LOCUS       NM_003176               3462 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens synaptonemal complex protein 1 (SYCP1), transcript
            variant 1, mRNA.
ACCESSION   NM_003176
VERSION     NM_003176.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Nabi,S., Askari,M., Rezaei-Gazik,M., Salehi,N., Almadani,N.,
            Tahamtani,Y. and Totonchi,M.
  TITLE     A rare frameshift mutation in SYCP1 is associated with human male
            infertility
  JOURNAL   Mol Hum Reprod 28 (4) (2022)
   PUBMED   35377450
  REMARK    GeneRIF: A rare frameshift mutation in SYCP1 is associated with
            human male infertility.
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   Dunce,J.M., Dunne,O.M., Ratcliff,M., Millan,C., Madgwick,S.,
            Uson,I. and Davies,O.R.
  TITLE     Structural basis of meiotic chromosome synapsis through SYCP1
            self-assembly
  JOURNAL   Nat Struct Mol Biol 25 (7), 557-569 (2018)
   PUBMED   29915389
  REMARK    GeneRIF: SYCP1 has an obligate tetrameric structure in which an
            N-terminal four-helical bundle bifurcates into two elongated
            C-terminal dimeric coiled-coils. This building block assembles into
            a zipper-like lattice through two self-assembly sites. N-terminal
            sites undergo cooperative head-to-head assembly in the midline,
            while C-terminal sites interact back to back on the chromosome
            axis.
REFERENCE   3  (bases 1 to 3462)
  AUTHORS   Seo,E.K., Choi,J.Y., Jeong,J.H., Kim,Y.G. and Park,H.H.
  TITLE     Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals
            Non-Canonical Anti-Parallel Dimeric Structure of Transverse
            Filament at the Synaptonemal Complex
  JOURNAL   PLoS One 11 (8), e0161379 (2016)
   PUBMED   27548613
  REMARK    GeneRIF: Crystal structure of C-terminal coiled-coil domain of
            SYCP1 reveals non-canonical anti-parallel dimeric structure of
            transverse filament at the synaptonemal complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3462)
  AUTHORS   Park,H.H.
  TITLE     X-ray crystallographic studies of the middle part of the human
            synaptonemal complex protein 1 coiled-coil domain
  JOURNAL   Acta Crystallogr F Struct Biol Commun 71 (Pt 9), 1131-1134 (2015)
   PUBMED   26323297
  REMARK    GeneRIF: crystal structure of the middle part of the human
            synaptonemal complex protein 1 coiled-coil domain
REFERENCE   5  (bases 1 to 3462)
  AUTHORS   Litvinov,I.V., Cordeiro,B., Huang,Y., Zargham,H., Pehr,K.,
            Dore,M.A., Gilbert,M., Zhou,Y., Kupper,T.S. and Sasseville,D.
  TITLE     Ectopic expression of cancer-testis antigens in cutaneous T-cell
            lymphoma patients
  JOURNAL   Clin Cancer Res 20 (14), 3799-3808 (2014)
   PUBMED   24850846
  REMARK    GeneRIF: SYCP1, cTAGE1, and GTSF1 are expressed in cutaneous T-cell
            lymphoma, but not in normal skin or benign inflammatory dermatoses.
REFERENCE   6  (bases 1 to 3462)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   7  (bases 1 to 3462)
  AUTHORS   Tureci,O., Sahin,U., Zwick,C., Koslowski,M., Seitz,G. and
            Pfreundschuh,M.
  TITLE     Identification of a meiosis-specific protein as a member of the
            class of cancer/testis antigens
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5211-5216 (1998)
   PUBMED   9560255
REFERENCE   8  (bases 1 to 3462)
  AUTHORS   Meuwissen,R.L., Meerts,I., Hoovers,J.M., Leschot,N.J. and
            Heyting,C.
  TITLE     Human synaptonemal complex protein 1 (SCP1): isolation and
            characterization of the cDNA and chromosomal localization of the
            gene
  JOURNAL   Genomics 39 (3), 377-384 (1997)
   PUBMED   9119375
REFERENCE   9  (bases 1 to 3462)
  AUTHORS   Kondoh,N., Nishina,Y., Tsuchida,J., Koga,M., Tanaka,H., Uchida,K.,
            Inazawa,J., Taketo,M., Nozaki,M., Nojima,H., Matsumiya,K.,
            Namiki,M., Okuyama,A. and Nishimune,Y.
  TITLE     Assignment of synaptonemal complex protein 1 (SCP1) to human
            chromosome 1p13 by fluorescence in situ hybridization and its
            expression in the testis
  JOURNAL   Cytogenet Cell Genet 78 (2), 103-104 (1997)
   PUBMED   9371398
REFERENCE   10 (bases 1 to 3462)
  AUTHORS   Meuwissen,R.L., Offenberg,H.H., Dietrich,A.J., Riesewijk,A., van
            Iersel,M. and Heyting,C.
  TITLE     A coiled-coil related protein specific for synapsed regions of
            meiotic prophase chromosomes
  JOURNAL   EMBO J 11 (13), 5091-5100 (1992)
   PUBMED   1464329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI561137.1, BC126266.1 and AA868393.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003176.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026162.2, HM005504.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369522.8/ ENSP00000358535.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BI561137.1         66-128
            64-3202             BC126266.1         1-3139
            3203-3462           AA868393.1         8-267               c
FEATURES             Location/Qualifiers
     source          1..3462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..3462
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /note="synaptonemal complex protein 1"
                     /db_xref="GeneID:6847"
                     /db_xref="HGNC:HGNC:11487"
                     /db_xref="MIM:602162"
     exon            1..156
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..288
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3111
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 8; testicular tissue protein Li 191"
                     /codon_start=1
                     /product="synaptonemal complex protein 1 isoform 1"
                     /protein_id="NP_003167.2"
                     /db_xref="CCDS:CCDS879.1"
                     /db_xref="GeneID:6847"
                     /db_xref="HGNC:HGNC:11487"
                     /db_xref="MIM:602162"
                     /translation="MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTED
                     DFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGL
                     SRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL
                     KLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI
                     EKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQIT
                     EKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRS
                     VSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLR
                     TEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYEN
                     KQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELEN
                     EKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQ
                     ETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKA
                     LKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEV
                     EKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQ
                     EQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQT
                     FLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYT
                     VKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEETLKTLY
                     RNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIAKMDRKKKLKEAE
                     KLFV"
     exon            289..373
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..417
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..471
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..636
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..704
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..778
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..837
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..907
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..981
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1090
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1185
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1370
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1438
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1500
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1605
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1709
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1827
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1898
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1980
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2043
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2106
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2223
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2334
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2427
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2502
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2562
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2739
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2883
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2973
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3462
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3462
                     /gene="SYCP1"
                     /gene_synonym="CT8; HOM-TES-14; SCP-1; SCP1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcccacg cgctccgggc cgctcaggct gagcgatttc ccgccttttc tgaggttctg
       61 aggcgggagc cattggttct ttctgttgcc ctcatagacc gtatgtagca gttcgcgtgg
      121 gcacagaacc cacggtttcc cgctagttct tcaaagatat ttacaaccgt aacagagaaa
      181 atggaaaagc aaaagccctt tgcattgttc gtaccaccga gatcaagcag cagtcaggtg
      241 tctgcggtga aacctcagac cctgggaggc gattccactt tcttcaagag tttcaacaaa
      301 tgtactgaag atgattttga gtttccattt gcaaagacta atctctccaa aaatggggaa
      361 aacattgatt cagatcctgc tttacaaaaa gttaatttct tgcccgtgct tgagcaggtt
      421 ggtaattctg actgtcacta tcaggaagga ctaaaagact ctgatttgga gaattcagag
      481 ggattgagca gagtgtattc aaaactgtat aaggaggctg aaaagataaa aaaatggaaa
      541 gtaagtacag aagctgaact gagacagaaa gaaagtaagt tgcaagaaaa cagaaagata
      601 attgaagcac agcgaaaagc cattcaggaa ctgcaatttg gaaatgaaaa agtaagtttg
      661 aaattagaag aaggaataca agaaaataaa gatttaataa aagagaataa tgccacaagg
      721 catttatgta atctactcaa agaaacctgt gctagatctg cagaaaagac aaagaaatat
      781 gaatatgaac gggaagaaac caggcaagtt tatatggatc taaataataa cattgagaaa
      841 atgataacag cttttgagga acttcgtgtg caagctgaga attccagact ggaaatgcat
      901 tttaagttaa aggaagatta tgaaaaaatc caacaccttg aacaagaata caagaaggaa
      961 ataaatgaca aggaaaagca ggtatcacta ctattgatcc aaatcactga gaaagaaaat
     1021 aaaatgaaag atttaacatt tctgctagag gaatccagag ataaagttaa tcaattagag
     1081 gaaaagacaa aattacagag tgaaaactta aaacaatcaa ttgagaaaca gcatcatttg
     1141 actaaagaac tagaagatat taaagtgtca ttacaaagaa gtgtgagtac tcaaaaggct
     1201 ttagaggaag atttacagat agcaacaaaa acaatttgtc agctaactga agaaaaagaa
     1261 actcaaatgg aagaatctaa taaagctaga gctgctcatt cgtttgtggt tactgaattt
     1321 gaaactactg tctgcagctt ggaagaatta ttgagaacag aacagcaaag attggaaaaa
     1381 aatgaagatc aattgaaaat acttaccatg gagcttcaaa agaaatcaag tgagctggaa
     1441 gagatgacta agcttacaaa taacaaagaa gtagaacttg aagaattgaa aaaagtcttg
     1501 ggagaaaagg aaacactttt atatgaaaat aaacaatttg agaagattgc tgaagaatta
     1561 aaaggaacag aacaagaact aattggtctt ctccaagcca gagagaaaga agtacatgat
     1621 ttggaaatac agttaactgc cattaccaca agtgaacagt attattcaaa agaggttaaa
     1681 gatctaaaaa ctgagcttga aaacgagaag cttaagaata ctgaattaac ttcacactgc
     1741 aacaagcttt cactagaaaa caaagagctc acacaggaaa caagtgatat gaccctagaa
     1801 ctcaagaatc agcaagaaga tattaataat aacaaaaagc aagaagaaag gatgttgaaa
     1861 caaatagaaa atcttcaaga aacagaaacc caattaagaa atgaactaga atatgtgaga
     1921 gaagagctaa aacagaaaag agatgaagtt aaatgtaaat tggacaagag tgaagaaaat
     1981 tgtaacaatt taaggaaaca agttgaaaat aaaaacaagt atattgaaga acttcagcag
     2041 gagaataagg ccttgaaaaa aaaaggtaca gcagaaagca agcaactgaa tgtttatgag
     2101 ataaaggtca ataaattaga gttagaacta gaaagtgcca aacagaaatt tggagaaatc
     2161 acagacacct atcagaaaga aattgaggac aaaaagatat cagaagaaaa tcttttggaa
     2221 gaggttgaga aagcaaaagt aatagctgat gaagcagtaa aattacagaa agaaattgat
     2281 aagcgatgtc aacataaaat agctgaaatg gtagcactta tggaaaaaca taagcaccaa
     2341 tatgataaga tcattgaaga aagagactca gaattaggac tttataagag caaagaacaa
     2401 gaacagtcat cactgagagc atctttggag attgaactat ccaatctcaa agctgaactt
     2461 ttgtctgtta agaagcaact tgaaatagaa agagaagaga aggaaaaact caaaagagag
     2521 gcaaaagaaa acacagctac tcttaaagaa aaaaaagaca agaaaacaca aacattttta
     2581 ttggaaacac ctgaaattta ttggaaattg gattctaaag cagttccttc acaaactgta
     2641 tctcgaaatt tcacatcagt tgatcatggc atatccaaag ataaaagaga ctatctgtgg
     2701 acatctgcca aaaatacttt atctacacca ttgccaaagg catatacagt gaagacacca
     2761 acaaaaccaa aactacagca aagagaaaac ttgaatatac ccattgaaga aagtaaaaaa
     2821 aagagaaaaa tggcctttga atttgatatt aattcagata gttcagaaac tactgatctt
     2881 ttgagcatgg tttcagaaga agagacattg aaaacactgt ataggaacaa taatccacca
     2941 gcttctcatc tttgtgtcaa aacaccaaaa aaggcccctt catctctaac aacccctgga
     3001 tctacactga agtttggagc tataagaaaa atgcgggagg accgttgggc tgtaattgct
     3061 aaaatggata gaaaaaaaaa actaaaagaa gctgaaaagt tatttgttta atttcagaga
     3121 atcagtgtag ttaaggagcc taataacgtg aaacttatag ttaatatttt gttcttattt
     3181 gccagagcca aattttatct ggaagttgag acttaaaaaa tacttgcatg aatgatttgt
     3241 gtttctttat atttttagcc taaatgttaa ctacatattg tctggaaacc tgtcattgta
     3301 ttcagataat tagatgatta tatattgttg ttactttttc ttgtattcat gaaaactgtt
     3361 tttactaagt tttcaaattt gtaaagttag cctttgaatg ctaagaatgc attattgagg
     3421 gtcattcttt attctttact attaaaatat tttggatgca aa
//
