LOCUS       NM_001177949            1119 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens synaptonemal complex protein 3 (SYCP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001177949
VERSION     NM_001177949.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Kobayashi,W., Hosoya,N., Machida,S., Miyagawa,K. and Kurumizaka,H.
  TITLE     SYCP3 regulates strand invasion activities of RAD51 and DMC1
  JOURNAL   Genes Cells 22 (9), 799-809 (2017)
   PUBMED   28745000
  REMARK    GeneRIF: SYCP3 binds to RAD51 and attenuates RAD51 activity during
            meiosis.
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Kitano,H., Chung,J.Y., Noh,K.H., Lee,Y.H., Kim,T.W., Lee,S.H.,
            Eo,S.H., Cho,H.J., Choi,C.H., Inoue,S., Hanaoka,J., Fukuoka,J. and
            Hewitt,S.M.
  TITLE     Synaptonemal complex protein 3 is associated with lymphangiogenesis
            in non-small cell lung cancer patients with lymph node metastasis
  JOURNAL   J Transl Med 15 (1), 138 (2017)
   PUBMED   28623914
  REMARK    GeneRIF: SCP3 is associated with lymphangiogenesis and provides
            insight into the SCP3-VEGF-C/VEGF-D axis based cancer therapy
            strategy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   de Boer,P., Giele,M., Lock,M.T., de Rooij,D.G., Giltay,J.,
            Hochstenbach,R. and te Velde,E.R.
  TITLE     Kinetics of meiosis in azoospermic males: a joint histological and
            cytological approach
  JOURNAL   Cytogenet Genome Res 105 (1), 36-46 (2004)
   PUBMED   15218256
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Miyamoto,T., Hasuike,S., Yogev,L., Maduro,M.R., Ishikawa,M.,
            Westphal,H. and Lamb,D.J.
  TITLE     Azoospermia in patients heterozygous for a mutation in SYCP3
  JOURNAL   Lancet 362 (9397), 1714-1719 (2003)
   PUBMED   14643120
  REMARK    GeneRIF: We suggest that SYCP3 has an essential meiotic function in
            human spermatogenesis that is compromised by the mutant protein via
            dominant negative interference.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 1119)
  AUTHORS   Mallon,A.M., Platzer,M., Bate,R., Gloeckner,G., Botcherby,M.R.,
            Nordsiek,G., Strivens,M.A., Kioschis,P., Dangel,A., Cunningham,D.,
            Straw,R.N., Weston,P., Gilbert,M., Fernando,S., Goodall,K.,
            Hunter,G., Greystrong,J.S., Clarke,D., Kimberley,C., Goerdes,M.,
            Blechschmidt,K., Rump,A., Hinzmann,B., Mundy,C.R., Miller,W.,
            Poustka,A., Herman,G.E., Rhodes,M., Denny,P., Rosenthal,A. and
            Brown,S.D.
  TITLE     Comparative genome sequence analysis of the Bpa/Str region in mouse
            and Man
  JOURNAL   Genome Res 10 (6), 758-775 (2000)
   PUBMED   10854409
REFERENCE   10 (bases 1 to 1119)
  AUTHORS   Chen,J., Silver,D.P., Walpita,D., Cantor,S.B., Gazdar,A.F.,
            Tomlinson,G., Couch,F.J., Weber,B.L., Ashley,T., Livingston,D.M.
            and Scully,R.
  TITLE     Stable interaction between the products of the BRCA1 and BRCA2
            tumor suppressor genes in mitotic and meiotic cells
  JOURNAL   Mol Cell 2 (3), 317-328 (1998)
   PUBMED   9774970
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC063950.37, AF492003.1 and
            BG201028.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001177949.1.
            
            Summary: This gene encodes an essential structural component of the
            synaptonemal complex. This complex is involved in synapsis,
            recombination and segregation of meiotic chromosomes. Mutations in
            this gene are associated with azoospermia in males and
            susceptibility to pregnancy loss in females. Alternate splicing
            results in multiple transcript variants that encode the same
            protein. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.173503.1,
                                           SRR5189667.105331.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392924.2/ ENSP00000376655.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC063950.37        19040-19088         c
            50-894              AF492003.1         1-845
            895-1119            BG201028.1         316-540
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..1119
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /note="synaptonemal complex protein 3"
                     /db_xref="GeneID:50511"
                     /db_xref="HGNC:HGNC:18130"
                     /db_xref="MIM:604759"
     exon            1..112
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            113..262
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..840
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /codon_start=1
                     /product="synaptonemal complex protein 3"
                     /protein_id="NP_001171420.1"
                     /db_xref="CCDS:CCDS9087.1"
                     /db_xref="GeneID:50511"
                     /db_xref="HGNC:HGNC:18130"
                     /db_xref="MIM:604759"
                     /translation="MVSSGKKYSRKSGKPSVEDQFTRAYDFETEDKKDLSGSEEDVIE
                     GKTAVIEKRRKKRSSAGVVEDMGGEVQNMLEGVGVDINKALLAKRKRLEMYTKASLKT
                     SNQKIEHVWKTQQDQRQKLNQEYSQQFLTLFQQWDLDMQKAEEQEEKILNMFRQQQKI
                     LQQSRIVQSQRLKTIKQLYEQFIKSMEELEKNHDNLLTGAQNEFKKEMAMLQKKIMME
                     TQQQEIASVRKSLQSMLF"
     exon            263..329
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            330..364
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            365..482
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            483..582
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            583..681
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..786
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1119
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /note="hexamer: AATAAA"
     polyA_site      1119
                     /gene="SYCP3"
                     /gene_synonym="COR1; RPRGL4; SCP3; SPGF4"
                     /note="major polyA site"
ORIGIN      
        1 agaagcgtcg cggagaaggg gccacctcag gtgaagcgcg cttgtggagg agttgtggag
       61 gacgcctgtc gacgaccagt aactggtcct cggccattgc ggtgtgtttc agtcaggaag
      121 catctaaata tggtgtcctc cggaaaaaag tattccagga aatctgggaa gccgtctgtg
      181 gaagatcagt ttacgagagc ctatgacttt gagactgaag ataagaaaga tctgagtgga
      241 tcagaggaag atgttattga agggaagact gcagtcattg agaaacgtag gaagaaaagg
      301 tcttctgcag gagtagttga agatatgggg ggtgaagtgc agaatatgct ggaaggagtt
      361 ggagttgaca ttaacaaggc tcttcttgcc aagagaaaga gactagaaat gtataccaag
      421 gcttctctca aaactagtaa ccagaaaatt gaacatgttt ggaaaacaca acaagatcaa
      481 aggcagaagc ttaaccaaga atattctcag cagtttctga ctttgtttca gcagtgggat
      541 ttagatatgc agaaagctga ggaacaagaa gaaaaaatac ttaatatgtt tcgacagcaa
      601 caaaagattc ttcaacaatc tagaattgtt cagagccaga gattgaaaac aattaaacag
      661 ttatatgagc agttcataaa gagtatggaa gagttggaga agaatcatga taatctactt
      721 actggtgcac aaaatgaatt taaaaaagaa atggctatgt tgcaaaaaaa aattatgatg
      781 gaaactcagc agcaagagat agcaagtgtt cggaagtctc ttcaatccat gttattctga
      841 tgactctttg aagaaagaac ttgaacctaa gtaatatgat acaattataa cgttagctaa
      901 gaagcatatt gtaagtcttt agaatagttt aattgtaaca tctttaatca taaacctgtt
      961 tcattgtaag acctcccttt ctgttaagtc aaatctaaat agttatgagt tagttagcaa
     1021 ctattcctaa agaatatgta ttaagctttc agctctttag taatgatagt gaatttttct
     1081 ctctaacact gtcaattaaa taaagacgat ttaatttta
//
