LOCUS       NM_199342                807 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens small vasohibin binding protein (SVBP), mRNA.
ACCESSION   NM_199342 XM_353201
VERSION     NM_199342.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 807)
  AUTHORS   Iqbal,Z., Tawamie,H., Ba,W., Reis,A., Halak,B.A., Sticht,H.,
            Uebe,S., Kasri,N.N., Riazuddin,S., van Bokhoven,H. and Abou
            Jamra,R.
  TITLE     Loss of function of SVBP leads to autosomal recessive intellectual
            disability, microcephaly, ataxia, and hypotonia
  JOURNAL   Genet Med 21 (8), 1790-1796 (2019)
   PUBMED   30607023
  REMARK    GeneRIF: SVBP is not only involved in angiogenesis, but also has
            vital functions in the central nervous system. Biallelic
            loss-of-function variants in SVBP lead to intellectual disability.
REFERENCE   2  (bases 1 to 807)
  AUTHORS   Zhou,C., Yan,L., Zhang,W.H. and Liu,Z.
  TITLE     Structural basis of tubulin detyrosination by VASH2/SVBP
            heterodimer
  JOURNAL   Nat Commun 10 (1), 3212 (2019)
   PUBMED   31324789
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 807)
  AUTHORS   Adamopoulos,A., Landskron,L., Heidebrecht,T., Tsakou,F.,
            Bleijerveld,O.B., Altelaar,M., Nieuwenhuis,J., Celie,P.H.N.,
            Brummelkamp,T.R. and Perrakis,A.
  TITLE     Crystal structure of the tubulin tyrosine carboxypeptidase complex
            VASH1-SVBP
  JOURNAL   Nat Struct Mol Biol 26 (7), 567-570 (2019)
   PUBMED   31270470
  REMARK    GeneRIF: This study describes the crystal and solution structure of
            the tubulin carboxypeptidase complex between vasohibin (VASH1) and
            small vasohibin-binding protein (SVBP), which folds in a long
            helix, which stabilizes the VASH1 catalytic domain.
REFERENCE   4  (bases 1 to 807)
  AUTHORS   Wang,N., Bosc,C., Ryul Choi,S., Boulan,B., Peris,L., Olieric,N.,
            Bao,H., Krichen,F., Chen,L., Andrieux,A., Olieric,V., Moutin,M.J.,
            Steinmetz,M.O. and Huang,H.
  TITLE     Structural basis of tubulin detyrosination by the vasohibin-SVBP
            enzyme complex
  JOURNAL   Nat Struct Mol Biol 26 (7), 571-582 (2019)
   PUBMED   31235911
  REMARK    GeneRIF: This study examined the crystal structures of human
            vasohibin 1 and 2 in complex with small vasohibin-binding protein
            (SVBP) in the absence and presence of different inhibitors and a
            C-terminal alpha-tubulin peptide.
REFERENCE   5  (bases 1 to 807)
  AUTHORS   Li,F., Hu,Y., Qi,S., Luo,X. and Yu,H.
  TITLE     Structural basis of tubulin detyrosination by vasohibins
  JOURNAL   Nat Struct Mol Biol 26 (7), 583-591 (2019)
   PUBMED   31235910
REFERENCE   6  (bases 1 to 807)
  AUTHORS   Liao,S., Rajendraprasad,G., Wang,N., Eibes,S., Gao,J., Yu,H.,
            Wu,G., Tu,X., Huang,H., Barisic,M. and Xu,C.
  TITLE     Molecular basis of vasohibins-mediated detyrosination and its
            impact on spindle function and mitosis
  JOURNAL   Cell Res 29 (7), 533-547 (2019)
   PUBMED   31171830
  REMARK    GeneRIF: The authors identified a core heterodimeric complex of
            human small vasohibin-binding protein (SVBP) and vasohibin 1
            (VASH1) that catalyzes the detyrosination of a peptide derived from
            C-terminus of alpha-tubulin.
            Erratum:[Cell Res. 2019 Sep;29(9):778. doi:
            10.1038/s41422-019-0215-y.. PMID: 31395957]
REFERENCE   7  (bases 1 to 807)
  AUTHORS   Nieuwenhuis,J., Adamopoulos,A., Bleijerveld,O.B., Mazouzi,A.,
            Stickel,E., Celie,P., Altelaar,M., Knipscheer,P., Perrakis,A.,
            Blomen,V.A. and Brummelkamp,T.R.
  TITLE     Vasohibins encode tubulin detyrosinating activity
  JOURNAL   Science 358 (6369), 1453-1456 (2017)
   PUBMED   29146869
REFERENCE   8  (bases 1 to 807)
  AUTHORS   Kadonosono,T., Yimchuen,W., Tsubaki,T., Shiozawa,T., Suzuki,Y.,
            Kuchimaru,T., Sato,Y. and Kizaka-Kondoh,S.
  TITLE     Domain architecture of vasohibins required for their
            chaperone-dependent unconventional extracellular release
  JOURNAL   Protein Sci 26 (3), 452-463 (2017)
   PUBMED   27879017
  REMARK    GeneRIF: identified a novel UPS regulatory system in which
            essential domain architecture (VASH-PS) of VASHs, comprising
            regions VASH191-180 and VASH280-169 , regulate the cytosolic
            punctate structure formation in the absence of SVBP.
REFERENCE   9  (bases 1 to 807)
  AUTHORS   Xue,X., Gao,W., Sun,B., Xu,Y., Han,B., Wang,F., Zhang,Y., Sun,J.,
            Wei,J., Lu,Z., Zhu,Y., Sato,Y., Sekido,Y., Miao,Y. and Kondo,Y.
  TITLE     Vasohibin 2 is transcriptionally activated and promotes
            angiogenesis in hepatocellular carcinoma
  JOURNAL   Oncogene 32 (13), 1724-1734 (2013)
   PUBMED   22614011
  REMARK    GeneRIF: VASH2 contributes to the angiogenesis in hepatocellular
            carcinoma via an SVBP-mediated paracrine mechanism.
REFERENCE   10 (bases 1 to 807)
  AUTHORS   Suzuki,Y., Kobayashi,M., Miyashita,H., Ohta,H., Sonoda,H. and
            Sato,Y.
  TITLE     Isolation of a small vasohibin-binding protein (SVBP) and its role
            in vasohibin secretion
  JOURNAL   J Cell Sci 123 (Pt 18), 3094-3101 (2010)
   PUBMED   20736312
  REMARK    GeneRIF: SVBP(CCDC23)acts as a secretory chaperone for VASH1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512353.16, BQ712089.1, BC029427.1 and BM675639.1.
            
            On Nov 22, 2018 this sequence version replaced NM_199342.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.314606.1,
                                           SRR1803612.203740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2148874,
                                           SAMEA2151358 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372521.9/ ENSP00000361599.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL512353.16        5532-5540           c
            10-145              BQ712089.1         1-136
            146-687             BC029427.1         1-542
            688-807             BM675639.1         19-138              c
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..807
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /note="small vasohibin binding protein"
                     /db_xref="GeneID:374969"
                     /db_xref="HGNC:HGNC:29204"
                     /db_xref="MIM:617853"
     exon            1..208
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /inference="alignment:Splign:2.1.0"
     exon            209..358
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..445
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /note="coiled-coil domain-containing protein 23;
                     coiled-coil domain containing 23"
                     /codon_start=1
                     /product="small vasohibin-binding protein"
                     /protein_id="NP_955374.1"
                     /db_xref="CCDS:CCDS474.1"
                     /db_xref="GeneID:374969"
                     /db_xref="HGNC:HGNC:29204"
                     /db_xref="MIM:617853"
                     /translation="MDPPARKEKTKVKESVSRVEKAKQKSAQQELKQRQRAEIYALNR
                     VMTELEQQQFDEFCKQMQPPGE"
     exon            359..807
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      781
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
     regulatory      786..791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /note="hexamer: AATAAA"
     polyA_site      807
                     /gene="SVBP"
                     /gene_synonym="CCDC23; NEDAHM"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgcacgc gcggccgctc ctgcgggcgg aagcctcctg gcgctcggcc ctgcgcccct
       61 ccccccggcg cgcggccccg cccaggacga ggggcggtgg gcaggcagcg ctgggtccag
      121 tggtcggggg aaggcgagga ttaccctccc ggaggcgttg tctgcgactc ggcggaggct
      181 ccaacttcca gtggcccggt cgggaaagat cagagcctcc taagaaatat ccagaagtca
      241 agccatggat ccacctgcac gtaaagaaaa aaccaaagtt aaagaatctg tcagcagagt
      301 tgagaaggcc aaacagaaat cagcccagca ggagctgaag cagagacaaa gagcagagat
      361 ctatgccctc aacagagtca tgacagaact ggagcagcag cagtttgatg agttctgtaa
      421 acagatgcag cctcctggag aatgaggccc caggttcaaa ccagatggga tcctgagagc
      481 tttgagaggg tgttgccagt tttaagctga gatggcccat ttggagcctt acagaactag
      541 accagaagac atttgtggat aaatctgaac tcacttcctg tgtgtaactt ctaacttcac
      601 tggttcctcc catctgaatt ggccacatgc ttgctgaaga gacttgtttt cttcttctaa
      661 gacagtggtt ttgttttttg ggttttttta aaaaaaaaaa aaaaacacac acaaaaaaca
      721 ctttttctat tgtttgagaa aaatcagtgt ttctcatgaa actctatatc ttctccaaaa
      781 atacaaataa aatactaata aaatgtt
//
