LOCUS       NM_001139456            2023 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SVOP like (SVOPL), transcript variant 1, mRNA.
ACCESSION   NM_001139456
VERSION     NM_001139456.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020983.8 and AC013429.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 11, 2019 this sequence version replaced NM_001139456.1.
            
            Summary: The protein encoded by this gene is thought to be a member
            of solute carrier family 22, which includes transmembrane proteins
            that transport toxins and drugs from the body. This gene is a
            paralog of the SVOP gene that encodes synaptic vesicle 2-related
            protein. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2947704.1,
                                           SRR14038195.73065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151887, SAMN03465420
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674285.1/ ENSP00000501457.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC020983.8         116968-117152       c
            186-301             AC020983.8         94754-94869         c
            302-393             AC020983.8         94224-94315         c
            394-492             AC020983.8         87809-87907         c
            493-564             AC020983.8         78864-78935         c
            565-689             AC020983.8         75654-75778         c
            690-753             AC013429.12        98-161
            754-879             AC013429.12        7472-7597
            880-1008            AC013429.12        11764-11892
            1009-1082           AC013429.12        26487-26560
            1083-1288           AC013429.12        28246-28451
            1289-1400           AC013429.12        29148-29259
            1401-1482           AC013429.12        30559-30640
            1483-1572           AC013429.12        35474-35563
            1573-1686           AC013429.12        60079-60192
            1687-2023           AC013429.12        61988-62324
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2023
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /note="SVOP like"
                     /db_xref="GeneID:136306"
                     /db_xref="HGNC:HGNC:27034"
                     /db_xref="MIM:611700"
     exon            1..185
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            186..301
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1698
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /note="isoform 1 is encoded by transcript variant 1; SV2
                     related protein homolog-like; putative transporter SVOPL;
                     solute carrier family 22 member B5"
                     /codon_start=1
                     /product="putative transporter SVOPL isoform 1"
                     /protein_id="NP_001132928.1"
                     /db_xref="CCDS:CCDS47721.1"
                     /db_xref="GeneID:136306"
                     /db_xref="HGNC:HGNC:27034"
                     /db_xref="MIM:611700"
                     /translation="MATKPTEPVTILSLRKLSLGTAEPQVKEPKTFTVEDAVETIGFG
                     RFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVFFGYMVFSI
                     LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLII
                     KTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVA
                     FKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAK
                     YLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPC
                     YCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICT
                     SSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS
                     QVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK"
     exon            302..393
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            394..492
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            493..564
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            565..689
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            690..753
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            754..879
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1008
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1082
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1288
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1400
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1482
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1572
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1686
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..2023
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /note="hexamer: AATAAA"
     polyA_site      2023
                     /gene="SVOPL"
                     /gene_synonym="SLC22B5"
                     /note="major polyA site"
ORIGIN      
        1 aaagaatcct gatctgagac ccgacctgaa aggagaggat aagaccaggg agccaggcgt
       61 cttgggaaca caagtctggc cacccctgag aagccatctg tgctccaatt tccgtctaag
      121 acttggccac ggtgagggga gcaaaagagc ctgaaattgg aagactgtcc aaggaatata
      181 cagagggaag ctgtttgggg aacttgagct atttagaaga tggcaaccaa gccaacagag
      241 cctgtcacga tcctcagcct tcggaaattg agcctgggga ccgcagagcc acaggttaaa
      301 gagccaaaga cgttcaccgt ggaagatgca gtggagacta tcggcttcgg gcgtttccac
      361 attgccctct ttctgatcat gggcagtact ggggtggttg aggccatgga gatcatgttg
      421 atagctgttg tgtctcctgt catccgctgt gaatggcaac tggagaattg gcaggtggca
      481 ttagtaacca cgatggtgtt ttttggctac atggttttca gtatcctctt tggcctcctg
      541 gctgacagat atggccgctg gaagattctg ctcatctcgt tcctgtgggg agcctatttc
      601 tccttgctga cctcgtttgc tccttcgtac atctggtttg tcttcctgcg gacgatggtg
      661 ggctgtggtg tgtccggcca ctcgcaaggg ttaatcataa agactgaatt tttgcccacg
      721 aaataccgag gctatatgtt acccttgtct caggtgttct ggcttgcggg ctccctgctc
      781 atcattggct tggcctctgt gatcatcccc accatcgggt ggcgctggct cattcgcgtc
      841 gcctccatcc cgggcatcat cctcatcgtg gccttcaagt ttattcctga atctgcccgg
      901 ttcaatgtct ccactgggaa cactcgggct gccctggcca ctctggagcg cgttgccaag
      961 atgaaccgct cggtcatgcc ggaggggaag ctggtggagc ccgtcctgga aaaaagagga
     1021 agatttgcag acctattgga tgctaaatat ttacggacca cattacagat ctgggtcata
     1081 tggcttggaa tctcttttgc ctactatggg gttatcctgg ccagtgctga gctgctggag
     1141 cgggacttgg tctgtggttc aaagtcagac tctgcggtgg tggtgactgg gggggactca
     1201 ggggagagcc agagcccctg ctactgccac atgtttgcac cctctgacta tcggaccatg
     1261 atcatcagca ccatcggtga aattgctttg aatcctttaa atatactggg catcaatttc
     1321 ctgggaagac ggctgagcct ttctattacc atgggatgca cggctttatt cttccttctc
     1381 ctcaacattt gcacttcaag tgccggcctg attggcttcc tcttcatgct gagggctctg
     1441 gtagctgcaa acttcaacac cgtctacatt tacacagctg aggtctaccc caccacgatg
     1501 cgcgctttgg ggatgggaac cagcggctcc ctgtgtcgca ttggtgcaat ggtggcacca
     1561 tttatatccc aggttcttat gagtgcatca atactggggg ccctgtgtct cttctcatct
     1621 gtctgtgttg tatgcgccat ttctgcattc actctcccca tcgaaaccaa aggacgggcc
     1681 ctccagcaaa ttaaatgaag acctgcaaag ctatgtctac cagatgagaa aaatgaattc
     1741 tatcttcaga actgcggtgc atttttttaa aacttggttt tacttctgta tgctactcgg
     1801 taattagtaa agtgattttt tttttaaagg catatatggg aatggggtag gtaactgtat
     1861 attgatctct tccttgagga acaatatata aagtactttt ataaaatata atttaagctt
     1921 tcaaaggggt gtgagaggga gatggtgggg gggaagatgg cttttcttca ttgaaatcaa
     1981 gtctgtaaac ctttatatga ataaatacta aattttaaac tta
//
