LOCUS       NM_001123225             462 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens synaptonemal complex central element protein 3
            (SYCE3), mRNA.
ACCESSION   NM_001123225 XM_927380
VERSION     NM_001123225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 462)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 462)
  AUTHORS   Schramm,S., Fraune,J., Naumann,R., Hernandez-Hernandez,A., Hoog,C.,
            Cooke,H.J., Alsheimer,M. and Benavente,R.
  TITLE     A novel mouse synaptonemal complex protein is essential for loading
            of central element proteins, recombination, and fertility
  JOURNAL   PLoS Genet 7 (5), e1002088 (2011)
   PUBMED   21637789
REFERENCE   5  (bases 1 to 462)
  AUTHORS   Wang,Z.Y., Tong,Q.S., Zeng,F.Q., Liu,Y., Gu,Z.H., Zheng,L.D.,
            Cai,J.B. and Jiang,G.S.
  TITLE     [Cloning and expression of a novel mouse testis gene TSEG-2]
  JOURNAL   Zhonghua Nan Ke Xue 15 (2), 99-105 (2009)
   PUBMED   19323366
  REMARK    GeneRIF: Cloning and expression analysis of a similar gene in
            mouse.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY041215.1 and BQ027928.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001123225.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ027928.1, HY000834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406915.4/ ENSP00000385480.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               HY041215.1         34-407
            375-462             BQ027928.1         16-103              c
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..462
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /note="synaptonemal complex central element protein 3"
                     /db_xref="GeneID:644186"
                     /db_xref="HGNC:HGNC:35245"
                     /db_xref="MIM:615775"
     exon            1..62
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..329
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /note="testis highly expressed gene 2 protein; testis
                     highly expressed protein 2"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 3"
                     /protein_id="NP_001116697.1"
                     /db_xref="CCDS:CCDS46733.1"
                     /db_xref="GeneID:644186"
                     /db_xref="HGNC:HGNC:35245"
                     /db_xref="MIM:615775"
                     /translation="MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAY
                     DMVVMRTNPTLAESMRRLEDAFVNCKEEMEKNWQELLHETKQRL"
     exon            63..171
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..462
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      441..446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /note="hexamer: AATAAA"
     polyA_site      462
                     /gene="SYCE3"
                     /gene_synonym="C22orf41; THEG2"
                     /note="major polyA site"
ORIGIN      
        1 cttgttcctc aagcggccgc tgggggcgcc agagcaggac cggagcgcgg gccaagctgg
       61 agatggatga tgctgaccct gaggaaagaa actatgacaa catgctgaaa atgctgtcag
      121 atctgaataa ggacttggaa aagctattag aagagatgga gaaaatctca gtgcaggcga
      181 cctggatggc ctatgacatg gtggtgatgc gcaccaaccc tacgctggcc gagtccatgc
      241 gtcggctgga ggatgccttc gtcaactgca aggaggagat ggagaagaac tggcaagagc
      301 tgctgcatga gaccaagcaa aggctgtagg ccccactggc ccaccacagc tgccatgcca
      361 ccctctgccc gtatgaagag gtcactgggg gatggagctg gcacccacat gaatagctgt
      421 atgcactgta cttgtttctt aataaactta tttttaagca ca
//
