LOCUS       NM_001099754            3083 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens syntabulin (SYBU), transcript variant 6, mRNA.
ACCESSION   NM_001099754
VERSION     NM_001099754.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3083)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3083)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3083)
  AUTHORS   Xu,J., Wang,N., Luo,J.H. and Xia,J.
  TITLE     Syntabulin regulates the trafficking of PICK1-containing vesicles
            in neurons
  JOURNAL   Sci Rep 6, 20924 (2016)
   PUBMED   26868290
  REMARK    GeneRIF: syntabulin forms a complex with PICK1 and ASICs, regulates
            ASIC protein expression in neurons, and participates in
            ASIC-induced acidotoxicity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3083)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 3083)
  AUTHORS   Cai,Q., Gerwin,C. and Sheng,Z.H.
  TITLE     Syntabulin-mediated anterograde transport of mitochondria along
            neuronal processes
  JOURNAL   J Cell Biol 170 (6), 959-969 (2005)
   PUBMED   16157705
REFERENCE   8  (bases 1 to 3083)
  AUTHORS   Funakoshi,E., Nakagawa,K.Y., Hamano,A., Hori,T., Shimizu,A.,
            Asakawa,S., Shimizu,N. and Ito,F.
  TITLE     Molecular cloning and characterization of gene for Golgi-localized
            syntaphilin-related protein on human chromosome 8q23
  JOURNAL   Gene 344, 259-271 (2005)
   PUBMED   15656992
REFERENCE   9  (bases 1 to 3083)
  AUTHORS   Su,Q., Cai,Q., Gerwin,C., Smith,C.L. and Sheng,Z.H.
  TITLE     Syntabulin is a microtubule-associated protein implicated in
            syntaxin transport in neurons
  JOURNAL   Nat Cell Biol 6 (10), 941-953 (2004)
   PUBMED   15459722
REFERENCE   10 (bases 1 to 3083)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB127917.1, AK096558.1, AB195676.1, BU607867.1 and AC079061.8.
            
            On Nov 22, 2018 this sequence version replaced NM_001099754.1.
            
            Summary: Syntabulin/GOLSYN is part of a kinesin motor-adaptor
            complex that is critical for the anterograde axonal transport of
            active zone components and contributes to activity-dependent
            presynaptic assembly during neuronal development (Cai et al., 2007
            [PubMed 17611281]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Variants 1-6 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096558.1, SRR14038191.2802682.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276646.14/ ENSP00000276646.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB127917.1         1-5
            6-723               AK096558.1         1-718
            724-2874            AB195676.1         885-3035
            2875-2885           BU607867.1         14-24               c
            2886-3083           AC079061.8         170459-170656
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.2"
     gene            1..3083
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="syntabulin"
                     /db_xref="GeneID:55638"
                     /db_xref="HGNC:HGNC:26011"
                     /db_xref="MIM:611568"
     exon            1..187
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2155
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="isoform a is encoded by transcript variant 6;
                     syntaxin-1-binding protein; Golgi-localized protein;
                     GOLSYN A protein; GOLSYN B protein; GOLSYN C protein;
                     microtubule-associated protein; implicated in syntaxin
                     trafficking in neurons; golgi-localized
                     syntaphilin-related protein; syntabulin
                     (syntaxin-interacting)"
                     /codon_start=1
                     /product="syntabulin isoform a"
                     /protein_id="NP_001093224.1"
                     /db_xref="CCDS:CCDS47912.1"
                     /db_xref="GeneID:55638"
                     /db_xref="HGNC:HGNC:26011"
                     /db_xref="MIM:611568"
                     /translation="MGPLRESKKEHRVQHHDKEISRSRIPRLILRPHMPQQQHKVSPA
                     SESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIG
                     FCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSEADFSSSSSTGSISAP
                     EVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNI
                     HPSYAPSSPSSSNSGSYKGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEV
                     TVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEI
                     KQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDF
                     PCDSPEKSLTLNPPLDTMADGLSLEEQVTGEGADRELLVGDSIANSTDLFDEIVTATT
                     TESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQSVLQ
                     KLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDA
                     EVHANRLMRELDFAACVEERLDGVIPLARGGVVRQYWSSSFLVDLLAVAAPVVPTVLW
                     AFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFRIKT"
     exon            188..392
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            393..590
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            591..693
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            694..897
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1047
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..3083
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="hexamer: AATAAA"
     regulatory      2854..2859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="hexamer: AATAAA"
     polyA_site      2874
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="major polyA site"
     polyA_site      2879
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="major polyA site"
     regulatory      3056..3061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="hexamer: AATAAA"
     polyA_site      3083
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
ORIGIN      
        1 agagcaatcg gcggcagtgg cggcggcggc gcgttggagc ctcaccaaga gccgccgccc
       61 gcagcccgcg ccggctcagc gcagtctcct cgctccgtgc tcgcaggtgc ctcctcctgg
      121 acggcggcag cggcggcgcg aggagccggc gggcagcggc gcgatggggc ccctccgcga
      181 gagcaagaag gagcacagag tgcagcatca tgacaaggag atttctcgaa gccgaattcc
      241 ccggttgatt cttcggcccc atatgcccca acaacagcac aaagtgtccc cagcctctga
      301 gtctcctttc tctgaggaag agagcagaga gttcaacccc agcagctctg ggcgctcagc
      361 gaggaccgtt agcagcaaca gcttctgctc agatgacaca ggctgtccta gcagccagtc
      421 agtgtctcct gtgaagacac cctcagatgc tggaaacagc cccattggct tttgccctgg
      481 aagtgatgaa ggcttcacca gaaagaaatg cacgattgga atggttggtg aaggaagcat
      541 tcagtcctct cgatataaga aggaatcaaa gtcaggcctt gtgaaaccag gtagtgaagc
      601 tgattttagc tcctcgagca gcacaggcag catttccgct cctgaggtcc atatgtcgac
      661 tgcgggaagc aagcggtctt cttcttcacg caatcgaggt cctcatgggc ggagtaatgg
      721 agcttcgtca cacaagcctg gcagcagccc atcatccccg cgggaaaagg accttctgtc
      781 catgctgtgc aggaatcagc tgagccctgt caatatccat cccagttatg caccttcttc
      841 cccaagcagt agcaactcag gctcctacaa aggaagcgac tgtagcccca tcatgaggcg
      901 ttctggaagg tacatgtctt gcggtgaaaa tcatggtgtc agacccccaa acccagagca
      961 gtatttgact ccactgcagc agaaagaggt gacagtgaga cacctcaaaa ccaagctgaa
     1021 ggaatctgag cgccgactcc atgaaaggga aagtgaaatc gtggagctta agtcccagct
     1081 ggcccgcatg cgagaggact ggattgagga ggagtgtcac cgggtagagg cccagttggc
     1141 actcaaagaa gccaggaaag agattaaaca gctcaaacag gtcatcgaaa ccatgcggag
     1201 cagcttggct gataaagata aaggcattca gaaatatttt gtggacataa acatccaaaa
     1261 caagaagctg gagtctctcc ttcagagcat ggagatggca cacagtggct ctctgaggga
     1321 cgaactgtgc ctagactttc catgtgattc cccagagaag agcttaaccc tcaacccccc
     1381 tcttgacaca atggcagatg ggttatctct ggaagagcag gtcacggggg aaggggctga
     1441 cagggagcta ctggtaggag atagcatagc caacagcaca gatttgttcg atgagatagt
     1501 gacagccacc accacagaat ctggtgacct ggagcttgtg cattccaccc ctggggctaa
     1561 cgtcctggag ctgctgccca tagtcatggg tcaggaggag ggcagtgtgg tggtggagcg
     1621 agccgttcag accgacgtgg tgccctacag cccagccatc tcagagctca ttcagagtgt
     1681 gctgcagaag ctccaggacc cctgtccctc gagcttggcg tcccctgatg agtctgaacc
     1741 agactcgatg gagagcttcc cagagtccct ctctgcctta gtggttgatt taactccaag
     1801 aaatccaaac tcagccatcc ttttgtctcc cgtggagacc ccctacgcca atgtggatgc
     1861 agaagttcat gcaaaccgcc tcatgagaga gctggatttt gcagcctgcg tggaagagag
     1921 gttggatggt gtcatcccac tggctcgcgg gggcgtcgtg aggcagtact ggagcagcag
     1981 cttcctggtg gatctcctgg ctgtggctgc ccccgtggtc cccacggttc tgtgggcatt
     2041 cagtactcag agagggggaa cggatcctgt gtataacatc ggggccttgc tcaggggctg
     2101 ttgcgtggtt gccctgcatt cgctccgccg caccgccttc cgtatcaaaa cctaaataga
     2161 agttgttgtt accgtgtgcc aatgtgtccc atgtgggttg tgccaggtag agaaacagga
     2221 agtcaatcat ctgtgacagt ctctattctg tcgttttgct ccttggtatt tgatttgcac
     2281 tatatttagt tgaagcctgt tcactgttta aaaccggagg tatcttcaaa ggcatggaga
     2341 cctggttcca gtaaatgtcc caccagtggg gtatagaaag catgctcatg accctgccgt
     2401 gtcgtctgag gtacccgttc ttatcctagt ggttcaggaa gagaaaacgc agtttgcact
     2461 ttcaagacag cttctctaag gctggcatgt tatctccttg ctttgctttt tgccgtttta
     2521 aaatgtgtaa ttgttccagc attccaatgg tcttgtgcat agcaggggac tgtaaccaaa
     2581 aataaacatg tatttgtgta attggtttga agaagtcttg aatagctctt tactgtctta
     2641 cttggggttg ataagatttg agtgtttgca attttttact aaatgtagct ccaaagtctt
     2701 aaatggcttg tttgttctta aactgttaat tgatgaaact gtgcataagt ttacaatgta
     2761 ctaacttatt ttgcttatta tatatagtgt tttattggaa attgtaacca cacacttcag
     2821 catgatgaaa ataaagatta gtgtttccat ttaaataaat gttttatcct cccataaaat
     2881 aataattatt tctgtgattt tacttctatg tataagaaag acaatgaata gcagatctta
     2941 catctttatc aatagggggt ctgtaaaaat tgaattaaat taggaagagg gaaaaagagt
     3001 tagttattaa agaaaatgaa gatttcctac ccttacttaa aaagcatcat ttctgaataa
     3061 aagtagattt gtttactttt aaa
//
