LOCUS       NM_175871                921 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens SWIM-type zinc finger 7 associated protein 1 (SWSAP1),
            mRNA.
ACCESSION   NM_175871
VERSION     NM_175871.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 921)
  AUTHORS   Hengel,S.R., Oppenheimer,K.G., Smith,C.M., Schaich,M.A., Rein,H.L.,
            Martino,J., Darrah,K.E., Witham,M., Ezekwenna,O.C., Burton,K.R.,
            Van Houten,B., Spies,M. and Bernstein,K.A.
  TITLE     The human Shu complex promotes RAD51 activity by modulating RPA
            dynamics on ssDNA
  JOURNAL   Nat Commun 15 (1), 7197 (2024)
   PUBMED   39169038
  REMARK    GeneRIF: The human Shu complex promotes RAD51 activity by
            modulating RPA dynamics on ssDNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 921)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 921)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 921)
  AUTHORS   Martino,J., Brunette,G.J., Barroso-Gonzalez,J., Moiseeva,T.N.,
            Smith,C.M., Bakkenist,C.J., O'Sullivan,R.J. and Bernstein,K.A.
  TITLE     The human Shu complex functions with PDS5B and SPIDR to promote
            homologous recombination
  JOURNAL   Nucleic Acids Res 47 (19), 10151-10165 (2019)
   PUBMED   31665741
  REMARK    GeneRIF: our study uncovers a protein complex, which consists of
            SWS1, SWSAP1, SPIDR and PDS5B, involved in DNA repair and provides
            insight into Shu complex function and composition.
REFERENCE   5  (bases 1 to 921)
  AUTHORS   Matsuzaki,K., Kondo,S., Ishikawa,T. and Shinohara,A.
  TITLE     Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating
            the anti-recombinase FIGNL1 AAA+ ATPase
  JOURNAL   Nat Commun 10 (1), 1407 (2019)
   PUBMED   30926776
  REMARK    GeneRIF: SWSAP1 protects RAD51 filaments by antagonizing the
            anti-recombinase, FIGNL1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 921)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 921)
  AUTHORS   Liu,T., Wan,L., Wu,Y., Chen,J. and Huang,J.
  TITLE     hSWS1.SWSAP1 is an evolutionarily conserved complex required for
            efficient homologous recombination repair
  JOURNAL   J Biol Chem 286 (48), 41758-41766 (2011)
   PUBMED   21965664
  REMARK    GeneRIF: the human Shu complex (hSWS1.SWSAP1) has an evolutionarily
            conserved function in homologous recombination
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024575.6.
            
            On Aug 21, 2019 this sequence version replaced NM_175871.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU677559.1, BC068071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674460.1/ ENSP00000501355.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AC024575.6         49947-50210
            265-921             AC024575.6         50794-51450
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..921
                     /gene="SWSAP1"
                     /gene_synonym="C19orf39; SWS1AP1; ZSWIM7AP1"
                     /note="SWIM-type zinc finger 7 associated protein 1"
                     /db_xref="GeneID:126074"
                     /db_xref="HGNC:HGNC:26638"
                     /db_xref="MIM:614536"
     exon            1..264
                     /gene="SWSAP1"
                     /gene_synonym="C19orf39; SWS1AP1; ZSWIM7AP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..768
                     /gene="SWSAP1"
                     /gene_synonym="C19orf39; SWS1AP1; ZSWIM7AP1"
                     /note="SWS1-associated protein 1; zinc finger, SWIM-type
                     containing 7 associated protein 1; ZSWIM7-associated
                     protein 1"
                     /codon_start=1
                     /product="ATPase SWSAP1"
                     /protein_id="NP_787067.3"
                     /db_xref="CCDS:CCDS12259.2"
                     /db_xref="GeneID:126074"
                     /db_xref="HGNC:HGNC:26638"
                     /db_xref="MIM:614536"
                     /translation="MAETLRRVLTRGGAAWSGEENMPAAGPPLLLLGTPGSGKTALLF
                     AAALEAAGEGQGPVLFLTRRPLQSMPRGTGTTLDPMRLQKIRFQYPPSTRELFRLLCS
                     AHEAPGPAPSLLLLDGLEEYLAEDPEPQEAAYLIALLLDTAAHFSHRLGPGRDCGLMV
                     ALQTQEEAGSGDVLHLALLQRYFPAQCWLQPDAPGPGEHGLRACLEPGGLGPRTEWWV
                     TFRSDGEMMIAPWPTQAGDPSSGKGSSSGGQP"
     exon            265..921
                     /gene="SWSAP1"
                     /gene_synonym="C19orf39; SWS1AP1; ZSWIM7AP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      885
                     /gene="SWSAP1"
                     /gene_synonym="C19orf39; SWS1AP1; ZSWIM7AP1"
     polyA_site      921
                     /gene="SWSAP1"
                     /gene_synonym="C19orf39; SWS1AP1; ZSWIM7AP1"
                     /note="major polyA site"
ORIGIN      
        1 agagctacgc ggcgaatggc ggagacgctg aggcgggtgc taaccagggg cggtgcggcc
       61 tggtccgggg aggagaacat gcctgccgcc ggaccgcctt tgctgctgct cggtacacca
      121 ggatctggaa aaacagcgct gctatttgct gcggccctag aggcggcggg ggagggccaa
      181 ggcccagtcc tcttcctgac acgaaggcct cttcaaagca tgccccgcgg gaccggaacg
      241 actctagacc caatgcgact ccagaagatc cgcttccagt acccaccctc aacccgagag
      301 cttttccggc tcctgtgctc tgcccatgag gccccggggc cagccccctc ccttctgctg
      361 ctcgacggcc tagaagagta cctagcggaa gacccagagc cccaggaagc cgcctacctc
      421 attgccttac ttctagacac agctgcccac ttcagccacc ggcttgggcc tggccgggat
      481 tgtgggctca tggtggccct ccagacccag gaggaagcag gtagtgggga cgtcctgcac
      541 ctggcactgc tccagcggta ttttcctgcc cagtgctggc tgcagccaga tgcaccaggt
      601 ccaggagagc acggcctccg agcctgcctg gagccaggcg ggctgggccc cagaacagag
      661 tggtgggtga ctttccgatc agatggagaa atgatgatcg ctccgtggcc cacccaggct
      721 ggtgacccca gctcaggcaa gggttcaagc tctggaggcc agccctgagc tttggtgggt
      781 gactacctct ctgtgcttca gtttcccatg gctggaatac ttacctcagg gacatatgca
      841 gatccaaaga cctaaacaat gtaaagtgct ttttctcttt taaaagtata gcattatctt
      901 gtatatattt tacccaatca a
//
