LOCUS       NM_001167580           11721 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens synaptic vesicle glycoprotein 2B (SV2B), transcript
            variant 2, mRNA.
ACCESSION   NM_001167580 XM_001720588 XM_001722037 XM_001722047
VERSION     NM_001167580.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11721)
  AUTHORS   Lekholm,E., Ceder,M.M., Forsberg,E.C., Schioth,H.B. and
            Fredriksson,R.
  TITLE     Differentiation of two human neuroblastoma cell lines alters SV2
            expression patterns
  JOURNAL   Cell Mol Biol Lett 26 (1), 5 (2021)
   PUBMED   33588752
  REMARK    GeneRIF: Differentiation of two human neuroblastoma cell lines
            alters SV2 expression patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11721)
  AUTHORS   Zhang,Y., Yang,X., Zhu,X.L., Hao,J.Q., Bai,H., Xiao,Y.C.,
            Wang,Z.Z., Hao,C.Y. and Duan,H.B.
  TITLE     Bioinformatics analysis of potential core genes for glioblastoma
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32667033
  REMARK    GeneRIF: Bioinformatics analysis of potential core genes for
            glioblastoma.
REFERENCE   3  (bases 1 to 11721)
  AUTHORS   Fransen,E., Bonneux,S., Corneveaux,J.J., Schrauwen,I., Di
            Berardino,F., White,C.H., Ohmen,J.D., Van de Heyning,P.,
            Ambrosetti,U., Huentelman,M.J., Van Camp,G. and Friedman,R.A.
  TITLE     Genome-wide association analysis demonstrates the highly polygenic
            character of age-related hearing impairment
  JOURNAL   Eur J Hum Genet 23 (1), 110-115 (2015)
   PUBMED   24939585
REFERENCE   4  (bases 1 to 11721)
  AUTHORS   Crevecoeur,J., Kaminski,R.M., Rogister,B., Foerch,P.,
            Vandenplas,C., Neveux,M., Mazzuferi,M., Kroonen,J., Poulet,C.,
            Martin,D., Sadzot,B., Rikir,E., Klitgaard,H., Moonen,G. and
            Deprez,M.
  TITLE     Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in
            patients with temporal lobe epilepsy and hippocampal sclerosis
  JOURNAL   Neuropathol Appl Neurobiol 40 (2), 191-204 (2014)
   PUBMED   23617838
  REMARK    GeneRIF: In classical mesial temporal sclerosis 1A, the expression
            of SV2 isoforms is altered with a marked decrease of SV2B
            paralleling synaptic loss.
REFERENCE   5  (bases 1 to 11721)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 11721)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 11721)
  AUTHORS   Lazzell,D.R., Belizaire,R., Thakur,P., Sherry,D.M. and Janz,R.
  TITLE     SV2B regulates synaptotagmin 1 by direct interaction
  JOURNAL   J Biol Chem 279 (50), 52124-52131 (2004)
   PUBMED   15466855
REFERENCE   8  (bases 1 to 11721)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   9  (bases 1 to 11721)
  AUTHORS   Janz,R., Goda,Y., Geppert,M., Missler,M. and Sudhof,T.C.
  TITLE     SV2A and SV2B function as redundant Ca2+ regulators in
            neurotransmitter release
  JOURNAL   Neuron 24 (4), 1003-1016 (1999)
   PUBMED   10624962
REFERENCE   10 (bases 1 to 11721)
  AUTHORS   Bajjalieh,S.M., Peterson,K., Linial,M. and Scheller,R.H.
  TITLE     Brain contains two forms of synaptic vesicle protein 2
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2150-2154 (1993)
   PUBMED   7681585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK294902.1, AC123784.2 and
            AL109781.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001167580.2.
            
            Summary: This gene encodes a member of the synaptic vesicle
            proteins 2 (SV2) family and major facilitator superfamily of
            proteins. This protein and other members of the family are
            localized to synaptic vesicles and may function in the regulation
            of vesicle trafficking and exocytosis. Studies in mice suggest that
            the encoded protein may act as a protein receptor for botulinum
            neurotoxin E in neurons, and that this protein may be important for
            the integrity of the glomerular filtration barrier. This gene shows
            reduced expression in areas of synaptic loss in the hippocampus of
            human temporal lobe epilepsy patients. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (2) lacks two internal exons in
            the 5' region, as compared to variant 1. This results in a
            downstream in-frame AUG start codon and a shorter isoform (2), as
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.28155.1,
                                           SRR1803612.113070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1792              AK294902.1         308-2099
            1793-9159           AC123784.2         24315-31681         c
            9160-10465          AL109781.1         72-1377
            10466-11721         AC123784.2         21753-23008         c
FEATURES             Location/Qualifiers
     source          1..11721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..11721
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="synaptic vesicle glycoprotein 2B"
                     /db_xref="GeneID:9899"
                     /db_xref="HGNC:HGNC:16874"
                     /db_xref="MIM:185861"
     exon            1..107
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            108..288
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1708
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synaptic vesicle protein 2B homolog; solute carrier family
                     22 member B2"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2B isoform 2"
                     /protein_id="NP_001161052.1"
                     /db_xref="CCDS:CCDS53972.1"
                     /db_xref="GeneID:9899"
                     /db_xref="HGNC:HGNC:16874"
                     /db_xref="MIM:185861"
                     /translation="MIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFV
                     QGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAM
                     AWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHD
                     EAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKT
                     IFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKM
                     KVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTST
                     DTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSF
                     LGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCG
                     TSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILL
                     AAASLVGGGLIALRLPETREQVLM"
     exon            289..440
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..574
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..664
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..775
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..864
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1029
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1163
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1364
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1524
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..11721
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4420..4425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: ATTAAA"
     polyA_site      4439
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="major polyA site"
     regulatory      10441..10446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: TATAAA"
     polyA_site      10465
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="major polyA site"
     regulatory      10590..10595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: ATTAAA"
     polyA_site      10612
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
     regulatory      11264..11269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
                     /note="hexamer: AATAAA"
     polyA_site      11285
                     /gene="SV2B"
                     /gene_synonym="HsT19680; SLC22B2"
ORIGIN      
        1 gcccggatcg cccagctccg cgttagccgg agctgcacgc ggggctgccg gggcggacgc
       61 tgctctgcct gcatccggag gcggccgcca gcggatttgc cacccaggga tgatagtcta
      121 cttgggaatg atggcgggcg ccttcatcct gggaggcctg gctgataagc tgggaaggaa
      181 gcgagtcctc agcatgtctc tggccgtcaa tgcctccttc gcctccctct cttccttcgt
      241 gcagggatat ggagccttcc tcttctgccg actcatctca ggcatcggta ttgggggtgc
      301 tctaccgatt gtttttgcct atttttctga attcttgtct cgggagaagc gaggagaaca
      361 cctcagttgg ctgggcatct tctggatgac tgggggcctg tacgcatctg ccatggcctg
      421 gagcatcatc ccacactatg gctggggctt cagcatgggg accaattacc acttccatag
      481 ctggagagtg tttgtcatcg tctgtgctct gccctgcacc gtgtccatgg tggccctgaa
      541 gttcatgcca gagagcccaa ggtttctgct agagatgggc aaacatgatg aagcctggat
      601 gattctcaag caagtccatg acaccaacat gagagctaag gggaccccag agaaagtgtt
      661 cacggtttcc aacatcaaaa ctcccaagca aatggatgaa ttcattgaga tccaaagttc
      721 aacaggaacc tggtaccagc gctggctggt cagattcaag accattttca agcaggtctg
      781 ggataatgcc ctgtactgtg tgatggggcc ctacagaatg aatacactga ttctggccgt
      841 ggtttggttt gccatggcat tcagttacta tggactgaca gtttggtttc ctgatatgat
      901 ccgctatttt caagatgaag aatacaagtc taaaatgaag gtgttttttg gtgagcatgt
      961 gtacggcgcc acaatcaact tcacgatgga aaatcagatc caccaacatg ggaaacttgt
     1021 gaatgataag ttcacaagaa tgtactttaa acatgtactc tttgaggaca cattctttga
     1081 cgagtgctat tttgaagacg taacatcaac agatacctac ttcaaaaatt gtaccattga
     1141 atcaaccatc ttttacaaca cagacctcta cgagcacaag ttcatcaact gtcggtttat
     1201 caactccacc ttcctggagc agaaggaggg ctgccacatg gacttggagc aagataatga
     1261 cttcctgatt tacctcgtca gcttcctggg cagcctgtct gtcttacccg ggaacatcat
     1321 ttctgccctg ctcatggata gaattggaag gctcaagatg attggtggct ccatgctaat
     1381 ctctgcagtc tgctgcttct tcctgttttt tggcaacagt gagtctgcaa tgatcggctg
     1441 gcagtgcctg ttctgtggga caagcattgc agcctggaat gctctggatg tgatcacagt
     1501 ggagctgtat cccaccaacc agagagcaac agccttcggc attctcaatg gattatgcaa
     1561 atttggcgcc atcctgggaa acaccatctt tgcttctttt gttgggataa ccaaagtggt
     1621 ccccatcctt ctggctgctg cttctctggt tgggggtggc ctgattgccc ttcgactgcc
     1681 agagactcga gaacaggtcc tgatgtgaac aacctatggg aaaaggaaag gtcgagagaa
     1741 tcttgtccag gacactgaaa tgcatccaca cttcctgcct atcacggtcc ggaggacacc
     1801 ttggatagca cgggaggaga agttgacttt gtgaccccta gtttaggacc cacttcagct
     1861 gtcaatatgt ttgtaactca ggtgactgat ttgggggtgc cctgagccac ccttagaatc
     1921 acagagctgc gtgtttaact tcaagtcttc ccagtccaag gcagggagag gattctccag
     1981 tgagtgcaca cactatgcga ggagcaagca tttctctaag tcaagtgcaa ggacttaact
     2041 tgcgtttgaa aaggaattag agggtcagaa acacccaggt tcctccagaa agctccttgg
     2101 agcccaacaa cttaacaaat caacttggct ggaagttaga gtcattatat gaagattggg
     2161 cttgaagtat atatttttgc atttaaaagt atcacctatc atattttcca ctcgaaaatt
     2221 gacatagtag cattgaggat actctgatct agaaagccaa gtatttgagc aacatctata
     2281 gagatctact tttctcctat gtctcctagg ctttccatga taattaggta atacatttaa
     2341 gaaggatatt tatttctgtt ttgctctatt caaagaaacg gaatgggata gttattctgt
     2401 aaactaagtt tgtatataac tttatttggg tttaatttcc acaactggta tctgcaaata
     2461 ttgccagcat tttagccata ttttgggaga acttggtgtt tgaggtccca ggaaatgagg
     2521 tctgatcaaa tgaaatgcaa gcacaatttc ttacagccat ttaactttct gttgggagga
     2581 tgaattaaca aactcacatt gtgcagtctg cttaatccag gcacttttct ttgtgcaggt
     2641 gtagtgagta gttacttctc tcccttacac agatgacttg tgaaactcaa gctcaccatc
     2701 ttcagtgctg gcattttact ttgccactac ccaaaaacaa tgtgagatgt gttcagtggc
     2761 ctctggtact ctttgcaggc aagaatcaaa caacatgggg actgagggaa ggatggggaa
     2821 gtgtagccac agttcttcca aatgtaaata ctttttgttt gttctagtgg taaaatgcaa
     2881 atgcaatcca tatttgttag gatggtcagg tctcatgaga aatctatgct atgtgtccag
     2941 agcttttgaa acagagtcca ttggagtggg agttagggag tgtagtggat gccaaatatg
     3001 tttttcttca gtgcttaaga gaactgtttc ctgaagtcca gctttgaaca taaacagggg
     3061 tgtgggttgg gggaggagct taggacaaac ctctctgatg aaggtcagca atagactgaa
     3121 gtcttgactg catggaagag gaaaaacatc agaactgtct gacaatggag gggacagtga
     3181 gctacgcaca actgccagcg gaggtgaact tgcacctgcc caggccggat gaacatcagc
     3241 ctgcaagaac tagttgtttg agttgatttg cagtgctctc aatgggcaag tgccacattt
     3301 tccctggcag agatctccaa aaatttaaaa cagaataata atggctatat cgagtgtttt
     3361 ctcagtattg gagaaatgct taggtcctat gatagcttcg ggacatcttt ctgtaatttt
     3421 cctcaattaa cgggttggta ggggtaaatc ttatgacacc tttccaccgt cgatttgaga
     3481 tcagttttaa tggttaaaat gtttactctc cttctgtcaa ccctcacctt tttatttaca
     3541 cccctccctt tttttctgta cagggagaga agacatattg actctgactg gacaccctga
     3601 ttcctccaaa tatatatacc actgtgtatt aatctttctc tcagtgtttt ataggagtac
     3661 taacatttat tgctctgtca ataatgaaag gctcgatgta atatagctgt aatttacttt
     3721 ccatatgaat acagtggcta ggttcataaa agagaattgt gtgagtctgg gattaccaca
     3781 tctaaaacat tattctttaa tgggataata caattcattg agcagctacc acttaaaaaa
     3841 cttgcaggac agttagagcc tgcatttcta gttaagatgg atcttgtaaa tttaaaattg
     3901 gattaacatt ggagtgctgg ggtggctgca ataatttggg ggctaactcc atttggtttc
     3961 caagatctca cttctgcatt atctttatgg ctctttaaac cagccaccta gccaatcaag
     4021 ggcaattccc atctcatcca tcactcaggt ctttgtaaag ggtgcagcca agctctgcag
     4081 acttttgcag gattgtctag cctgagtacc gggctacttc ttaaatgccg tcactcctgc
     4141 tgagataaat gcgtctttaa aaatagtctc tgtggcaggt cactggggga caatgtacag
     4201 cattctggcc atccacttct ttttcacttc atgttctacc ccaagagact cccgatgtcg
     4261 gctgtggagg gttaaaggga tgaggctttc ctttgtttag caaatctgtt cacagttctt
     4321 gatgatgtat tttatgatgc ccagcttgga aatagttgct ttccatagtc tcaactgtat
     4381 tgtgtcatct cctgatgctg atttttgatc ttttgtttta ttaaaaataa ttagtgaaag
     4441 aggtgtgcct atctgtgaag tttgtagtac atcatcctga ggtcatgtaa caagtaaacc
     4501 ccaacccagc gttccctcct acgttgtgtt agttcattaa aactaaataa taaaaataac
     4561 tgtaagaaaa ccttaaggac tggggttaga gattattttc aggcactaag gtctcttctg
     4621 tattccaaaa ttgattgaat cagctgggag aaacattgag aatcgcttcc ttcaactttt
     4681 attttgcaac atggggacct tgagaggtta aacgatgtgg cccagattac atgtaatgtg
     4741 aggagtgggc gagaaggcct aaggtgatgc tctcatgaca gttctgggga agcctgcagt
     4801 ttggggaatg ggacaatgtg acaaatactc gccattccct gagaccattc attgactatt
     4861 cccttgatgg ctttactata atgagaggaa gcatcagttt aaacataaaa agattagtat
     4921 ttatccatcc atttattcat tcagcaaatc cttattgagc cctgaccatg ggccagtctc
     4981 tctgccaagc cctggggaca cagtgatgaa aaaactggcc acagtttctg cttcctgcct
     5041 cattccactt gcagtgagcg gatattaaat tggccataaa caccgagtac gatgacctta
     5101 caatccgcaa actgcacctt tcatgtgtaa aaggattgct actactttac ttgtcagctg
     5161 tggatttcca aatgtggtgg ctccctctta tttttttttc tttgaggagt gtaccaattt
     5221 tttatcttta taaaccaggt aagggaaatg atgcccttgc ccattttcta cagacctaat
     5281 cgatttttac ctaatcagtt ttacagaaag ggttacatgg aagaagagat aggggccagg
     5341 aatgcaagag ggacattggt gagtggggta agaatccccg tagccctggg aaaggtgtct
     5401 ccacttccac atctggcttt tctagggggc atctgtgcta actgacctgg gattatgttg
     5461 gatggcatat gactgcaaat tcaaagaaac caatttataa taagtttata gtaagttaaa
     5521 ggtttgtttt actctcatgt gaagggaatc tggaggaagg aaagccaggg ctggagtggc
     5581 tgcctttgat catgggagca cactccttct gcccgatcat tgggagcaca ctccttctgc
     5641 ctgatcgttg ggagcacact cctgcctgat catgggcgca cgttccttct gcctgatcgt
     5701 tgggagcaca ctccttctgc ctgatcatgg gagcacactc cttctgcctg atcattggga
     5761 gcacgctcct tctgcctgat cgttgggagc acactctttc tgcctgatcg ttgggagcac
     5821 accccttctg cctgatcatt gggagcacac tccttctgcc tgatcatggg cacacgctcc
     5881 ttctgcccga tcatgggcac acgctccttc tgcccgatcg ttgggagcac actccttctg
     5941 cccaatcatt gggctcacgc tccttctgcc cgatcgctgg gctcacgctc cttctgcccg
     6001 atcttgggcg cacgctcctt ctgcccgatc gttgggcgca cgctccttct gcccgatcgt
     6061 tgggcgcatg ctccttctgc ccgatcgttg ggagcacgct cattctgccc gattgttggg
     6121 agcacgctcc ttctgcccga tcgttgggcg cacgctcctt ctgcccgatc gttgggcgca
     6181 cgcttcttct gcctgatcgt tgggcgcacg ctccttctgc ctgatcgttg ggcgcacgct
     6241 ccttctgcct gatcgttggg agcacgctcc ttctgcctga ttgttggaag cacgctcctt
     6301 ctgccttcag actccttgat ttttagtgca gtttccatca ctgaggctgc ctcatgggct
     6361 gagatggctg ttgaagcact gaacctcaca tccacaattc aggcaggaag cagaaggaag
     6421 ggcaatgggc aaaggggctg tgccttgcag ccgatccagc ctccctttgc tgcagaggag
     6481 gcagggaaat gcggtattta ctgggaacat tgctgcccct cctccaaatt gagggtcttg
     6541 gctcgaagga caaaagccag aaaggatagg tggattagtg cttcttaaac ttttgcgtgc
     6601 atcagaatca cccagaaaga tgttaaaact cactcttcaa ggccccatcc ccagagattc
     6661 ggattctggg gatttggaat ctggggtggg gtctgaagaa tctgcatttt ttaacaaact
     6721 cccaggtgac atagatggca tcaattctca agccatattt tgagtagcac tgacactctt
     6781 ccaataggtg gtactttgac ttgtcaggga agttctattg ctctgataac ttaaaaccaa
     6841 cccaaccaga agctcacaaa aactagcagc ctgtgaaaaa tgatcaccat tttcctagag
     6901 ctccgagaca actagtggta gtgcaacagt aacccaaaaa tgtcaatgaa aatatttcct
     6961 tccccagaaa ctgcttggtt tcactcaggt cctgtcctta tgggcctgtg tctggttgca
     7021 gggcttgaag tatttcggaa gctcagcaga ggttgaaccc tttcccctgg gggttggtga
     7081 tctttgtttt ggccatttcc acctggtgaa gattttcata gacaaatatg cttgtggcat
     7141 cctgtaattc attgtgcctt atgatggacc tctgattcta taagcttccc cctagctagg
     7201 gatgcacggg ggtgatcaag acatgactag atgtgaacct gacctgcaga cagtccacct
     7261 gaacgtgcct ggaaatgtct cccgaaaagg atgaaaagcc tcctccttta gacaaggaag
     7321 acagagtgga gcaaatttct ctacatagat ctcattcgaa aacaaattta cagaatgcag
     7381 aatggctact gtgtgtcttg tgctatgcta ggtctctctc tctctaagtg gactctgacc
     7441 ctgtccaaaa cattgtgctt ttgcatgtag ctgtgtcgca tttaggccca gctctaagaa
     7501 ccgtttggaa ataaatcaca tagagccttt gattgtgagg caggcttaaa gtacattttg
     7561 tttgatttgc agaggcatgg tgaggaattt atatgcatgg ctgttgtggc agcagcgaga
     7621 tttccaaaaa gatgaatgat gaaatgaaac agactgaagc tatctcacaa atgttaaatg
     7681 gagaaataaa agttgttata gtcattgcta attacagaat gagcaagaga tttatttagc
     7741 aggaccatac tatgccccct ggaaggttca gtttatgagc tggagcacaa ggatttactg
     7801 tcatttcacc tgaaaacaca catttagctg tccatttacc tttaatccta caggcttaaa
     7861 atactttaaa atttcagaga ccattaatat gtattccttt agaaagcaaa ggtctttcag
     7921 aagctgtcct ctaccaaagt taatgtggtc accacatttg atgattttgc taggtaggga
     7981 ggtttattta atcacagcta ctgtcactca ggaggatgag ccatttaaaa atggtggccc
     8041 tgtcctccac ttcttaccta ccatatataa tctcagtaat tcagatttct ctaaatcagc
     8101 attagtgatc atttcaatag ggtatgaaca aaaggcctat aaaaatagct ttccaattcg
     8161 ccaccaaaaa tgcaaaaatg acaagtaagt gaggtaacgc atgagctaaa tagcttgatt
     8221 tagtcactct aaaatgtggg tgtgtatata tacatacata tatatacaca cacacattat
     8281 gttatacacc ataaatatat agaagtttta cttgtcaatt aaaactataa ataaagtggc
     8341 tttccagaaa aattagatat tggactctat cacaaaggaa ttgcataaaa atacttacaa
     8401 acataactat aagcaattga tgagcaaatt acaaatgact gttttttatt aaaacattcc
     8461 tccaaaagaa cggcaaagca aatcccatag acacccaaaa tactaaaagt gacaaaacaa
     8521 tacttcttta aaaatgtatt ttatgatcta tttattgata ttctaatggt tttaagaagg
     8581 ataattttcc aaaacctaaa tgctacacat tttacagtgg caatatcaac cttatcatga
     8641 gctaaagatt tgcaatcaga acattggtag agtgcattgc tgagttataa caagtgtctc
     8701 aggacgagga tatttggtag gtatccttaa atatatagat gcttaccagt aggtttaata
     8761 gaagatttct gaaaggtagc gcaagttttt atttcattat ttttattttt atttttttga
     8821 gacagagtct cactctgtca tctaggctgg agtgcagtgg tgcaatcttg gcttgctgca
     8881 atctccacct cccaggttca agcgattctc ccacctcagc ctcccgagta gctgggatta
     8941 caggcatgcg ccaccatgcc tggctaattt ttgtattttt agtagagacg gggtttcgcc
     9001 atgttggcca ggctcgtctc gaactcctgg cctcaagtga tctgcccgcc tcagcctccc
     9061 aaagtgctgg gattacaaat gtgagctact atgcctggtc ccaacttctt aaaattaaat
     9121 tttggggaag ttcatggaga tatttttgac atgtaaaagt agaaaacaaa ccatccatag
     9181 tgtgtgcata tatacacaca aggtttggtt taatatactt gctgtgcact agtcagtttt
     9241 gattcaggtt acataaggga taaaatatag aaagacattt taaagtttga aatatgtgct
     9301 aagtagttag agatttggca gttttgccac atttcaaatg ggccaaacat taaaataact
     9361 tatccatgaa tttcaggttt caaggaagga ggaatatctg actatttttt tttgtgtgtg
     9421 agatttggtc tcagcttttt ggtccatctg aatcctggaa gtccccaact ctaccagacc
     9481 aaaagggtgt ctctattttt tgttgttact tctctgttct tgatgtaatg agttaagtag
     9541 atgaaagaga ttaaggtgca gggaagggct cttaaaagtt taatgtttca gctttccata
     9601 gtcattcata cttgtgaatc ttcttcctct tctacttcaa agtagccaaa acttggaaag
     9661 ttcaaattaa tctttgggct ccaaagagca attctgaagg attaacaggt ttcattctct
     9721 ccagtgggag gtggcctaga caggtgccgg ttttggggag aggtgagagt acccagatgt
     9781 gggtgactat ttcctgttct tccctgaaag tcaggccagt ggtctcgaat cattcccaca
     9841 gcaactgcta caaaagtgac tatcttaatc ctttggctag atgggatacc tcttctacct
     9901 tttcagaggt gagctgttga gtagtaatgt ccgctacaac accacgctcc cggaatggtg
     9961 gttcctaaga gcaaagtcag ttaatacaat ttctccaggt atccagctat ctccaggtgt
    10021 gcggtcctgt gaagcactct aagaactgta aaaaatattt cataggtata gaaggcattt
    10081 gtaatactgt tggttcaaat gtgctgacat gtagccagtg gaggaagatg tttctttgga
    10141 agcctgccat ctttctgtaa cgcaccttca acctgagata attaagagtc attacgtttc
    10201 ccagtcccat gtcacattga ccagtcctgt ggtcctatgg ctaagcggag gacacggcca
    10261 caagctgtga gtcatgaaaa ggagggtgca ggtgataggc aaagggaccc attagccagt
    10321 ttacaatgac tggcaactga ccagatagag cttaccgtat gtccatgtag agttgctcat
    10381 attagtctgt aaataattct atgcatagtg aatgcagctt ctgaattatt aaactgatgc
    10441 tataaatgtg aactgacaaa acccactttt ggtctctctt catatttttc gtggtttcat
    10501 ttatctctcc cttcagatgt ttttccatct gactgtcact ggatagtgga attgctctga
    10561 ttaccgatgc cttttttgtt ctttggtata ttaaaatagt agtaacagtt gatctggtga
    10621 ttggtgaata cagtttaatc tttaatacct tgtgatccag atatttaaca aacacacatg
    10681 aaatttactg aatgacaaga actgtgataa agacttttaa agcctatccc ctttaacctt
    10741 cataataacc taatgagtaa gtgttatttt cttcccttta gaagtgggga aactggaaca
    10801 caggaaagtc acttgtcaaa ggccaaatag ctacagactg agtattcctt atcccaaatg
    10861 tttgggacca gaagtgttct ggatttccgg ttttaaaaga ttttgggata ttggcattat
    10921 acctaccagc tgagcatccc aagtctgcac atttgatatc taaaatactc cagtgagctt
    10981 ttccttggag tacacgttgg cgctcaaaaa gttttcaatt tgggagcatt tcggattttt
    11041 gacttttgga tttggatttg gaatgctcaa cctgttttca gagtcagagc caagttctga
    11101 atgctcatca cctggcatat agtatggtat aatcacccca ccaaacctct tccaaaagaa
    11161 gccagggtca tctgctgcag atgtttctgg gccactaggc caatattaac caaattatta
    11221 tagacaccat cttaatgtag aggatcccac aagactgtga cctaataaaa ccctcatttt
    11281 ccctatgcat tgtgactaac acagtatttg atacgtagta ggtctcaata gatgatgaat
    11341 agaccgatga atgagcacat gagttgaatg gtgaggagca agtgaagtgt catatgtaaa
    11401 agagttaatt ctcagattga ttcaaatgcg gacttaacac tgcagctgta actctgggtc
    11461 cgggtcttgg tggctcctgc tttgctgagc tttaaaactt tagtaacctg atgatggaga
    11521 gatctggggg gtgcagagga gggacctggt tctggagtgg tgatgctggt tgtcagaggg
    11581 ctgagggtgg tggccttttg ctaactggta tggaagcatt tcggtatttt aacaagtatg
    11641 aaagtagcta tgtgaatttg ccaaatagaa atcttggagg ccaggtgcag tggttcacac
    11701 ctgtaatccc agcattttgg g
//
