LOCUS       NM_145006               1196 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sushi domain containing 3 (SUSD3), transcript variant
            1, mRNA.
ACCESSION   NM_145006
VERSION     NM_145006.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1196)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1196)
  AUTHORS   Moy,I., Todorovic,V., Dubash,A.D., Coon,J.S., Parker,J.B.,
            Buranapramest,M., Huang,C.C., Zhao,H., Green,K.J. and Bulun,S.E.
  TITLE     Estrogen-dependent sushi domain containing 3 regulates cytoskeleton
            organization and migration in breast cancer cells
  JOURNAL   Oncogene 34 (3), 323-333 (2015)
   PUBMED   24413080
  REMARK    GeneRIF: Data indicate that sushi domain containing 3 (SUSD3) is a
            promoter of estrogen-dependent cell proliferation and regulator of
            cell-cell and cell-substrate interactions and migration in breast
            cancer.
REFERENCE   3  (bases 1 to 1196)
  AUTHORS   Zhao,S., Chen,S.S., Gu,Y., Jiang,E.Z. and Yu,Z.H.
  TITLE     Expression and Clinical Significance of Sushi Domain- Containing
            Protein 3 (SUSD3) and Insulin-like Growth Factor-I Receptor
            (IGF-IR) in Breast Cancer
  JOURNAL   Asian Pac J Cancer Prev 16 (18), 8633-8636 (2015)
   PUBMED   26745129
  REMARK    GeneRIF: High expression of SUSD3 is associated with breast cancer.
REFERENCE   4  (bases 1 to 1196)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   5  (bases 1 to 1196)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   6  (bases 1 to 1196)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DT220823.1, BC014601.2 and AY358190.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145006.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014601.2, SRR1163655.418783.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375472.8/ ENSP00000364621.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DT220823.1         14-24
            12-963              BC014601.2         6-957
            964-1196            AY358190.1         1019-1251
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..1196
                     /gene="SUSD3"
                     /note="sushi domain containing 3"
                     /db_xref="GeneID:203328"
                     /db_xref="HGNC:HGNC:28391"
                     /db_xref="MIM:616429"
     exon            1..130
                     /gene="SUSD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..810
                     /gene="SUSD3"
                     /note="isoform a is encoded by transcript variant 1; sushi
                     domain-containing protein 3"
                     /codon_start=1
                     /product="sushi domain-containing protein 3 isoform a"
                     /protein_id="NP_659443.1"
                     /db_xref="CCDS:CCDS6701.1"
                     /db_xref="GeneID:203328"
                     /db_xref="HGNC:HGNC:28391"
                     /db_xref="MIM:616429"
                     /translation="MRWAAATLRGKARPRGRAGVTTPAPGNRTGTCAKLRLPPQATFQ
                     VLRGNGASVGTVLMFRCPSNHQMVGSGLLTCTWKGSIAEWSSGSPVCKLVPPHETFGF
                     KVAVIASIVSCAIILLMSMAFLTCCLLKCVKKSKRRRSNRSAQLWSQLKDEDLETVQA
                     AYLGLKHFNKPVSGPSQAHDNHSFTTDHGESTSKLASVTRSVDKDPGIPRALSLSGSS
                     SSPQAQVMVHMANPRQPLPASGLATGMPQQPAAYALG"
     exon            131..319
                     /gene="SUSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..467
                     /gene="SUSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..599
                     /gene="SUSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            600..1196
                     /gene="SUSD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUSD3"
                     /note="hexamer: AATAAA"
     polyA_site      1196
                     /gene="SUSD3"
                     /note="major polyA site"
ORIGIN      
        1 actcccctgg cagaccccgc caagcgcctc ggagcgcgca ggatgcgctg ggcggccgcc
       61 accctccgtg gcaaggcgag gccccggggg cgggccgggg tcaccacgcc tgccccaggg
      121 aaccgcacag gcacgtgcgc taagctgcgg ctacccccgc aagcaacctt ccaagtcctt
      181 cgtggcaatg gtgcttccgt ggggaccgtg ctcatgttcc gctgcccctc caaccaccag
      241 atggtggggt ctgggctcct cacctgcacc tggaagggga gcatcgctga gtggtcttca
      301 gggtccccag tgtgcaaact ggtgccacca cacgagacct ttggcttcaa ggtggccgtg
      361 atcgcctcca ttgtgagctg tgccatcatc ctgctcatgt ccatggcctt cctcacctgc
      421 tgcctcctca agtgcgtgaa gaagagcaag cggcggcgct ccaacaggtc agcccagctg
      481 tggtcccagc tgaaagatga ggacttggag acggtgcagg ccgcatacct tggcctcaag
      541 cacttcaaca aacccgtgag cgggcccagc caggcgcacg acaaccacag cttcaccaca
      601 gaccatggtg agagcaccag caagctggcc agtgtgaccc gcagcgtgga caaggaccct
      661 gggatcccca gagctctaag cctcagtggc tcctccagct caccccaagc ccaggtgatg
      721 gtgcacatgg caaaccccag acagcccctg cctgcctctg ggctggccac aggaatgcca
      781 caacagcccg cagcatatgc cctagggtga ccacgcagtg aggctggtgc ccatgctcca
      841 cactgggagg ccaggctgac cccaccagcc agtcagctac aactccacat caactccaca
      901 tgcgcccagc tcgagactga tgagtggaat cagcttccag gtgtagggac cccttgaggg
      961 gccgagctga catccaaggc tgaggacccc agtggggagt gttctgttcc ggcatatcct
     1021 ggccgtaacg atttttatag ttatggacta cttgaaacca ctactgaggg taatttacta
     1081 gctgtggcct cccactaact agcattcctt taaagagact gggaaatgtt ttaagcaaat
     1141 ctagttttgt ataataaaat aagaaaatag caataaactt cttttcagca actaca
//
