LOCUS       NM_033025               3252 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens synapse defective Rho GTPase homolog 1 (SYDE1),
            transcript variant 1, mRNA.
ACCESSION   NM_033025
VERSION     NM_033025.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Lo,H.F., Tsai,C.Y., Chen,C.P., Wang,L.J., Lee,Y.S., Chen,C.Y.,
            Liang,C.T., Cheong,M.L. and Chen,H.
  TITLE     Association of dysfunctional synapse defective 1 (SYDE1) with
            restricted fetal growth - SYDE1 regulates placental cell migration
            and invasion
  JOURNAL   J Pathol 241 (3), 324-336 (2017)
   PUBMED   27917469
  REMARK    GeneRIF: a novel mechanism for GCM1 and SYDE1 in regulation of
            trophoblast cell migration and invasion during placental
            development
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Huang,R.Y., Kuay,K.T., Tan,T.Z., Asad,M., Tang,H.M., Ng,A.H.,
            Ye,J., Chung,V.Y. and Thiery,J.P.
  TITLE     Functional relevance of a six mesenchymal gene signature in
            epithelial-mesenchymal transition (EMT) reversal by the triple
            angiokinase inhibitor, nintedanib (BIBF1120)
  JOURNAL   Oncotarget 6 (26), 22098-22113 (2015)
   PUBMED   26061747
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Trifonova,E.A., Gabidulina,T.V., Ershov,N.I., Serebrova,V.N.,
            Vorozhishcheva,A.Y. and Stepanov,V.A.
  TITLE     Analysis of the placental tissue transcriptome of normal and
            preeclampsia complicated pregnancies
  JOURNAL   Acta Naturae 6 (2), 71-83 (2014)
   PUBMED   25093114
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Wentzel,C., Sommer,J.E., Nair,R., Stiefvater,A., Sibarita,J.B. and
            Scheiffele,P.
  TITLE     mSYD1A, a mammalian synapse-defective-1 protein, regulates
            synaptogenic signaling and vesicle docking
  JOURNAL   Neuron 78 (6), 1012-1023 (2013)
   PUBMED   23791195
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004794.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033025.5.
            
            Summary: The protein encoded by this gene is a Rho
            GTPase-activating protein highly expressed in placenta. The encoded
            protein is involved in cytoskeletal remodeling and trophoblast cell
            migration. Decreased expression of this gene has been associated
            with intrauterine growth restriction (IUGR). [provided by RefSeq,
            Feb 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123686.1, SRR14372079.3429777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342784.7/ ENSP00000341489.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC004794.1         26369-26489
            122-463             AC004794.1         28024-28365
            464-1108            AC004794.1         28672-29316
            1109-1323           AC004794.1         29489-29703
            1324-1450           AC004794.1         30281-30407
            1451-1611           AC004794.1         30600-30760
            1612-1837           AC004794.1         31314-31539
            1838-3252           AC004794.1         32528-33942
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..3252
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /note="synapse defective Rho GTPase homolog 1"
                     /db_xref="GeneID:85360"
                     /db_xref="HGNC:HGNC:25824"
                     /db_xref="MIM:617377"
     exon            1..121
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2241
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein SYDE1; protein syd-1 homolog 1;
                     synapse defective protein 1 homolog 1; synapse defective
                     1, Rho GTPase, homolog 1"
                     /codon_start=1
                     /product="rho GTPase-activating protein SYDE1 isoform 1"
                     /protein_id="NP_149014.3"
                     /db_xref="CCDS:CCDS12324.1"
                     /db_xref="GeneID:85360"
                     /db_xref="HGNC:HGNC:25824"
                     /db_xref="MIM:617377"
                     /translation="MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPE
                     PQAPEGSQAGAEGPSSPEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPG
                     TGEPAGEIWYNPIPEEDPRPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSP
                     GPARRLSIKMKKLPELRRRLSLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAG
                     PGGTRSPRAGYLSDGDSPERPAGPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLG
                     GLRPAPGATPRDLCCLLQVDGEARARTGPLRGGPDFLRLDHTFHLELEAARLLRALVL
                     AWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAKLTLSEQQEAPATAE
                     PRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDA
                     FERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVP
                     PTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ
                     APTRPRARSSGPGLASAVDFKHHIEVLHYLLQSWPDPRLPRQSPDVAPYLRPKRQPPL
                     HLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGRDFLPCGRDFLSGPDYDHVTGSD
                     SEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALILDLERELSKQINVCL"
     exon            122..463
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1108
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1323
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1450
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1611
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1837
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..3252
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /note="hexamer: AATAAA"
     polyA_site      3252
                     /gene="SYDE1"
                     /gene_synonym="7h3; SYD1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcactcgg ctcggcccgg cccgggccgc agcatggccg agccgctact caggaaaacc
       61 ttctcccgcc tgcggggccg ggagaaactt ccccggaaaa agtcggacgc caaggagcgc
      121 ggccacccag cccagcgccc agagcccagc cctccagagc cagagcccca ggctcccgaa
      181 gggtcccagg ccggagcaga ggggccctcc agccccgagg catcaaggag ccctgcacgg
      241 ggagcctacc tgcaaagcct ggagcccagt agccgccgat gggtgctggg tggggccaag
      301 ccagctgagg acacctcttt agggcctggg gtacctggca ctggggagcc cgccggcgag
      361 atctggtaca accccatccc tgaggaagac cccagacctc cagcacctga gcccccgggg
      421 ccacagcctg gctcagctga gtcagagggc ctggcccccc aaggtgcagc ccccgccagc
      481 cccccaacca aagcctcccg caccaagtcc ccgggccccg ccaggcgcct ctccataaag
      541 atgaagaagc tgccggaact gcggcgccgc ctgagcctgc gaggcccccg ggctggcagg
      601 gagcgcgaga gggctgcccc tgcgggctcc gtcatcagcc gctaccacct ggacagcagc
      661 gtggggggcc ccgggccggc agcagggcct gggggcaccc ggagcccgag ggccggttac
      721 ctcagcgacg gggactcacc ggagcgccca gctgggcccc catcacccac ctccttccgg
      781 ccctacgagg tgggtcccgc agcccgggca cccccggccg cactctgggg ccgcctcagc
      841 ctgcacctgt acggtctcgg ggggctgcgg ccagcgccgg gggccacccc cagggacctc
      901 tgctgcctac tgcaagtgga tggggaggcc agggcccgaa cagggccact gcgagggggg
      961 ccggacttcc tgcggctgga ccacaccttc cacctggagc tggaggccgc caggctcctg
     1021 cgcgccctgg tgcttgcgtg ggaccctggc gtgagaaggc accggccctg tgcccagggc
     1081 accgtgctgc tgcccacggt cttccgaggg tgccaggccc aacagctggc cgtgcgcctg
     1141 gagcctcagg ggctgctgta tgccaagctg accctgtcgg agcagcagga agcccctgcc
     1201 acagctgagc cccgcgtctt tgggctgccc ctgccactgc tggtggagcg ggagcggccc
     1261 cccggccagg tgcccctcat catccagaag tgcgttgggc agatcgagcg ccgagggctg
     1321 cgggtagtgg gactgtaccg tctttgtggc tcagcggcag tgaagaaaga gcttcgggat
     1381 gcctttgagc gggacagtgc agcggtctgc ctatctgagg acctgtaccc cgatatcaat
     1441 gtcatcactg gcatcctcaa ggattatctt cgagagttgc ccaccccact catcacccag
     1501 cccctgtata aggtggtact ggaggccatg gcccgggacc ccccaaacag agttcccccc
     1561 accactgagg gcacccgagg gctcctcagc tgcctgccag atgtggaaag ggccacgctg
     1621 acgcttctcc tggaccacct gcgcctcgtc tcctccttcc atgcctacaa ccgcatgacc
     1681 ccacagaact tggccgtgtg cttcgggcct gtgctgctgc cggcacgcca ggcgcccaca
     1741 aggcctcgtg cccgcagctc cggcccaggc cttgccagtg cagtggactt caagcaccac
     1801 atcgaggtgc tgcactacct gctgcagtct tggccagatc cccgcctgcc ccgacaatct
     1861 ccagatgtcg cgccttactt gcgacccaaa cgacagccac ctctgcacct gccgctggca
     1921 gaccccgaag tggtgactcg gccccgcggt cgaggaggcc ccgaaagccc cccgagcaac
     1981 cgctacgccg gcgactggag cgtttgcggg cgggacttcc tgccctgtgg gcgggatttc
     2041 ctgtccgggc cagactacga ccacgtgacg ggcagtgaca gcgaggacga ggacgaggag
     2101 gtcggcgagc cgagggtcac cggtgacttc gaagacgact tcgatgcgcc cttcaacccg
     2161 cacctgaatc tcaaagactt cgacgccctc atcctggatc tggagagaga gctctccaag
     2221 caaatcaacg tgtgcctctg agccagatga cggggtggga ccccggttag taaggaccgg
     2281 gcgcccagtg gctaaggcgg tgccctggtg accaaggaga gccagacctg ttgctcaggc
     2341 cgagctcctg gttgccagcg agttaccacg ggaccagtcg cgtgtatggc tgagactcat
     2401 tcccagtttc cagggcccgg tatttggaca ctagttgcca agtctggggc ctggggattt
     2461 tagggaccag cggttgtgac catctttcct gagcaccaag ggcttcccct tttgttgcca
     2521 aaaaggtagt tctcgcgctt gctaggctgg cctctcttgc ctccccttgg ccggggcaac
     2581 accagttact gtgagcatca ccctggtgtg gtgagtcacc tctagtcggc cctcttgctg
     2641 ctgccaacca aatcagtatt agctttgagc actgcactgt ttctccctcc cttggacgac
     2701 acaaagacta gcatgaggca ctgtttgtgg ggggcagccc ctatcctggg ttccagcatg
     2761 gacacagggg tagcctgggg cttatagaga aacagctggt ttcccctacc cttttccggg
     2821 gaagtcccca cgattggcct ctagtcagca aatggagata acagagtctg gcctttccaa
     2881 tccccatctc cttgcccccc ccttgccccc ccccccgaaa aaaattgagc acttaaaccc
     2941 ctcccttttg gagggggccc cctgaagcgt caggctgggg gcagtctggt acggaacata
     3001 tttattgcct ccatgcatgt gtgtgtgtgt ctgtgaggac tggtgtgcgt ggacacgtct
     3061 gaagcaggcg tgtggggctc tttcagggac cacagaggag ggagcagttt gcagtgccca
     3121 gccaccctga aatccccaat aatggtgcct cagtgggccc cagagttcca gtgggagagt
     3181 acggttccct cctgtctccc tcttcttttc cgcacctcca tctttgtgga taataaataa
     3241 atatgcacag gt
//
