LOCUS       NM_015484               1757 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SYF2 pre-mRNA splicing factor (SYF2), transcript
            variant 1, mRNA.
ACCESSION   NM_015484
VERSION     NM_015484.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Tanaka,I., Chakraborty,A., Saulnier,O., Benoit-Pilven,C.,
            Vacher,S., Labiod,D., Lam,E.W.F., Bieche,I., Delattre,O.,
            Pouzoulet,F., Auboeuf,D., Vagner,S. and Dutertre,M.
  TITLE     ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are
            involved in breast cancer cell resistance to doxorubicin
  JOURNAL   Nucleic Acids Res 48 (5), 2676-2693 (2020)
   PUBMED   31943118
  REMARK    GeneRIF: These data identify Aletrnative splicing programs
            controlled by ZRANB2 and SYF2 and converging on ECT2, that
            participate to breast cancer cell resistance to doxorubicin.
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Chen,Z.Y., Liu,H.Y., Jiang,N. and Yuan,J.M.
  TITLE     LncRNA HOST2 enhances gefitinib-resistance in non-small cell lung
            cancer by down-regulating miRNA-621
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (22), 9939-9946 (2019)
   PUBMED   31799663
  REMARK    GeneRIF: LncRNA HOST2 enhances gefitinib-resistance in non-small
            cell lung cancer by down-regulating miRNA-621.
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Zhang,S., Shi,W., Chen,Y., Xu,Z., Zhu,J., Zhang,T., Huang,W.,
            Ni,R., Lu,C. and Zhang,X.
  TITLE     Overexpression of SYF2 correlates with enhanced cell growth and
            poor prognosis in human hepatocellular carcinoma
  JOURNAL   Mol Cell Biochem 410 (1-2), 1-9 (2015)
   PUBMED   26260052
  REMARK    GeneRIF: SYF2 might play a regulatory role in the proliferation of
            hepatocellular carcinoma cells.
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Chu,P.C., Yang,Y.C., Lu,Y.T., Chen,H.T., Yu,L.C. and Chang,M.S.
  TITLE     Silencing of p29 affects DNA damage responses with UV irradiation
  JOURNAL   Cancer Res 66 (17), 8484-8491 (2006)
   PUBMED   16951160
  REMARK    GeneRIF: novel function of p29 in the regulation of DNA replication
            checkpoint responses in Hela cells.
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Chang,M.S., Chang,C.L., Huang,C.J. and Yang,Y.C.
  TITLE     p29, a novel GCIP-interacting protein, localizes in the nucleus
  JOURNAL   Biochem Biophys Res Commun 279 (2), 732-737 (2000)
   PUBMED   11118353
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR155437.1, BC010862.1 and
            AL031432.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015484.4.
            
            Summary: This gene encodes a nuclear protein that interacts with
            cyclin D-type binding-protein 1, which is thought to be a cell
            cycle regulator at the G1/S transition. Alternate transcriptional
            splice variants, encoding different isoforms, have been
            characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.285144.1,
                                           SRR3476690.1175308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000236273.9/ ENSP00000236273.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DR155437.1         23-31
            10-1354             BC010862.1         1-1345
            1355-1757           AL031432.1         83550-83952         c
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1757
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="SYF2 pre-mRNA splicing factor"
                     /db_xref="GeneID:25949"
                     /db_xref="HGNC:HGNC:19824"
                     /db_xref="MIM:607090"
     exon            1..59
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..767
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GCIP-interacting protein p29; CCNDBP1 interactor;
                     functional spliceosome-associated protein 29;
                     pre-mRNA-splicing factor SYF2; SYF2 homolog, RNA splicing
                     factor"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SYF2 isoform 1"
                     /protein_id="NP_056299.1"
                     /db_xref="CCDS:CCDS259.1"
                     /db_xref="GeneID:25949"
                     /db_xref="HGNC:HGNC:19824"
                     /db_xref="MIM:607090"
                     /translation="MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMR
                     NEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLE
                     ISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEF
                     FPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKF
                     NKKAERFYGKYTAEIKQNLERGTAV"
     exon            60..167
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            168..293
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            294..411
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            412..502
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            503..601
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1757
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      898..903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: AATAAA"
     polyA_site      923
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="major polyA site"
     regulatory      1019..1024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: ATTATA"
     polyA_site      1039
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
     regulatory      1327..1332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: AATAAA"
     polyA_site      1347
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="major polyA site"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: GATAAA"
     polyA_site      1663
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
     regulatory      1679..1684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: AATAGA"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: TATAAA"
     polyA_site      1704
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
     polyA_site      1712
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
                     /note="hexamer: ATTAAA"
     polyA_site      1757
                     /gene="SYF2"
                     /gene_synonym="CBPIN; fSAP29; NTC31; P29"
ORIGIN      
        1 cttgttgccg gaagtgggaa gagagaaagg ttgtgatggc ggctatagct gcatccgagg
       61 tgctggtgga cagcgcggag gaggggtccc tcgctgcggc ggcggagctg gccgctcaga
      121 agcgcgaaca gagactgcgc aaattccggg agctgcacct gatgcggaat gaagctcgta
      181 aattaaatca ccaggaagtt gtggaagaag ataaaagact aaaattacct gcaaattggg
      241 aagccaaaaa agctcgtttg gagtgggaac taaaggaaga ggaaaagaaa aaggaatgtg
      301 cggcaagagg agaagactat gagaaagtga agttgctgga gatcagtgca gaagatgcag
      361 aaagatggga gaggaaaaag aagaggaaaa accctgatct gggattttca gattatgctg
      421 ctgcccagtt acgccagtat catcggttga ccaagcagat caaacctgac atggaaacat
      481 atgagagact gagagaaaaa catggagaag agtttttccc aacatccaat agtcttcttc
      541 atggaacaca tgtgccttcc acagaggaaa ttgacaggat ggtcatagat ctggaaaaac
      601 agattgaaaa acgagacaaa tatagccgga gacgtcctta taatgatgat gcagatatcg
      661 actacattaa tgaaaggaat gccaaattca acaagaaagc tgaaagattc tatgggaaat
      721 acacagctga aattaaacag aatttggaaa gaggaacagc tgtctaatcc cttcaagaac
      781 tgtttataga agcttgagaa tggggtaaaa atttctgcta gcaaaatcaa gttctttttg
      841 aaattttatc agtaatccag aatttagtag tccatgcctt ctcactcagc atttagaaat
      901 aaaaatgtgg tttcttaaac gtatatcctt tcatgtatat ttccacattt ttgtgcttgg
      961 atataagatg tatttcttgt agtgaagttg ttttgtaatc tactttgtat acattctaat
     1021 tatattattt ttctatgtat tttaaatgta tatggctgtt taatctttga agcattttgg
     1081 gcttaagatt gccagcagca cacatcagat gcagtcattg ttgctatcag tgtggaattt
     1141 gatagagtct agactcgggc cacttggagt tgtgtactcc aaagctaagg acagtgatga
     1201 ggaagatggc agtggccacc ggaggactgg agcagtccct cctcatggcg gcctgtgacc
     1261 aaggtcgggg aggagtggag ctatccttcc atgatctgat catgtacagt tcccttttta
     1321 aaaagcaata aatgcttggg attagaattt ctaacatttt tagtctatca tttaaaacaa
     1381 acatttgtat atatacattt gtttatatac atacatgctt ccattctaca aacactgaaa
     1441 gaatatttta ttatgggaaa ttccatacac ccaatacccc tggtgagtcc catataccca
     1501 gtaccctgtt caacaatcat taactcatgg ccagtcctgc ttcatcttta tttccattta
     1561 ctttcttcat gactcttatt ttgacgcata tactagatat ataatttcat ctataattat
     1621 tttagtatgt atctctgaaa gataaagact taaatgacca caatactatt atcactgcaa
     1681 tagatttatt tttataaaac tccagaggga aaggttgtta ttttttctct atgttgaatt
     1741 aaatgctaaa tatctaa
//
