LOCUS       NM_017982               2989 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens sushi domain containing 4 (SUSD4), transcript variant
            1, mRNA.
ACCESSION   NM_017982
VERSION     NM_017982.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Zhong,Y., Zheng,C., Zhang,W., Wu,H., Zhang,Q., Li,D., Ju,H.,
            Feng,H., Chen,Y., Fan,Y., Chen,W., Wang,M. and Wang,G.
  TITLE     Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4)
            and validated in colorectal cancer
  JOURNAL   Aging (Albany NY) 16 (7), 6417-6444 (2024)
   PUBMED   38579174
  REMARK    GeneRIF: Pan-cancer analysis of Sushi domain-containing protein 4
            (SUSD4) and validated in colorectal cancer.
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Papadakos,K.S., Ekstrom,A., Slipek,P., Skourti,E., Reid,S.,
            Pietras,K. and Blom,A.M.
  TITLE     Sushi domain-containing protein 4 binds to epithelial growth factor
            receptor and initiates autophagy in an EGFR phosphorylation
            independent manner
  JOURNAL   J Exp Clin Cancer Res 41 (1), 363 (2022)
   PUBMED   36578014
  REMARK    GeneRIF: Sushi domain-containing protein 4 binds to epithelial
            growth factor receptor and initiates autophagy in an EGFR
            phosphorylation independent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Englund,E., Reitsma,B., King,B.C., Escudero-Esparza,A., Owen,S.,
            Orimo,A., Okroj,M., Anagnostaki,L., Jiang,W.G., Jirstrom,K. and
            Blom,A.M.
  TITLE     The human complement inhibitor Sushi Domain-Containing Protein 4
            (SUSD4) expression in tumor cells and infiltrating T cells is
            associated with better prognosis of breast cancer patients
  JOURNAL   BMC Cancer 15, 737 (2015)
   PUBMED   26480818
  REMARK    GeneRIF: SUSD4 expression in both breast cancer cells and T cells
            infiltrating the tumor-associated stroma is useful to predict
            better prognosis of breast cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Holmquist,E., Okroj,M., Nodin,B., Jirstrom,K. and Blom,A.M.
  TITLE     Sushi domain-containing protein 4 (SUSD4) inhibits complement by
            disrupting the formation of the classical C3 convertase
  JOURNAL   FASEB J 27 (6), 2355-2366 (2013)
   PUBMED   23482636
  REMARK    GeneRIF: Membrane-bound isoform SUSD4a inhibits the classical and
            alternative complement pathways when expressed on the surface of
            Chinese hamster cells but not when expressed as a soluble,
            truncated protein.
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Tu,Z., Cohen,M., Bu,H. and Lin,F.
  TITLE     Tissue distribution and functional analysis of Sushi
            domain-containing protein 4
  JOURNAL   Am J Pathol 176 (5), 2378-2384 (2010)
   PUBMED   20348246
  REMARK    GeneRIF: analysis of cloning, expression, refolding, and tissue
            distribution of Sushi domain-containing protein 4
REFERENCE   7  (bases 1 to 2989)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2989)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA125047.1, AY358495.1, AK096265.1 and BF446433.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017982.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.169269.1,
                                           SRR1803611.82764.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366878.9/ ENSP00000355843.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               DA125047.1         32-507
            477-878             AY358495.1         480-881
            879-2554            AK096265.1         1359-3034
            2555-2989           BF446433.1         16-450              c
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2989
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /note="sushi domain containing 4"
                     /db_xref="GeneID:55061"
                     /db_xref="HGNC:HGNC:25470"
                     /db_xref="MIM:615827"
     exon            1..120
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            121..303
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1628
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; YHGM196; sushi domain-containing protein 4;
                     testicular secretory protein Li 55"
                     /codon_start=1
                     /product="sushi domain-containing protein 4 isoform a
                     precursor"
                     /protein_id="NP_060452.3"
                     /db_xref="CCDS:CCDS41471.1"
                     /db_xref="GeneID:55061"
                     /db_xref="HGNC:HGNC:25470"
                     /db_xref="MIM:615827"
                     /translation="MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGP
                     AQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH
                     FNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHN
                     MVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDG
                     SAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP
                     GYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVL
                     LLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAVSGGLSALGP
                     GYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQ
                     ESTHPASDNPDIIASTAEEVASTSPGIDIADEIPLMEEDP"
     exon            304..516
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            517..690
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            691..879
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1071
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1216
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1599
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..2989
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2971..2976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /note="hexamer: ATTAAA"
     polyA_site      2989
                     /gene="SUSD4"
                     /gene_synonym="PRO222"
                     /note="major polyA site"
ORIGIN      
        1 gaagcttccg tctcgctcgc tcgcgcagcg gcggcagcag aggtcgcgca cagatgcggg
       61 ttagactggc ggggggagga ggcggaggag ggaaggaagc tgcatgcatg agacccacag
      121 actcttgcaa gctggatgcc ctctgtggat gaaagatgta tcatggaatg aacccgagca
      181 atggagatgg atttctagag cagcagcagc agcagcagca acctcagtcc ccccagagac
      241 tcttggccgt gatcctgtgg tttcagctgg cgctgtgctt cggccctgca cagctcacgg
      301 gcgggttcga tgaccttcaa gtgtgtgctg accccggcat tcccgagaat ggcttcagga
      361 cccccagcgg aggggttttc tttgaaggct ctgtagcccg atttcactgc caagacggat
      421 tcaagctgaa gggcgctaca aagagactgt gtttgaagca ttttaatgga accctaggct
      481 ggatcccaag tgataattcc atctgtgtgc aagaagattg ccgtatccct caaatcgaag
      541 atgctgagat tcataacaag acatatagac atggagagaa gctaatcatc acttgtcatg
      601 aaggattcaa gatccggtac cccgacctac acaatatggt ttcattatgt cgcgatgatg
      661 gaacgtggaa taatctgccc atctgtcaag gctgcctgag acctctagcc tcttctaatg
      721 gctatgtaaa catctctgag ctccagacct ccttcccggt ggggactgtg atctcctatc
      781 gctgctttcc cggatttaaa cttgatgggt ctgcgtatct tgagtgctta caaaacctta
      841 tctggtcgtc cagcccaccc cggtgccttg ctctggaagt ctgtccacta cctccaatgg
      901 tgagtcacgg agatttcgtc tgccacccgc ggccttgtga gcgctacaac cacggaactg
      961 tggtggagtt ttactgcgat cctggctaca gcctcaccag cgactacaag tacatcacct
     1021 gccagtatgg agagtggttt ccttcttatc aagtctactg catcaaatca gagcaaacgt
     1081 ggcccagcac ccatgagacc ctcctgacca cgtggaagat tgtggcgttc acggcaacca
     1141 gtgtgctgct ggtgctgctg ctcgtcatcc tggccaggat gttccagacc aagttcaagg
     1201 cccactttcc ccccaggggg cctccccgga gttccagcag tgaccctgac tttgtggtgg
     1261 tagacggcgt gcccgtcatg ctcccgtcct atgacgaagc tgtgagtggc ggcttgagtg
     1321 ccttaggccc cgggtacatg gcctctgtgg gccagggctg ccccttaccc gtggacgacc
     1381 agagcccccc agcatacccc ggctcagggg acacggacac aggcccaggg gagtcagaaa
     1441 cctgtgacag cgtctcaggc tcttctgagc tgctccaaag tctgtattca cctcccaggt
     1501 gccaagagag cacccaccct gcttcggaca accctgacat aattgccagc acggcagagg
     1561 aggtggcatc caccagccca ggcatcgaca ttgcagatga gattcctcta atggaagaag
     1621 atccctaata tgggtcaaga tccagatgac tctcctgctc cttcggggaa aggaccttgt
     1681 atcttggagt gaggtcacag aaggatagag cctgggggca aaatgtctaa cttgtctaca
     1741 tggggaccac agttcacatt atgcatctca ggctccacag tgaggctgac aaactgcaat
     1801 ggcagtgctt ttaaatgaga tttgaggatt caccaagacc catggggaac cggggcagca
     1861 gggaagccct cgcgtggtct tggatgaggg gtgttaaatg tgtatcgtgc tgtggaacat
     1921 gggacaattc cacgcacatc ccaccgaatc atcacgcatc ccattgactg gcaagtactc
     1981 cccgccccct ctgaaagcat gtcacatcat gtaaatttgc ttctaacatc tgcttcaaac
     2041 tgtctctgga ctccaaattt ggatgggtca gcctctgcag aaagtttgtg ttgagatgct
     2101 ggaagaacag cagagcctcc tgcaccctca gcaagggacc agctcccaaa ggaaaggtcc
     2161 ttgtgtgaca tttggagaat cttccttcat ccagacaact ctactcgaag caagacgaaa
     2221 gcaggatgtg gcagttgcag tgagaaagga aaggaaagat gggcagactc tgctttctgg
     2281 aaatttcttc acaaagtaga gctcatgaac tctgtgctgt cttctggtaa catatcatca
     2341 gtgtttgtat tcatggtgtg gcacatggat ccatggcatt gggtaaatct ggtggttttt
     2401 acacatggtc agaatgtgtt caaatacatc tcatgatgga gacagtaacc aaggtaatgt
     2461 tttgtttcag cattttaaaa agactccact taacatttat ctcagaatca tgagcctctc
     2521 tctagttgac aattgtcatt gttcccccag ccccaaattg aaccatacat ttattttcca
     2581 aaacagaaat tgtttctgta aacatatccg accttcaaaa gaagtgtgag gttggatttt
     2641 tccccctttt atttgtccta agattccagg aggctggcct cccagcccag atagctcagc
     2701 cacctcacct gcctatcatt cctgcattcc tactttgagg gtctcatcat gcccactggg
     2761 tgttgttcct aagaaactga ttgattaaaa aatttcccaa agtgtcctga agtgtctctt
     2821 caaatacatg ttgatctgtg gagttgattc ctttccttct cttggtttta gacaaatgta
     2881 aacaaagctc tgatccttaa aattgctatg ctgatagagt ggtgagggct ggaagcttga
     2941 tcaagtcctg tttcttcttg acacagactg attaaaaatt aaaagaaaa
//
