LOCUS       NM_019601               3172 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens sushi domain containing 2 (SUSD2), mRNA.
ACCESSION   NM_019601
VERSION     NM_019601.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3172)
  AUTHORS   Bai,H., Xian,N., Zhao,F., Zhou,Y. and Qin,S.
  TITLE     The dual role of SUSD2 in cancer development
  JOURNAL   Eur J Pharmacol 977, 176754 (2024)
   PUBMED   38897441
  REMARK    GeneRIF: The dual role of SUSD2 in cancer development.
            Review article
REFERENCE   2  (bases 1 to 3172)
  AUTHORS   Wu,Y., Duan,Y., Li,X., Zhao,R., Lan,B., Zhang,X., Wang,X., Chen,H.,
            Feng,S., Liu,Z., Cheng,Y., Xi,L., Wang,Y., Xue,F. and Xuan,C.
  TITLE     CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and
            Metastasis by Suppressing the Transcription of SUSD2
  JOURNAL   Mol Cancer Res 20 (11), 1611-1622 (2022)
   PUBMED   35894945
  REMARK    GeneRIF: CBX8 Together with SET Facilitates Ovarian Carcinoma
            Growth and Metastasis by Suppressing the Transcription of SUSD2.
REFERENCE   3  (bases 1 to 3172)
  AUTHORS   Liu,S. and Wen,C.
  TITLE     miR-141-3p promotes retinoblastoma progression via inhibiting sushi
            domain-containing protein 2
  JOURNAL   Bioengineered 13 (3), 7410-7424 (2022)
   PUBMED   35259051
  REMARK    GeneRIF: miR-141-3p promotes retinoblastoma progression via
            inhibiting sushi domain-containing protein 2.
REFERENCE   4  (bases 1 to 3172)
  AUTHORS   Xia,L., Zhu,G., Huang,H., He,Y. and Liu,X.
  TITLE     LncRNA small nucleolar RNA host gene 16 (SNHG16) silencing protects
            lipopolysaccharide (LPS)-induced cell injury in human lung
            fibroblasts WI-38 through acting as miR-141-3p sponge
  JOURNAL   Biosci Biotechnol Biochem 85 (5), 1077-1087 (2021)
   PUBMED   33836533
  REMARK    GeneRIF: LncRNA small nucleolar RNA host gene 16 (SNHG16) silencing
            protects lipopolysaccharide (LPS)-induced cell injury in human lung
            fibroblasts WI-38 through acting as miR-141-3p sponge.
REFERENCE   5  (bases 1 to 3172)
  AUTHORS   Sang,J., Li,X., Lv,L., Zhang,C., Zhang,X. and Li,G.
  TITLE     Circ-TOP2A acts as a ceRNA for miR-346 and contributes to glioma
            progression via the modulation of sushi domain-containing 2
  JOURNAL   Mol Med Rep 23 (4) (2021)
   PUBMED   33537815
  REMARK    GeneRIF: CircTOP2A acts as a ceRNA for miR346 and contributes to
            glioma progression via the modulation of sushi domaincontaining 2.
REFERENCE   6  (bases 1 to 3172)
  AUTHORS   Sivasubramaniyan,K., Harichandan,A., Schumann,S., Sobiesiak,M.,
            Lengerke,C., Maurer,A., Kalbacher,H. and Buhring,H.J.
  TITLE     Prospective isolation of mesenchymal stem cells from human bone
            marrow using novel antibodies directed against Sushi domain
            containing 2
  JOURNAL   Stem Cells Dev 22 (13), 1944-1954 (2013)
   PUBMED   23406305
REFERENCE   7  (bases 1 to 3172)
  AUTHORS   Watson,A.P., Evans,R.L. and Egland,K.A.
  TITLE     Multiple functions of sushi domain containing 2 (SUSD2) in breast
            tumorigenesis
  JOURNAL   Mol Cancer Res 11 (1), 74-85 (2013)
   PUBMED   23131994
  REMARK    GeneRIF: Authors found significantly fewer CD4 tumor infiltrating
            lymphocytes in breast tumors expressing Susd2.
REFERENCE   8  (bases 1 to 3172)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3172)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   10 (bases 1 to 3172)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC033107.1 and BI822588.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019601.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033107.1, SRR1803615.96957.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358321.4/ ENSP00000351075.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3067              BC033107.1         12-3078
            3068-3163           BI822588.1         235-330
            3164-3172           BC033107.1         3175-3183
FEATURES             Location/Qualifiers
     source          1..3172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..3172
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /note="sushi domain containing 2"
                     /db_xref="GeneID:56241"
                     /db_xref="HGNC:HGNC:30667"
                     /db_xref="MIM:615825"
     exon            1..109
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2502
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /note="Sushi domain (SCR repeat) containing; sushi
                     domain-containing protein 2; testicular tissue protein Li
                     190"
                     /codon_start=1
                     /product="sushi domain-containing protein 2 precursor"
                     /protein_id="NP_062547.1"
                     /db_xref="CCDS:CCDS13824.1"
                     /db_xref="GeneID:56241"
                     /db_xref="HGNC:HGNC:30667"
                     /db_xref="MIM:615825"
                     /translation="MKPALLPWALLLLATALGPGPGPTADAQESCSMRCGALDGPCSC
                     HPTCSGLGTCCLDFRDFCLEILPYSGSMMGGKDFVVRHFKMSSPTDASVICRFKDSIQ
                     TLGHVDSSGQVHCVSPLLYESGRIPFTVSLDNGHSFPRAGTWLAVHPNKVSMMEKSEL
                     VNETRWQYYGTANTSGNLSLTWHVKSLPTQTITIELWGYEETGMPYSQEWTAKWSYLY
                     PLATHIPNSGSFTFTPKPAPPSYQRWRVGALRIIDSKNYAGQKDVQALWTNDHALAWH
                     LSDDFREDPVAWARTQCQAWEELEDQLPNFLEELPDCPCTLTQARADSGRFFTDYGCD
                     MEQGSVCTYHPGAVHCVRSVQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHDW
                     GAPPFRTPPRVPSMSHWLYDVLSFYYCCLWAPDCPRYMQRRPSNDCRNYRPPRLASAF
                     GDPHFVTFDGTNFTFNGRGEYVLLEAALTDLRVQARAQPGTMSNGTETRGTGLTAVAV
                     QEGNSDVVEVRLANRTGGLEVLLNQEVLSFTEQSWMDLKGMFLSVAAGDRVSIMLASG
                     AGLEVSVQGPFLSVSVLLPEKFLTHTHGLLGTLNNDPTDDFTLHSGRVLPPGTSPQEL
                     FLFGANWTVHNASSLLTYDSWFLVHNFLYQPKHDPTFEPLFPSETTLNPSLAQEAAKL
                     CGDDHFCNFDVAATGSLSTGTATRVAHQLHQRRMQSLQPVVSCGWLAPPPNGQKEGNR
                     YLAGSTIYFHCDNGYSLAGAETSTCQADGTWSSPTPKCQPGRSYAVLLGIIFGGLAVV
                     AAVALVYVLLRRRKGNTHVWGAQP"
     exon            110..320
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            321..472
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            473..640
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            641..815
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1017
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1103
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1372
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1516
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1675
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1924
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2197
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2374
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2477
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..3172
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /note="hexamer: AACAAG"
     polyA_site      3172
                     /gene="SUSD2"
                     /gene_synonym="BK65A6.2; W5C5"
                     /note="major polyA site"
ORIGIN      
        1 actgcactgc tggctgcaga cacaggctgc accatgaagc cagccctcct gccctgggcc
       61 ctgctgctgc tggcgacagc cctcggcccg ggccccggac ccacagcaga tgcccaagag
      121 agctgctcca tgcgctgtgg cgccctggac gggccatgtt cctgccaccc gacgtgctct
      181 ggccttggca cctgctgctt ggatttccgg gacttctgcc tggagatatt gccctactca
      241 ggatccatga tgggcggcaa ggactttgtg gtgcggcact tcaagatgtc cagccccaca
      301 gacgccagtg tgatctgcag gtttaaggac agcatccaga ccctcggcca tgtggactcc
      361 tccgggcaag tgcactgtgt gtcacctctg ctctatgaga gcggccgcat ccccttcact
      421 gtgtcactgg acaacggcca ctccttccct cgtgcgggca cctggctggc tgtgcacccc
      481 aacaaagtgt caatgatgga gaagagcgag ttggtgaacg agacgcgttg gcaatactac
      541 ggcaccgcca acacctcagg caacctcagc ctgacctggc atgtcaagtc gctgcccacg
      601 cagaccatca ccatcgaact gtggggctac gaggagacag gaatgcccta ctcacaggag
      661 tggactgcaa agtggtcgta cctgtacccc ctggccacac acatccccaa ctccggctct
      721 ttcactttca ccccaaaacc tgctcctccc agctaccaga gatggcgagt gggtgcactt
      781 cggatcatcg acagcaaaaa ttacgcaggg cagaaggacg tgcaggcgct ctggaccaac
      841 gaccacgcac tggcctggca cctgagcgat gacttccgag aggaccctgt ggcctgggca
      901 cgaactcagt gccaggcctg ggaggagctg gaggatcagc tgcccaactt cctggaggag
      961 ctgccggact gcccctgcac cctgacccag gcccgggctg actccggccg cttcttcacg
     1021 gactacggct gtgacatgga gcagggcagc gtgtgcacct accaccccgg ggccgtgcac
     1081 tgtgtgcgtt ctgtgcaggc cagcctccgg tacggctcag gtcagcagtg ctgctacaca
     1141 gcggacggga cgcagctcct gacagctgac tccagcggcg gcagcactcc cgaccgcggc
     1201 catgactggg gcgcaccccc gttccgcacg ccaccccgag tgcccagcat gtcccactgg
     1261 ctctacgatg tcctcagctt ctattactgc tgcctctggg cacccgactg cccccgctac
     1321 atgcaacggc ggccctccaa tgactgccgc aactaccggc ccccaagact ggcctccgcc
     1381 ttcggagacc cacactttgt gaccttcgac ggcaccaact tcacattcaa tgggcgcgga
     1441 gagtacgtgc tgctggaggc agcgctgacc gacctgaggg tgcaggcgcg ggcccagccc
     1501 gggacgatgt ccaacggcac ggagacccgt ggcactgggc tgaccgcagt ggccgtccag
     1561 gagggcaact cagatgtggt ggaagtcagg ctggccaaca ggaccggagg tctggaggtg
     1621 ctgctgaacc aggaggtgct gagcttcacc gagcagagct ggatggacct gaaaggaatg
     1681 ttcctgtcgg tggctgccgg ggacagggtc tccatcatgc tggcatcagg ggccggcctg
     1741 gaggtcagcg tgcagggccc gttcctgagt gtgtccgtcc tgctgcctga gaagttcctc
     1801 acccacaccc acggcctcct cgggacactc aacaacgacc ccaccgacga cttcaccctg
     1861 cacagcgggc gcgtcctgcc cccaggcacc agtccccagg agctgttcct gtttggggcc
     1921 aactggaccg tgcacaatgc gtcctccctg ctcacctacg attcctggtt cctggtccac
     1981 aacttcctgt accaacccaa gcacgacccc accttcgagc ccctcttccc cagtgagacc
     2041 accctcaacc ccagcctggc acaagaggca gccaaactat gtggggacga tcatttctgc
     2101 aactttgatg tggcagccac tgggagcctg agcacgggca ctgccactcg ggtggcccac
     2161 cagctgcacc agcgtcgcat gcagagcctg cagccagtgg tgtcctgtgg ctggctggcc
     2221 ccacctccca acggacaaaa ggagggcaac aggtacctgg cgggttccac catctacttc
     2281 cactgtgaca acggctacag cctggccggg gcagagacca gcacctgcca ggctgacggc
     2341 acctggtcct cacccacccc gaagtgccag ccaggacgca gctacgcggt gctgttgggc
     2401 atcatctttg ggggcctcgc ggtggtggcg gcggttgcgc tcgtctatgt gctgctgcgc
     2461 cgcaggaagg gcaacacgca cgtctggggt gcacagccct gatgggagca gcttggctgt
     2521 gagcaccagg ccaagactcc tgagaacagg cagcccagtc ctgcgactcc cgcatcccca
     2581 ggaccagaca cctgggacct ggatacttga tacctgggca tttaaccccc tactctgtca
     2641 tctcagaccc caggcaggag gcccagtgtt ccaacaccca agccccgtgc tagcagcgct
     2701 ccgtgctctt ccccaaatac tcacggctct aattccccaa acctgaaact tcataccctg
     2761 ggattctaat acctatgtcc tgagccctga cactcccaca cctgagcctc agattccaat
     2821 agctcactcc ctagagcctg acgccggggc ccctgacccc tgagcctcag attccaatac
     2881 ctcactcccc agagcctgat gccggggccc ctgacccctg atctacggag gcctgctccc
     2941 ggaccgtgcg ggcaccagtg cagtgctgcc ttggttcctg gacccctggg cccatcctgg
     3001 gaccccagat ggggtaagga gaggccccag aaccccaaag cagacagcga gacccccagc
     3061 ggcagaggcc tccctcggca ctccaggctt ataatttcga actcttctgg aaggtcactc
     3121 aggaacaccc tccctgcctg tgcaaagaga aaacaagcgc cttgtttcct tc
//
