LOCUS       NM_001080468             576 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens syncollin (SYCN), mRNA.
ACCESSION   NM_001080468 XM_371167
VERSION     NM_001080468.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 576)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 576)
  AUTHORS   Makawita,S., Dimitromanolakis,A., Soosaipillai,A., Soleas,I.,
            Chan,A., Gallinger,S., Haun,R.S., Blasutig,I.M. and Diamandis,E.P.
  TITLE     Validation of four candidate pancreatic cancer serological
            biomarkers that improve the performance of CA19.9
  JOURNAL   BMC Cancer 13, 404 (2013)
   PUBMED   24007603
  REMARK    GeneRIF: Additional serum biomarkers, particularly SYCN and REG1B,
            when combined with CA19.9, show promise as improved diagnostic
            indicators of pancreatic cancer, which therefore warrants further
            validation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 576)
  AUTHORS   Antonin,W., Wagner,M., Riedel,D., Brose,N. and Jahn,R.
  TITLE     Loss of the zymogen granule protein syncollin affects pancreatic
            protein synthesis and transport but not secretion
  JOURNAL   Mol Cell Biol 22 (5), 1545-1554 (2002)
   PUBMED   11839820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC121075.2, BC039541.1 and BE045769.1.
            
            On Aug 5, 2019 this sequence version replaced NM_001080468.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE045769.1, BC039541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318438.7/ ENSP00000325564.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               BC121075.2         8-486
            480-570             BC039541.1         469-559
            571-576             BE045769.1         3-8                 c
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..576
                     /gene="SYCN"
                     /gene_synonym="INSSA1; SYL"
                     /note="syncollin"
                     /db_xref="GeneID:342898"
                     /db_xref="HGNC:HGNC:18442"
                     /db_xref="MIM:620140"
     exon            1..404
                     /gene="SYCN"
                     /gene_synonym="INSSA1; SYL"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..414
                     /gene="SYCN"
                     /gene_synonym="INSSA1; SYL"
                     /note="insulin synthesis associated 1; insulin
                     synthesis-associated protein 1"
                     /codon_start=1
                     /product="syncollin precursor"
                     /protein_id="NP_001073937.1"
                     /db_xref="CCDS:CCDS46070.1"
                     /db_xref="GeneID:342898"
                     /db_xref="HGNC:HGNC:18442"
                     /db_xref="MIM:620140"
                     /translation="MSPLRPLLLALALASVPCAQGACPASADLKHSDGTRTCAKLYDK
                     SDPYYENCCGGAELSLESGADLPYLPSNWANTASSLVVAPRCELTVWSRQGKAGKTHK
                     FSAGTYPRLEEYRRGILGDWSNAISALYCRCS"
     exon            405..576
                     /gene="SYCN"
                     /gene_synonym="INSSA1; SYL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      548..553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYCN"
                     /gene_synonym="INSSA1; SYL"
                     /note="hexamer: AATACA"
     polyA_site      576
                     /gene="SYCN"
                     /gene_synonym="INSSA1; SYL"
                     /note="major polyA site"
ORIGIN      
        1 actgccacca tgtccccgct gcgcccgctg ctgctggccc tggcccttgc ctccgtgcct
       61 tgcgcccagg gcgcctgccc cgcctccgcc gacctcaagc actcggacgg gacgcgcact
      121 tgcgccaagc tctatgacaa gagcgacccc tactatgaga actgctgcgg gggcgccgag
      181 ctgtcgctgg agtcgggcgc agacctgccc tacctgccct ccaactgggc caacaccgcc
      241 tcctcacttg tggtggcccc gcgctgcgag ctcaccgtgt ggtcccggca aggcaaggcg
      301 ggcaagacgc acaagttctc tgccggcacc tacccgcgcc tggaggagta ccgccggggc
      361 atcttaggag actggtccaa cgctatctcc gcgctctact gcaggtgcag ctgatgcatt
      421 gctggtctct catctgcagc ttccacagag tgccaagccc ctcactcagc ccatccctgg
      481 gctctgctcc ggggccccaa gacccaggag gaggagcgtt ctgcctgccc cctcccacct
      541 cccctgcaat acagcctttg tgcagttgtc cccgtc
//
