LOCUS       NM_032184               5466 bp    mRNA    linear   PRI 22-MAY-2024
DEFINITION  Homo sapiens synapse defective Rho GTPase homolog 2 (SYDE2), mRNA.
ACCESSION   NM_032184 XM_086186 XM_936457
VERSION     NM_032184.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5466)
  AUTHORS   Lo,H.F., Tsai,C.Y., Chen,C.P., Wang,L.J., Lee,Y.S., Chen,C.Y.,
            Liang,C.T., Cheong,M.L. and Chen,H.
  TITLE     Association of dysfunctional synapse defective 1 (SYDE1) with
            restricted fetal growth - SYDE1 regulates placental cell migration
            and invasion
  JOURNAL   J Pathol 241 (3), 324-336 (2017)
   PUBMED   27917469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603750.7.
            
            On Nov 23, 2018 this sequence version replaced NM_032184.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1306780.1,
                                           SRR11853566.1276.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341460.6/ ENSP00000340594.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-765               AL603750.7         59580-60344         c
            766-1461            AL603750.7         49385-50080         c
            1462-2564           AL603750.7         41426-42528         c
            2565-2691           AL603750.7         37474-37600         c
            2692-2873           AL603750.7         28372-28553         c
            2874-3105           AL603750.7         23854-24085         c
            3106-4682           AL603750.7         17001-18577         c
            4683-5466           AL603750.7         16217-17000         c
FEATURES             Location/Qualifiers
     source          1..5466
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..5466
                     /gene="SYDE2"
                     /note="synapse defective Rho GTPase homolog 2"
                     /db_xref="GeneID:84144"
                     /db_xref="HGNC:HGNC:25841"
                     /db_xref="MIM:620834"
     exon            1..765
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3605
                     /gene="SYDE2"
                     /note="protein syd-1 homolog 2; synapse defective 1, Rho
                     GTPase, homolog 2; synapse defective protein 1 homolog 2"
                     /codon_start=1
                     /product="rho GTPase-activating protein SYDE2"
                     /protein_id="NP_115560.1"
                     /db_xref="CCDS:CCDS44169.1"
                     /db_xref="GeneID:84144"
                     /db_xref="HGNC:HGNC:25841"
                     /db_xref="MIM:620834"
                     /translation="MHDLPPDSGARRGGRGLADHSFPAGARAPGQPPSRGAAYRRACP
                     RDGERGGGGRPRQQVSPPRSPQREPRGGQLRTPRMRPSCSRSLESLRVGAKPPPFQRW
                     PSDSWIRCGAHRDWDEPPPRGGRMDGWSGDRARAAAPTGLQPPGCKDHGCSSGSPFRD
                     PAGSSVIRSGKGDRQEGPSFLRPPAVTVKKLQKWMYKGRLLSLGMKGRARGTAPKVTG
                     TQAASPNVGALKVRENRVLSVPPDQRITLTDLFENAYGSSMKGRELEELKDNIEFRGH
                     KPLNSITVSKKRNWLYQSTLRPLNLEEENKKCQDRSHLSISPVSLPKHQLSQSFLKSS
                     KEYCTYVVCNATNSSLSKNCALDFNEENDADDEGEIWYNPIPEDDDLGISSALSFGEA
                     DSAVLKLPAVNLSMLSGSDLMKAERHTEDSLCSSEHAGDIQTTRSNGMNPIHPAHSTE
                     FVQQYKQKLGHKTQEGIMVEDSPMLKSPFAGSGILAATNSTELGIMEPSSPNPSPVKK
                     GSSINWSLPDKIKSPRTVRKLSMKMKKLPEFSRKLSVKGTLNYINSPDNTPSLSKYNC
                     REVHHTDILPSGNTTTAAKRNVISRYHLDTSVSSQQSYQKKNSMSSKYSCKGGYLSDG
                     DSPELTTKASKHGSENKFGKGKEIISNSCSKNEIDIDAFRHYSFSDQPKCSQYISGLM
                     SVHFYGAEDLKPPRIDSKDVFCAIQVDSVNKARTALLTCRTTFLDMDHTFNIEIENAQ
                     HLKLVVFSWEPTPRKNRVCCHGTVVLPTLFRVTKTHQLAVKLEPRGLIYVKVTLMEQW
                     ENSLHGLDINQEPIIFGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLC
                     GSAAVKKELREAFERDSKAVGLCENQYPDINVITGVLKDYLRELPSPLITKQLYEAVL
                     DAMAKSPLKMSSNGCENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNK
                     MTCQNLAVCFGPVLLSQRQEPSTHNNRVFTDSEELASALDFKKHIEVLHYLLQLWPVQ
                     RLTVKKSTDNLFPEQKSSLNYLRQKKERPHMLNLSGTDSSGVLRPRQNRLDSPLSNRY
                     AGDWSSCGENYFLNTKENLNDVDYDDVPSEDRKIGENYSKMDGPEVMIEQPIPMSKEC
                     TFQTYLTMQTVESTVDRKNNLKDLQESIDTLIGNLERELNKNKLNMSF"
     exon            766..1461
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2564
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2691
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2873
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3105
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..5466
                     /gene="SYDE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYDE2"
                     /note="hexamer: AATAAA"
     polyA_site      4414
                     /gene="SYDE2"
                     /note="major polyA site"
     regulatory      5441..5446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYDE2"
                     /note="hexamer: AATAAA"
     polyA_site      5466
                     /gene="SYDE2"
ORIGIN      
        1 attatctgct gatccaggcc atgcacgacc tgccccctga ctcgggcgcg cggcggggcg
       61 gcaggggctt ggcggatcac agcttccccg cgggagcccg ggctccgggc cagccgcctt
      121 cccgcggcgc cgcgtaccgc cgagcctgcc cccgggacgg ggagcgggga ggcggcggac
      181 gccctcggca gcaggtgtcc ccgccccggt cgcctcagag ggagccgcgg ggaggccagc
      241 tgcggactcc tcggatgcgg ccgtcctgca gcagaagcct cgagagcctc cgggtgggtg
      301 ccaagccgcc tcccttccag cggtggccga gcgacagctg gatcaggtgc ggcgcgcacc
      361 gggactggga cgagcccccg ccacgtggag gcaggatgga cggctggagt ggggaccgcg
      421 cccgggcggc tgcacccacc ggcctccagc ctccaggctg caaggaccac ggctgctcct
      481 cgggaagccc tttcagggat ccagcggggt cctctgtgat acgcagtggc aaaggagacc
      541 gccaggaagg cccctccttc ctcaggccgc cggcagtgac agtcaagaag ctgcagaagt
      601 ggatgtacaa agggcgtctg ctgtccctgg gaatgaaggg tcgtgcccgt gggacggctc
      661 ccaaagtcac aggaacgcag gcagcctccc caaatgtggg cgctttgaaa gtgcgtgaaa
      721 accgtgtcct gtcggtgcct ccagaccaaa gaattacgct gacagattta tttgaaaatg
      781 cctatgggtc ttcaatgaag ggaagagaac ttgaagagct gaaggataat attgaattca
      841 gaggtcataa gccacttaac agcatcactg tttcaaagaa acgcaattgg ctatatcaga
      901 gtactctgag gcctcttaat ctggaagaag aaaataagaa atgccaagat agaagtcatt
      961 tatccatctc acctgtgtct ctacctaaac atcagctatc acagtctttc ctcaaatcat
     1021 ctaaagagta ctgtacatat gtggtatgta acgctacaaa ctcttcatta tcgaaaaact
     1081 gtgctttaga ttttaatgag gaaaatgatg cagatgatga aggagaaata tggtacaatc
     1141 ccattcctga ggatgatgac cttggtatat caagtgcctt gagttttggt gaggccgact
     1201 ctgctgttct gaagctccct gctgtcaatt tgagcatgtt gtctggcagt gacctgatga
     1261 aagcagagcg gcatactgaa gactcactgt gctcttccga acatgcaggt gatattcaga
     1321 ccacacggtc aaatggaatg aatcctatac atcctgccca ttccacagaa tttgtgcagc
     1381 agtacaagca aaagctagga cacaagacac aagaaggtat aatggtggag gacagtccca
     1441 tgttgaaatc tccttttgca ggttctggga tcctggctgc tacaaatagt actgaattgg
     1501 gaattatgga accatcttct ccaaatccta gccctgtgaa aaaaggcagt tcaattaatt
     1561 ggtcattgcc agataaaata aaatctccac gaactgtgag gaaactttcc atgaaaatga
     1621 aaaagttgcc agaatttagc cgaaagctaa gcgttaaggg aacattgaat tatataaaca
     1681 gtccagataa tactccttct ttgtctaaat ataactgccg agaagttcat catactgata
     1741 ttctgccctc tgggaacaca accaccgctg ctaagaggaa tgttataagc cgataccatc
     1801 ttgataccag tgtatcctcc cagcagagct accagaagaa aaactctatg agttctaagt
     1861 attcctgcaa aggtggttac cttagtgatg gagactcacc tgaacttaca actaaagcta
     1921 gcaaacatgg atctgaaaac aaatttggaa aaggaaaaga aataatttca aatagttgta
     1981 gcaagaatga aatagacatt gatgctttta ggcattatag cttttctgat caacctaagt
     2041 gttcacagta catatctggg ctcatgagtg tacatttcta tggtgctgag gatttaaaac
     2101 cacctcggat agattcaaaa gacgtctttt gtgcaattca ggtagattca gtaaacaaag
     2161 caagaacagc tttgctcaca tgccgaacaa catttttaga catggatcac actttcaaca
     2221 tagaaattga aaatgcacaa catttgaaac tagtagtatt cagttgggaa cccactccaa
     2281 gaaaaaatcg agtttgttgt catggaactg ttgttcttcc caccttattt agagtgacaa
     2341 agactcatca gttggctgtc aaacttgaac ctagaggtct tatttatgtg aaagtgactc
     2401 ttatggaaca gtgggagaat tctcttcatg gactagatat aaaccaagaa ccaataatat
     2461 ttggagttga tattcaaaaa gttgtagaga aagaaaatat aggactgatg gtgccccttc
     2521 tgatacagaa atgtattatg gaaattgaaa agagaggctg tcaggtagta ggcctgtatc
     2581 gattatgtgg ttcggcagca gtcaagaaag aactgcgaga ggcttttgag agagatagca
     2641 aagctgttgg tctgtgtgaa aaccagtacc cagatataaa tgtaataaca ggtgttctta
     2701 aggattattt aagagaactc ccttctcctc tgataacaaa gcagctttat gaggctgtat
     2761 tagatgcaat ggcaaaaagt cctttgaaaa tgtcatcaaa tggttgtgag aatgacccag
     2821 gtgactctaa gtacactgtt gacctgctgg attgtctgcc agagattgag aaggcaaccc
     2881 taaagatgtt gttggatcat ttgaaattgg tggcttccta tcatgaagtg aataagatga
     2941 cgtgccagaa tttggctgtg tgctttggac cagtattatt aagtcagagg caagagcctt
     3001 ccacccataa caacagagtc tttactgatt cagaagaact tgcaagtgct ttggatttta
     3061 aaaaacacat tgaagttctt cattacttac tccaactctg gccagtgcag cgtttaactg
     3121 tcaaaaaatc aacagacaat ttattcccag agcagaagtc ttctctgaat tatctgaggc
     3181 agaagaaaga acgacctcat atgttaaatt tgagtggtac tgattcatca ggagtactta
     3241 ggccaaggca aaaccgatta gacagtccac ttagcaatcg ttatgcagga gactggagca
     3301 gctgtgggga aaactacttt ttaaatacaa aagaaaattt aaatgatgtg gattatgatg
     3361 atgtcccttc agaagataga aaaatcggag aaaattatag caaaatggat gggccagaag
     3421 taatgattga acagccaatt cccatgtcca aagagtgtac atttcagaca tatttgacaa
     3481 tgcagacagt tgagtctaca gtggatcgaa aaaacaatct caaagatcta caagaaagta
     3541 ttgatacttt gattggaaat ctggaacgtg agctcaacaa aaacaagctt aatatgagtt
     3601 tttgagattg agggtttttt tttgtaatgt cttaaagttt caaatctgtt tttgttttat
     3661 tttcttatac cacccacagc gatgttttca tttttttact cttgaaatct ttaattaatt
     3721 tttaataagt ttatctgatt caattaaaaa cactattcat taatacaatt tttacttatc
     3781 tcactagaaa acttttctgg ggatcaataa aacttggact tcttgggata ttttactaaa
     3841 tcttgccaac tctatggaga taactttcaa atgcacttaa gaaggttcac ataagttatt
     3901 agcccctcaa ggtttttctg ctttatggga accactcttc tgtagctgag acagatgtcc
     3961 ttttttttgt tgttttttga gacagagtct cactctgtcg cccaggctgg agtgcactgg
     4021 tgcgatctca ggtcactgca acctccacct ccctggttca agtgattctc ctgccacagc
     4081 ctcccgagta gctgtgatga cggggcccac caccatgccc agctaattat tgtattttta
     4141 gtaaagatgg ggtttcacca tgttggccag gctggtctcg aactcctgat ctcagatgat
     4201 ccgcccacct tggcctccca aagtgctggg attacaggcg tgagccactg cgcctggcct
     4261 ctagatgttc ttttagagga acatcacagc tgctcagtct gatttgcagt actggtcctg
     4321 gtacactgca acatcctttg gtcaaatttt atttgtaatg caaatgctgc tataagaaaa
     4381 tctttttata aataaaagtg aaattataca agtattaatg ttttctgtat taacagtaat
     4441 tatttaagct tataaaaatt aaatattttt ataatcctga aactgtatat atttataaat
     4501 gcatatatgt atagatatca ggatggggga ggggttattg tagaatcaca tgtattttta
     4561 aagtatatat gtcatgaggc caaaattatt atcttaaagt atttttttca gggaaagaac
     4621 atttaaatta aaggaggaat tacataaaaa cacttgaaca ataatactct agaagcatct
     4681 gaatagaaat aatagacttt ctttccttta ttcacagaaa gtcacaatgt cccctgggaa
     4741 aagtcatctt ttaaatttga aatcctctaa ctccttaagg gattaagtac ccagatttct
     4801 gcactggtga cttagattta ataaatctgc tcctgttcta tgcattttta tattctgctt
     4861 tgttttaatt atttatttgt agtagtacat ttataacatt gactttataa ttacccccat
     4921 ttgtttctaa atagtcttgc cagcatatta catgttactg atttttaaaa attaacttat
     4981 tttggctaag tatatataca atgttataga atcacagtaa tgtttgaaaa tgtaaattta
     5041 gaaggctttt gtattaaatc aaaatgtatt tttttaactt ttatatctac agaatatgta
     5101 attttaaaat tataaataga ctttaagtta ccaactttta agacatggca gccattgaaa
     5161 aactggcttc ctgatgtttt tctaaatatt aaagtactta aaatatttct atgcaataaa
     5221 tattgataaa cagacattat ttaatttgaa aacccattgt taaaaaagat aaatattttt
     5281 atatgaaatt ttcatttttt aaaactttgt gttaacaatt cagaagaata ccaagagaac
     5341 atatatattg agtaaacagt caaaggaaag tactcttgaa tgttttatag gaaagctgtc
     5401 tcagtttcct tccttttgtt gctatatcat gtatgaattg aataaattgc tctagaaatg
     5461 taaaaa
//
