LOCUS       NM_017673               3838 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SWT1 RNA endoribonuclease homolog (SWT1), transcript
            variant 1, mRNA.
ACCESSION   NM_017673
VERSION     NM_017673.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3838)
  AUTHORS   Anantharaman,V., Makarova,K.S., Burroughs,A.M., Koonin,E.V. and
            Aravind,L.
  TITLE     Comprehensive analysis of the HEPN superfamily: identification of
            novel roles in intra-genomic conflicts, defense, pathogenesis and
            RNA processing
  JOURNAL   Biol Direct 8, 15 (2013)
   PUBMED   23768067
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3838)
  AUTHORS   Ichikawa,S., Koller,D.L., Padgett,L.R., Lai,D., Hui,S.L.,
            Peacock,M., Foroud,T. and Econs,M.J.
  TITLE     Replication of previous genome-wide association studies of bone
            mineral density in premenopausal American women
  JOURNAL   J Bone Miner Res 25 (8), 1821-1829 (2010)
   PUBMED   20200978
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3838)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3838)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3838)
  AUTHORS   Skruzny,M., Schneider,C., Racz,A., Weng,J., Tollervey,D. and
            Hurt,E.
  TITLE     An endoribonuclease functionally linked to perinuclear mRNP quality
            control associates with the nuclear pore complexes
  JOURNAL   PLoS Biol 7 (1), e8 (2009)
   PUBMED   19127978
REFERENCE   6  (bases 1 to 3838)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030781.2, AF288392.1, AK000128.1, DB518900.1 and BI756018.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017673.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030781.2, AK291443.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367500.9/ ENSP00000356470.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               BC030781.2         11-292
            283-514             AF288392.1         137-368
            515-598             BC030781.2         525-608
            599-1444            AF288392.1         453-1298
            1445-1710           BC030781.2         1455-1720
            1711-2617           AF288392.1         1565-2471
            2618-3365           AK000128.1         625-1372
            3366-3801           DB518900.1         12-447
            3802-3838           BI756018.1         603-639
FEATURES             Location/Qualifiers
     source          1..3838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..3838
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="SWT1 RNA endoribonuclease homolog"
                     /db_xref="GeneID:54823"
                     /db_xref="HGNC:HGNC:16785"
                     /db_xref="MIM:619513"
     exon            1..148
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..241
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2860
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /codon_start=1
                     /product="transcriptional protein SWT1"
                     /protein_id="NP_060143.4"
                     /db_xref="CCDS:CCDS1367.1"
                     /db_xref="GeneID:54823"
                     /db_xref="HGNC:HGNC:16785"
                     /db_xref="MIM:619513"
                     /translation="MSSKESCGKKETSQRKDTTTSSPNFGEKDKKERKTPASSTSSSS
                     IRSVSSEKRKLKSDHTDVLYYNIKRRQGLKRLSVEIDTLRRRPKIGSSSQRPIKLKEA
                     SYSNDNQIILQSPSSNGTKKDIHKCVDFKPKDIKLTNAGSKLDHGIKSLSSPKIASDV
                     KPKAEGQASENKWSHLLVQREKMKELKKGRNSKFRDNSEKCVLEKWKRNQFSQDYNSN
                     KIIKEPLGSRRQKISFKIPIKSRDTLQKLVEENVFNIDSNNSKTKQEEREYLESSQVS
                     LNVTRQKTEHLLSDFTYKRTVHEWKRKHHYDHQESNDSHSRENLTQSFEAPCCSVSSE
                     SIQDADQEMQIVEELHAARVGKSVDLPGELMSMEIDLEDDVHSSSANNTSDRKLLIVI
                     DTNILMNHLKFVRILKTTEVPGFDKLVLIIPWVVMQELDRMKEGKLLKRAQHKAIPAV
                     HFINDSLKNQDRKLWGQSIQLASQKHYGLSDENNDDRVLKCCLQHQELFPCSFVILCT
                     DDRNLRNKGLISGVKSLSKEELSAELLHLSLNTDVCHQPCIPKQQLKAETTPLKESYK
                     EESTNSGLSILLESIVSDLEKSLGTGLSSILETEMKIAFGNLWMEILYLKPPWTLLHL
                     LQCFKKHWLAVFGLVMEKNLLLTIESLYKNLRKANKAVDFTTVKFLLQDSRSLLHAFS
                     TRSNYDGILPQTFAQVNNLLQTFAEVKTKLKPNSSENTVTKKQEGTSLKNSHNQEITV
                     FSSSHLPQPSRHQEIWSILESVWITIYQNSTDVFQRLGSNSALTTSNIASFEEAFICL
                     QKLMAAVRDILEGIQRILAPNSNYQDVETLYNFLIKYEVNKNVKFTAQEIYDCVSQTE
                     YREKLTIGCRQLVEMEYTMQQCNASVYMEAKNRGWCEDMLNYRI"
     exon            242..322
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..381
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..1123
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1183
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1295
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1397
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1586
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1680
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1826
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1990
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2129
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2278
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2466
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2598
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2665
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2730
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..3838
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="hexamer: AATAAA"
     polyA_site      3066
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="major polyA site"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="hexamer: AATAAA"
     polyA_site      3552
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="major polyA site"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="hexamer: AATAAA"
     polyA_site      3745
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="major polyA site"
     regulatory      3816..3821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
                     /note="hexamer: AATAAA"
     polyA_site      3838
                     /gene="SWT1"
                     /gene_synonym="C1orf26; HsSwt1"
ORIGIN      
        1 gagtaggtag tgcggatgcg ggcgcagaac tacgtttccc agcaggcata cagttggtgg
       61 ggcggggtgt gtgtgtgtgt tgggaggcgg gggtccctct cctttggctt ggggctccgg
      121 agttgccact gccgccggcg ctggtaagct tttcaggatg tccagcaaag aatcctgtgg
      181 gaaaaaagag acatctcaga ggaaagacac caccacctca tcacccaatt ttggtgaaaa
      241 agacaagaaa gagagaaaaa ccccagcaag ttctactagt tcatcttcta taagatcagt
      301 ttcatcagaa aagagaaaac tgaaatcaga tcatacagat gttctgtact ataatataaa
      361 aagaagacaa ggactgaaaa gattgagtgt agaaattgac actctcagaa ggagaccaaa
      421 aatcggttct tcatcccaaa gacctattaa actcaaagaa gcatcatatt caaatgataa
      481 tcaaattatt ttgcagagtc cttcttcaaa tggaactaaa aaagacatac ataaatgtgt
      541 agactttaaa cctaaagata tcaaattgac aaatgctggg agcaagcttg accatggaat
      601 taaaagcctt agtagtccta agattgccag tgatgtgaaa cctaaagccg aaggccaggc
      661 aagtgaaaat aaatggtctc atttacttgt tcagagagag aagatgaaag aactcaagaa
      721 aggaagaaac agtaaattta gagacaattc tgaaaaatgt gtcttagaga aatggaagag
      781 aaatcaattt tctcaggatt ataactccaa caagataatt aaggaaccct tgggatctag
      841 aagacagaag atcagtttca aaatccctat aaaatcccgt gacaccctcc agaaacttgt
      901 agaagaaaat gtcttcaaca tagattctaa taattcgaag actaagcagg aagaaagaga
      961 atacctggaa agctcccagg tttcattaaa tgtgactagg cagaaaactg aacatttact
     1021 ttcagatttt acatataagc ggactgttca tgagtggaaa cgaaaacatc attatgacca
     1081 tcaagaaagt aatgattcac attctaggga aaacctaacc cagagttttg aagcaccatg
     1141 ttgttccgtg tcatctgaaa gtatccagga tgcagatcaa gagatgcaga tagtagaaga
     1201 gcttcatgct gcacgtgtgg gaaaaagtgt ggatttacct ggagagttaa tgagtatgga
     1261 aattgactta gaagatgatg tacattcctc ctctgcaaat aatacttcag acagaaagct
     1321 tctaattgtt attgacacaa atattctgat gaatcatctc aaatttgtta gaattttgaa
     1381 gacaacagaa gtaccaggtt ttgacaaact tgtgttaata attccctggg tcgttatgca
     1441 agagctagat cgtatgaagg aaggaaaact actaaaacgt gcccagcaca aagctatacc
     1501 tgcagttcat ttcatcaacg acagtctcaa aaatcaagat agaaagctat ggggtcagtc
     1561 aatacaactt gcatcccaaa aacattatgg attgagtgat gagaacaatg atgatcgagt
     1621 actaaaatgc tgtctccagc accaggaatt attcccttgt tcttttgtta ttctgtgcac
     1681 ggatgataga aacttaagaa acaaaggcct aataagtggt gtgaagtcac tcagtaaaga
     1741 agaattgagt gcagagttat tacacttatc tctgaacaca gatgtgtgtc atcagccttg
     1801 tattcctaag caacagttga aagcagaaac aacacccttg aaagagagct ataaggagga
     1861 atctacaaat tctggactgt ccattctgct tgagagcatt gtatctgatc ttgaaaaatc
     1921 tcttggaaca ggtttatctt caatattaga aacagaaatg aaaattgctt ttggaaacct
     1981 ttggatggag atcctgtacc tgaaaccacc atggactcta ctacatttac tacagtgctt
     2041 taaaaaacat tggttggctg tatttggatt agttatggaa aagaacttgc ttttaactat
     2101 tgagagccta tacaaaaatc tccgtaaagc taataaggca gtggatttta caacagtcaa
     2161 attcttgctt caggattcta gaagtttgtt acatgctttc agtacaaggt caaattatga
     2221 tggtattctt ccacagacct ttgctcaagt aaacaacctc cttcagacat ttgcagaggt
     2281 caagacaaaa cttaagccaa attcttcaga aaacacagtg actaaaaagc aggaaggtac
     2341 ttcattgaag aattctcata atcaagaaat cactgttttc tcgagttctc atcttcccca
     2401 acccagcagg catcaagaaa tctggtctat cctagagagt gtttggatta caatatatca
     2461 gaacagcacg gatgtatttc aaagattggg ctcaaattca gctctgacta cttcaaatat
     2521 agcatcattt gaagaagcat ttatatgtct tcaaaagtta atggcagctg tgagggatat
     2581 tcttgaagga attcaaagga ttttggcccc aaacagtaat tatcaagatg ttgagaccct
     2641 ctataacttc ctaatcaagt atgaggtaaa taaaaatgtc aaatttactg cccaggaaat
     2701 ttatgattgt gtttctcaga ctgagtatag ggaaaagtta accattggat gccgccagct
     2761 ggttgagatg gaatatacca tgcagcagtg caatgcatct gtttatatgg aggccaaaaa
     2821 caggggatgg tgtgaagaca tgctcaacta taggatataa gtactgattt gtaactttaa
     2881 aggaattgca tttgtcctta agaataacag agtagttttc aatctggtca ctcttttggg
     2941 ccaaacccaa gagaatttta agaaatgttt cataggtata aaaaggtgat cgcctattac
     3001 tgacagtctc attgtagctc taaaaagcct aatgtatcca ctgtggaata aactccatag
     3061 actcaactct tctggagttc acaatgcctc cctacctcta ttcttgatag tgagccagta
     3121 tctctaagga aaggagagcc gtatttttag tcatcctagg gcaggagcca ctgtggcatc
     3181 tgaggaagac ccagggtaca gtattagcat ttctttcaac cctaagtatg ggcatgtgac
     3241 cagagacact gccaaaccct aagaaatcat tagggcatga tcatgctcac catatttcac
     3301 aaatgaaatc ttaatgtggg ctgtttttta tgatcaaact gtcatccatg ttgacctgat
     3361 gaaaataaca ccctccttca cctccctcag ggtaatgaaa gtagaaattt gactgaagct
     3421 cctacttcct tatacagcct ttccttctgt gggcttgtca cttttcagta catttctagt
     3481 ggggaagagc agggcgaccc ctctgctggg tttctcctta aatgtgaagc aaaataaatt
     3541 tatataatgg aatttggtgg cagtgactga tgtttgtctc tagctaaaac caactgttta
     3601 gttgactttt tagttatagg ataagttgga agtccttgtt tactggaata tattatgctt
     3661 ttgttaacac attagattaa atagaatttg gtattctatt ataaatgttt attttttaaa
     3721 gcaataaata acttattttt ggtaagattt ggctttttac ttccaaattg tttctgatat
     3781 gtacataagg tatgattata aaagtgactg tctgcaataa aagagaactt gttcagga
//
