LOCUS       NM_014734               5390 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens sushi domain containing 6 (SUSD6), mRNA.
ACCESSION   NM_014734
VERSION     NM_014734.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Xu,Y., Ren,H., Jiang,J., Wang,Q., Wudu,M., Zhang,Q., Su,H.,
            Wang,C., Jiang,L. and Qiu,X.
  TITLE     KIAA0247 inhibits growth, migration, invasion of non-small-cell
            lung cancer through regulating the Notch pathway
  JOURNAL   Cancer Sci 109 (4), 1055-1065 (2018)
   PUBMED   29451718
  REMARK    GeneRIF: KIAA0247 is a candidate prognostic biomarker and potential
            therapeutic target in NSCLC.
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Tan,Y., Huang,N., Zhang,X., Hu,J., Cheng,S., Pi,L. and Cheng,Y.
  TITLE     KIAA0247 suppresses the proliferation, angiogenesis and promote
            apoptosis of human glioma through inactivation of the AKT and Stat3
            signaling pathway
  JOURNAL   Oncotarget 7 (52), 87100-87113 (2016)
   PUBMED   27893430
  REMARK    GeneRIF: overexpression of KIAA0247 is able to inhibit
            phosphorylation of AKT and Stat3 in glioma cells, resulting in
            inactivation of the AKT and Stat3 signaling pathways, this
            ultimately decreases the expression of PCNA, CyclinD1, Bcl2 and
            VEGF.
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Polato,F., Rusconi,P., Zangrossi,S., Morelli,F., Boeri,M., Musi,A.,
            Marchini,S., Castiglioni,V., Scanziani,E., Torri,V. and Broggini,M.
  TITLE     DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene
            that cooperates with p53 as oncosuppressor. [Corrected]
  JOURNAL   J Natl Cancer Inst 106 (4), dju053 (2014)
   PUBMED   24652652
  REMARK    GeneRIF: DRAGO (drug-activated gene overexpressed) KIAA0247
            represents a new p53-dependent gene highly regulated in human cells
            and whose expression cooperates with p53 in tumor suppressor
            functions.
            Erratum:[J Natl Cancer Inst. 2014 Aug;106(8):dju199
            doi:10.1093/jnci/dju199]
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Huang,C.J., Yang,S.H., Huang,S.M., Lin,C.M., Chien,C.C., Chen,Y.C.,
            Lee,C.L., Wu,H.H. and Chang,C.C.
  TITLE     A predicted protein, KIAA0247, is a cell cycle modulator in
            colorectal cancer cells under 5-FU treatment
  JOURNAL   J Transl Med 9, 82 (2011)
   PUBMED   21619678
  REMARK    GeneRIF: This is the first description of a linkage between
            KIAA0247 and colorectal cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5390)
  AUTHORS   Schwanzer-Pfeiffer,D., Rossmanith,E., Schildberger,A. and
            Falkenhagen,D.
  TITLE     Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell
            culture model of endotoxemia
  JOURNAL   Cell Immunol 263 (1), 65-70 (2010)
   PUBMED   20236627
  REMARK    GeneRIF: gene silencing in umbilical vein endothelial cells causes
            decrease in monocyte chemoattractant protein-1 production during
            endotoxemia
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC346928.1, D87434.1 and AL355837.6.
            
            On Nov 22, 2018 this sequence version replaced NM_014734.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064697.1, D87434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342745.5/ ENSP00000344424.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DC346928.1         5-49
            46-1865             D87434.1           1-1820
            1866-5390           AL355837.6         50625-54149         c
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..5390
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /note="sushi domain containing 6"
                     /db_xref="GeneID:9766"
                     /db_xref="HGNC:HGNC:19956"
                     /db_xref="MIM:616761"
     exon            1..233
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /inference="alignment:Splign:2.1.0"
     exon            234..434
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1225
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /note="drug-activated gene overexpressed protein; sushi
                     domain-containing protein 6"
                     /codon_start=1
                     /product="sushi domain-containing protein 6 precursor"
                     /protein_id="NP_055549.1"
                     /db_xref="CCDS:CCDS9796.1"
                     /db_xref="GeneID:9766"
                     /db_xref="HGNC:HGNC:19956"
                     /db_xref="MIM:616761"
                     /translation="MCHGRIAPKSTSVFAVASVGHGVFLPLVILCTLLGDGLASVCPL
                     PPEPENGGYICHPRPCRDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWKPAMEISC
                     RLNEDKDTHTSLGVPTLSIVASTASSVALILLLVVLFVLLQPKLKSFHHSRRDQGVSG
                     DQVSIMVDGVQVALPSYEEAVYGSSGHCVPPADPRVQIVLSEGSGPSGRSVPREQQLP
                     DQGACSSAGGEDEAPGQSGLCEAWGSRASETVMVHQATTSSWVAGSGNRQLAHKETAD
                     SENSDIQSLLSLTSEEYTDDIPLLKEA"
     exon            435..632
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /inference="alignment:Splign:2.1.0"
     exon            633..771
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1199
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..5390
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5361
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
     regulatory      5364..5369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /note="hexamer: ATTAAA"
     polyA_site      5390
                     /gene="SUSD6"
                     /gene_synonym="DRAGO; KIAA0247"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgcgg gcgctgcagc cgtcgctacc gccgcgttct attctccgaa gccggcgacc
       61 gccccacctc ctccctccct cccgcccgct tcctctgccc acagcgccgg ccagagcgag
      121 ctagacaagg gcacgcgggg cctcgcctag acccgagaag actgcgggcg cgcgcaagcg
      181 gcggcgtgga agctgtgagc gcccccatcc cggaggtctc cgccggctcc cgggtgaatc
      241 agctcccggc cgactttagg attcttctgg attttaaatt ttttcttttt aaaaaaactt
      301 ggacggataa aagatgtgcc atggcaggat agcaccaaag agcacctcag tgtttgccgt
      361 ggcctccgtg ggacatggag tgttccttcc gctagtgatc ctttgcaccc tgcttggaga
      421 cggacttgct tccgtgtgcc ccctaccacc ggagccagag aatggtggct acatctgcca
      481 cccccggccc tgcagagacc ccctgacagc aggcagtgtc atcgaatacc tgtgtgctga
      541 aggctacatg ttgaagggcg attacaaata cctgacgtgt aagaatggcg agtggaaacc
      601 agccatggag attagctgcc gtctcaacga ggataaagac acccacacat cacttggggt
      661 ccccacgctg tctatagtgg cttctactgc cagctccgtg gcgctcattc tcctcctcgt
      721 ggtgctgttt gtgctgctgc agccaaagct gaagtctttc catcatagca ggcgtgacca
      781 gggggtatct ggggaccagg tctccatcat ggtggatgga gtccaggttg cactaccatc
      841 atacgaggag gctgtatatg gcagttctgg tcactgtgtg ccacctgctg accccagagt
      901 acagattgtg ctgtcagaag ggtctgggcc cagtgggagg agcgtgccaa gggagcaaca
      961 gctgccggac caaggggcct gctcctctgc aggtggagaa gatgaggccc caggccagtc
     1021 tggactatgt gaagcctggg gctctcgggc ctcagagact gtgatggtgc atcaggcaac
     1081 cacctcttcc tgggtggccg gctcagggaa ccgccaactg gcacacaaag aaactgcaga
     1141 ttcagagaac agtgacatac aaagcctttt atccctcacg tcagaggagt acacagatga
     1201 tattccactg ttgaaagaag catgagggca gcggccagcc tttcctctct gcgaggttct
     1261 ctcagccctt cctccctctc cctgtgggat tgagcaccct gtactctcca gccaccttac
     1321 ctggatacct gagctgccac ctgtgtatct gtgtatctct gagggcccta taggcccacc
     1381 ttgctggaaa ctcaaggaag attctcgcca tctgcctgtt ggacagctgg aggagctggc
     1441 tctttgcctg gccccgcctt cccatctgtc agagacatat ttgaatgtgc tggatcaaac
     1501 cctccctttt cctaagcctc tgggtcccct ccagccagct ctttggcggc agcccccacc
     1561 agctcctgtg ggcctgagtg ctgctgtgtt tacttgtgcc tttcccccac cctgtccagt
     1621 ttccctgtca tgcagacttg ttgctgtcca caagccttag tggctgcact gctgccccct
     1681 gccacacagg gggccgggcc tgggtctgtc ctgtttcctt tgagggttgc ccctactgcc
     1741 ctttgcagga acagatccag gtgtgagagc tcttgagtca agagtggcag aagtggctct
     1801 aattggggtg agagtgtagt ccctgggctt gccctgggtt gaccctggtg gcatatttcc
     1861 ttggctgagg atggaagatt tggagaatca tgtccatgct ggcccaggac ccagccatct
     1921 ggcccaaagg cacaagctcc tggccctgtt gagttgagag tttccaagaa gcatccagaa
     1981 gatcccaagg gagagaagga aaatggctga taatgattgt cttcctaata tgcaagttct
     2041 cacttcctac ttccagcatc ggccttcctg gccttgtctt ttttttgttt ccctggagta
     2101 taatgggaag ttgcatgctg cctcctgggt tttatcccag atagctctgg ctttcttgct
     2161 gcccacaggg gcctggggca ggaaggagac ttgctgagat gccatggagt gcccatctgg
     2221 tcactggcag tctgggcagg ttgccccttt ctgggtttgt ggtgacggag gggaggccga
     2281 gaggcacaga ccaagtcccc gggtggctgc aggcagctcc agcccggtcc tgaggatcct
     2341 cctcaccatg gtcacgtgcc ttagtaactg tgcccaggaa gtggcctgct gcttgctgtg
     2401 ctgctgcttt tcctacttct gcccttccct gccacccctc gcatgtcaca gctgacaagc
     2461 aattccttgt cttccctggc cccctggggg aagggctgag aaacagtccg tgtgcacccc
     2521 aaccttaatg gcctgaggtg ggcagagggg tgtggagcag cctggagtac agggccctgg
     2581 gggaggagcc cactgatgag gggcgctctc ccatagccat gtgttgaatg ctaactaggc
     2641 tggggtggac gaactctgcc aactgctgtc atcttagaag atagatgcag cagtaaggaa
     2701 tgtttgtttt gcttttttct gaaattttct gaagcactgt ggctgggaaa cttcgaagcg
     2761 gaccctgtgc tgcatgtctg ctcctcccct gagcctgtct gcttgggggt ggtaaaaata
     2821 aaaatcccag tttattttca gtaccttacc taacagggtt ggctccaggc gtgggtggcc
     2881 tagaagatga ggggagtggt cttctcccag ccttttaccc tcttgcctcc tgcctccgcg
     2941 cttacacacg cactttacca cccggtcatt ccctggcctc ttgctgccac ttgtagtctt
     3001 ccttccttcc tctcagggta agggcagtgc ctgctgtgcc tgttggccac tcccacactt
     3061 cccctccccc aggagccctc atctgctgtg ctgagtccag gaaagcatag ttaggtaggg
     3121 agctggttgg agaaggtgct agaactagaa ggcagatgag actagcatgg gcccacctgg
     3181 agggctgtcc ctaatggccc cagtcgcctt acctcaccca cagcagtgcc cttgtcttcc
     3241 tccaaaacag aaagcagtga caaaaggggg aggggtggta atctgaagtc tcactgctga
     3301 gccttcagct tttatttttc actgtttcaa aacccgcatt ctattctaga atggttttta
     3361 aaatggaaga tcttaccttt ttctatcttg ttactctggg gttttgtccc cctaagagat
     3421 tgcacttttt gtttggggtt tattcagctg catagatgac cagcttgatc cctggtgaaa
     3481 tgaaaagcct tccttctcct gaagcctctt tccgccctgc cctccactaa caacactgag
     3541 gagcacaagc ccaggcttgc ccacctggta ggaaaggaag aaattagaac aatgggagcc
     3601 ttggctcccc tctcgtctcc tcccctcctt cttgtcactg gctttgatga ggcccacttc
     3661 ccagaggctc ctgggcctgt gagtgcagga gctcattctc ccctcactgc tgaagtctgt
     3721 gacagcttct tcctccagtt atgtctttct tccaaagcaa tttcttaacc atcagccatg
     3781 tgctgctatt tctagggctt ctgggctttg tcccttactg agagattagg gactccacag
     3841 ctgccttgag gtagggcctg gctgagagac aagggtagca gcaggtggca ggctgttaaa
     3901 agacaggctg cctgaggagc ctggagcagg tggaaacagg tggaagaaac cggccacagc
     3961 cctgctttac cgggctcacc tctagggcat tccagcaaga ggctgatgca ggagaatggc
     4021 cagcaccaaa ggacatttaa aagagttttt gggttttttt gtttgtttgt tgttggtgtt
     4081 tgtttttttt tttttttttt tggcacactt gagctgactc agtgcaggtt taatatcctg
     4141 gtgacttgca gtcacattct aatgactttc aagggccaga atatggtgaa aatcacttaa
     4201 aatatccgtc ccttccatgc cttagtttag caggtaggct ctatcttttg ccatttctgt
     4261 attttatgtg ctgtgttccc gtttcactgg gtatgaactg tgaaatcgac tgaatcctgg
     4321 ccactttatg agtttgtttg gttttataag gcatttcaat gtacattcta taaatacaag
     4381 cactccattt gcaaacagat cttaagctaa tattttcttt cccattcatc ttgccctccc
     4441 cctcctcccg ccagctttaa agttcagtgg agaagccaga tggcaattca gacaaaggta
     4501 tactcttcct gcttcatggg tggtggcacg ggaatagata gcccttagcc ctttccctcc
     4561 cagtcccagc tgagccctca gaccacttgc ttcccacata acaatgtcgc ctccatttcc
     4621 gaggaacatc cttgcgtaga gaatgaaata tgctgcaatc atttctgcat ccttactcct
     4681 cacccccaaa gaaaaaaaaa aggcctagca gggaagcagc atgcaggctt cacagcttaa
     4741 tgccaaggac agcgagtgag gctgggagct tctcttgggc ctgctgggtc tgtcagctct
     4801 cggaataggg acagtcctta ctggtgcccc aaggtgggac ttggagaata ttttgcttgg
     4861 catatgtttg gtctgaatgg tgtagttgct ggttccctag agaggaaaag gtggcaggcc
     4921 cagctttgct gggaaatggc tcttaatttc cagttgaaac cctagtagaa ttgtgaatga
     4981 aaacctcaag gttgagcccc tctgccaagc agcagagcta gtagaagggg atgcaggggc
     5041 aaagcactca gttgccaagc aaggaggaga gatgtacgtg ggctgtgtgg cagtccccac
     5101 accctgccct ggcttcttca ggttatcgca ccactatgga atcctttgca gaatggtact
     5161 catataatgg tttaaaacaa cacattcata attgactctg tgcaggatgt cactcaatca
     5221 gtttgggttt gctttatttt attttatata tatatttttt ggtatcctgt acattgcagt
     5281 gggtgtgaag atagtatttt aatatttgta caaagtttaa tttaatttta attgttctat
     5341 gtatataact gcatttctaa ataattaaaa aaaagttctt atgaaggcaa
//
