LOCUS       NM_001323032           12563 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens synaptic vesicle glycoprotein 2B (SV2B), transcript
            variant 4, mRNA.
ACCESSION   NM_001323032 XM_005254997
VERSION     NM_001323032.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12563)
  AUTHORS   Lekholm,E., Ceder,M.M., Forsberg,E.C., Schioth,H.B. and
            Fredriksson,R.
  TITLE     Differentiation of two human neuroblastoma cell lines alters SV2
            expression patterns
  JOURNAL   Cell Mol Biol Lett 26 (1), 5 (2021)
   PUBMED   33588752
  REMARK    GeneRIF: Differentiation of two human neuroblastoma cell lines
            alters SV2 expression patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12563)
  AUTHORS   Zhang,Y., Yang,X., Zhu,X.L., Hao,J.Q., Bai,H., Xiao,Y.C.,
            Wang,Z.Z., Hao,C.Y. and Duan,H.B.
  TITLE     Bioinformatics analysis of potential core genes for glioblastoma
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32667033
  REMARK    GeneRIF: Bioinformatics analysis of potential core genes for
            glioblastoma.
REFERENCE   3  (bases 1 to 12563)
  AUTHORS   Fransen,E., Bonneux,S., Corneveaux,J.J., Schrauwen,I., Di
            Berardino,F., White,C.H., Ohmen,J.D., Van de Heyning,P.,
            Ambrosetti,U., Huentelman,M.J., Van Camp,G. and Friedman,R.A.
  TITLE     Genome-wide association analysis demonstrates the highly polygenic
            character of age-related hearing impairment
  JOURNAL   Eur J Hum Genet 23 (1), 110-115 (2015)
   PUBMED   24939585
REFERENCE   4  (bases 1 to 12563)
  AUTHORS   Crevecoeur,J., Kaminski,R.M., Rogister,B., Foerch,P.,
            Vandenplas,C., Neveux,M., Mazzuferi,M., Kroonen,J., Poulet,C.,
            Martin,D., Sadzot,B., Rikir,E., Klitgaard,H., Moonen,G. and
            Deprez,M.
  TITLE     Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in
            patients with temporal lobe epilepsy and hippocampal sclerosis
  JOURNAL   Neuropathol Appl Neurobiol 40 (2), 191-204 (2014)
   PUBMED   23617838
  REMARK    GeneRIF: In classical mesial temporal sclerosis 1A, the expression
            of SV2 isoforms is altered with a marked decrease of SV2B
            paralleling synaptic loss.
REFERENCE   5  (bases 1 to 12563)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 12563)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 12563)
  AUTHORS   Lazzell,D.R., Belizaire,R., Thakur,P., Sherry,D.M. and Janz,R.
  TITLE     SV2B regulates synaptotagmin 1 by direct interaction
  JOURNAL   J Biol Chem 279 (50), 52124-52131 (2004)
   PUBMED   15466855
REFERENCE   8  (bases 1 to 12563)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   9  (bases 1 to 12563)
  AUTHORS   Janz,R., Goda,Y., Geppert,M., Missler,M. and Sudhof,T.C.
  TITLE     SV2A and SV2B function as redundant Ca2+ regulators in
            neurotransmitter release
  JOURNAL   Neuron 24 (4), 1003-1016 (1999)
   PUBMED   10624962
REFERENCE   10 (bases 1 to 12563)
  AUTHORS   Bajjalieh,S.M., Peterson,K., Linial,M. and Scheller,R.H.
  TITLE     Brain contains two forms of synaptic vesicle protein 2
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2150-2154 (1993)
   PUBMED   7681585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127520.5 and AC123784.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001323032.2.
            
            Summary: This gene encodes a member of the synaptic vesicle
            proteins 2 (SV2) family and major facilitator superfamily of
            proteins. This protein and other members of the family are
            localized to synaptic vesicles and may function in the regulation
            of vesicle trafficking and exocytosis. Studies in mice suggest that
            the encoded protein may act as a protein receptor for botulinum
            neurotoxin E in neurons, and that this protein may be important for
            the integrity of the glomerular filtration barrier. This gene shows
            reduced expression in areas of synaptic loss in the hippocampus of
            human temporal lobe epilepsy patients. [provided by RefSeq, Sep
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.28571.1,
                                           SRR1803615.75376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394232.6/ ENSP00000377779.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC127520.5         91993-92099         c
            108-949             AC123784.2         97604-98445         c
            950-1130            AC123784.2         72319-72499         c
            1131-1282           AC123784.2         71798-71949         c
            1283-1416           AC123784.2         65764-65897         c
            1417-1506           AC123784.2         63909-63998         c
            1507-1617           AC123784.2         57626-57736         c
            1618-1706           AC123784.2         56675-56763         c
            1707-1871           AC123784.2         55713-55877         c
            1872-2005           AC123784.2         42457-42590         c
            2006-2206           AC123784.2         40097-40297         c
            2207-2366           AC123784.2         34638-34797         c
            2367-12563          AC123784.2         21753-31949         c
FEATURES             Location/Qualifiers
     source          1..12563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..12563
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="synaptic vesicle glycoprotein 2B"
                     /db_xref="GeneID:9899"
                     /db_xref="HGNC:HGNC:16874"
                     /db_xref="MIM:185861"
     exon            1..107
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            108..949
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..2550
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     synaptic vesicle protein 2B homolog; solute carrier family
                     22 member B2"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2B isoform 1"
                     /protein_id="NP_001309961.1"
                     /db_xref="CCDS:CCDS10370.1"
                     /db_xref="GeneID:9899"
                     /db_xref="HGNC:HGNC:16874"
                     /db_xref="MIM:185861"
                     /translation="MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDE
                     IYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDEC
                     GHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMA
                     GAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPI
                     VFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSW
                     RVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV
                     FTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLI
                     LAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQ
                     HGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHK
                     FINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRL
                     KMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRA
                     TAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL
                     M"
     exon            950..1130
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1282
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1416
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1506
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1617
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1706
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1871
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2005
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2206
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2366
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..12563
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5262..5267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: ATTAAA"
     polyA_site      5281
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="major polyA site"
     regulatory      11283..11288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: TATAAA"
     polyA_site      11307
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="major polyA site"
     regulatory      11432..11437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: ATTAAA"
     polyA_site      11454
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
     regulatory      12106..12111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: AATAAA"
     polyA_site      12127
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
ORIGIN      
        1 gcccggatcg cccagctccg cgttagccgg agctgcacgc ggggctgccg gggcggacgc
       61 tgctctgcct gcatccggag gcggccgcca gcggatttgc cacccagagc ataaccttcg
      121 gtggcaggac aaatcaggcc agcacgcagt ctgccaagtc ctgctcgctc cctgtcaaga
      181 aaaacagctg gatccatttc taatcaacac ttcccaacgc aacacttctg agtctctgaa
      241 ggagaccaga gcttgaaact ttccagactt ccaacagaca tcgagtgcaa aaggatattt
      301 aggttgtctt tgcacaaatc tggttgattt gagagataaa ggggggggga accagtgtga
      361 ctttcaccta agaagtcaca tgaacatatt tcacatttga actacataat gaatgatggt
      421 tattgaaata gcccaaacct ctaccacaga gcgagggata tagctcaagg ggcaaccagg
      481 cagtcgcaga accaaggaat ggatgactac aagtatcagg acaattatgg gggctatgct
      541 cccagtgatg gctattaccg cggcaatgag tccaacccag aagaagatgc acagagtgat
      601 gtcaccgaag gccatgatga ggaagacgag atctatgagg gcgagtacca gggtatccct
      661 cacccagatg atgtcaaggc caagcaggcc aagatggcgc cctccagaat ggacagcctt
      721 cggggccaga cagacctgat ggctgagagg ctggaagatg aggagcagtt ggcccaccag
      781 tacgagacca tcatggatga gtgtggccat ggccgcttcc agtggatcct ctttttcgtc
      841 ttgggtttgg ccctgatggc cgatggggtg gaagtgttcg tggtgagttt tgccctgccc
      901 agtgcagaga aggacatgtg tctgtccagt tccaaaaaag gaatgctagg gatgatagtc
      961 tacttgggaa tgatggcggg cgccttcatc ctgggaggcc tggctgataa gctgggaagg
     1021 aagcgagtcc tcagcatgtc tctggccgtc aatgcctcct tcgcctccct ctcttccttc
     1081 gtgcagggat atggagcctt cctcttctgc cgactcatct caggcatcgg tattgggggt
     1141 gctctaccga ttgtttttgc ctatttttct gaattcttgt ctcgggagaa gcgaggagaa
     1201 cacctcagtt ggctgggcat cttctggatg actgggggcc tgtacgcatc tgccatggcc
     1261 tggagcatca tcccacacta tggctggggc ttcagcatgg ggaccaatta ccacttccat
     1321 agctggagag tgtttgtcat cgtctgtgct ctgccctgca ccgtgtccat ggtggccctg
     1381 aagttcatgc cagagagccc aaggtttctg ctagagatgg gcaaacatga tgaagcctgg
     1441 atgattctca agcaagtcca tgacaccaac atgagagcta aggggacccc agagaaagtg
     1501 ttcacggttt ccaacatcaa aactcccaag caaatggatg aattcattga gatccaaagt
     1561 tcaacaggaa cctggtacca gcgctggctg gtcagattca agaccatttt caagcaggtc
     1621 tgggataatg ccctgtactg tgtgatgggg ccctacagaa tgaatacact gattctggcc
     1681 gtggtttggt ttgccatggc attcagttac tatggactga cagtttggtt tcctgatatg
     1741 atccgctatt ttcaagatga agaatacaag tctaaaatga aggtgttttt tggtgagcat
     1801 gtgtacggcg ccacaatcaa cttcacgatg gaaaatcaga tccaccaaca tgggaaactt
     1861 gtgaatgata agttcacaag aatgtacttt aaacatgtac tctttgagga cacattcttt
     1921 gacgagtgct attttgaaga cgtaacatca acagatacct acttcaaaaa ttgtaccatt
     1981 gaatcaacca tcttttacaa cacagacctc tacgagcaca agttcatcaa ctgtcggttt
     2041 atcaactcca ccttcctgga gcagaaggag ggctgccaca tggacttgga gcaagataat
     2101 gacttcctga tttacctcgt cagcttcctg ggcagcctgt ctgtcttacc cgggaacatc
     2161 atttctgccc tgctcatgga tagaattgga aggctcaaga tgattggtgg ctccatgcta
     2221 atctctgcag tctgctgctt cttcctgttt tttggcaaca gtgagtctgc aatgatcggc
     2281 tggcagtgcc tgttctgtgg gacaagcatt gcagcctgga atgctctgga tgtgatcaca
     2341 gtggagctgt atcccaccaa ccagagagca acagccttcg gcattctcaa tggattatgc
     2401 aaatttggcg ccatcctggg aaacaccatc tttgcttctt ttgttgggat aaccaaagtg
     2461 gtccccatcc ttctggctgc tgcttctctg gttgggggtg gcctgattgc ccttcgactg
     2521 ccagagactc gagaacaggt cctgatgtga acaacctatg ggaaaaggaa aggtcgagag
     2581 aatcttgtcc aggacactga aatgcatcca cacttcctgc ctatcacggt ccggaggaca
     2641 ccttggatag cacgggagga gaagttgact ttgtgacccc tagtttagga cccacttcag
     2701 ctgtcaatat gtttgtaact caggtgactg atttgggggt gccctgagcc acccttagaa
     2761 tcacagagct gcgtgtttaa cttcaagtct tcccagtcca aggcagggag aggattctcc
     2821 agtgagtgca cacactatgc gaggagcaag catttctcta agtcaagtgc aaggacttaa
     2881 cttgcgtttg aaaaggaatt agagggtcag aaacacccag gttcctccag aaagctcctt
     2941 ggagcccaac aacttaacaa atcaacttgg ctggaagtta gagtcattat atgaagattg
     3001 ggcttgaagt atatattttt gcatttaaaa gtatcaccta tcatattttc cactcgaaaa
     3061 ttgacatagt agcattgagg atactctgat ctagaaagcc aagtatttga gcaacatcta
     3121 tagagatcta cttttctcct atgtctccta ggctttccat gataattagg taatacattt
     3181 aagaaggata tttatttctg ttttgctcta ttcaaagaaa cggaatggga tagttattct
     3241 gtaaactaag tttgtatata actttatttg ggtttaattt ccacaactgg tatctgcaaa
     3301 tattgccagc attttagcca tattttggga gaacttggtg tttgaggtcc caggaaatga
     3361 ggtctgatca aatgaaatgc aagcacaatt tcttacagcc atttaacttt ctgttgggag
     3421 gatgaattaa caaactcaca ttgtgcagtc tgcttaatcc aggcactttt ctttgtgcag
     3481 gtgtagtgag tagttacttc tctcccttac acagatgact tgtgaaactc aagctcacca
     3541 tcttcagtgc tggcatttta ctttgccact acccaaaaac aatgtgagat gtgttcagtg
     3601 gcctctggta ctctttgcag gcaagaatca aacaacatgg ggactgaggg aaggatgggg
     3661 aagtgtagcc acagttcttc caaatgtaaa tactttttgt ttgttctagt ggtaaaatgc
     3721 aaatgcaatc catatttgtt aggatggtca ggtctcatga gaaatctatg ctatgtgtcc
     3781 agagcttttg aaacagagtc cattggagtg ggagttaggg agtgtagtgg atgccaaata
     3841 tgtttttctt cagtgcttaa gagaactgtt tcctgaagtc cagctttgaa cataaacagg
     3901 ggtgtgggtt gggggaggag cttaggacaa acctctctga tgaaggtcag caatagactg
     3961 aagtcttgac tgcatggaag aggaaaaaca tcagaactgt ctgacaatgg aggggacagt
     4021 gagctacgca caactgccag cggaggtgaa cttgcacctg cccaggccgg atgaacatca
     4081 gcctgcaaga actagttgtt tgagttgatt tgcagtgctc tcaatgggca agtgccacat
     4141 tttccctggc agagatctcc aaaaatttaa aacagaataa taatggctat atcgagtgtt
     4201 ttctcagtat tggagaaatg cttaggtcct atgatagctt cgggacatct ttctgtaatt
     4261 ttcctcaatt aacgggttgg taggggtaaa tcttatgaca cctttccacc gtcgatttga
     4321 gatcagtttt aatggttaaa atgtttactc tccttctgtc aaccctcacc tttttattta
     4381 cacccctccc tttttttctg tacagggaga gaagacatat tgactctgac tggacaccct
     4441 gattcctcca aatatatata ccactgtgta ttaatctttc tctcagtgtt ttataggagt
     4501 actaacattt attgctctgt caataatgaa aggctcgatg taatatagct gtaatttact
     4561 ttccatatga atacagtggc taggttcata aaagagaatt gtgtgagtct gggattacca
     4621 catctaaaac attattcttt aatgggataa tacaattcat tgagcagcta ccacttaaaa
     4681 aacttgcagg acagttagag cctgcatttc tagttaagat ggatcttgta aatttaaaat
     4741 tggattaaca ttggagtgct ggggtggctg caataatttg ggggctaact ccatttggtt
     4801 tccaagatct cacttctgca ttatctttat ggctctttaa accagccacc tagccaatca
     4861 agggcaattc ccatctcatc catcactcag gtctttgtaa agggtgcagc caagctctgc
     4921 agacttttgc aggattgtct agcctgagta ccgggctact tcttaaatgc cgtcactcct
     4981 gctgagataa atgcgtcttt aaaaatagtc tctgtggcag gtcactgggg gacaatgtac
     5041 agcattctgg ccatccactt ctttttcact tcatgttcta ccccaagaga ctcccgatgt
     5101 cggctgtgga gggttaaagg gatgaggctt tcctttgttt agcaaatctg ttcacagttc
     5161 ttgatgatgt attttatgat gcccagcttg gaaatagttg ctttccatag tctcaactgt
     5221 attgtgtcat ctcctgatgc tgatttttga tcttttgttt tattaaaaat aattagtgaa
     5281 agaggtgtgc ctatctgtga agtttgtagt acatcatcct gaggtcatgt aacaagtaaa
     5341 ccccaaccca gcgttccctc ctacgttgtg ttagttcatt aaaactaaat aataaaaata
     5401 actgtaagaa aaccttaagg actggggtta gagattattt tcaggcacta aggtctcttc
     5461 tgtattccaa aattgattga atcagctggg agaaacattg agaatcgctt ccttcaactt
     5521 ttattttgca acatggggac cttgagaggt taaacgatgt ggcccagatt acatgtaatg
     5581 tgaggagtgg gcgagaaggc ctaaggtgat gctctcatga cagttctggg gaagcctgca
     5641 gtttggggaa tgggacaatg tgacaaatac tcgccattcc ctgagaccat tcattgacta
     5701 ttcccttgat ggctttacta taatgagagg aagcatcagt ttaaacataa aaagattagt
     5761 atttatccat ccatttattc attcagcaaa tccttattga gccctgacca tgggccagtc
     5821 tctctgccaa gccctgggga cacagtgatg aaaaaactgg ccacagtttc tgcttcctgc
     5881 ctcattccac ttgcagtgag cggatattaa attggccata aacaccgagt acgatgacct
     5941 tacaatccgc aaactgcacc tttcatgtgt aaaaggattg ctactacttt acttgtcagc
     6001 tgtggatttc caaatgtggt ggctccctct tatttttttt tctttgagga gtgtaccaat
     6061 tttttatctt tataaaccag gtaagggaaa tgatgccctt gcccattttc tacagaccta
     6121 atcgattttt acctaatcag ttttacagaa agggttacat ggaagaagag ataggggcca
     6181 ggaatgcaag agggacattg gtgagtgggg taagaatccc cgtagccctg ggaaaggtgt
     6241 ctccacttcc acatctggct tttctagggg gcatctgtgc taactgacct gggattatgt
     6301 tggatggcat atgactgcaa attcaaagaa accaatttat aataagttta tagtaagtta
     6361 aaggtttgtt ttactctcat gtgaagggaa tctggaggaa ggaaagccag ggctggagtg
     6421 gctgcctttg atcatgggag cacactcctt ctgcccgatc attgggagca cactccttct
     6481 gcctgatcgt tgggagcaca ctcctgcctg atcatgggcg cacgttcctt ctgcctgatc
     6541 gttgggagca cactccttct gcctgatcat gggagcacac tccttctgcc tgatcattgg
     6601 gagcacgctc cttctgcctg atcgttggga gcacactctt tctgcctgat cgttgggagc
     6661 acaccccttc tgcctgatca ttgggagcac actccttctg cctgatcatg ggcacacgct
     6721 ccttctgccc gatcatgggc acacgctcct tctgcccgat cgttgggagc acactccttc
     6781 tgcccaatca ttgggctcac gctccttctg cccgatcgct gggctcacgc tccttctgcc
     6841 cgatcttggg cgcacgctcc ttctgcccga tcgttgggcg cacgctcctt ctgcccgatc
     6901 gttgggcgca tgctccttct gcccgatcgt tgggagcacg ctcattctgc ccgattgttg
     6961 ggagcacgct ccttctgccc gatcgttggg cgcacgctcc ttctgcccga tcgttgggcg
     7021 cacgcttctt ctgcctgatc gttgggcgca cgctccttct gcctgatcgt tgggcgcacg
     7081 ctccttctgc ctgatcgttg ggagcacgct ccttctgcct gattgttgga agcacgctcc
     7141 ttctgccttc agactccttg atttttagtg cagtttccat cactgaggct gcctcatggg
     7201 ctgagatggc tgttgaagca ctgaacctca catccacaat tcaggcagga agcagaagga
     7261 agggcaatgg gcaaaggggc tgtgccttgc agccgatcca gcctcccttt gctgcagagg
     7321 aggcagggaa atgcggtatt tactgggaac attgctgccc ctcctccaaa ttgagggtct
     7381 tggctcgaag gacaaaagcc agaaaggata ggtggattag tgcttcttaa acttttgcgt
     7441 gcatcagaat cacccagaaa gatgttaaaa ctcactcttc aaggccccat ccccagagat
     7501 tcggattctg gggatttgga atctggggtg gggtctgaag aatctgcatt ttttaacaaa
     7561 ctcccaggtg acatagatgg catcaattct caagccatat tttgagtagc actgacactc
     7621 ttccaatagg tggtactttg acttgtcagg gaagttctat tgctctgata acttaaaacc
     7681 aacccaacca gaagctcaca aaaactagca gcctgtgaaa aatgatcacc attttcctag
     7741 agctccgaga caactagtgg tagtgcaaca gtaacccaaa aatgtcaatg aaaatatttc
     7801 cttccccaga aactgcttgg tttcactcag gtcctgtcct tatgggcctg tgtctggttg
     7861 cagggcttga agtatttcgg aagctcagca gaggttgaac cctttcccct gggggttggt
     7921 gatctttgtt ttggccattt ccacctggtg aagattttca tagacaaata tgcttgtggc
     7981 atcctgtaat tcattgtgcc ttatgatgga cctctgattc tataagcttc cccctagcta
     8041 gggatgcacg ggggtgatca agacatgact agatgtgaac ctgacctgca gacagtccac
     8101 ctgaacgtgc ctggaaatgt ctcccgaaaa ggatgaaaag cctcctcctt tagacaagga
     8161 agacagagtg gagcaaattt ctctacatag atctcattcg aaaacaaatt tacagaatgc
     8221 agaatggcta ctgtgtgtct tgtgctatgc taggtctctc tctctctaag tggactctga
     8281 ccctgtccaa aacattgtgc ttttgcatgt agctgtgtcg catttaggcc cagctctaag
     8341 aaccgtttgg aaataaatca catagagcct ttgattgtga ggcaggctta aagtacattt
     8401 tgtttgattt gcagaggcat ggtgaggaat ttatatgcat ggctgttgtg gcagcagcga
     8461 gatttccaaa aagatgaatg atgaaatgaa acagactgaa gctatctcac aaatgttaaa
     8521 tggagaaata aaagttgtta tagtcattgc taattacaga atgagcaaga gatttattta
     8581 gcaggaccat actatgcccc ctggaaggtt cagtttatga gctggagcac aaggatttac
     8641 tgtcatttca cctgaaaaca cacatttagc tgtccattta cctttaatcc tacaggctta
     8701 aaatacttta aaatttcaga gaccattaat atgtattcct ttagaaagca aaggtctttc
     8761 agaagctgtc ctctaccaaa gttaatgtgg tcaccacatt tgatgatttt gctaggtagg
     8821 gaggtttatt taatcacagc tactgtcact caggaggatg agccatttaa aaatggtggc
     8881 cctgtcctcc acttcttacc taccatatat aatctcagta attcagattt ctctaaatca
     8941 gcattagtga tcatttcaat agggtatgaa caaaaggcct ataaaaatag ctttccaatt
     9001 cgccaccaaa aatgcaaaaa tgacaagtaa gtgaggtaac gcatgagcta aatagcttga
     9061 tttagtcact ctaaaatgtg ggtgtgtata tatacataca tatatataca cacacacatt
     9121 atgttataca ccataaatat atagaagttt tacttgtcaa ttaaaactat aaataaagtg
     9181 gctttccaga aaaattagat attggactct atcacaaagg aattgcataa aaatacttac
     9241 aaacataact ataagcaatt gatgagcaaa ttacaaatga ctgtttttta ttaaaacatt
     9301 cctccaaaag aacggcaaag caaatcccat agacacccaa aatactaaaa gtgacaaaac
     9361 aatacttctt taaaaatgta ttttatgatc tatttattga tattctaatg gttttaagaa
     9421 ggataatttt ccaaaaccta aatgctacac attttacagt ggcaatatca accttatcat
     9481 gagctaaaga tttgcaatca gaacattggt agagtgcatt gctgagttat aacaagtgtc
     9541 tcaggacgag gatatttggt aggtatcctt aaatatatag atgcttacca gtaggtttaa
     9601 tagaagattt ctgaaaggta gcgcaagttt ttatttcatt atttttattt ttattttttt
     9661 gagacagagt ctcactctgt catctaggct ggagtgcagt ggtgcaatct tggcttgctg
     9721 caatctccac ctcccaggtt caagcgattc tcccacctca gcctcccgag tagctgggat
     9781 tacaggcatg cgccaccatg cctggctaat ttttgtattt ttagtagaga cggggtttcg
     9841 ccatgttggc caggctcgtc tcgaactcct ggcctcaagt gatctgcccg cctcagcctc
     9901 ccaaagtgct gggattacaa atgtgagcta ctatgcctgg tcccaacttc ttaaaattaa
     9961 attttgggga agttcatgga gatatttttg acatgtaaaa gtagaaaaca aaccatccat
    10021 agtgtgtgca tatatacaca caaggtttgg tttaatatac ttgctgtgca ctagtcagtt
    10081 ttgattcagg ttacataagg gataaaatat agaaagacat tttaaagttt gaaatatgtg
    10141 ctaagtagtt agagatttgg cagttttgcc acatttcaaa tgggccaaac attaaaataa
    10201 cttatccatg aatttcaggt ttcaaggaag gaggaatatc tgactatttt tttttgtgtg
    10261 tgagatttgg tctcagcttt ttggtccatc tgaatcctgg aagtccccaa ctctaccaga
    10321 ccaaaagggt gtctctattt tttgttgtta cttctctgtt cttgatgtaa tgagttaagt
    10381 agatgaaaga gattaaggtg cagggaaggg ctcttaaaag tttaatgttt cagctttcca
    10441 tagtcattca tacttgtgaa tcttcttcct cttctacttc aaagtagcca aaacttggaa
    10501 agttcaaatt aatctttggg ctccaaagag caattctgaa ggattaacag gtttcattct
    10561 ctccagtggg aggtggccta gacaggtgcc ggttttgggg agaggtgaga gtacccagat
    10621 gtgggtgact atttcctgtt cttccctgaa agtcaggcca gtggtctcga atcattccca
    10681 cagcaactgc tacaaaagtg actatcttaa tcctttggct agatgggata cctcttctac
    10741 cttttcagag gtgagctgtt gagtagtaat gtccgctaca acaccacgct cccggaatgg
    10801 tggttcctaa gagcaaagtc agttaataca atttctccag gtatccagct atctccaggt
    10861 gtgcggtcct gtgaagcact ctaagaactg taaaaaatat ttcataggta tagaaggcat
    10921 ttgtaatact gttggttcaa atgtgctgac atgtagccag tggaggaaga tgtttctttg
    10981 gaagcctgcc atctttctgt aacgcacctt caacctgaga taattaagag tcattacgtt
    11041 tcccagtccc atgtcacatt gaccagtcct gtggtcctat ggctaagcgg aggacacggc
    11101 cacaagctgt gagtcatgaa aaggagggtg caggtgatag gcaaagggac ccattagcca
    11161 gtttacaatg actggcaact gaccagatag agcttaccgt atgtccatgt agagttgctc
    11221 atattagtct gtaaataatt ctatgcatag tgaatgcagc ttctgaatta ttaaactgat
    11281 gctataaatg tgaactgaca aaacccactt ttggtctctc ttcatatttt tcgtggtttc
    11341 atttatctct cccttcagat gtttttccat ctgactgtca ctggatagtg gaattgctct
    11401 gattaccgat gccttttttg ttctttggta tattaaaata gtagtaacag ttgatctggt
    11461 gattggtgaa tacagtttaa tctttaatac cttgtgatcc agatatttaa caaacacaca
    11521 tgaaatttac tgaatgacaa gaactgtgat aaagactttt aaagcctatc ccctttaacc
    11581 ttcataataa cctaatgagt aagtgttatt ttcttccctt tagaagtggg gaaactggaa
    11641 cacaggaaag tcacttgtca aaggccaaat agctacagac tgagtattcc ttatcccaaa
    11701 tgtttgggac cagaagtgtt ctggatttcc ggttttaaaa gattttggga tattggcatt
    11761 atacctacca gctgagcatc ccaagtctgc acatttgata tctaaaatac tccagtgagc
    11821 ttttccttgg agtacacgtt ggcgctcaaa aagttttcaa tttgggagca tttcggattt
    11881 ttgacttttg gatttggatt tggaatgctc aacctgtttt cagagtcaga gccaagttct
    11941 gaatgctcat cacctggcat atagtatggt ataatcaccc caccaaacct cttccaaaag
    12001 aagccagggt catctgctgc agatgtttct gggccactag gccaatatta accaaattat
    12061 tatagacacc atcttaatgt agaggatccc acaagactgt gacctaataa aaccctcatt
    12121 ttccctatgc attgtgacta acacagtatt tgatacgtag taggtctcaa tagatgatga
    12181 atagaccgat gaatgagcac atgagttgaa tggtgaggag caagtgaagt gtcatatgta
    12241 aaagagttaa ttctcagatt gattcaaatg cggacttaac actgcagctg taactctggg
    12301 tccgggtctt ggtggctcct gctttgctga gctttaaaac tttagtaacc tgatgatgga
    12361 gagatctggg gggtgcagag gagggacctg gttctggagt ggtgatgctg gttgtcagag
    12421 ggctgagggt ggtggccttt tgctaactgg tatggaagca tttcggtatt ttaacaagta
    12481 tgaaagtagc tatgtgaatt tgccaaatag aaatcttgga ggccaggtgc agtggttcac
    12541 acctgtaatc ccagcatttt ggg
//
