LOCUS       NM_015055               4884 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens switching B cell complex subunit SWAP70 (SWAP70),
            transcript variant 1, mRNA.
ACCESSION   NM_015055
VERSION     NM_015055.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4884)
  AUTHORS   Chang,C.Y., Pearce,G., Betaneli,V., Kapustsenka,T., Hosseini,K.,
            Fischer-Friedrich,E., Corbeil,D., Karbanova,J., Taubenberger,A.,
            Dahncke,B., Rauner,M., Furesi,G., Perner,S., Rost,F. and
            Jessberger,R.
  TITLE     The F-actin bundler SWAP-70 promotes tumor metastasis
  JOURNAL   Life Sci Alliance 7 (8), e202302307 (2024)
   PUBMED   38760173
  REMARK    GeneRIF: The F-actin bundler SWAP-70 promotes tumor metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4884)
  AUTHORS   Qian,Q., Hu,F., Yu,W., Leng,D., Li,Y., Shi,H., Deng,D., Ding,K.,
            Liang,C. and Liu,J.
  TITLE     SWAP70 Overexpression Protects Against Pathological Cardiac
            Hypertrophy in a TAK1-Dependent Manner
  JOURNAL   J Am Heart Assoc 12 (7), e028628 (2023)
   PUBMED   36974751
  REMARK    GeneRIF: SWAP70 Overexpression Protects Against Pathological
            Cardiac Hypertrophy in a TAK1-Dependent Manner.
REFERENCE   3  (bases 1 to 4884)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4884)
  AUTHORS   Betaneli,V. and Jessberger,R.
  TITLE     Mechanism of control of F-actin cortex architecture by SWAP-70
  JOURNAL   J Cell Sci 133 (2) (2020)
   PUBMED   31932501
  REMARK    GeneRIF: Mechanism of control of F-actin cortex architecture by
            SWAP-70.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4884)
  AUTHORS   Kriplani,N., Duncan,R.R. and Leslie,N.R.
  TITLE     SWAP70 undergoes dynamic conformational regulation at the leading
            edge of migrating cells
  JOURNAL   FEBS Lett 593 (4), 395-405 (2019)
   PUBMED   30636036
  REMARK    GeneRIF: Results show that SWAP70 regulates lamellipodia. SWAP70
            undergoes conformational regulation at the leading edge of
            migratory glioma cell line.
REFERENCE   6  (bases 1 to 4884)
  AUTHORS   Ihara,S., Oka,T. and Fukui,Y.
  TITLE     Direct binding of SWAP-70 to non-muscle actin is required for
            membrane ruffling
  JOURNAL   J Cell Sci 119 (Pt 3), 500-507 (2006)
   PUBMED   16418221
  REMARK    GeneRIF: the binding activity of SWAP-70 to non-muscle F-actin is
            required for membrane ruffling.
REFERENCE   7  (bases 1 to 4884)
  AUTHORS   Kimbara,N., Dohi,N., Miyamoto,M., Asai,S., Okada,H. and Okada,N.
  TITLE     Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells
  JOURNAL   Microbiol Immunol 50 (3), 235-242 (2006)
   PUBMED   16547421
  REMARK    GeneRIF: surface expression of SWAP-70 on HIV-1 infected cells as
            well as PBMCs; SWAP-70 may serve as a marker for T cell
            differentiation as well as for HIV-1 infection
REFERENCE   8  (bases 1 to 4884)
  AUTHORS   Hilpela,P., Oberbanscheidt,P., Hahne,P., Hund,M., Kalhammer,G.,
            Small,J.V. and Bahler,M.
  TITLE     SWAP-70 identifies a transitional subset of actin filaments in
            motile cells
  JOURNAL   Mol Biol Cell 14 (8), 3242-3253 (2003)
   PUBMED   12925760
  REMARK    GeneRIF: Overexpression of SWAP-70 altered the actin organization
            and lamellipodial morphology
REFERENCE   9  (bases 1 to 4884)
  AUTHORS   Rapalus,L., Minegishi,Y., Lavoie,A., Cunningham-Rundles,C. and
            Conley,M.E.
  TITLE     Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM
            syndrome and common variable immunodeficiency
  JOURNAL   Clin Immunol 101 (3), 270-275 (2001)
   PUBMED   11726218
  REMARK    GeneRIF: protein that functions as the only B cell-specific
            component of an isotype switch recombination
REFERENCE   10 (bases 1 to 4884)
  AUTHORS   Masat,L., Caldwell,J., Armstrong,R., Khoshnevisan,H.,
            Jessberger,R., Herndier,B., Wabl,M. and Ferrick,D.
  TITLE     Association of SWAP-70 with the B cell antigen receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2180-2184 (2000)
   PUBMED   10681448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096859.1, BC000616.2, AC026250.16 and AI693686.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015055.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014540.1, SRR1803615.208775.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318950.11/ ENSP00000315630.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK096859.1         1-27
            28-1869             BC000616.2         1-1842
            1870-4373           AC026250.16        122721-125224       c
            4374-4882           AI693686.1         1-509               c
            4883-4884           AC026250.16        122210-122211       c
FEATURES             Location/Qualifiers
     source          1..4884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4884
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /note="switching B cell complex subunit SWAP70"
                     /db_xref="GeneID:23075"
                     /db_xref="HGNC:HGNC:17070"
                     /db_xref="MIM:604762"
     exon            1..202
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1861
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /note="isoform 1 is encoded by transcript variant 1;
                     switch-associated protein 70; SWAP switching B-cell
                     complex subunit 70; SWAP switching B-cell complex 70kDa
                     subunit"
                     /codon_start=1
                     /product="switch-associated protein 70 isoform 1"
                     /protein_id="NP_055870.2"
                     /db_xref="CCDS:CCDS31426.1"
                     /db_xref="GeneID:23075"
                     /db_xref="HGNC:HGNC:17070"
                     /db_xref="MIM:604762"
                     /translation="MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLK
                     VPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKN
                     LTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFE
                     HYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMM
                     KKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFL
                     VKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ
                     EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELE
                     REKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQ
                     ARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLEL
                     ERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAF
                     TEAELEEREKNWKEKKTTE"
     exon            203..343
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            344..517
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            518..745
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            746..892
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1001
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1183
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1291
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1458
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1657
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1754
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..4884
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3689..3694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /note="hexamer: AATAAA"
     polyA_site      3712
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /note="major polyA site"
     regulatory      4824..4829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /note="hexamer: ATTAAA"
     polyA_site      4852
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
     regulatory      4864..4869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
                     /note="hexamer: AATAAA"
     polyA_site      4884
                     /gene="SWAP70"
                     /gene_synonym="HSPC321; SWAP-70"
ORIGIN      
        1 aggtgactgc gcggcgggct gtggctgcgg aggttgaggg gcgtccgagg cgcggagggg
       61 ctggctgggc aggaggggtt ggcggggcag cagggccgcg gccatgggga gcttgaagga
      121 ggagctgctc aaagccatct ggcacgcctt caccgcactc gaccaggacc acagcggcaa
      181 ggtctccaag tcccagctca aggtcctttc ccataacctg tgcacggtgc tgaaggttcc
      241 tcatgaccca gttgcccttg aagagcactt cagggatgat gatgagggtc cagtgtccaa
      301 ccagggctac atgccttatt taaacaggtt cattttggaa aaggtccaag acaactttga
      361 caagattgaa ttcaatagga tgtgttggac cctctgtgtc aaaaaaaacc tcacaaagaa
      421 tcccctgctc attacagaag aagatgcatt taaaatatgg gttattttca actttttatc
      481 tgaggacaag tatccattaa ttattgtgtc agaagagatt gaatacctgc ttaagaagct
      541 tacagaagct atgggaggag gttggcagca agaacaattt gaacattata aaatcaactt
      601 tgatgacagt aaaaatggcc tttctgcatg ggaacttatt gagcttattg gaaatggaca
      661 gtttagcaaa ggcatggacc ggcagactgt gtctatggca attaatgaag tctttaatga
      721 acttatatta gatgtgttaa agcagggtta catgatgaaa aagggccaca gacggaaaaa
      781 ctggactgaa agatggtttg tactaaaacc caacataatt tcttactatg tgagtgagga
      841 tctgaaggat aagaaaggag acattctctt ggatgaaaat tgctgtgtag agtccttgcc
      901 tgacaaagat ggaaagaaat gcctttttct cgtaaaatgt tttgataaga cttttgaaat
      961 cagtgcttca gataagaaga agaaacagga gtggattcaa gccattcatt ctactattca
     1021 tctgttgaag ctgggcagcc ctccaccaca caaagaagcc cgccagcgtc ggaaagaact
     1081 ccggaagaag cagctggctg aacaagagga actggagcga caaatgaagg aactccaggc
     1141 cgccaacgaa agcaagcagc aggagctgga ggccgtgcgg aagaaactgg aggaagcagc
     1201 atctcgtgca gcagaagagg aaaagaaacg ccttcagact caagtggaac ttcaggccag
     1261 gttcagcaca gagctggaaa gagagaagct tatcagacag cagatggaag aacaggttgc
     1321 tcaaaagtcc tctgaactgg aacagtattt acagcgagta cgggagctgg aagacatgta
     1381 cctaaagctg caggaggctc ttgaagatga gagacaggcc cggcaagatg aagagacagt
     1441 gcggaagctt caggccaggt tgttggagga agagtcttcc aagagggctg aactagaaaa
     1501 gtggcacttg gagcagcagc aggccattca gacaaccgag gcggagaagc aggagttgga
     1561 gaatcagcgt gtcctgaagg aacaggccct gcaggaggcc atggagcagc tggagcagct
     1621 tgagttagaa cggaagcaag cacttgagca gtacgaggaa gttaaaaaga agctggagat
     1681 ggcaactaat aagaccaaga gctggaagga caaagtggcc catcatgaag gattaattcg
     1741 actgatagaa ccaggttcaa agaaccctca cctgatcact aactggggac ctgcagcttt
     1801 cactgaggca gaacttgaag agagagagaa gaactggaaa gagaaaaaga ccacggagtg
     1861 actgagcttg ctggcagtca cgtcagttat gtagatactg catggcagga gagctttacg
     1921 ctaaagacaa aagaaacagc tttgggggcc gggcgtggtg gctcacgcct gtaatcccag
     1981 cactttggga ggccgaggcg ggtggatcac ctgaggtcag gagttcaaga gcagcctggc
     2041 caacctggtg aaaccctgtc tctactaaaa atacaaaaaa aattagctga gcgtggtggc
     2101 gggcgcctgt aatcccagct acttgggagg ctgaggcagg agaatcactt gaacgtggga
     2161 ggcggaggtt gcagcgagct gagatcatgc cgttgtactc cagcttgggc aacagagtga
     2221 gactccatct caaaacaaaa caaaacaaaa caaaacaaaa aaacccggct ttgctgcttt
     2281 taactcttct tccttctgtg cctctctaag tgggtcagta tcctaaggaa gccttcttat
     2341 ttatcttcct gcaaacaagg gttacctgaa aagaaaaaaa aagtcaacat tgtcaagctg
     2401 tttgtttact ctttctttga aaacatcacc ttctgaaatt tgtcttttag ctctctcaga
     2461 ttcttcccca aatgaggcag ggtgcagaca gcacagtcag ctctgcagag tttggagggg
     2521 ctcactgcca ctgggtactc agaacctctg tggactggat gtcagctctt tcctttggca
     2581 gcgtgtttcc ttttccgagt atgtgctgtt aaactagatt ggccggttcg ctttccattt
     2641 cctgacactt gacatggaat gcctttgacc attggtgctc tgacagagaa gtcatggagt
     2701 cattgccatt tcctggttgc ccttttggaa tgtgatcctg ttagtagagg ttttctagct
     2761 tctactaaga tatttctttc cctaaccatc atacacttgg catgtttcat tcccatctcc
     2821 tttcccctca ccttaaagga gactacccct ttgccccata ttgtcaacct aattttctct
     2881 cgtactctct ctagtgaatg atgtgctacc aagtatatgc caggctgtga gaggattata
     2941 ctgagtagta gaaagaagct aatttgaaat aaaaattatt tgtataatta agaaagcaga
     3001 ttagatgcac atggtcaaca ggaagttgac tgtatgtctg ctagttagat tcaaaacatc
     3061 ataaagatga tagcatgtca atatattagc ctagccatta tgttagcctt tgttaggtgg
     3121 gcagcttttc tgctttttcc cttcctctgt ggtgacaacg gaggaaatat ccaacagaaa
     3181 tacgtctaac agggaaattg ggatcatagt ttatatgcat ctgatttgaa aggagtattg
     3241 aggaaggttt tcatatatga tctatctttg gattaaaaag aacatttatg aaatcaagcc
     3301 ttctaacact agttataatt gagaagcaac agtaactccg tggacagcaa tcaagcttaa
     3361 aattgtaaat aaatatgggg ataattcagt tgttgcaaaa aaagggcaga attcagtaga
     3421 ataaagtcct tttctcttac aggtattaaa tgaggacaga gaacctcagg tgttcttatg
     3481 ctagtgcttg ctgagtgcat actaagaaag caattccaaa tagatgtata catctagaga
     3541 gagtggtatt agagattcag tgtatgtatt tatttacatg agaggaaact ggaatataat
     3601 cccataaatt atcacctttt atgactggaa aatatttgcc aatgaagaaa tggtctgtag
     3661 gtatttgtct taagattttt ggctgtttaa taaaaatgta actttaacgg tttcttatag
     3721 ttgcctttat aaagtgtatt gtctaaaata tttttgtatc atgtgccttt gaaatttgac
     3781 agctgatttg ggtgttggat ttctgcccag ccatttatca gtattatcat tttattcagt
     3841 agctggcagg tgtattagac caacgagact taggtaagga atggaacctt tcctgtggtt
     3901 tgactgcaca ttacaccaga agactccagt atccctcatt ccagaatgag gaaaaagtat
     3961 tctacaaaga acctaatcac ctctgtgaaa tctatgggat ggaaacagtg tggccttagg
     4021 agtcaaatag tctctgcatg gtggggagga tcatgatgga atatgtgaat ttctacttct
     4081 agaagttgtg aaataggtcc tgcacttttg cagaatgtcc ttctttaaac ctggcttatt
     4141 ccacagctgt agctgataac atgacctggg gcttagctgc tctagccctg ggttcttgga
     4201 gacctcacac tgcctggccc ctggccatcc acctaaggac tgcctgcttt ctggtcacat
     4261 gtggaccttg atacgactaa gcggttacat atgtggttgt gcaaaagctt tctgtttaat
     4321 gcatagtgtt accgatttac atcttggttt tcagtggcac tatgtctagg aggcaatatc
     4381 cttttaaaca gtgctttggc taagatagat acttgtgaat caaagatagc acagaaatga
     4441 actaagtata tcccatttgg aattatattt tgatactatt taaaatggtt tcacctgtta
     4501 aagggccaac agaactcttg gttttacttt tgtaattact gtacagaaaa tttcaagagt
     4561 gtttgagtgc ttgtcatcag gtgttttcct taataagtag ggatatgatc atttacagga
     4621 attatatatg aaaaaagttt ttgaaatgta tttttgtgat gtgctatgtt gaggggaaac
     4681 caaatattta tgattttaaa acattcgtat gaaaacattg tacaatgtaa tatgctcaac
     4741 tttctcaatt ttttgctaat ttttctaaga tacattaaaa atgttttata ttttttttta
     4801 agtaaaatgg acccagtaag aaaattaaaa ataccagaac atacacttta aactgtctga
     4861 tttaataaaa cagtgggggg taaa
//
