LOCUS       NM_014979              10824 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens synaptic vesicle glycoprotein 2C (SV2C), transcript
            variant 1, mRNA.
ACCESSION   NM_014979 XM_043493
VERSION     NM_014979.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10824)
  AUTHORS   Tan,Z., Lin,Y., Zhou,M., Guo,W., Qiu,J., Ding,L., Wu,Z., Xu,P. and
            Chen,X.
  TITLE     Correlation of SV2C rs1423099 single nucleotide polymorphism with
            sporadic Parkinson's disease in Han population in Southern China
  JOURNAL   Neurosci Lett 813, 137426 (2023)
   PUBMED   37544580
  REMARK    GeneRIF: Correlation of SV2C rs1423099 single nucleotide
            polymorphism with sporadic Parkinson's disease in Han population in
            Southern China.
REFERENCE   2  (bases 1 to 10824)
  AUTHORS   Lekholm,E., Ceder,M.M., Forsberg,E.C., Schioth,H.B. and
            Fredriksson,R.
  TITLE     Differentiation of two human neuroblastoma cell lines alters SV2
            expression patterns
  JOURNAL   Cell Mol Biol Lett 26 (1), 5 (2021)
   PUBMED   33588752
  REMARK    GeneRIF: Differentiation of two human neuroblastoma cell lines
            alters SV2 expression patterns.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10824)
  AUTHORS   Foo,J.N., Chew,E.G.Y., Chung,S.J., Peng,R., Blauwendraat,C.,
            Nalls,M.A., Mok,K.Y., Satake,W., Toda,T., Chao,Y., Tan,L.C.S.,
            Tandiono,M., Lian,M.M., Ng,E.Y., Prakash,K.M., Au,W.L., Meah,W.Y.,
            Mok,S.Q., Annuar,A.A., Chan,A.Y.Y., Chen,L., Chen,Y., Jeon,B.S.,
            Jiang,L., Lim,J.L., Lin,J.J., Liu,C., Mao,C., Mok,V., Pei,Z.,
            Shang,H.F., Shi,C.H., Song,K., Tan,A.H., Wu,Y.R., Xu,Y.M., Xu,R.,
            Yan,Y., Yang,J., Zhang,B., Koh,W.P., Lim,S.Y., Khor,C.C., Liu,J.
            and Tan,E.K.
  TITLE     Identification of Risk Loci for Parkinson Disease in Asians and
            Comparison of Risk Between Asians and Europeans: A Genome-Wide
            Association Study
  JOURNAL   JAMA Neurol 77 (6), 746-754 (2020)
   PUBMED   32310270
  REMARK    GeneRIF: Identification of Risk Loci for Parkinson Disease in
            Asians and Comparison of Risk Between Asians and Europeans: A
            Genome-Wide Association Study.
REFERENCE   4  (bases 1 to 10824)
  AUTHORS   Dunn,A.R., Stout,K.A., Ozawa,M., Lohr,K.M., Hoffman,C.A.,
            Bernstein,A.I., Li,Y., Wang,M., Sgobio,C., Sastry,N., Cai,H.,
            Caudle,W.M. and Miller,G.W.
  TITLE     Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release
            and is disrupted in Parkinson disease
  JOURNAL   Proc Natl Acad Sci U S A 114 (11), E2253-E2262 (2017)
   PUBMED   28246328
  REMARK    GeneRIF: These data establish SV2C as a mediator of dopamine neuron
            function and suggest that SV2C disruption is a unique feature of PD
            that likely contributes to dopaminergic dysfunction.
REFERENCE   5  (bases 1 to 10824)
  AUTHORS   Yao,G., Zhang,S., Mahrhold,S., Lam,K.H., Stern,D., Bagramyan,K.,
            Perry,K., Kalkum,M., Rummel,A., Dong,M. and Jin,R.
  TITLE     N-linked glycosylation of SV2 is required for binding and uptake of
            botulinum neurotoxin A
  JOURNAL   Nat Struct Mol Biol 23 (7), 656-662 (2016)
   PUBMED   27294781
  REMARK    GeneRIF: N-linked glycosylation of SV2C is required for binding and
            uptake of botulinum neurotoxin A.
REFERENCE   6  (bases 1 to 10824)
  AUTHORS   Crevecoeur,J., Kaminski,R.M., Rogister,B., Foerch,P.,
            Vandenplas,C., Neveux,M., Mazzuferi,M., Kroonen,J., Poulet,C.,
            Martin,D., Sadzot,B., Rikir,E., Klitgaard,H., Moonen,G. and
            Deprez,M.
  TITLE     Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in
            patients with temporal lobe epilepsy and hippocampal sclerosis
  JOURNAL   Neuropathol Appl Neurobiol 40 (2), 191-204 (2014)
   PUBMED   23617838
  REMARK    GeneRIF: In classical mesial temporal sclerosis 1A, the expression
            of SV2 isoforms is altered with a selective increase of SV2C in
            sprouting mossy fibres.
REFERENCE   7  (bases 1 to 10824)
  AUTHORS   Tang,W., Teichert,M., Chasman,D.I., Heit,J.A., Morange,P.E., Li,G.,
            Pankratz,N., Leebeek,F.W., Pare,G., de Andrade,M., Tzourio,C.,
            Psaty,B.M., Basu,S., Ruiter,R., Rose,L., Armasu,S.M., Lumley,T.,
            Heckbert,S.R., Uitterlinden,A.G., Lathrop,M., Rice,K.M.,
            Cushman,M., Hofman,A., Lambert,J.C., Glazer,N.L., Pankow,J.S.,
            Witteman,J.C., Amouyel,P., Bis,J.C., Bovill,E.G., Kong,X.,
            Tracy,R.P., Boerwinkle,E., Rotter,J.I., Tregouet,D.A., Loth,D.W.,
            Stricker,B.H.C., Ridker,P.M., Folsom,A.R. and Smith,N.L.
  TITLE     A genome-wide association study for venous thromboembolism: the
            extended cohorts for heart and aging research in genomic
            epidemiology (CHARGE) consortium
  JOURNAL   Genet Epidemiol 37 (5), 512-521 (2013)
   PUBMED   23650146
REFERENCE   8  (bases 1 to 10824)
  AUTHORS   Lynch,J.M., Tate,S.K., Kinirons,P., Weale,M.E., Cavalleri,G.L.,
            Depondt,C., Murphy,K., O'Rourke,D., Doherty,C.P., Shianna,K.V.,
            Wood,N.W., Sander,J.W., Delanty,N., Goldstein,D.B. and
            Sisodiya,S.M.
  TITLE     No major role of common SV2A variation for predisposition or
            levetiracetam response in epilepsy
  JOURNAL   Epilepsy Res 83 (1), 44-51 (2009)
   PUBMED   18977120
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 10824)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   10 (bases 1 to 10824)
  AUTHORS   Janz,R., Hofmann,K. and Sudhof,T.C.
  TITLE     SVOP, an evolutionarily conserved synaptic vesicle protein,
            suggests novel transport functions of synaptic vesicles
  JOURNAL   J Neurosci 18 (22), 9269-9281 (1998)
   PUBMED   9801366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026774.7, AK094917.1, DA725900.1, BC100825.1, AC108091.3,
            AB028977.1, AC113404.3 and R44558.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014979.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.223336.1,
                                           SRR1660807.7929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502798.7/ ENSP00000423541.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC026774.7         45155-45185         c
            32-173              AK094917.1         2-143
            174-174             DA725900.1         385-385
            175-590             BC100825.1         78-493
            591-591             AC108091.3         24177-24177         c
            592-2459            BC100825.1         495-2362
            2460-3856           AB028977.1         1490-2886
            3857-3913           AC113404.3         18108-18164         c
            3914-4917           AB028977.1         2944-3947
            4918-10638          AC113404.3         11383-17103         c
            10639-10824         R44558.1           9-194               c
FEATURES             Location/Qualifiers
     source          1..10824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..10824
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /note="synaptic vesicle glycoprotein 2C"
                     /db_xref="GeneID:22987"
                     /db_xref="HGNC:HGNC:30670"
                     /db_xref="MIM:610291"
     exon            1..130
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            131..811
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2415
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptic vesicle protein 2C; solute carrier family 22
                     member B3"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2C isoform 1"
                     /protein_id="NP_055794.3"
                     /db_xref="CCDS:CCDS43331.1"
                     /db_xref="GeneID:22987"
                     /db_xref="HGNC:HGNC:30670"
                     /db_xref="MIM:610291"
                     /translation="MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQR
                     SYSRFQDEEDDDDYYPAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQA
                     KDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGM
                     ALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRK
                     QSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRG
                     EHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSV
                     VALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDEL
                     IEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGL
                     SVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFK
                     SVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNK
                     TGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISC
                     FFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAA
                     VLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVLM"
     exon            812..992
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1144
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1278
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1368
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1479
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1568
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1733
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1867
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2071
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2231
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..10824
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /note="hexamer: AATAAA"
     polyA_site      3040
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /note="major polyA site"
     regulatory      10782..10787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /note="hexamer: AATAAA"
     polyA_site      10824
                     /gene="SV2C"
                     /gene_synonym="SLC22B3"
                     /note="major polyA site"
ORIGIN      
        1 accactccgc gcgctgcagg cgagagtggc agacggaggc agcccgggga agcgagccgg
       61 agcggcgccc gcactgaggc ggctgcagtg ctgacaccac tcagggcaag ggtgtccgac
      121 ggctggagcg ttctgttttg aacccaaagt ggatgatgct gtcagagctg aaccactgaa
      181 aggaggctgt gaaaatttcc catcttctca ttggccatca gttgagataa gatggaagac
      241 tcttacaagg ataggacttc actgatgaag ggtgccaagg acattgccag agaggtgaag
      301 aaacaaacag taaagaaggt gaatcaagct gtggaccgag cccaggatga atacacccag
      361 aggtcctaca gtcggttcca agatgaagaa gatgatgatg actactaccc ggctggagaa
      421 acctataatg gtgaggccaa cgatgacgaa ggctcaagtg aagccactga ggggcatgat
      481 gaagatgatg agatctatga gggggagtat cagggcatcc ccagtatgaa ccaagcgaag
      541 gacagcatcg tgtcagtggg gcagcccaag ggcgatgagt acaaggaccg gcgggagctg
      601 gaatcagaaa ggagagctga cgaggaagag ttagcccagc agtatgagct gataatccaa
      661 gaatgcggtc atggtcgttt tcagtgggcc cttttcttcg tcctgggcat ggctcttatg
      721 gcagacggtg tagaggtgtt tgtcgttggc ttcgtgttac ccagtgctga gacagacctc
      781 tgcatcccaa attcaggatc tggatggcta ggcagcatag tgtacctcgg gatgatggtg
      841 ggggcgttct tctggggagg actggcagac aaagtgggaa ggaaacagtc tcttctgatt
      901 tgcatgtctg tcaacggatt ctttgccttc ctttcttcat ttgtccaagg ttatggcttc
      961 tttctcttct gtcgcttact ttctggattc gggattggag gagccatacc cactgtgttc
     1021 tcgtactttg ctgaagtcct ggcccgggaa aagcggggcg aacacttgag ctggctctgc
     1081 atgttctgga tgatcggtgg catctacgcc tctgccatgg cctgggccat catcccgcac
     1141 tacgggtgga gcttcagcat gggatcggcc taccagtttc acagttggcg tgtgtttgtc
     1201 atcgtctgtg cactcccctg tgtctcctcc gtggtggccc tcacattcat gcctgaaagc
     1261 ccacgattct tgttggaggt tggaaaacat gatgaagctt ggatgattct gaagttaatt
     1321 catgacacca acatgagagc ccggggtcag cctgagaagg tcttcacggt aaacaaaata
     1381 aaaactccta aacaaataga tgagctgatt gaaattgaga gtgacacagg aacatggtat
     1441 aggaggtgtt ttgttcggat ccgcaccgag ctgtacggaa tttggttgac ttttatgaga
     1501 tgtttcaact acccagtcag ggataataca ataaagctta caattgtttg gttcaccctg
     1561 tcctttgggt actatggatt atccgtttgg ttccctgatg tcattaaacc tctgcagtcc
     1621 gatgaatatg cattgctaac cagaaatgtg gagagagata aatatgcaaa tttcactatt
     1681 aactttacaa tggaaaatca gattcatact ggaatggaat acgacaatgg cagattcata
     1741 ggggtcaagt tcaaatctgt aactttcaaa gactctgttt ttaagtcctg cacctttgag
     1801 gatgtaactt cagtgaacac ctacttcaag aactgcacat ttattgacac tgtttttgac
     1861 aacacagatt ttgagccata taaattcatt gacagtgaat ttaaaaactg ctcgtttttt
     1921 cacaacaaga cgggatgtca gattaccttt gatgatgact atagtgccta ctggatttat
     1981 tttgtcaact ttctggggac attggcagta ttgccaggga acattgtgtc tgctctgctg
     2041 atggacagaa ttgggcgctt aacaatgcta ggtggctcta tggtgctttc ggggatcagc
     2101 tgtttcttcc tttggttcgg caccagtgaa tccatgatga taggcatgct gtgtctgtac
     2161 aatggattga ccatctcagc ctggaactct cttgacgtgg tcactgtgga actgtacccc
     2221 acagaccgga gggcaacagg ctttggcttc ttaaatgcgc tatgcaaggc agcagccgtc
     2281 ctgggaaact taatatttgg ctctctggtc agcatcacca aatcaatccc catcctgctg
     2341 gcttctactg tgctcgtgtg tggaggactc gttgggctgt gcctgcctga cacacgaacc
     2401 caggttctga tgtaatggga aaaaaagcca tccttcctgc gtttcttcct cctgccctgg
     2461 gtcaattctc cttcctgact caaggcttca gagttttcct atatagaaag gtgatcaagt
     2521 atcagaacat aaacacgtgc tgtgacttaa aatttagaag catatcatct tgcccctttg
     2581 tgattttgca caggttgttt gtttgttttg ttttgtttga atgcattgtt atctttccaa
     2641 actgtgatgc tactgcctcc cgcaaatcag tggaagcatt tctaaaatgc cctaggcagc
     2701 caggcttccc tggggttctg ctcattgaaa gtttagaagc taagaagact gggctggtgt
     2761 aagaaataga tcctgctcct aatttaacat taacaggaaa tataagtcgg cacattattg
     2821 catttgtgct gagaagaggg attctttttt tttttttttc taacagagtg atatttcctg
     2881 tttacttaga aaaggacacc cagtaattct cactgttata gcagagcctt tcaaagaaaa
     2941 ccatgtggca ccaaacaggg ctgggtgggg ctctttgggg caagacaatt aaggtgaccg
     3001 ctgacaagaa aaataaaagc tctgcaatta gcagcaaaaa tctgagtgtg ctgcataagc
     3061 aagatttctg tcagaaagcc caattaaacc tctgaaaagt gtgaggaaaa agaactgtaa
     3121 cagtatctgt gactgtggca tgtggttcag aatgtttgaa aatcagagat ccgagagaga
     3181 gcttctgcct ccatttacca ctcccactcc ttcagctgcc cttggtcttg ccagacagca
     3241 gattcaggga aagaaagctg cttcttaaaa actgtctgcc tacctgattc tgccacttac
     3301 ccacactgtc tctagtctag agattgccag tggatagcta aattgtaaat tgcaaattag
     3361 gaagaaattc acacccagag ccatttggaa atacaaaatg gtacctcttt ccagtacctc
     3421 tttgctgtgg gactggcccg ccaggacccc caccccacct ggcccgcagt tgacattcag
     3481 cttcccagct ggcatcagca aagagggttt gtccctctag cttccccagg gctggcccac
     3541 tgctcaatgc gctcctggct ccctgtaaaa tcacagcccg cctgcactcc tgagggcccc
     3601 tctcacagac agaccatctc cctgtggttg tttgactgct cattttacct ctggaatctg
     3661 cctgggcttg gaagaaagag gtcagccagg acattcccac gggcccgctg tcagctacat
     3721 gaccttctcg cctctcaggc tccccttccc ccaggctcgt cctttttaca cctcttcttt
     3781 gaaatctgaa ccttccttgt agacttgcag ccaatgacca gaagccagga ataaatccca
     3841 tatttaaaca atattccttt tttaactgcc tcgatagagg tttattcttg ttacttatta
     3901 taggcatttt caggcaagcc atagcttggg gcctccagga agggaaagct tttgtttcca
     3961 ctgatcatta ttttcagaga tgtcctaact cccctgaggc ccccctgcct ccccctcccc
     4021 ttcctaatga tccctcgcag agctcagact aagtgaaaag cttctttcat taacataagc
     4081 cattaatcga cttccccttg aagtaattca ggtctgcaga ggggggaaga ctggtgttgg
     4141 gggcagtggg aagagggtgg ttccctgggg gtctgtgatc agggctagaa catcaggaaa
     4201 acccgaacca aaaactgcaa aggtggcagg aagaagaaaa atcactgaag gctagacaag
     4261 atgcatttga aagataccaa ccgcacaggg aaagaaacaa ctttctctca cttctgcctc
     4321 ctatcatttt attggagaac aaagacagca gtcaaacaac ccaagaaagt accctgtatg
     4381 tttttcttct tccacatgta cccattttcc cacctatctc tccctgattt gtcttcttta
     4441 aaaagacatt tggggacctg agcaggtctt ttagttgaat gcagcatgtg cagaaataac
     4501 tgcaaaagcc aggagtgcat ctccatcaac ccatcaaaag aaaaatagaa atgtacatgg
     4561 gcatcgctgt ctctagtcct ctgtgatagt tcactttgct aactagacta cctttacttt
     4621 tcaaaatatc tctaatgtct gctctggggt ctaaatgcat aaaacatctc ccaagctgca
     4681 gagcacagtt attcagaatt ttatttgaac actgggttgg gtcagcatag gataaaccag
     4741 caaaacctta cttcatgaga cctgccatcc gtgtcccctg cagaaggacc gttcttggcc
     4801 tacttgttac ctaatccaag catccttggt ggcctaagag ggatcttttc tcatctcctg
     4861 gacagtctgt ggtcacaaac cttcttggtc accacctctc ccaccttttg tgcactcttc
     4921 cctgcctcct tgagactgtt catcaccttg attttctaag agagctcaaa tcatttccaa
     4981 agcatgtggt gtggcctgta tagcttgctc cagatttagc tggagattaa gaaacagcca
     5041 ggatattaaa cagaaactct cagttgtatc agtgtagcag gccactggca cctaaacacg
     5101 caactggcat ctcatttcgc ctacagtaga aggaaaatga aaatttgtac aaaaatgaaa
     5161 acctaggaaa tagtccactt gctcctatat ttttaccacc ttttctaact aaaatttccc
     5221 tgttgctctt tggaatcaat ccagaatgct cccaagtccc attattatca cagaatcttc
     5281 tcagtaggga aaaacaaaca actgcttcaa actgtgaatt ctgtatgtac cacattctat
     5341 cccaggtatt gggttttaag gcacccaact cacattcagt cctgctgcct gaatcatctc
     5401 acaccagagt acagaccttg gagacgcgat agatgggtcc tagcctgacc ttcaccacta
     5461 agcggtacag ggacccagat cttgctgtgg agactgtaag tcgttgaaca tctctagttc
     5521 tcactttccc cgtgcacaaa ataaaggatt gggactagtc tgctctccac tctccagcat
     5581 tgtagaagac agtaatgaaa atagcttcat cttatctgcc ttcttatgct aaactcattt
     5641 tttttttttt taggtggagt ttcactctgt tgcccaggct ggagtgcagt ggtgggaact
     5701 ctgctcactg caacctccgc ctcccaggtt caagtgattc tcccacctca gcctcccaag
     5761 tagctgggac cacacgcatg cgccaccacg cccagctaat ttttgtatct tttagtagag
     5821 gtggggtttc accgtgttgg tcaggctggt ctcgaactcc tgacctcaag tgatcggccc
     5881 acctcagcct cccaaaatgc tgggattaca ggcgtgagcc actggcggcc tcaactcatt
     5941 tttacaagca ctaaataggt ttagtttata aactgaaaaa ttaggaaata ggcacgcata
     6001 aaaagagtgt aggaagttgt ttgggaagcc cgcatggaat aggccagaaa gcacagtccc
     6061 catgctgtct gccctgccag catctcagca tcctgactag tatctctgtt cactgcaggt
     6121 ttgacagtta ccatcaccca gccagaaaag ggccccgcct tgccagataa acgcgcttag
     6181 gttagaagac tataattgca atattaccct acagctctcc tgactgttta ttccattatt
     6241 ttcttgaaac atggccttaa gtattataca taggcttcag aaacagtttt tcagtgattt
     6301 tacctatatt ggcaaataga caaatctcac caaatcagag ttcaggtttt caccaaaaac
     6361 tgcttagttg tctttcaaga taccttaaga gatcaaaggg gaggtgggaa aagaaatgta
     6421 gtgacagaag ggagagtcca agataccact gataaggttc cagcaaagag attaggacac
     6481 agcagagact ttctaaatgc tggggtcatt tccaaagcag tccaggggaa tactttctga
     6541 ttccctctgc caatcaaaat agatagaata tgatattctc caattttttt tctgtttgat
     6601 gtcaaaatgg cctttaccta tttcttcagt aatatacctg atctgttcat gcactaaagg
     6661 ctctggagcc aggaatgtct gaatttggcc ttcacctggt atcacagaaa gacaactggg
     6721 atattggtgt taaggggcat atcggctgta tgttaggttt tctttaatcc tcacatcgtg
     6781 ccaaacttag tctggttact aagcctaaaa acaccagtat tgcaacaact tctgaaactc
     6841 tgaagtggac tatatgtttc tcacagtttt tgtttatgct cagcaaagta tgtattttaa
     6901 gtaaagcttc tcttgttatc tgtaatgtag acaaaaaaaa aaaaaaacct gttagtatat
     6961 tctggatgta ttgtgtgtcc cttcattgtt tcaggtatgg cgtaacagtt ctccgtgtga
     7021 tgttcttttg ctctaaatgt tgaccattcc tcttgtcgcc cgtctctcac caaccagtca
     7081 cagagccatt gccagggctc ccttcagtct ttcttaaaca atatctaaat gcagtttagt
     7141 aatcccagga ttttgagtta caagaataca gtttatgggt ctgtttcagc tcttacttaa
     7201 ggctagcatg gttgggcagg ggaagagctg agccgagcct tcactgatct cttgtcattt
     7261 catatgatta tccagtaaat acttattgag cacctcccat gtgatacgta ttgagacact
     7321 gctgtgtgca ataattaagc ctatggagga cttaaatgag ggcaaggaaa acagaatgag
     7381 agaagacact ctcacactga cccccattac atgtgaaccc tccgcgcccc cccccataaa
     7441 tacaaagtgt tatttttcca catttaaaac aaataatagc cttcagcagg cagtgcagga
     7501 actattcagt cattgagata acctttgatg agaggagaaa gctccttgat tacctggttt
     7561 ttgttggaga gactattaac tagtacttgg aaaatgagaa aaatgaaacc acacataagt
     7621 tgttccctta aataatctca gcaggatatt gcactaagat attattcaag gaaaagaatc
     7681 aggagcagag atagccccat ctctctagag catttttttt ttttttttgg gcgggggggc
     7741 gggggacgga gtctcgctct attacttagg ccggagtgca gtggtgcaat ctcggctcaa
     7801 tgcaacttcc gcctcccagg ttcaagcaat tctcctgcct cagcctccca ggtagctggg
     7861 attacaggtg catgccacta tgtccggcta attttttgta tttttagtag agacgaggtt
     7921 tcaccatttt ggccaggctg gtctccaact cctaacttca agtgatctac ccaccttggc
     7981 ctcccaaagt gctgggatta caggcatgag ccactacacc tggcctaaag tcccgctttc
     8041 ttctgaggtg ttcttttcat ggtgtgaaac cagagacagg agctaggggg tctgttcccc
     8101 agcgaatagt gttggggttt tctcttcaga gctaagtcag caaagcctgc agctgctgcc
     8161 actcccctgg tctgtgcctc ccagggtgtt tcctttctga ttttgaagat ttgtgggtga
     8221 gtcaattatc tttgcagaca tcctaaagca gcttccctcc tcgctaccct cagcagataa
     8281 gccatccaga aaacaggttc tgacagccag tagcaggggt attttgggtt tcagtttaaa
     8341 actggtgcgt gttgttgcaa gtgtcttgaa gttgcaaagg atgtttgggg ttctagggcc
     8401 tgcagggggg cagagcagaa agagggtagt tgtcagtgac cctctaccct cctctgagag
     8461 ccccattgcc atttttgccc accagttctc ttcttacctc ctcagggcag tgcccactca
     8521 tttcctttat ttcccttttg ttttttttct tttcctcctc tggtcgacaa cctcttaatt
     8581 ctagcagtgt acaaaagcaa ggccaagctt tcctggggca cttgggatga aaggcccatc
     8641 catgcctgtt gtggaggcac agaggaggag aaggtgaaga acaggaatgg gtgcaggggg
     8701 agtgtgaacg caaggctgct ggctttggca cagctccctg tgcagggctg gatttccaat
     8761 tgcttttcag tgcctgtgcc ctgataggat gggcacagct ggtatggaat cagagcagcc
     8821 catctccaga gcagaagtct gagagctcag cgtttgactc ctgaaagacc aggatgttcc
     8881 tacctgggtt cttgagattc attggctagt ggaggtagat ggtactctcc atgtctgcag
     8941 aagattcccc acttggtgct gaaggctagg tgccttccag tcaggtctga atgctgaaat
     9001 tgctgagatt gtccactctc tgcctacttt attgcattca tgctcccctt agatccaaga
     9061 gtgcccagga ctaggagcag aaagcagttt tcaacccttt gttcagactc agacgggttt
     9121 caactcaagc gggtaatcta ccccagcagc aggggtgcaa agtccaaaac agctttgtgg
     9181 tgcctgggga gtgactaggc agcctgctca caggggctgg agtcatctaa agctagtgat
     9241 gagctggaat agctttgaac cggttcatcc gaactgattg ttaaactttc agaacttttg
     9301 agagtcagtt gagaaacata gctattacta aaaaattaaa taagattaga taaattatag
     9361 ctaaaagcaa aggcaacata tagtcaaagc tcatcacttt ctacttattt tactacattt
     9421 taccattatc tgtgcccatg aggtaatgta tgcctattat gtctgtatgg tagaaatact
     9481 gtatacaggt atactactac acacaccttc ccaagtgaca gtatttttgt agtttgagat
     9541 cagctatagt ggtggtattt ataccatgga aagcaacaaa gccatggaaa gcaacaaagc
     9601 catgcaaatc agactcctcc taacccctaa gacagttgtt aaacatttgc cagcatacca
     9661 ccatctaaag ccctaaagaa tgcttggcct cccactgcat agacacaggc cacatcacat
     9721 tgagtatcat ggatttatgg gtcagcattg cccctaagtc caaggaaggg gaaagactta
     9781 gcaagctcaa cctcatgtga ttcacaaagg gtttctttct gcatttgtat tgactcagaa
     9841 taggacccag tacagagaat ccactgttat ctatgggtgt cattccttca gaaagaatgt
     9901 acagtaaaat tggctatttc atgctatgca aacaaaatga aactagtttg aagttgcaaa
     9961 gtgtctcccc tcttgcgccc acgtagtcat ccaagaagga aactcctttc ttgccttgat
    10021 attcaccagg cctacctaga tagaacttga caaattggcc taacttcatc tccgctgcta
    10081 ttgttatata tttgctttac tgaatctatg tcctatgtca gtcagaagaa aaaagaaatg
    10141 tcttttttaa tatacacttt cttagcatcc atgcagttat gtatcctcat cctgatccag
    10201 gaacatattg aacagatcat atgtcttttg ttactatcta gatacactaa ataacatgat
    10261 agaagagttt tctctttcag gtgaacttcc attttgaaca tatgctaaac gtactatcca
    10321 ctgtctattt taatgagatc ttggcaatgg tcctgtcggt tttggtgttt ggattgtttg
    10381 gctttgtttt ccttttttat tcttcctgtt tttaatgctg tgtaagatct cctgctatga
    10441 atgttccagt tacccctatt gtactgtata tacgtgtgct gcatgtgtaa attctgtttc
    10501 aggttttgga gttttcatct taagtacagc tggtcctgtt gtgaactcat ctttcctgta
    10561 tgctcctctg tgtctgattt ccaattgcca aaatgtttga ccaaatgtgt tttgacaaat
    10621 atcccgagac agccatgcgt atccttgtga aagggcatgc tccatgtggg atggctcgtg
    10681 tacagcataa atctatcaaa cttggaattg tgtatacatt tatatgccag ataactaaca
    10741 ttcatgtaac agctgcaaag atatttagtg tatatcagat taataaaaga gcattttttt
    10801 tttgctccat tatattcaaa taca
//
