LOCUS       NM_001318089             731 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SWI5 homologous recombination repair protein (SWI5),
            transcript variant 2, mRNA.
ACCESSION   NM_001318089 XM_011518654
VERSION     NM_001318089.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 731)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 731)
  AUTHORS   Yao,X.K., Pan,Z.P., Li,Y., Lun,Y.Z., Chi,Q., Jiang,S.J., Wang,F.
            and Sui,W.
  TITLE     Downregulation of SWI5 and CTC1 genes: hepatitis B virus DNA
            polymerase transactivated protein 1-mediated inhibition of DNA
            repair
  JOURNAL   Acta Virol 60 (2), 190-195 (2016)
   PUBMED   27265469
  REMARK    GeneRIF: HBV DNAPTP1 downregulated the expression of SWI5 and CTC1
            at translation level.
REFERENCE   3  (bases 1 to 731)
  AUTHORS   Yuan,J. and Chen,J.
  TITLE     FIGNL1-containing protein complex is required for efficient
            homologous recombination repair
  JOURNAL   Proc Natl Acad Sci U S A 110 (26), 10640-10645 (2013)
   PUBMED   23754376
REFERENCE   4  (bases 1 to 731)
  AUTHORS   Yuan,J. and Chen,J.
  TITLE     The role of the human SWI5-MEI5 complex in homologous recombination
            repair
  JOURNAL   J Biol Chem 286 (11), 9888-9893 (2011)
   PUBMED   21252223
  REMARK    GeneRIF: that human SWI5-MEI5 has an evolutionarily conserved
            function in homologous recombination repair.
REFERENCE   5  (bases 1 to 731)
  AUTHORS   Akamatsu,Y. and Jasin,M.
  TITLE     Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair
            through homologous recombination
  JOURNAL   PLoS Genet 6 (10), e1001160 (2010)
   PUBMED   20976249
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG541668.1 and AL590708.18.
            
            On Mar 27, 2020 this sequence version replaced NM_001318089.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CT003601.1, BU502470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000418976.3/ ENSP00000411469.3
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               BG541668.1         34-535
            503-731             AL590708.18        190066-190294
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..731
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /note="SWI5 homologous recombination repair protein"
                     /db_xref="GeneID:375757"
                     /db_xref="HGNC:HGNC:31412"
                     /db_xref="MIM:616528"
     exon            1..127
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..458
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (CUG) translation initiation codon; DNA repair
                     protein SWI5 homolog; HBV DNAPTP1-transactivated protein
                     A; protein SAE3 homolog; SWI5 recombination repair
                     homolog"
                     /codon_start=1
                     /product="DNA repair protein SWI5 homolog isoform 2"
                     /protein_id="NP_001305018.2"
                     /db_xref="CCDS:CCDS94496.1"
                     /db_xref="GeneID:375757"
                     /db_xref="HGNC:HGNC:31412"
                     /db_xref="MIM:616528"
                     /translation="MDPLAPLNPLIRGPRTPGLRRTEPRLTRSCRGAFRSPRPLPKSG
                     QADGTSEESLHLDIQKLKEKRDMLDKEISQFVSEGYSVDELEDHITQLHEYNDIKDVG
                     QMLMGKLAVIRGVTTKELYPEFGLDMND"
     exon            128..176
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /inference="alignment:Splign:2.1.0"
     exon            177..298
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..393
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /inference="alignment:Splign:2.1.0"
     exon            394..731
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /note="hexamer: AATAAA"
     polyA_site      731
                     /gene="SWI5"
                     /gene_synonym="C9orf119; SAE3"
                     /note="major polyA site"
ORIGIN      
        1 agttcacact ccgggtcaga gttcctggcc cggtgcacct gagaggtcgc tctccgactc
       61 ccgcgctgga ccctcttgcg ccattgaacc ccctgatccg ggggcctcgg accccagggc
      121 tcaggaggac tgaaccaaga cttacccgaa gttgccgcgg ggccttccga tcccctaggc
      181 cattgcccaa gtctggccag gctgatggga ccagcgagga gtctctgcac cttgacattc
      241 agaaactgaa ggagaagagg gacatgctgg acaaggagat ctcccagttc gtatctgaag
      301 gctacagtgt ggatgaactg gaggaccaca ttacccagct tcacgagtac aatgacatca
      361 aggatgtggg gcagatgctg atgggcaaac tagctgtgat ccgaggtgtc accaccaaag
      421 agttgtatcc agagtttggg ctggacatga atgactgagc aggctcatcg ccccttgtcc
      481 acagctccca gggacagaag ggtgtggaca tgataaacac tgagagccca accagcacac
      541 ctacagagtt tccagcgaga caatgccaga agcacttttc tagagagccc aagcccaatc
      601 aggaggaggc tagagaagag gcgggcaggg aggaaggggc gttcccagct ccaaggttcc
      661 tgaaatgtcg cagtgatact tgtgtagggg tacatgtact ttatttgtca ataaacgtat
      721 ctgtacactg a
//
