LOCUS       NM_015355               4495 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens SUZ12 polycomb repressive complex 2 subunit (SUZ12),
            transcript variant 1, mRNA.
ACCESSION   NM_015355
VERSION     NM_015355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4495)
  AUTHORS   Hu,X., Hu,C. and Zhong,P.
  TITLE     The expression and role of SUZ12 in lung adenocarcinoma
  JOURNAL   Cancer Med 13 (19), e70190 (2024)
   PUBMED   39400513
  REMARK    GeneRIF: The expression and role of SUZ12 in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 4495)
  AUTHORS   Li,L., Li,C., Cao,S., Zhou,G., Jiang,Y. and Feng,J.
  TITLE     Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced Dysfunction
            Through Upregulating SUZ12 Expression to Activate Wnt/beta-catenin
            Signaling Pathway
  JOURNAL   Int Heart J 64 (6), 1113-1124 (2023)
   PUBMED   37967992
  REMARK    GeneRIF: Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced
            Dysfunction Through Upregulating SUZ12 Expression to Activate
            Wnt/beta-catenin Signaling Pathway.
REFERENCE   3  (bases 1 to 4495)
  AUTHORS   Matsui,Y., Djekidel,M.N., Lindsay,K., Samir,P., Connolly,N., Wu,G.,
            Yang,X., Fan,Y., Xu,B. and Peng,J.C.
  TITLE     SNIP1 and PRC2 coordinate cell fates of neural progenitors during
            brain development
  JOURNAL   Nat Commun 14 (1), 4754 (2023)
   PUBMED   37553330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4495)
  AUTHORS   Yuksel Ulker,A., Uludag Alkaya,D., Caglayan,A.O., Usluer,E.,
            Aykut,A., Aslanger,A., Vural,M. and Tuysuz,B.
  TITLE     An investigation of the etiology and follow-up findings in 35
            children with overgrowth syndromes, including biallelic SUZ12
            variant
  JOURNAL   Am J Med Genet A 191 (6), 1530-1545 (2023)
   PUBMED   36919607
  REMARK    GeneRIF: An investigation of the etiology and follow-up findings in
            35 children with overgrowth syndromes, including biallelic SUZ12
            variant.
REFERENCE   5  (bases 1 to 4495)
  AUTHORS   Imagawa,E., Seyama,R., Aoi,H., Uchiyama,Y., Marcarini,B.G.,
            Furquim,I., Honjo,R.S., Bertola,D.R., Kim,C.A. and Matsumoto,N.
  TITLE     Imagawa-Matsumoto syndrome: SUZ12-related overgrowth disorder
  JOURNAL   Clin Genet 103 (4), 383-391 (2023)
   PUBMED   36645289
  REMARK    GeneRIF: Imagawa-Matsumoto syndrome: SUZ12-related overgrowth
            disorder.
            Review article
REFERENCE   6  (bases 1 to 4495)
  AUTHORS   Kuzmichev,A., Nishioka,K., Erdjument-Bromage,H., Tempst,P. and
            Reinberg,D.
  TITLE     Histone methyltransferase activity associated with a human
            multiprotein complex containing the Enhancer of Zeste protein
  JOURNAL   Genes Dev 16 (22), 2893-2905 (2002)
   PUBMED   12435631
REFERENCE   7  (bases 1 to 4495)
  AUTHORS   Cao,R., Wang,L., Wang,H., Xia,L., Erdjument-Bromage,H., Tempst,P.,
            Jones,R.S. and Zhang,Y.
  TITLE     Role of histone H3 lysine 27 methylation in Polycomb-group
            silencing
  JOURNAL   Science 298 (5595), 1039-1043 (2002)
   PUBMED   12351676
REFERENCE   8  (bases 1 to 4495)
  AUTHORS   Weinmann,A.S., Bartley,S.M., Zhang,T., Zhang,M.Q. and Farnham,P.J.
  TITLE     Use of chromatin immunoprecipitation to clone novel E2F target
            promoters
  JOURNAL   Mol Cell Biol 21 (20), 6820-6832 (2001)
   PUBMED   11564866
REFERENCE   9  (bases 1 to 4495)
  AUTHORS   Birve,A., Sengupta,A.K., Beuchle,D., Larsson,J., Kennison,J.A.,
            Rasmuson-Lestander,A. and Muller,J.
  TITLE     Su(z)12, a novel Drosophila Polycomb group gene that is conserved
            in vertebrates and plants
  JOURNAL   Development 128 (17), 3371-3379 (2001)
   PUBMED   11546753
REFERENCE   10 (bases 1 to 4495)
  AUTHORS   Koontz,J.I., Soreng,A.L., Nucci,M., Kuo,F.C., Pauwels,P., van Den
            Berghe,H., Dal Cin,P., Fletcher,J.A. and Sklar,J.
  TITLE     Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal
            tumors
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6348-6353 (2001)
   PUBMED   11371647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129917.6, BI668506.1,
            DR000680.1, D63881.2 and BM975130.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015355.3.
            
            Summary: This zinc finger gene has been identified at the
            breakpoints of a recurrent chromosomal translocation reported in
            endometrial stromal sarcoma. Recombination of these breakpoints
            results in the fusion of this gene and JAZF1. The protein encoded
            by this gene contains a zinc finger domain in the C terminus of the
            coding region. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63881.2, SRR1803611.66483.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322652.10/ ENSP00000316578.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC129917.6         60778-60780
            4-14                BI668506.1         9-19
            15-46               DR000680.1         8-39
            47-4284             D63881.2           1-4238
            4285-4495           BM975130.1         26-236              c
FEATURES             Location/Qualifiers
     source          1..4495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4495
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /note="SUZ12 polycomb repressive complex 2 subunit"
                     /db_xref="GeneID:23512"
                     /db_xref="HGNC:HGNC:17101"
                     /db_xref="MIM:606245"
     exon            1..514
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2460
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polycomb protein SUZ12; chET 9 protein; joined to JAZF1
                     protein; suppressor of zeste 12 protein homolog; chromatin
                     precipitated E2F target 9 protein"
                     /codon_start=1
                     /product="polycomb protein SUZ12 isoform 1"
                     /protein_id="NP_056170.2"
                     /db_xref="CCDS:CCDS11270.1"
                     /db_xref="GeneID:23512"
                     /db_xref="HGNC:HGNC:17101"
                     /db_xref="MIM:606245"
                     /translation="MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGG
                     SCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRT
                     RNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLT
                     FTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPD
                     LNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDV
                     NEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATW
                     ETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPG
                     SVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHC
                     PWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHR
                     QPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYF
                     HSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKH
                     GFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLR
                     EMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL"
     exon            515..561
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..626
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..695
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..745
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..831
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1063
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1157
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1263
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1441
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1533
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1677
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1835
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2034
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2114
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..4495
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2664..2669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /note="hexamer: ATTAAA"
     polyA_site      2694
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /note="major polyA site"
     polyA_site      3310
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
     regulatory      4436..4441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /note="hexamer: ATTAAA"
     polyA_site      4459
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
     regulatory      4470..4475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
                     /note="hexamer: CATAAA"
     polyA_site      4495
                     /gene="SUZ12"
                     /gene_synonym="CHET9; IMMAS; JJAZ1"
ORIGIN      
        1 ggagcgaggc cagggtaggg tgagcggcct ccgaagcgga gcggggctct gaggagacac
       61 tttttttttc ctccctcctt ccctcctctc ctcctccctt cccttcccct ctcctcccct
      121 ctctcctcct tcccccctcg gtccgccgga gcctgctggg gcgagcggtt ggtattgcag
      181 gcgcttgctc tccggggccg cccggcgggt agctggcggg gggaggaggc aggaaccgcg
      241 atggcgcctc agaagcacgg cggtggggga gggggcggct cggggcccag cgcggggtcc
      301 gggggaggcg gcttcggggg ttcggcggcg gtggcggcgg cgacggcttc gggcggcaaa
      361 tccggcggcg ggagctgtgg agggggtggc agttactcgg cctcctcctc ctcctccgcg
      421 gcggcagcgg cgggggctgc ggtgttaccg gtgaagaagc cgaaaatgga gcacgtccag
      481 gctgaccacg agcttttcct ccaggccttt gagaagccaa cacagatcta tagatttctt
      541 cgaactcgga atctcatagc accaatattt ttgcacagaa ctcttactta catgtctcat
      601 cgaaactcca gaacaaacat caaaaggaaa acatttaaag ttgatgatat gttatcaaaa
      661 gtagagaaaa tgaaaggaga gcaagaatct catagcttgt cagctcattt gcagcttacg
      721 tttactggtt tcttccacaa aaatgataag ccatcaccaa actcagaaaa tgaacaaaat
      781 tctgttaccc tggaagtcct gcttgtgaaa gtttgccaca aaaaaagaaa ggatgtaagt
      841 tgtccaataa ggcaagttcc cacaggtaaa aagcaggtgc ctttgaatcc tgacctcaat
      901 caaacaaaac ccggaaattt cccgtccctt gcagtttcca gtaatgaatt tgaacctagt
      961 aacagccata tggtgaagtc ttactcgttg ctatttagag tgactcgtcc aggaagaaga
     1021 gagtttaatg gaatgattaa tggagaaacc aatgaaaata ttgatgtcaa tgaagagctt
     1081 ccagccagaa gaaaacgaaa tcgtgaggat ggggaaaaga catttgttgc acaaatgaca
     1141 gtatttgata aaaacaggcg cttacagctt ttagatgggg aatatgaagt agccatgcag
     1201 gaaatggaag aatgtccaat aagcaagaaa agagcaacat gggagactat tcttgatggg
     1261 aagaggctgc ctccattcga aacattttct cagggaccta cgttgcagtt cactcttcgt
     1321 tggacaggag agaccaatga taaatctacg gctcctattg ccaaacctct tgccactaga
     1381 aattcagaga gtctccatca ggaaaacaag cctggttcag ttaaacctac tcaaactatt
     1441 gctgttaaag aatcattgac tacagatcta caaacaagaa aagaaaagga tactccaaat
     1501 gaaaaccgac aaaaattaag aatattttat cagtttctct ataacaacaa tacaaggcaa
     1561 caaactgaag caagagatga cctgcattgc ccttggtgta ctctgaactg ccgcaaactt
     1621 tatagtttac tcaagcatct taaactctgc catagcagat ttatcttcaa ctatgtttat
     1681 catccaaaag gtgctaggat agatgtttct atcaatgagt gttatgatgg ctcctatgca
     1741 ggaaatcctc aggatattca tcgccaacct ggatttgctt ttagtcgcaa cggaccagtt
     1801 aagagaacac ctatcacaca tattcttgtg tgcaggccaa aacgaacaaa agcaagcatg
     1861 tctgaatttc ttgaatctga agatggggaa gtagaacagc aaagaacata tagtagtggc
     1921 cacaatcgtc tgtatttcca tagtgatacc tgcttacctc tccgtccaca agaaatggaa
     1981 gtagatagtg aagatgaaaa ggatcctgaa tggctaagag aaaaaaccat tacacaaatt
     2041 gaagagtttt ctgatgttaa tgaaggagag aaagaagtga tgaaactctg gaatctccat
     2101 gtcatgaagc atgggtttat tgctgacaat caaatgaatc atgcctgtat gctgtttgta
     2161 gaaaattatg gacagaaaat aattaagaag aatttatgtc gaaacttcat gcttcatcta
     2221 gtcagcatgc atgactttaa tcttattagc ataatgtcaa tagataaagc tgttaccaag
     2281 ctccgtgaaa tgcagcaaaa attagaaaag ggggaatctg cttcccctgc aaacgaagaa
     2341 ataactgaag aacaaaatgg gacagcaaat ggatttagtg aaattaactc aaaagagaaa
     2401 gctttggaaa cagatagtgt ctcaggggtt tcaaaacaga gcaaaaaaca aaaactctga
     2461 aaagctctaa ccccatgtta tggacaaaca ctgaaattac attttaggga attcatcctc
     2521 taagaattat gtttttgttt ttaatcatat gttccaaaca ggcactgtta gatgaagtaa
     2581 atgatttcaa caaggatatt tgtatcaggg ttctacttca cttcattatg cagcattaca
     2641 tgtatatcac ttttattgat gtcattaaaa cattctgtac tttaagcatg aaaagcaata
     2701 tttcaaagta tttttaaact caacaaatgt catcaaatat gttgaattga tctagaaatt
     2761 atttcatata taaatcagaa tttttttgca tttatgaacg gctgtttttc tactttgtaa
     2821 ttgtgagaca ttttcttggg gagggaaaat tggaatggtt ccctttttta gaaattgaag
     2881 tggtcttcat atgtcaacta cagaaaagga aaaaaataga aattgaagga tttttatgaa
     2941 attatattgc attactattt gcagtcaaac tttgatcctt gtttttgaaa tcatttgtca
     3001 attcggaatg aaaaattata atgtaatttt acattacata agttcctttt acaattaaaa
     3061 aatagcactt cttcatctta tgcctgtttg agaagatatt aaattttcac attgttgaca
     3121 gtgaaatgct atgttggttt ataagattac agaccatttg ttttcatgtg gataatttta
     3181 gtgcattgct cacccggtat gttttttttt tttaacttga acattttgct tgttttgttt
     3241 ttctttttta attagataat cacacggaaa attaagctgt tcatatcttt aaattaggat
     3301 tgcaaaccaa ggaaagaacg catttgagat tttaagatgt cacttataag gggagaagtg
     3361 ttcttaaaaa gtcaaccaga aaactgttat gccttttatt tgtttgcaag gatgtctttg
     3421 taatgtgttt catgaataga atatccaata gagataagct gacttgaatc attttgagca
     3481 attttgccct gtgttatatg tgtttcacgc acatatttgc agttggattt tctccaacag
     3541 aaagtggatt cactactggc acattaacaa gcaccaatag gtttttattc caactccgag
     3601 cactgtggtt gagtaacatc acctcaattt tttattatcc ttaaagatat tgcattttca
     3661 tattctttat ttataaagga tcaatgctgc tgtaaataca ggtattttta attttaaaat
     3721 ttcattccac caccatcaga tgcagttccc tattttgttt aatgaaggga tatataagct
     3781 ttctaatggt gtcttcagaa atttataaaa tgtaaatact gatttgactg gtctttaaga
     3841 tgtgtttaac tgtgaggcta tttaacgaat agtgtggatg tgatttgtca tccagtatta
     3901 agttcttagt cattgatttt tgtgtttaaa aaaaaatagg aaagagggaa actgcagctt
     3961 tcattacaga ttccttgatt ggtaagctct ccaaatgatg agttctagta aactctgatt
     4021 tttgcctctg gatagtagat ctcgagcgtt tatctcgggc tttaatttgc taaagctgtg
     4081 cacatatgta aaaaaaaaaa aaaaaagatt attttagggg agatgtaggt gtagaattat
     4141 tgcttatgtc atttcttaag cagttatgct cttaatgctt aaaagaaggc tagcattgtt
     4201 tgcacaaaaa gttggtgatt cccaccccaa atagtaataa aattacttct gttgagtaaa
     4261 ctttttatgt catcgtaaaa gctgaaaaaa tccctttgtt tctatttata aaaaaagtgc
     4321 ttttctatat gtacccttga taacagattt tgaagaaatc ctgtaagatg ataaagcatt
     4381 tgaatggtac agtagatgta aaaaaaattc agtttaaaag aacatttgtt tttacattaa
     4441 atgtttattt gaaatcaaat gattttgtac ataaagttca ataatataaa agctg
//
