LOCUS       NM_001105578            1248 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens synaptonemal complex central element protein 2
            (SYCE2), mRNA.
ACCESSION   NM_001105578
VERSION     NM_001105578.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1248)
  AUTHORS   Dunce,J.M., Salmon,L.J. and Davies,O.R.
  TITLE     Structural basis of meiotic chromosome synaptic elongation through
            hierarchical fibrous assembly of SYCE2-TEX12
  JOURNAL   Nat Struct Mol Biol 28 (8), 681-693 (2021)
   PUBMED   34373646
  REMARK    GeneRIF: Structural basis of meiotic chromosome synaptic elongation
            through hierarchical fibrous assembly of SYCE2-TEX12.
REFERENCE   2  (bases 1 to 1248)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1248)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1248)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1248)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 1248)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 1248)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1248)
  AUTHORS   Bolcun-Filas,E., Costa,Y., Speed,R., Taggart,M., Benavente,R., De
            Rooij,D.G. and Cooke,H.J.
  TITLE     SYCE2 is required for synaptonemal complex assembly, double strand
            break repair, and homologous recombination
  JOURNAL   J Cell Biol 176 (6), 741-747 (2007)
   PUBMED   17339376
REFERENCE   9  (bases 1 to 1248)
  AUTHORS   Costa,Y., Speed,R., Ollinger,R., Alsheimer,M., Semple,C.A.,
            Gautier,P., Maratou,K., Novak,I., Hoog,C., Benavente,R. and
            Cooke,H.J.
  TITLE     Two novel proteins recruited by synaptonemal complex protein 1
            (SYCP1) are at the centre of meiosis
  JOURNAL   J Cell Sci 118 (Pt 12), 2755-2762 (2005)
   PUBMED   15944401
REFERENCE   10 (bases 1 to 1248)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092069.2, DB449708.1,
            BC035819.2 and AD000092.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001105578.1.
            
            Summary: The protein encoded by this gene is part of the
            synaptonemal complex formed between homologous chromosomes during
            meiotic prophase. The encoded protein associates with SYCP1 and
            SYCE1 and is found only where chromosome cores are synapsed.
            [provided by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302373.1, DRR138512.481004.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293695.8/ ENSP00000293695.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC092069.2         70384-70404
            22-121              DB449708.1         5-104
            122-954             BC035819.2         70-902
            955-1248            AD000092.1         45321-45614         c
FEATURES             Location/Qualifiers
     source          1..1248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1248
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /note="synaptonemal complex central element protein 2"
                     /db_xref="GeneID:256126"
                     /db_xref="HGNC:HGNC:27411"
                     /db_xref="MIM:611487"
     exon            1..51
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..693
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 2"
                     /protein_id="NP_001099048.1"
                     /db_xref="CCDS:CCDS42509.1"
                     /db_xref="GeneID:256126"
                     /db_xref="HGNC:HGNC:27411"
                     /db_xref="MIM:611487"
                     /translation="MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPAS
                     ASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTK
                     VSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDL
                     CLQPEQSLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQATASEVQTNRDGEC
                     "
     exon            52..167
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..342
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..531
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..648
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..1248
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /note="hexamer: ATTAAA"
     polyA_site      954
                     /gene="SYCE2"
                     /gene_synonym="CESC1"
                     /note="major polyA site"
ORIGIN      
        1 gcagagggtg cgagcttgaa ggcgggaaaa tacggaatgg agcgacaggg agtggacgtg
       61 ccccatgtga aatgcaaaga ccaggaaccg cagcccttgg gggagagcaa ggagcatccg
      121 cggtgggaag agaactgcga ggaggaagct ggtggagggc cagctagtgc cagttgccag
      181 ctgacggtcc tggaagggaa gtcgggactc tacttctcct ctctggactc aagcattgac
      241 atcctgcaga agagagccca ggagctgatc gaaaacatca acaagagccg gcaaaaggac
      301 catgcactca tgaccaactt caggaacagc ctgaagacca aggtttcgga tctgacagag
      361 aaattagagg agaggatcta tcagatttat aatgaccaca acaagatcat ccaggaaaag
      421 ctccaagagt tcacccagaa aatggcaaag atcagccatt tggagacaga gctcaaacaa
      481 gtctgccaca gcgtggagac tgtgtacaaa gacctgtgtc tccagcctga gcagagccta
      541 agactcagat gggggccaga ccactctagg ggaaagtccc caccacgtcc cggcaactca
      601 cagcccccag acgtgttcgt ttcttctgtg gctgaaacta cttctcaggc cactgcttca
      661 gaagtacaga ccaacagaga tggtgaatgc tgacagctgc cgggagactc acgccttagt
      721 gacagtctcc aggagaagac tgtgaggcca ccatttgggc cacactgaga aattgttttt
      781 catggttcta taatgcatct tggcagaaaa aaacaaaaac ccaaagctcc ttgtgctgaa
      841 ctcccaaaat gtagcaagtc cagcccctgc cataggccca ggcttcgtgc tccccaccct
      901 tggcaagttc tccccacccc cagccccaca gtttattaaa tgtttgattt tcaacctggc
      961 cacgcttcct tgccacagag gctgaaagca cccctgagct ccaaggaaac acagcaagcc
     1021 ctttcttacc ctcgggaggg ataggaggga cagcacatcg gaagagcagt cacttgcctc
     1081 agctgacctc tgcccatctg aagccgcctc tcccagagaa tcccacaccc catgccctgg
     1141 tgtctcatcc tttgctcctc cccagctcct tgaagcagaa ggcagattgt agcctccttt
     1201 ttagagccaa ttctgtttac ttcctaaagt acaaacctat ttttttta
//
