LOCUS       NM_001099749            2806 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens syntabulin (SYBU), transcript variant 14, mRNA.
ACCESSION   NM_001099749
VERSION     NM_001099749.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2806)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2806)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2806)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2806)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2806)
  AUTHORS   Xu,J., Wang,N., Luo,J.H. and Xia,J.
  TITLE     Syntabulin regulates the trafficking of PICK1-containing vesicles
            in neurons
  JOURNAL   Sci Rep 6, 20924 (2016)
   PUBMED   26868290
  REMARK    GeneRIF: syntabulin forms a complex with PICK1 and ASICs, regulates
            ASIC protein expression in neurons, and participates in
            ASIC-induced acidotoxicity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2806)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 2806)
  AUTHORS   Cai,Q., Gerwin,C. and Sheng,Z.H.
  TITLE     Syntabulin-mediated anterograde transport of mitochondria along
            neuronal processes
  JOURNAL   J Cell Biol 170 (6), 959-969 (2005)
   PUBMED   16157705
REFERENCE   8  (bases 1 to 2806)
  AUTHORS   Funakoshi,E., Nakagawa,K.Y., Hamano,A., Hori,T., Shimizu,A.,
            Asakawa,S., Shimizu,N. and Ito,F.
  TITLE     Molecular cloning and characterization of gene for Golgi-localized
            syntaphilin-related protein on human chromosome 8q23
  JOURNAL   Gene 344, 259-271 (2005)
   PUBMED   15656992
REFERENCE   9  (bases 1 to 2806)
  AUTHORS   Su,Q., Cai,Q., Gerwin,C., Smith,C.L. and Sheng,Z.H.
  TITLE     Syntabulin is a microtubule-associated protein implicated in
            syntaxin transport in neurons
  JOURNAL   Nat Cell Biol 6 (10), 941-953 (2004)
   PUBMED   15459722
REFERENCE   10 (bases 1 to 2806)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB195678.1, BU607867.1 and AC079061.8.
            
            On May 31, 2019 this sequence version replaced NM_001099749.1.
            
            Summary: Syntabulin/GOLSYN is part of a kinesin motor-adaptor
            complex that is critical for the anterograde axonal transport of
            active zone components and contributes to activity-dependent
            presynaptic assembly during neuronal development (Cai et al., 2007
            [PubMed 17611281]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (14) has multiple differences in
            the presence and absence of exons at its 5' end, compared to
            variant 1. These differences produce a unique 5' UTR and cause
            translation initiation at a downstream start codon, compared to
            variant 1. The encoded protein (isoform d) is shorter than isoform
            a. Variants 13-15 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.230192.1,
                                           SRR1803617.15939.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2597              AB195678.1         35-2631
            2598-2608           BU607867.1         14-24               c
            2609-2806           AC079061.8         170459-170656
FEATURES             Location/Qualifiers
     source          1..2806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.2"
     gene            1..2806
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="syntabulin"
                     /db_xref="GeneID:55638"
                     /db_xref="HGNC:HGNC:26011"
                     /db_xref="MIM:611568"
     exon            1..115
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            116..313
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1878
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="isoform d is encoded by transcript variant 14;
                     syntaxin-1-binding protein; Golgi-localized protein;
                     GOLSYN A protein; GOLSYN B protein; GOLSYN C protein;
                     microtubule-associated protein; implicated in syntaxin
                     trafficking in neurons; golgi-localized
                     syntaphilin-related protein; syntabulin
                     (syntaxin-interacting)"
                     /codon_start=1
                     /product="syntabulin isoform d"
                     /protein_id="NP_001093219.1"
                     /db_xref="CCDS:CCDS55271.1"
                     /db_xref="GeneID:55638"
                     /db_xref="HGNC:HGNC:26011"
                     /db_xref="MIM:611568"
                     /translation="MVGEGSIQSSRYKKESKSGLVKPGSEADFSSSSSTGSISAPEVH
                     MSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPS
                     YAPSSPSSSNSGSYKGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVR
                     HLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQL
                     KQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCD
                     SPEKSLTLNPPLDTMADGLSLEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTES
                     GDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQSVLQKLQ
                     DPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVH
                     ANRLMRELDFAACVEERLDGVIPLARGGVVRQYWSSSFLVDLLAVAAPVVPTVLWAFS
                     TQRGGTDPVYNIGALLRGCCVVALHSLRRTAFRIKT"
     exon            314..416
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            417..620
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            621..770
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     exon            771..2806
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2553..2558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="hexamer: AATAAA"
     regulatory      2577..2582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="hexamer: AATAAA"
     polyA_site      2597
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="major polyA site"
     polyA_site      2602
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="major polyA site"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
                     /note="hexamer: AATAAA"
     polyA_site      2806
                     /gene="SYBU"
                     /gene_synonym="GOLSYN; OCSYN; SNPHL"
ORIGIN      
        1 acccaacatt aggtcaccga gagagacagc agctcttgct cacacagctg ataggattag
       61 gagatggtgc tttgtcagcc ctgattgagc ccaagaaaac cccctgcata cacagatgac
      121 acaggctgtc ctagcagcca gtcagtgtct cctgtgaaga caccctcaga tgctggaaac
      181 agccccattg gcttttgccc tggaagtgat gaaggcttca ccagaaagaa atgcacgatt
      241 ggaatggttg gtgaaggaag cattcagtcc tctcgatata agaaggaatc aaagtcaggc
      301 cttgtgaaac caggtagtga agctgatttt agctcctcga gcagcacagg cagcatttcc
      361 gctcctgagg tccatatgtc gactgcggga agcaagcggt cttcttcttc acgcaatcga
      421 ggtcctcatg ggcggagtaa tggagcttcg tcacacaagc ctggcagcag cccatcatcc
      481 ccgcgggaaa aggaccttct gtccatgctg tgcaggaatc agctgagccc tgtcaatatc
      541 catcccagtt atgcaccttc ttccccaagc agtagcaact caggctccta caaaggaagc
      601 gactgtagcc ccatcatgag gcgttctgga aggtacatgt cttgcggtga aaatcatggt
      661 gtcagacccc caaacccaga gcagtatttg actccactgc agcagaaaga ggtgacagtg
      721 agacacctca aaaccaagct gaaggaatct gagcgccgac tccatgaaag ggaaagtgaa
      781 atcgtggagc ttaagtccca gctggcccgc atgcgagagg actggattga ggaggagtgt
      841 caccgggtag aggcccagtt ggcactcaaa gaagccagga aagagattaa acagctcaaa
      901 caggtcatcg aaaccatgcg gagcagcttg gctgataaag ataaaggcat tcagaaatat
      961 tttgtggaca taaacatcca aaacaagaag ctggagtctc tccttcagag catggagatg
     1021 gcacacagtg gctctctgag ggacgaactg tgcctagact ttccatgtga ttccccagag
     1081 aagagcttaa ccctcaaccc ccctcttgac acaatggcag atgggttatc tctggaagag
     1141 caggtcacgg gggaaggggc tgacagggag ctactggtag gagatagcat agccaacagc
     1201 acagatttgt tcgatgagat agtgacagcc accaccacag aatctggtga cctggagctt
     1261 gtgcattcca cccctggggc taacgtcctg gagctgctgc ccatagtcat gggtcaggag
     1321 gagggcagtg tggtggtgga gcgagccgtt cagaccgacg tggtgcccta cagcccagcc
     1381 atctcagagc tcattcagag tgtgctgcag aagctccagg acccctgtcc ctcgagcttg
     1441 gcgtcccctg atgagtctga accagactcg atggagagct tcccagagtc cctctctgcc
     1501 ttagtggttg atttaactcc aagaaatcca aactcagcca tccttttgtc tcccgtggag
     1561 accccctacg ccaatgtgga tgcagaagtt catgcaaacc gcctcatgag agagctggat
     1621 tttgcagcct gcgtggaaga gaggttggat ggtgtcatcc cactggctcg cgggggcgtc
     1681 gtgaggcagt actggagcag cagcttcctg gtggatctcc tggctgtggc tgcccccgtg
     1741 gtccccacgg ttctgtgggc attcagtact cagagagggg gaacggatcc tgtgtataac
     1801 atcggggcct tgctcagggg ctgttgcgtg gttgccctgc attcgctccg ccgcaccgcc
     1861 ttccgtatca aaacctaaat agaagttgtt gttaccgtgt gccaatgtgt cccatgtggg
     1921 ttgtgccagg tagagaaaca ggaagtcaat catctgtgac agtctctatt ctgtcgtttt
     1981 gctccttggt atttgatttg cactatattt agttgaagcc tgttcactgt ttaaaaccgg
     2041 aggtatcttc aaaggcatgg agacctggtt ccagtaaatg tcccaccagt ggggtataga
     2101 aagcatgctc atgaccctgc cgtgtcgtct gaggtacccg ttcttatcct agtggttcag
     2161 gaagagaaaa cgcagtttgc actttcaaga cagcttctct aaggctggca tgttatctcc
     2221 ttgctttgct ttttgccgtt ttaaaatgtg taattgttcc agcattccaa tggtcttgtg
     2281 catagcaggg gactgtaacc aaaaataaac atgtatttgt gtaattggtt tgaagaagtc
     2341 ttgaatagct ctttactgtc ttacttgggg ttgataagat ttgagtgttt gcaatttttt
     2401 actaaatgta gctccaaagt cttaaatggc ttgtttgttc ttaaactgtt aattgatgaa
     2461 actgtgcata agtttacaat gtactaactt attttgctta ttatatatag tgttttattg
     2521 gaaattgtaa ccacacactt cagcatgatg aaaataaaga ttagtgtttc catttaaata
     2581 aatgttttat cctcccataa aataataatt atttctgtga ttttacttct atgtataaga
     2641 aagacaatga atagcagatc ttacatcttt atcaataggg ggtctgtaaa aattgaatta
     2701 aattaggaag agggaaaaag agttagttat taaagaaaat gaagatttcc tacccttact
     2761 taaaaagcat catttctgaa taaaagtaga tttgtttact tttaaa
//
