LOCUS       NM_018711               6641 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SV2 related protein (SVOP), mRNA.
ACCESSION   NM_018711
VERSION     NM_018711.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6641)
  AUTHORS   Jeanguenin,L., Lara-Nunez,A., Rodionov,D.A., Osterman,A.L.,
            Komarova,N.Y., Rentsch,D., Gregory,J.F. 3rd and Hanson,A.D.
  TITLE     Comparative genomics and functional analysis of the NiaP family
            uncover nicotinate transporters from bacteria, plants, and mammals
  JOURNAL   Funct Integr Genomics 12 (1), 25-34 (2012)
   PUBMED   21953179
REFERENCE   3  (bases 1 to 6641)
  AUTHORS   Yao,J. and Bajjalieh,S.M.
  TITLE     SVOP is a nucleotide binding protein
  JOURNAL   PLoS One 4 (4), e5315 (2009)
   PUBMED   19390693
REFERENCE   4  (bases 1 to 6641)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
REFERENCE   5  (bases 1 to 6641)
  AUTHORS   Janz,R., Hofmann,K. and Sudhof,T.C.
  TITLE     SVOP, an evolutionarily conserved synaptic vesicle protein,
            suggests novel transport functions of synaptic vesicles
  JOURNAL   J Neurosci 18 (22), 9269-9281 (1998)
   PUBMED   9801366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA793417.1, BC033587.1, AC087893.15, BC094722.1, BC037811.1 and
            DB297770.1.
            
            On May 17, 2019 this sequence version replaced NM_018711.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.60343.1,
                                           SRR1803615.265571.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610966.5/ ENSP00000479104.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA793417.1         12-39
            29-2282             BC033587.1         1-2254
            2283-2292           AC087893.15        179950-179959       c
            2293-3497           BC094722.1         2111-3315
            3498-5186           AC087893.15        177056-178744       c
            5187-6018           BC037811.1         741-1572
            6019-6253           DB297770.1         309-543
            6254-6641           AC087893.15        175601-175988       c
FEATURES             Location/Qualifiers
     source          1..6641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..6641
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /note="SV2 related protein"
                     /db_xref="GeneID:55530"
                     /db_xref="HGNC:HGNC:25417"
                     /db_xref="MIM:611699"
     exon            1..235
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1847
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /note="SV2 related protein homolog; solute carrier family
                     22 member B4"
                     /codon_start=1
                     /product="synaptic vesicle 2-related protein"
                     /protein_id="NP_061181.1"
                     /db_xref="CCDS:CCDS73520.1"
                     /db_xref="GeneID:55530"
                     /db_xref="HGNC:HGNC:25417"
                     /db_xref="MIM:611699"
                     /translation="MEEDLFQLRQLPVVKFRRTGESARSEDDTASGEHEVQIEGVHVG
                     LEAVELDDGAAVPKEFANPTDDTFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMM
                     ILSILAPQLHCEWRLPSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWT
                     LYYGILSAFAPVYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWA
                     IGTVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIA
                     TLKRIATENGAPMPLGKLIISRQEDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGL
                     VLLTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLW
                     IIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPE
                     VYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFL
                     PIETKGRGLQESSHREWGQEMVGRGMHGAGVTRSNSGSQE"
     exon            236..396
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            397..482
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            483..581
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            582..653
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            654..778
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            779..842
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            843..968
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1097
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1171
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1248
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1356
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1468
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1550
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1640
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..6641
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3474..3479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /note="hexamer: ATTAAA"
     polyA_site      3500
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /note="major polyA site"
     regulatory      5997..6002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /note="hexamer: AATAAA"
     polyA_site      6018
                     /gene="SVOP"
                     /gene_synonym="SLC22B4"
                     /note="major polyA site"
ORIGIN      
        1 actctcgccg cggtctcctg gcggcggagg ctttgtctcg tgggctggtc cccagcggct
       61 ccctccccga acagctgctg ctccagggag gaagcggcgc gggtgctgtc cagcttcccg
      121 gtgctgaaaa ccggagggct cgtcatccac cactaccatg taagggccat gagaagggct
      181 catcctggcg cagcgcggac atggaggagg acttattcca gctaaggcag ctgccggttg
      241 tgaaattccg tcgcacaggc gagagtgcaa ggtcagagga cgacacggct tcaggagagc
      301 atgaagtcca gattgaaggg gtccacgtgg gcctagaggc tgtggagctg gatgatgggg
      361 cagctgtgcc caaggagttt gccaatccca ctgatgatac tttcatggtg gaagatgcag
      421 tggaagccat tggctttgga aaatttcagt ggaagctgtc tgttctcact ggcttggctt
      481 ggatggctga tgccatggag atgatgatcc tcagcatcct ggcaccacag ctgcattgcg
      541 agtggaggct cccaagctgg caggtggcat tgctgacctc ggtggtcttt gtaggcatga
      601 tgtccagctc cacgctctgg ggaaatatct cagaccagta cggcaggaaa acagggctga
      661 agatcagcgt gctgtggact ctgtactatg gcatccttag tgcatttgcg cccgtgtata
      721 gctggatcct ggtgctccgg ggcctggtgg gcttcgggat cggaggagtt ccccagtcgg
      781 tgacgctgta tgccgagttc cttcccatga aagccagagc taaatgtatt ttgctgattg
      841 aggtattctg ggccatcggg acagtgttcg aggtcgtcct ggctgtgttc gtgatgccca
      901 gcctgggctg gcgttggctg ctcatcctct cagctgtccc gctcctcctc tttgccgtgc
      961 tgtgtttctg gctgcctgaa agtgcaaggt atgatgtgct gtcagggaac caggaaaagg
     1021 caatcgccac cttaaagagg atagcaactg aaaacggagc tcccatgccg ctggggaaac
     1081 tcatcatctc cagacaggaa gaccgaggca aaatgaggga ccttttcaca ccccatttta
     1141 gatggacaac tttgctgctg tggtttatat ggttttccaa tgcattctct tactacgggt
     1201 tagttctact caccacagaa ctcttccagg caggagatgt ctgcggcatc tccagtcgga
     1261 agaaggctgt agaggcaaaa tgcagcctgg cctgcgagta cctgagtgag gaggattaca
     1321 tggacttgct gtggaccacc ctctctgagt ttccaggtgt ccttgtgact ctgtggatta
     1381 ttgaccgcct ggggcgcaag aagaccatgg ccctgtgctt tgtcatcttc tccttctgca
     1441 gcctcctgct gtttatctgt gttggaagaa atgtgctcac tctgttactc ttcattgcaa
     1501 gagcgtttat ttctggaggc tttcaagcgg catatgttta cacacctgag gtctacccca
     1561 cggcaacgcg ggccctcggc ctgggcacct gcagcggcat ggcaagagtg ggtgctctca
     1621 tcactccgtt catcgcccag gtgatgctgg aatcctctgt gtacctgact ctggcagttt
     1681 acagtggctg ctgcctcctg gctgccctgg cctcctgctt tttgcccatt gagaccaaag
     1741 gccgaggact gcaggagtcc agccaccggg agtggggcca ggagatggtc ggccgaggaa
     1801 tgcacggtgc aggtgttacc aggtcgaact ctggctctca ggaatagtga ccgatggggg
     1861 actgagctgg tctttgaggc tgcagagctt ggggggctgg caggccccaa ctggggcact
     1921 gattgtcact gccgacatca agaactcacc caagagtatg acctggacca acagggtttt
     1981 gtgtcttgac tcagtttgct catcttcatt gaggtccacc cagggatggg gagatgtttg
     2041 ctctaggggg ttctctgtat atgtggtgaa agctttgttc ataacctgtg gatctacatg
     2101 ggaagactac ccatattagg agggtctggt aatgccagca accaatcaga caccacccag
     2161 agtcacccgg ccaaaccctc agtgaacaac caaaatatct ctctgtagat accgtccagg
     2221 ctcaggccca tgtgacacct gctgtccacc caccggacct gttcagtagg tttctcccac
     2281 actcacagcc ccaggctttc ttctttgaaa ttgcaggcga tctaggtgtg gtctgagcag
     2341 ctatttcctg gcaggggccc cccggtttgc ctccctagag cctgaccagt ggattctctg
     2401 gcagatggac atggtgcatt caaactggag ccacatgccc ccacccagcc ccctctggag
     2461 ttgccgttgt tggcaccaag agatccagat gtgtccctgg ggacagctgg tcttgcacca
     2521 ggtgacaacc tcagaacgcc gttaccccct gggaactgag gactgaggcc aaagtgaatc
     2581 aagctgaagt cagagcacgg gcctcccctt ctgaagcagc gaaggccacg gttccgactt
     2641 ctttcctggc cccctccttg gtcaggctga atggtgactt ttattgtttt ttgagacgga
     2701 gtcttgatct gtcgcccagg ctggagtgca gtagcgtgat ctcggctcac tgcaactctg
     2761 cctcccgggt tcaagcaatt ctcctgtctc agcctcccga gtagctggga ttacaggtgc
     2821 ccacctgtac tttttagtag agacagggtt tcaccatgtt ggccaggctg gtctcgaact
     2881 cctgacctca agtgatccac ccgcctcggc ctcccacagt gctgagatta caggtgggag
     2941 ccactgcacc cggcctgaat gatgactctt gaggggaaaa agtttactca ggtttgcagg
     3001 tacaaaatcc aaaatccagg gctttgggtt ttgtgcatgg gtagacagct gaatgggcag
     3061 agaaaccaga aggatgctac acccaccatc tcatcccatg gggatcaggg gaccaggatt
     3121 ccctgatgcg aagctgctcc tctgtccagg gacgtcttga tcattacaca aaggcagccc
     3181 ctggagttcc attcatggag cctgccgtgg agtggagagg ggtgggagga ctcaggtgtg
     3241 tgaaatgtat atgttttcaa aggaagcagt gggaggccag ttggttttga gttggtctcc
     3301 gcaggcaaca tcacttctgg gatttggttt actggagcct tttttcccat ggtgaaggca
     3361 ggggacatag acaaggaggg aggaagctgg cagatcccat caaaggccag agcagacaga
     3421 cctactgctt gaagtaaaca ttgcaaggaa gccaatttgt gcgttcaact cttattaaaa
     3481 catgtcagtg atggacattg caagagccta agtttattca ttgtcatcat gtcctagtga
     3541 cagtccagcc taacggtctg actacctttg ttcatcggaa ttcatctcaa tgctttagtg
     3601 tgataatctc ctttccaatg agtggggaaa gacataccgt tggcagccaa cattgtggct
     3661 gagcttgttg gagacaacac tttcttctaa tggtgtgcag gtcatgatgg gggacttctt
     3721 ccagctcaag ttctaaatca actgcaaaca atactgtgtc tctaaaatgt gggctgcagc
     3781 cccctccgcc caggcagttg aagaggagat ggcttggcag atctctgtct ctctctgaca
     3841 accacatttc cttgaaccac gtgtggctgt agctctaatt atttctggac agctgagctc
     3901 tcctgggtaa cacagaactt ttgcttgtct cttttgcctt ccggctggtc agacgctact
     3961 ggatgatcat gtccgctccc tcaccctaga ataacccagt ggagctgggg gctggggggg
     4021 atagagtgct tggtgggcag gaatatttcc cagagactag ggtaaagggg tttacagttg
     4081 agggccttct ctacttgaga aagtgaaagt taaaaactcc tgctgggtat ggtggctcat
     4141 gcctataatc ccagcacttt tggaggccga ggcgggcgga tcacaaggtc aggagatcga
     4201 gaccatcctg gctaacatgg tgaaaccccg tctctactaa aaatacaaaa aaaaattagc
     4261 caggtgtggt ggcgggtgcc tgtagtccca gctactcagg aggctgaggc cggagaatgg
     4321 cgtgaaccca ggaggcagag cttgcagtga gccgagatcg cgccactgca ctccagcctg
     4381 ggcgacagag caagactcca tctcaaaaac aaaacaaaac aaaacaaaaa ctctttgcct
     4441 tgtaaatagc ctgccttttt caaaaaaatc aatattatca aatgatacaa gagctatcac
     4501 aaaaggcacc caaacttctg aatatgtgag acctttagct gagaacattt gtatctaatt
     4561 ttgaacaatc ctattcaaaa agctcctatt ttcgttaatg gaaatgccat gtttctctta
     4621 gagttacgaa agatctcaga aagtggcaaa agatatttaa tgtagccaga gctatatatt
     4681 tctgtttttc tcgtacttca agtattctga aaaacatata actgaccttg gtggtgttca
     4741 caatgggatg aaacagtatc ttaggaattg actttgaaat tagtatggaa attcattgtt
     4801 tttaatataa cattgagcaa cagaaagcct tgaatgataa gatcaagagt ctcccctgcc
     4861 attattttca atggcaaaaa ctgcaattac tttttttttt tttttgagat gaagtctcag
     4921 ctcactgcaa ctctgtctcc caggttcaag cgattctccc tcctcagcct cctgagtagc
     4981 tgggattaca ggtgcccgcc ttgatgcttg gctaattttt gtatttttag tatagacaag
     5041 gtttcaccat gttggtcagg ctggtctcaa actcctgacc tcaagtgatc cgcccacctt
     5101 ggcctcccaa atgcaattac ttttgcacca acctaagaac agtaatctca gtcaatagtg
     5161 gcttaaacca ttagaaccaa aaccaggcag agatcagaga aggttcaacg ctcaacaatg
     5221 ttatcaagaa cccagcttct ttttgccttt tcttttcacc atcctctgca tgttggccat
     5281 ctgaccctgt gcttgaaacc tcatggtcac aaaatggctg cccctgtgct ggacatcata
     5341 tttcttttca aagaaggtag aatgggaaag gagcagtcat aaaaggtttt ctttcagaag
     5401 agtctgttgg ttttggttag aaaaggaagt cccctggcag atttaccatt gcttctcatt
     5461 gatcagacct gggtgtcatg cccatcccag catgagtcct gctgtagggc tggaaggaag
     5521 ggcctacgag caccaaggga tacccacagc ctcctgaaca caaaattggg attctgttag
     5581 cacagaagaa ggatagcaat ggctgttgga tgggcgatgg ttgcaaggag cctgccgtgg
     5641 atgtgtaggc cacagagctc tcatcagcac tgttttcgtg gccaggaaca gaaattctac
     5701 tcaggataat taaaattaag gaacagagct ttattataag actgggatcg gtagttaatt
     5761 tcctacaggg gaaattcagg gcatgtaaat cagtgaaatg gaaaaggtgt aaggacaaga
     5821 gaaacaccag ccctgtctgc aggggggggc tgcaactccc ttccagctga tgttgttcca
     5881 ccatgggtcc agtgtgacca gatcttacaa tgttcaaaag aggagtctag gtttttctgt
     5941 gaaatctcca aatattagta tattggatca aaaatgttca aatgatgtgt gagctcaata
     6001 aaatgcatct gcagtgcagc tttggttgat gggctgatgg ttcactctga cagtttagag
     6061 agattgcata ggaataaagt acagcctggt gtcattcaga ggaacaggga tctgggaaac
     6121 cactggggcc caagacagct gcccctctga atctgtggct cttgtttctt cccttttctg
     6181 gcagaaatga gtctagcttc catctgtttc cttgtggctg ctgtgtatgc ataatcatgc
     6241 acagagcttc catagcctca taacccagct ctgcaaacat acctgactca gctgctcagt
     6301 gccccactcc cagatcttca ggaatgaagc tgattggccc agtttagtgt tggattgagt
     6361 cttggtccaa ttcaattggg tcaggaagaa gtggtggaga ggtacagaca cggtggcatt
     6421 ggcctgccct ttagcagggt ggtgcagaca attgctggta tgcctggaat ctgcagtgac
     6481 atgtgcataa actctcaagt ctattcatca gaactctctt acagatcata acgtggcaag
     6541 tggtcagtat gcatggaata tccagcatgt cctggacatg ttattcaaca ctgaggatgc
     6601 aaaatatcat aagacatggt cctggctggg tgcagtggct c
//
