt ctggtcttaa ctaatcctca
     3121 tcttcatgtt tgatctttaa gaagtcatca cccattgatt tcagttttgc tgtacctctt
     3181 gaaagttaaa gagacatctc agcactttag gaggccgagg cgggtggatc acttgaggta
     3241 aggagtttga gactagcctg gccaatatgg taaaacccca tctctactaa aaatacaaaa
     3301 attagccggg catggtggca tgtgtctgta gtcccagcta ctcgggaggc tgaggcagga
     3361 gaatcgcttg aacccaggaa acggaggtcg cagtgagcca agatcatgcc actgcactcc
     3421 agcttgggca tcacagcgag actctgtcaa aacaaacaaa caaaaaaaca acttaaagag
     3481 gtaatttagc catcattctt atgccagcag atataaataa acttggaccc atctggtctt
     3541 cagctaaacc tgagacattt taaagtgcat ggacagccat ggacagcagg ccctcctcta
     3601 acaggggatg caaggcatgg agaaagacaa tcagtaccca agctcagcca cagaagacag
     3661 gagtcactca tataacttgt gtttagaagt ttttggtagc cacgcacact ttctgaaatc
     3721 acactatctg gtggtttaat catattttta aagacagaat ccctgagtgc tgagcagatt
     3781 ctcaaaacac atttagaatc cctgaaatta gaaagatcaa tgacaaaata tctgtcagcc
     3841 aggccacaaa caggtgtaaa attatgaaag gagtggttgg atgtgccaag tttggtaaag
     3901 tggtgactgc atctgagaaa gaggctgtga ggctgaactc ttggtggctt ccttctgtaa
     3961 cttccagagg gagtcttcaa cacaggcccc gtgctcgtag gaatacggta gcacctatgt
     4021 aggaagtgcg tggagttttc tgtcttcttt ctgtgtgatt tttggccttt ttatcagcac
     4081 ttctcccctc ccaggagcct ggggatgcca aacatccaga atgtgatggg acaagatggg
     4141 ggcaggggcc tcacctccct gcagaggtcc ggccaggtct ccttgtccct ggacaatctc
     4201 ctgagcctct ctgcttggtg gagcaggcac ctgtgtgcag aattcccact gtggccagca
     4261 cgaggaagtc ttttctagtg aaaatgtgtc ttgtggtcag gaataattat cctttcccct
     4321 gtagccacca aggagggcaa atagagaaag gtaacctaat tgaaggattg gtcatgtgaa
     4381 aagggctaca tttgggaagc tgggaaaggc ctccaggctt ctagagcagc tagcttgggc
     4441 tggattctca tacccaggct gccccttgga ttgttctacc caagcttttc cctggggtct
     4501 gggctcactc cataaggtaa ggtgcctttt accttatggt ccttctttag caggtaacaa
     4561 aggagcatca ggggcaggct gccctggtgg catcacactg gctagtgagg ccgtgaatat
     4621 cttgtccccc agcagggccg acagtttcta tcacagaaaa cagtgtgttc agtggtgaaa
     4681 atcgttgcat gcatgttttc atctgagcgt gtccttctcc catactccct atcagccagc
     4741 cctgcctgta gctgctgtat ggtgattgca cttggacatc agtccaatga ctgcaagtcg
     4801 gcctggattt tcacttgcag aggctacagc tgcattgtca ggtctcccag ccctgcagag
     4861 agctccctcc actggttagc agtgtgttgt gttttccatt catttcagaa gagctacatt
     4921 gtgtcactgg acatttttaa aaactgtgat ttttaataaa aatttaaaat ttg
//
