LOCUS       NM_001323038           12604 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens synaptic vesicle glycoprotein 2B (SV2B), transcript
            variant 9, mRNA.
ACCESSION   NM_001323038 XM_011522264
VERSION     NM_001323038.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12604)
  AUTHORS   Lekholm,E., Ceder,M.M., Forsberg,E.C., Schioth,H.B. and
            Fredriksson,R.
  TITLE     Differentiation of two human neuroblastoma cell lines alters SV2
            expression patterns
  JOURNAL   Cell Mol Biol Lett 26 (1), 5 (2021)
   PUBMED   33588752
  REMARK    GeneRIF: Differentiation of two human neuroblastoma cell lines
            alters SV2 expression patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12604)
  AUTHORS   Zhang,Y., Yang,X., Zhu,X.L., Hao,J.Q., Bai,H., Xiao,Y.C.,
            Wang,Z.Z., Hao,C.Y. and Duan,H.B.
  TITLE     Bioinformatics analysis of potential core genes for glioblastoma
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32667033
  REMARK    GeneRIF: Bioinformatics analysis of potential core genes for
            glioblastoma.
REFERENCE   3  (bases 1 to 12604)
  AUTHORS   Fransen,E., Bonneux,S., Corneveaux,J.J., Schrauwen,I., Di
            Berardino,F., White,C.H., Ohmen,J.D., Van de Heyning,P.,
            Ambrosetti,U., Huentelman,M.J., Van Camp,G. and Friedman,R.A.
  TITLE     Genome-wide association analysis demonstrates the highly polygenic
            character of age-related hearing impairment
  JOURNAL   Eur J Hum Genet 23 (1), 110-115 (2015)
   PUBMED   24939585
REFERENCE   4  (bases 1 to 12604)
  AUTHORS   Crevecoeur,J., Kaminski,R.M., Rogister,B., Foerch,P.,
            Vandenplas,C., Neveux,M., Mazzuferi,M., Kroonen,J., Poulet,C.,
            Martin,D., Sadzot,B., Rikir,E., Klitgaard,H., Moonen,G. and
            Deprez,M.
  TITLE     Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in
            patients with temporal lobe epilepsy and hippocampal sclerosis
  JOURNAL   Neuropathol Appl Neurobiol 40 (2), 191-204 (2014)
   PUBMED   23617838
  REMARK    GeneRIF: In classical mesial temporal sclerosis 1A, the expression
            of SV2 isoforms is altered with a marked decrease of SV2B
            paralleling synaptic loss.
REFERENCE   5  (bases 1 to 12604)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 12604)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 12604)
  AUTHORS   Lazzell,D.R., Belizaire,R., Thakur,P., Sherry,D.M. and Janz,R.
  TITLE     SV2B regulates synaptotagmin 1 by direct interaction
  JOURNAL   J Biol Chem 279 (50), 52124-52131 (2004)
   PUBMED   15466855
REFERENCE   8  (bases 1 to 12604)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   9  (bases 1 to 12604)
  AUTHORS   Janz,R., Goda,Y., Geppert,M., Missler,M. and Sudhof,T.C.
  TITLE     SV2A and SV2B function as redundant Ca2+ regulators in
            neurotransmitter release
  JOURNAL   Neuron 24 (4), 1003-1016 (1999)
   PUBMED   10624962
REFERENCE   10 (bases 1 to 12604)
  AUTHORS   Bajjalieh,S.M., Peterson,K., Linial,M. and Scheller,R.H.
  TITLE     Brain contains two forms of synaptic vesicle protein 2
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2150-2154 (1993)
   PUBMED   7681585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127520.5 and AC123784.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001323038.2.
            
            Summary: This gene encodes a member of the synaptic vesicle
            proteins 2 (SV2) family and major facilitator superfamily of
            proteins. This protein and other members of the family are
            localized to synaptic vesicles and may function in the regulation
            of vesicle trafficking and exocytosis. Studies in mice suggest that
            the encoded protein may act as a protein receptor for botulinum
            neurotoxin E in neurons, and that this protein may be important for
            the integrity of the glomerular filtration barrier. This gene shows
            reduced expression in areas of synaptic loss in the hippocampus of
            human temporal lobe epilepsy patients. [provided by RefSeq, Sep
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.272472.1,
                                           SRR1660807.168246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC127520.5         91258-91405         c
            149-990             AC123784.2         97604-98445         c
            991-1171            AC123784.2         72319-72499         c
            1172-1323           AC123784.2         71798-71949         c
            1324-1457           AC123784.2         65764-65897         c
            1458-1547           AC123784.2         63909-63998         c
            1548-1658           AC123784.2         57626-57736         c
            1659-1747           AC123784.2         56675-56763         c
            1748-1912           AC123784.2         55713-55877         c
            1913-2046           AC123784.2         42457-42590         c
            2047-2247           AC123784.2         40097-40297         c
            2248-2407           AC123784.2         34638-34797         c
            2408-12604          AC123784.2         21753-31949         c
FEATURES             Location/Qualifiers
     source          1..12604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..12604
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="synaptic vesicle glycoprotein 2B"
                     /db_xref="GeneID:9899"
                     /db_xref="HGNC:HGNC:16874"
                     /db_xref="MIM:185861"
     exon            1..148
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..990
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..2591
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="isoform 1 is encoded by transcript variant 9;
                     synaptic vesicle protein 2B homolog; solute carrier family
                     22 member B2"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2B isoform 1"
                     /protein_id="NP_001309967.1"
                     /db_xref="CCDS:CCDS10370.1"
                     /db_xref="GeneID:9899"
                     /db_xref="HGNC:HGNC:16874"
                     /db_xref="MIM:185861"
                     /translation="MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDE
                     IYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDEC
                     GHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMA
                     GAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPI
                     VFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSW
                     RVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV
                     FTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLI
                     LAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQ
                     HGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHK
                     FINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRL
                     KMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRA
                     TAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL
                     M"
     exon            991..1171
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1323
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1457
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1547
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1658
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1747
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1912
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2046
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2247
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2407
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..12604
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5303..5308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: ATTAAA"
     polyA_site      5322
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="major polyA site"
     regulatory      11324..11329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: TATAAA"
     polyA_site      11348
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="major polyA site"
     regulatory      11473..11478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: ATTAAA"
     polyA_site      11495
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
     regulatory      12147..12152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: AATAAA"
     polyA_site      12168
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
ORIGIN      
        1 agcaaatgcg tttagccagg gaggagcaag gcaccgctgt gtcttcggca gacgggtggt
       61 agaaatctct gctgtccagg gttcagcagg gctgatgaaa tacactcctt tatccggaaa
      121 ttacagatgc aaattactcc gtttaaggag cataaccttc ggtggcagga caaatcaggc
      181 cagcacgcag tctgccaagt cctgctcgct ccctgtcaag aaaaacagct ggatccattt
      241 ctaatcaaca cttcccaacg caacacttct gagtctctga aggagaccag agcttgaaac
      301 tttccagact tccaacagac atcgagtgca aaaggatatt taggttgtct ttgcacaaat
      361 ctggttgatt tgagagataa aggggggggg aaccagtgtg actttcacct aagaagtcac
      421 atgaacatat ttcacatttg aactacataa tgaatgatgg ttattgaaat agcccaaacc
      481 tctaccacag agcgagggat atagctcaag gggcaaccag gcagtcgcag aaccaaggaa
      541 tggatgacta caagtatcag gacaattatg ggggctatgc tcccagtgat ggctattacc
      601 gcggcaatga gtccaaccca gaagaagatg cacagagtga tgtcaccgaa ggccatgatg
      661 aggaagacga gatctatgag ggcgagtacc agggtatccc tcacccagat gatgtcaagg
      721 ccaagcaggc caagatggcg ccctccagaa tggacagcct tcggggccag acagacctga
      781 tggctgagag gctggaagat gaggagcagt tggcccacca gtacgagacc atcatggatg
      841 agtgtggcca tggccgcttc cagtggatcc tctttttcgt cttgggtttg gccctgatgg
      901 ccgatggggt ggaagtgttc gtggtgagtt ttgccctgcc cagtgcagag aaggacatgt
      961 gtctgtccag ttccaaaaaa ggaatgctag ggatgatagt ctacttggga atgatggcgg
     1021 gcgccttcat cctgggaggc ctggctgata agctgggaag gaagcgagtc ctcagcatgt
     1081 ctctggccgt caatgcctcc ttcgcctccc tctcttcctt cgtgcaggga tatggagcct
     1141 tcctcttctg ccgactcatc tcaggcatcg gtattggggg tgctctaccg attgtttttg
     1201 cctatttttc tgaattcttg tctcgggaga agcgaggaga acacctcagt tggctgggca
     1261 tcttctggat gactgggggc ctgtacgcat ctgccatggc ctggagcatc atcccacact
     1321 atggctgggg cttcagcatg gggaccaatt accacttcca tagctggaga gtgtttgtca
     1381 tcgtctgtgc tctgccctgc accgtgtcca tggtggccct gaagttcatg ccagagagcc
     1441 caaggtttct gctagagatg ggcaaacatg atgaagcctg gatgattctc aagcaagtcc
     1501 atgacaccaa catgagagct aaggggaccc cagagaaagt gttcacggtt tccaacatca
     1561 aaactcccaa gcaaatggat gaattcattg agatccaaag ttcaacagga acctggtacc
     1621 agcgctggct ggtcagattc aagaccattt tcaagcaggt ctgggataat gccctgtact
     1681 gtgtgatggg gccctacaga atgaatacac tgattctggc cgtggtttgg tttgccatgg
     1741 cattcagtta ctatggactg acagtttggt ttcctgatat gatccgctat tttcaagatg
     1801 aagaatacaa gtctaaaatg aaggtgtttt ttggtgagca tgtgtacggc gccacaatca
     1861 acttcacgat ggaaaatcag atccaccaac atgggaaact tgtgaatgat aagttcacaa
     1921 gaatgtactt taaacatgta ctctttgagg acacattctt tgacgagtgc tattttgaag
     1981 acgtaacatc aacagatacc tacttcaaaa attgtaccat tgaatcaacc atcttttaca
     2041 acacagacct ctacgagcac aagttcatca actgtcggtt tatcaactcc accttcctgg
     2101 agcagaagga gggctgccac atggacttgg agcaagataa tgacttcctg atttacctcg
     2161 tcagcttcct gggcagcctg tctgtcttac ccgggaacat catttctgcc ctgctcatgg
     2221 atagaattgg aaggctcaag atgattggtg gctccatgct aatctctgca gtctgctgct
     2281 tcttcctgtt ttttggcaac agtgagtctg caatgatcgg ctggcagtgc ctgttctgtg
     2341 ggacaagcat tgcagcctgg aatgctctgg atgtgatcac agtggagctg tatcccacca
     2401 accagagagc aacagccttc ggcattctca atggattatg caaatttggc gccatcctgg
     2461 gaaacaccat ctttgcttct tttgttggga taaccaaagt ggtccccatc cttctggctg
     2521 ctgcttctct ggttgggggt ggcctgattg cccttcgact gccagagact cgagaacagg
     2581 tcctgatgtg aacaacctat gggaaaagga aaggtcgaga gaatcttgtc caggacactg
     2641 aaatgcatcc acacttcctg cctatcacgg tccggaggac accttggata gcacgggagg
     2701 agaagttgac tttgtgaccc ctagtttagg acccacttca gctgtcaata tgtttgtaac
     2761 tcaggtgact gatttggggg tgccctgagc cacccttaga atcacagagc tgcgtgttta
     2821 acttcaagtc ttcccagtcc aaggcaggga gaggattctc cagtgagtgc acacactatg
     2881 cgaggagcaa gcatttctct aagtcaagtg caaggactta acttgcgttt gaaaaggaat
     2941 tagagggtca gaaacaccca ggttcctcca gaaagctcct tggagcccaa caacttaaca
     3001 aatcaacttg gctggaagtt agagtcatta tatgaagatt gggcttgaag tatatatttt
     3061 tgcatttaaa agtatcacct atcatatttt ccactcgaaa attgacatag tagcattgag
     3121 gatactctga tctagaaagc caagtatttg agcaacatct atagagatct acttttctcc
     3181 tatgtctcct aggctttcca tgataattag gtaatacatt taagaaggat atttatttct
     3241 gttttgctct attcaaagaa acggaatggg atagttattc tgtaaactaa gtttgtatat
     3301 aactttattt gggtttaatt tccacaactg gtatctgcaa atattgccag cattttagcc
     3361 atattttggg agaacttggt gtttgaggtc ccaggaaatg aggtctgatc aaatgaaatg
     3421 caagcacaat ttcttacagc catttaactt tctgttggga ggatgaatta acaaactcac
     3481 attgtgcagt ctgcttaatc caggcacttt tctttgtgca ggtgtagtga gtagttactt
     3541 ctctccctta cacagatgac ttgtgaaact caagctcacc atcttcagtg ctggcatttt
     3601 actttgccac tacccaaaaa caatgtgaga tgtgttcagt ggcctctggt actctttgca
     3661 ggcaagaatc aaacaacatg gggactgagg gaaggatggg gaagtgtagc cacagttctt
     3721 ccaaatgtaa atactttttg tttgttctag tggtaaaatg caaatgcaat ccatatttgt
     3781 taggatggtc aggtctcatg agaaatctat gctatgtgtc cagagctttt gaaacagagt
     3841 ccattggagt gggagttagg gagtgtagtg gatgccaaat atgtttttct tcagtgctta
     3901 agagaactgt ttcctgaagt ccagctttga acataaacag gggtgtgggt tgggggagga
     3961 gcttaggaca aacctctctg atgaaggtca gcaatagact gaagtcttga ctgcatggaa
     4021 gaggaaaaac atcagaactg tctgacaatg gaggggacag tgagctacgc acaactgcca
     4081 gcggaggtga acttgcacct gcccaggccg gatgaacatc agcctgcaag aactagttgt
     4141 ttgagttgat ttgcagtgct ctcaatgggc aagtgccaca ttttccctgg cagagatctc
     4201 caaaaattta aaacagaata ataatggcta tatcgagtgt tttctcagta ttggagaaat
     4261 gcttaggtcc tatgatagct tcgggacatc tttctgtaat tttcctcaat taacgggttg
     4321 gtaggggtaa atcttatgac acctttccac cgtcgatttg agatcagttt taatggttaa
     4381 aatgtttact ctccttctgt caaccctcac ctttttattt acacccctcc ctttttttct
     4441 gtacagggag agaagacata ttgactctga ctggacaccc tgattcctcc aaatatatat
     4501 accactgtgt attaatcttt ctctcagtgt tttataggag tactaacatt tattgctctg
     4561 tcaataatga aaggctcgat gtaatatagc tgtaatttac tttccatatg aatacagtgg
     4621 ctaggttcat aaaagagaat tgtgtgagtc tgggattacc acatctaaaa cattattctt
     4681 taatgggata atacaattca ttgagcagct accacttaaa aaacttgcag gacagttaga
     4741 gcctgcattt ctagttaaga tggatcttgt aaatttaaaa ttggattaac attggagtgc
     4801 tggggtggct gcaataattt gggggctaac tccatttggt ttccaagatc tcacttctgc
     4861 attatcttta tggctcttta aaccagccac ctagccaatc aagggcaatt cccatctcat
     4921 ccatcactca ggtctttgta aagggtgcag ccaagctctg cagacttttg caggattgtc
     4981 tagcctgagt accgggctac ttcttaaatg ccgtcactcc tgctgagata aatgcgtctt
     5041 taaaaatagt ctctgtggca ggtcactggg ggacaatgta cagcattctg gccatccact
     5101 tctttttcac ttcatgttct accccaagag actcccgatg tcggctgtgg agggttaaag
     5161 ggatgaggct ttcctttgtt tagcaaatct gttcacagtt cttgatgatg tattttatga
     5221 tgcccagctt ggaaatagtt gctttccata gtctcaactg tattgtgtca tctcctgatg
     5281 ctgatttttg atcttttgtt ttattaaaaa taattagtga aagaggtgtg cctatctgtg
     5341 aagtttgtag tacatcatcc tgaggtcatg taacaagtaa accccaaccc agcgttccct
     5401 cctacgttgt gttagttcat taaaactaaa taataaaaat aactgtaaga aaaccttaag
     5461 gactggggtt agagattatt ttcaggcact aaggtctctt ctgtattcca aaattgattg
     5521 aatcagctgg gagaaacatt gagaatcgct tccttcaact tttattttgc aacatgggga
     5581 ccttgagagg ttaaacgatg tggcccagat tacatgtaat gtgaggagtg ggcgagaagg
     5641 cctaaggtga tgctctcatg acagttctgg ggaagcctgc agtttgggga atgggacaat
     5701 gtgacaaata ctcgccattc cctgagacca ttcattgact attcccttga tggctttact
     5761 ataatgagag gaagcatcag tttaaacata aaaagattag tatttatcca tccatttatt
     5821 cattcagcaa atccttattg agccctgacc atgggccagt ctctctgcca agccctgggg
     5881 acacagtgat gaaaaaactg gccacagttt ctgcttcctg cctcattcca cttgcagtga
     5941 gcggatatta aattggccat aaacaccgag tacgatgacc ttacaatccg caaactgcac
     6001 ctttcatgtg taaaaggatt gctactactt tacttgtcag ctgtggattt ccaaatgtgg
     6061 tggctccctc ttattttttt ttctttgagg agtgtaccaa ttttttatct ttataaacca
     6121 ggtaagggaa atgatgccct tgcccatttt ctacagacct aatcgatttt tacctaatca
     6181 gttttacaga aagggttaca tggaagaaga gataggggcc aggaatgcaa gagggacatt
     6241 ggtgagtggg gtaagaatcc ccgtagccct gggaaaggtg tctccacttc cacatctggc
     6301 ttttctaggg ggcatctgtg ctaactgacc tgggattatg ttggatggca tatgactgca
     6361 aattcaaaga aaccaattta taataagttt atagtaagtt aaaggtttgt tttactctca
     6421 tgtgaaggga atctggagga aggaaagcca gggctggagt ggctgccttt gatcatggga
     6481 gcacactcct tctgcccgat cattgggagc acactccttc tgcctgatcg ttgggagcac
     6541 actcctgcct gatcatgggc gcacgttcct tctgcctgat cgttgggagc acactccttc
     6601 tgcctgatca tgggagcaca ctccttctgc ctgatcattg ggagcacgct ccttctgcct
     6661 gatcgttggg agcacactct ttctgcctga tcgttgggag cacacccctt ctgcctgatc
     6721 attgggagca cactccttct gcctgatcat gggcacacgc tccttctgcc cgatcatggg
     6781 cacacgctcc ttctgcccga tcgttgggag cacactcctt ctgcccaatc attgggctca
     6841 cgctccttct gcccgatcgc tgggctcacg ctccttctgc ccgatcttgg gcgcacgctc
     6901 cttctgcccg atcgttgggc gcacgctcct tctgcccgat cgttgggcgc atgctccttc
     6961 tgcccgatcg ttgggagcac gctcattctg cccgattgtt gggagcacgc tccttctgcc
     7021 cgatcgttgg gcgcacgctc cttctgcccg atcgttgggc gcacgcttct tctgcctgat
     7081 cgttgggcgc acgctccttc tgcctgatcg ttgggcgcac gctccttctg cctgatcgtt
     7141 gggagcacgc tccttctgcc tgattgttgg aagcacgctc cttctgcctt cagactcctt
     7201 gatttttagt gcagtttcca tcactgaggc tgcctcatgg gctgagatgg ctgttgaagc
     7261 actgaacctc acatccacaa ttcaggcagg aagcagaagg aagggcaatg ggcaaagggg
     7321 ctgtgccttg cagccgatcc agcctccctt tgctgcagag gaggcaggga aatgcggtat
     7381 ttactgggaa cattgctgcc cctcctccaa attgagggtc ttggctcgaa ggacaaaagc
     7441 cagaaaggat aggtggatta gtgcttctta aacttttgcg tgcatcagaa tcacccagaa
     7501 agatgttaaa actcactctt caaggcccca tccccagaga ttcggattct ggggatttgg
     7561 aatctggggt ggggtctgaa gaatctgcat tttttaacaa actcccaggt gacatagatg
     7621 gcatcaattc tcaagccata ttttgagtag cactgacact cttccaatag gtggtacttt
     7681 gacttgtcag ggaagttcta ttgctctgat aacttaaaac caacccaacc agaagctcac
     7741 aaaaactagc agcctgtgaa aaatgatcac cattttccta gagctccgag acaactagtg
     7801 gtagtgcaac agtaacccaa aaatgtcaat gaaaatattt ccttccccag aaactgcttg
     7861 gtttcactca ggtcctgtcc ttatgggcct gtgtctggtt gcagggcttg aagtatttcg
     7921 gaagctcagc agaggttgaa ccctttcccc tgggggttgg tgatctttgt tttggccatt
     7981 tccacctggt gaagattttc atagacaaat atgcttgtgg catcctgtaa ttcattgtgc
     8041 cttatgatgg acctctgatt ctataagctt ccccctagct agggatgcac gggggtgatc
     8101 aagacatgac tagatgtgaa cctgacctgc agacagtcca cctgaacgtg cctggaaatg
     8161 tctcccgaaa aggatgaaaa gcctcctcct ttagacaagg aagacagagt ggagcaaatt
     8221 tctctacata gatctcattc gaaaacaaat ttacagaatg cagaatggct actgtgtgtc
     8281 ttgtgctatg ctaggtctct ctctctctaa gtggactctg accctgtcca aaacattgtg
     8341 cttttgcatg tagctgtgtc gcatttaggc ccagctctaa gaaccgtttg gaaataaatc
     8401 acatagagcc tttgattgtg aggcaggctt aaagtacatt ttgtttgatt tgcagaggca
     8461 tggtgaggaa tttatatgca tggctgttgt ggcagcagcg agatttccaa aaagatgaat
     8521 gatgaaatga aacagactga agctatctca caaatgttaa atggagaaat aaaagttgtt
     8581 atagtcattg ctaattacag aatgagcaag agatttattt agcaggacca tactatgccc
     8641 cctggaaggt tcagtttatg agctggagca caaggattta ctgtcatttc acctgaaaac
     8701 acacatttag ctgtccattt acctttaatc ctacaggctt aaaatacttt aaaatttcag
     8761 agaccattaa tatgtattcc tttagaaagc aaaggtcttt cagaagctgt cctctaccaa
     8821 agttaatgtg gtcaccacat ttgatgattt tgctaggtag ggaggtttat ttaatcacag
     8881 ctactgtcac tcaggaggat gagccattta aaaatggtgg ccctgtcctc cacttcttac
     8941 ctaccatata taatctcagt aattcagatt tctctaaatc agcattagtg atcatttcaa
     9001 tagggtatga acaaaaggcc tataaaaata gctttccaat tcgccaccaa aaatgcaaaa
     9061 atgacaagta agtgaggtaa cgcatgagct aaatagcttg atttagtcac tctaaaatgt
     9121 gggtgtgtat atatacatac atatatatac acacacacat tatgttatac accataaata
     9181 tatagaagtt ttacttgtca attaaaacta taaataaagt ggctttccag aaaaattaga
     9241 tattggactc tatcacaaag gaattgcata aaaatactta caaacataac tataagcaat
     9301 tgatgagcaa attacaaatg actgtttttt attaaaacat tcctccaaaa gaacggcaaa
     9361 gcaaatccca tagacaccca aaatactaaa agtgacaaaa caatacttct ttaaaaatgt
     9421 attttatgat ctatttattg atattctaat ggttttaaga aggataattt tccaaaacct
     9481 aaatgctaca cattttacag tggcaatatc aaccttatca tgagctaaag atttgcaatc
     9541 agaacattgg tagagtgcat tgctgagtta taacaagtgt ctcaggacga ggatatttgg
     9601 taggtatcct taaatatata gatgcttacc agtaggttta atagaagatt tctgaaaggt
     9661 agcgcaagtt tttatttcat tatttttatt tttatttttt tgagacagag tctcactctg
     9721 tcatctaggc tggagtgcag tggtgcaatc ttggcttgct gcaatctcca cctcccaggt
     9781 tcaagcgatt ctcccacctc agcctcccga gtagctggga ttacaggcat gcgccaccat
     9841 gcctggctaa tttttgtatt tttagtagag acggggtttc gccatgttgg ccaggctcgt
     9901 ctcgaactcc tggcctcaag tgatctgccc gcctcagcct cccaaagtgc tgggattaca
     9961 aatgtgagct actatgcctg gtcccaactt cttaaaatta aattttgggg aagttcatgg
    10021 agatattttt gacatgtaaa agtagaaaac aaaccatcca tagtgtgtgc atatatacac
    10081 acaaggtttg gtttaatata cttgctgtgc actagtcagt tttgattcag gttacataag
    10141 ggataaaata tagaaagaca ttttaaagtt tgaaatatgt gctaagtagt tagagatttg
    10201 gcagttttgc cacatttcaa atgggccaaa cattaaaata acttatccat gaatttcagg
    10261 tttcaaggaa ggaggaatat ctgactattt ttttttgtgt gtgagatttg gtctcagctt
    10321 tttggtccat ctgaatcctg gaagtcccca actctaccag accaaaaggg tgtctctatt
    10381 ttttgttgtt acttctctgt tcttgatgta atgagttaag tagatgaaag agattaaggt
    10441 gcagggaagg gctcttaaaa gtttaatgtt tcagctttcc atagtcattc atacttgtga
    10501 atcttcttcc tcttctactt caaagtagcc aaaacttgga aagttcaaat taatctttgg
    10561 gctccaaaga gcaattctga aggattaaca ggtttcattc tctccagtgg gaggtggcct
    10621 agacaggtgc cggttttggg gagaggtgag agtacccaga tgtgggtgac tatttcctgt
    10681 tcttccctga aagtcaggcc agtggtctcg aatcattccc acagcaactg ctacaaaagt
    10741 gactatctta atcctttggc tagatgggat acctcttcta ccttttcaga ggtgagctgt
    10801 tgagtagtaa tgtccgctac aacaccacgc tcccggaatg gtggttccta agagcaaagt
    10861 cagttaatac aatttctcca ggtatccagc tatctccagg tgtgcggtcc tgtgaagcac
    10921 tctaagaact gtaaaaaata tttcataggt atagaaggca tttgtaatac tgttggttca
    10981 aatgtgctga catgtagcca gtggaggaag atgtttcttt ggaagcctgc catctttctg
    11041 taacgcacct tcaacctgag ataattaaga gtcattacgt ttcccagtcc catgtcacat
    11101 tgaccagtcc tgtggtccta tggctaagcg gaggacacgg ccacaagctg tgagtcatga
    11161 aaaggagggt gcaggtgata ggcaaaggga cccattagcc agtttacaat gactggcaac
    11221 tgaccagata gagcttaccg tatgtccatg tagagttgct catattagtc tgtaaataat
    11281 tctatgcata gtgaatgcag cttctgaatt attaaactga tgctataaat gtgaactgac
    11341 aaaacccact tttggtctct cttcatattt ttcgtggttt catttatctc tcccttcaga
    11401 tgtttttcca tctgactgtc actggatagt ggaattgctc tgattaccga tgcctttttt
    11461 gttctttggt atattaaaat agtagtaaca gttgatctgg tgattggtga atacagttta
    11521 atctttaata ccttgtgatc cagatattta acaaacacac atgaaattta ctgaatgaca
    11581 agaactgtga taaagacttt taaagcctat cccctttaac cttcataata acctaatgag
    11641 taagtgttat tttcttccct ttagaagtgg ggaaactgga acacaggaaa gtcacttgtc
    11701 aaaggccaaa tagctacaga ctgagtattc cttatcccaa atgtttggga ccagaagtgt
    11761 tctggatttc cggttttaaa agattttggg atattggcat tatacctacc agctgagcat
    11821 cccaagtctg cacatttgat atctaaaata ctccagtgag cttttccttg gagtacacgt
    11881 tggcgctcaa aaagttttca atttgggagc atttcggatt tttgactttt ggatttggat
    11941 ttggaatgct caacctgttt tcagagtcag agccaagttc tgaatgctca tcacctggca
    12001 tatagtatgg tataatcacc ccaccaaacc tcttccaaaa gaagccaggg tcatctgctg
    12061 cagatgtttc tgggccacta ggccaatatt aaccaaatta ttatagacac catcttaatg
    12121 tagaggatcc cacaagactg tgacctaata aaaccctcat tttccctatg cattgtgact
    12181 aacacagtat ttgatacgta gtaggtctca atagatgatg aatagaccga tgaatgagca
    12241 catgagttga atggtgagga gcaagtgaag tgtcatatgt aaaagagtta attctcagat
    12301 tgattcaaat gcggacttaa cactgcagct gtaactctgg gtccgggtct tggtggctcc
    12361 tgctttgctg agctttaaaa ctttagtaac ctgatgatgg agagatctgg ggggtgcaga
    12421 ggagggacct ggttctggag tggtgatgct ggttgtcaga gggctgaggg tggtggcctt
    12481 ttgctaactg gtatggaagc atttcggtat tttaacaagt atgaaagtag ctatgtgaat
    12541 ttgccaaata gaaatcttgg aggccaggtg cagtggttca cacctgtaat cccagcattt
    12601 tggg
//
