LOCUS       NM_001193424            3059 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SUV39H2 histone lysine methyltransferase (SUV39H2),
            transcript variant 1, mRNA.
ACCESSION   NM_001193424
VERSION     NM_001193424.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3059)
  AUTHORS   Yang,J., Xu,P., Chen,Z., Zhang,X., Xia,Y., Fang,L., Xie,L., Li,B.
            and Xu,Z.
  TITLE     N6-methyadenosine modified SUV39H2 regulates homologous
            recombination through epigenetic repression of DUSP6 in gastric
            cancer
  JOURNAL   Cancer Lett 558, 216092 (2023)
   PUBMED   36806557
  REMARK    GeneRIF: N6-methyadenosine modified SUV39H2 regulates homologous
            recombination through epigenetic repression of DUSP6 in gastric
            cancer.
REFERENCE   2  (bases 1 to 3059)
  AUTHORS   Luu,J., Kallestad,L., Hoang,T., Lewandowski,D., Dong,Z.,
            Blackshaw,S. and Palczewski,K.
  TITLE     Epigenetic hallmarks of age-related macular degeneration are
            recapitulated in a photosensitive mouse model
  JOURNAL   Hum Mol Genet 29 (15), 2611-2624 (2020)
   PUBMED   32691052
  REMARK    GeneRIF: Epigenetic hallmarks of age-related macular degeneration
            are recapitulated in a photosensitive mouse model.
REFERENCE   3  (bases 1 to 3059)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3059)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3059)
  AUTHORS   Chao,C., You,J., Li,H., Xue,H. and Tan,X.
  TITLE     Elevated SUV39H2 attributes to the progression of nasopharyngeal
            carcinoma via regulation of NRIP1
  JOURNAL   Biochem Biophys Res Commun 510 (2), 290-295 (2019)
   PUBMED   30709585
  REMARK    GeneRIF: SUV39H2 elevation contributes to the progression of
            nasopharyngeal carcinoma via regulation of NRIP1
REFERENCE   6  (bases 1 to 3059)
  AUTHORS   Frontelo,P., Leader,J.E., Yoo,N., Potocki,A.C., Crawford,M.,
            Kulik,M. and Lechleider,R.J.
  TITLE     Suv39h histone methyltransferases interact with Smads and cooperate
            in BMP-induced repression
  JOURNAL   Oncogene 23 (30), 5242-5251 (2004)
   PUBMED   15107829
REFERENCE   7  (bases 1 to 3059)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 3059)
  AUTHORS   Ait-Si-Ali,S., Guasconi,V., Fritsch,L., Yahi,H., Sekhri,R.,
            Naguibneva,I., Robin,P., Cabon,F., Polesskaya,A. and
            Harel-Bellan,A.
  TITLE     A Suv39h-dependent mechanism for silencing S-phase genes in
            differentiating but not in cycling cells
  JOURNAL   EMBO J 23 (3), 605-615 (2004)
   PUBMED   14765126
REFERENCE   9  (bases 1 to 3059)
  AUTHORS   O'Carroll,D., Scherthan,H., Peters,A.H., Opravil,S., Haynes,A.R.,
            Laible,G., Rea,S., Schmid,M., Lebersorger,A., Jerratsch,M.,
            Sattler,L., Mattei,M.G., Denny,P., Brown,S.D., Schweizer,D. and
            Jenuwein,T.
  TITLE     Isolation and characterization of Suv39h2, a second histone H3
            methyltransferase gene that displays testis-specific expression
  JOURNAL   Mol Cell Biol 20 (24), 9423-9433 (2000)
   PUBMED   11094092
REFERENCE   10 (bases 1 to 3059)
  AUTHORS   Rea,S., Eisenhaber,F., O'Carroll,D., Strahl,B.D., Sun,Z.W.,
            Schmid,M., Opravil,S., Mechtler,K., Ponting,C.P., Allis,C.D. and
            Jenuwein,T.
  TITLE     Regulation of chromatin structure by site-specific histone H3
            methyltransferases
  JOURNAL   Nature 406 (6796), 593-599 (2000)
   PUBMED   10949293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB040298.1 and BC007754.2.
            
            On May 17, 2019 this sequence version replaced NM_001193424.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.41225.1,
                                           SRR6380202.33061.13 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354919.11/ ENSP00000346997.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-497               DB040298.1         84-580
            498-3059            BC007754.2         526-3087
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..3059
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="SUV39H2 histone lysine methyltransferase"
                     /db_xref="GeneID:79723"
                     /db_xref="HGNC:HGNC:17287"
                     /db_xref="MIM:606503"
     exon            1..54
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1256
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /EC_number="2.1.1.355"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase SUV39H2; H3-K9-HMTase
                     2; su(var)3-9 homolog 2; lysine N-methyltransferase 1B;
                     histone H3-K9 methyltransferase 2; suppressor of
                     variegation 3-9 homolog 2; histone methyltransferase
                     SUV39H2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SUV39H2
                     isoform 1"
                     /protein_id="NP_001180353.1"
                     /db_xref="CCDS:CCDS53494.1"
                     /db_xref="GeneID:79723"
                     /db_xref="HGNC:HGNC:17287"
                     /db_xref="MIM:606503"
                     /translation="MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNL
                     NNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLS
                     QVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTV
                     DLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQI
                     KIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSF
                     VMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCD
                     PNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKK
                     RVRTVCKCGAVTCRGYLN"
     exon            55..200
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            201..872
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1019
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1149
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..3059
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="hexamer: AATACA"
     polyA_site      1339
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="major polyA site"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1798
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="major polyA site"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="hexamer: TATAAA"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1829
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="major polyA site"
     polyA_site      1833
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="major polyA site"
     polyA_site      1866
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
                     /note="hexamer: GATAAA"
     polyA_site      2335
                     /gene="SUV39H2"
                     /gene_synonym="KMT1B"
ORIGIN      
        1 agtttgaatg aaagctctac aagatggcgg cggtcggggc cgaggcgcga ggagcttggt
       61 gtgtgccttg cctagtttca cttgatactc ttcaggaatt atgtagaaaa gaaaagctca
      121 catgtaaatc gattggaatc accaaaagga atctaaacaa ttatgaggtg gaatacttgt
      181 gtgactacaa ggtagtaaag gatatggaat attatcttgt aaaatggaaa ggatggccag
      241 attctacaaa tacttgggaa cctttgcaaa atctgaagtg cccgttactg cttcagcaat
      301 tctctaatga caagcataat tatttatctc aggtaaagaa aggcaaagca ataactccaa
      361 aagacaataa caaaactttg aaacctgcca ttgctgagta cattgtgaag aaggctaaac
      421 aaaggatagc tctgcagaga tggcaagatg aactcaacag aagaaagaat cataaaggaa
      481 tgatatttgt tgaaaatact gttgatttag agggcccacc ttcagacttc tattacatta
      541 acgaatacaa accagctcct ggaatcagct tagtcaatga agctaccttt ggttgttcat
      601 gcacagattg cttctttcaa aaatgttgtc ctgctgaagc tggagttctt ttggcttata
      661 ataaaaacca acaaattaaa atcccacctg gtactcccat ctatgaatgc aactcaaggt
      721 gtcagtgtgg tcctgattgt cccaatagga ttgtacaaaa aggcacacag tattcgcttt
      781 gcatctttcg aactagcaat ggacgtggct ggggtgtaaa gacccttgtg aagattaaaa
      841 gaatgagttt tgtcatggaa tatgttggag aggtaatcac aagtgaagaa gctgaaagac
      901 gaggacagtt ctatgacaac aagggaatca cgtatctctt tgatctggac tatgagtctg
      961 atgaattcac agtggatgcg gctcgatacg gcaatgtgtc tcattttgtg aatcacagct
     1021 gtgacccaaa tcttcaggtg ttcaatgttt tcattgataa cctcgatact cgtcttcccc
     1081 gaatagcatt gttttccaca agaaccataa atgctggaga agagctgact tttgattatc
     1141 aaatgaaagg ttctggagat atatcttcag attctattga ccacagccca gccaaaaaga
     1201 gggtcagaac agtatgtaaa tgtggagctg tgacttgcag aggttacctc aactgaactt
     1261 tttcaggaaa tagagctgat gattataata tttttttcct aatgttaaca tttttaaaaa
     1321 tacatatttg ggactcttat tatcaaggtt ctacctatgt taatttacaa ttcatgtttc
     1381 aagacatttg ccaaatgtat taccgatgcc tctgaaaagg gggtcactgg gtctcataga
     1441 ctgatatgaa gtcgacatat ttatagtgct tagagaccaa actaatggaa ggcagactat
     1501 ttacagctta gtatatgtgt acttaagtct atgtgaacag agaaatgcct cccgtagtgt
     1561 ttgaaagcgt taagctgata atgtaattaa caactgctga gagatcaaag attcaacttg
     1621 ccatacacct caaattcgga gaaacagtta atttgggcaa atctacagtt ctgtttttgc
     1681 tactctattg tcattcctgt ttaatactca ctgtacttgt atttgagaca aataggtgat
     1741 actgaatttt atactgtttt ctacttttcc attaaaacat tggcacctca atgataaaga
     1801 aatttaaggt ataaaattaa atgtaaaaat taatttcagc ttcatttcgt atttcgaagc
     1861 aatctagact gttgtgatga gtgtatgtct gaacctgtaa ttcttaaaag acttcttaat
     1921 cttctagaag aaaaatctcc gaagagctct ctctagaagt ccaaaatggc tagccattat
     1981 gcttctttga aaggacatga taatgggacc aggatggttt tttggagtac caagcaaggg
     2041 gaatggagca ctttaagggc gcctgttagt aacatgaatt ggaaatctgt gtcgagtacc
     2101 tctgatctaa acggtaaaac aagctgcctg gagagcagct gtacctaaca atactgtaat
     2161 gtacattaac attacagcct ctcaatttca ggcaggtgta acagttcctt tccaccagat
     2221 ttaatatttt tatacttcct gcaggttctt cttaaaaagt aatctatatt tttgaactga
     2281 tacttgtttt atacataaat tttttttaga tgtgataaag ctaaacttgg ccaaagtgtg
     2341 tgcctgaatt attagacctt tttattagtc aacctacgaa gactaaaata gaatatatta
     2401 gttttcaagg gagtgggagg cttccaacat agtattgaat ctcaggaaaa actattcttt
     2461 catgtctgat tctgagattt ctaattgtgt tgtgaaaatg ataaatgcag caaatctagc
     2521 tttcagtatt cctaattttt acctaagctc attgctccag gctttgatta cctaaaataa
     2581 gcttggataa aattgaacca acttcaagaa tgcagcactt cttaatcttt agctctttct
     2641 tgggagaagc tagactttat tcattatatt gctatgacaa cttcactctt tcataatata
     2701 taggataaat tgtttacatg attggaccct cagattctgt taaccaaaat tgcagaatgg
     2761 ggggccaggc ctgtgtggtg gctcacacct gtgatcccag cactttggga ggctgaggta
     2821 ggaggatcac gtgaggtcgg gagttcaaga ccagcctggc catcatggtg aaaccctgtc
     2881 tctactgaaa atacaaaaat tagccgggcg tggtggcaca cgcctgtagt cccagctact
     2941 caggaggctg aggcaggaga atcacttgaa ttcaggaggc ggaggttgca gtgagccaag
     3001 atcataccac tgcactgcag cctgagtgac acagtaagac tgtctccaaa aaaaaaaaa
//
