LOCUS       NM_022486               3015 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens sushi domain containing 1 (SUSD1), transcript variant
            2, mRNA.
ACCESSION   NM_022486
VERSION     NM_022486.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3015)
  AUTHORS   Tang,W., Teichert,M., Chasman,D.I., Heit,J.A., Morange,P.E., Li,G.,
            Pankratz,N., Leebeek,F.W., Pare,G., de Andrade,M., Tzourio,C.,
            Psaty,B.M., Basu,S., Ruiter,R., Rose,L., Armasu,S.M., Lumley,T.,
            Heckbert,S.R., Uitterlinden,A.G., Lathrop,M., Rice,K.M.,
            Cushman,M., Hofman,A., Lambert,J.C., Glazer,N.L., Pankow,J.S.,
            Witteman,J.C., Amouyel,P., Bis,J.C., Bovill,E.G., Kong,X.,
            Tracy,R.P., Boerwinkle,E., Rotter,J.I., Tregouet,D.A., Loth,D.W.,
            Stricker,B.H.C., Ridker,P.M., Folsom,A.R. and Smith,N.L.
  TITLE     A genome-wide association study for venous thromboembolism: the
            extended cohorts for heart and aging research in genomic
            epidemiology (CHARGE) consortium
  JOURNAL   Genet Epidemiol 37 (5), 512-521 (2013)
   PUBMED   23650146
REFERENCE   2  (bases 1 to 3015)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 3015)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3015)
  AUTHORS   Schymick,J.C., Scholz,S.W., Fung,H.C., Britton,A., Arepalli,S.,
            Gibbs,J.R., Lombardo,F., Matarin,M., Kasperaviciute,D.,
            Hernandez,D.G., Crews,C., Bruijn,L., Rothstein,J., Mora,G.,
            Restagno,G., Chio,A., Singleton,A., Hardy,J. and Traynor,B.J.
  TITLE     Genome-wide genotyping in amyotrophic lateral sclerosis and
            neurologically normal controls: first stage analysis and public
            release of data
  JOURNAL   Lancet Neurol 6 (4), 322-328 (2007)
   PUBMED   17362836
REFERENCE   5  (bases 1 to 3015)
  AUTHORS   Lewandrowski,U., Moebius,J., Walter,U. and Sickmann,A.
  TITLE     Elucidation of N-glycosylation sites on human platelet proteins: a
            glycoproteomic approach
  JOURNAL   Mol Cell Proteomics 5 (2), 226-233 (2006)
   PUBMED   16263699
REFERENCE   6  (bases 1 to 3015)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 3015)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 3015)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292868.1, AY358746.1, AL138756.23 and BC021125.1.
            
            On Jun 2, 2019 this sequence version replaced NM_022486.4.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region compared to variant 1. The encoded isoform (2) is
            shorter and has a distinct C-terminus compare to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358746.1, AK292868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374270.8/ ENSP00000363388.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2278              AK292868.1         1-2278
            2279-2460           AY358746.1         2258-2439
            2461-2745           AL138756.23        63561-63845         c
            2746-3015           BC021125.1         1478-1747
FEATURES             Location/Qualifiers
     source          1..3015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3-q32"
     gene            1..3015
                     /gene="SUSD1"
                     /note="sushi domain containing 1"
                     /db_xref="GeneID:64420"
                     /db_xref="HGNC:HGNC:25413"
     exon            1..165
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2306
                     /gene="SUSD1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; sushi domain-containing protein 1"
                     /codon_start=1
                     /product="sushi domain-containing protein 1 isoform 2
                     precursor"
                     /protein_id="NP_071931.2"
                     /db_xref="CCDS:CCDS6783.1"
                     /db_xref="GeneID:64420"
                     /db_xref="HGNC:HGNC:25413"
                     /translation="MGRGPWDAGPSRRLLPLLLLLGLARGAAGAPGPDGLDVCATCHE
                     HATCQQREGKKICICNYGFVGNGRTQCVDKNECQFGATLVCGNHTSCHNTPGGFYCIC
                     LEGYRATNNNKTFIPNDGTFCTDIDECEVSGLCRHGGRCVNTHGSFECYCMDGYLPRN
                     GPEPFHPTTDATSCTEIDCGTPPEVPDGYIIGNYTSSLGSQVRYACREGFFSVPEDTV
                     SSCTGLGTWESPKLHCQEINCGNPPEMRHAILVGNHSSRLGGVARYVCQEGFESPGGK
                     ITSVCTEKGTWRESTLTCTEILTKINDVSLFNDTCVRWQINSRRINPKISYVISIKGQ
                     RLDPMESVREETVNLTTDSRTPEVCLALYPGTNYTVNISTAPPRRSMPAVIGFQTAEV
                     DLLEDDGSFNISIFNETCLKLNRRSRKVGSEHMYQFTVLGQRWYLANFSHATSFNFTT
                     REQVPVVCLDLYPTTDYTVNVTLLRSPKRHSVQITIATPPAVKQTISNISGFNETCLR
                     WRSIKTADMEEMYLFHIWGQRWYQKEFAQEMTFNISSSSRDPEVCLDLRPGTNYNVSL
                     RALSSELPVVISLTTQITEPPLPEVEFFTVHRGPLPRLRLRKAKEKNGPISSYQVLVL
                     PLALQSTFSCDSEGASSFFSNASDADGYVAAELLAKDVPDDAMEIPIGDRLYYGEYYN
                     APLKRGSDYCIILRITSEWNKVRRHSCAVWAQVKDSSLMLLQMAGVGLGSLAVVIILT
                     FLSFSAV"
     exon            166..279
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..435
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..588
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..768
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..948
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1046
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1233
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1343
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1536
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1628
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1815
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1912
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2171
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2211
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2305
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..3015
                     /gene="SUSD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUSD1"
                     /note="hexamer: TATAAA"
     polyA_site      2719
                     /gene="SUSD1"
     polyA_site      2804
                     /gene="SUSD1"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUSD1"
                     /note="hexamer: AGTAAA"
     polyA_site      3015
                     /gene="SUSD1"
                     /note="major polyA site"
ORIGIN      
        1 atctctgcac cctgagggcc ccgggaggag gcgcgggcgc gccgggaggg accggcggcg
       61 gcatgggccg ggggccctgg gatgcgggcc cgtctcgccg cctgctgccg ctgttgctgc
      121 tgctcggcct ggcccgcggc gccgcgggag cgccgggccc cgacggttta gacgtctgtg
      181 ccacttgcca tgaacatgcc acatgccagc aaagagaagg gaagaagatc tgtatttgca
      241 actatggatt tgtagggaac gggaggactc agtgtgttga taaaaatgag tgccagtttg
      301 gagccactct tgtctgtggg aaccacacat cttgccacaa cacccccggg ggcttctatt
      361 gcatttgcct ggaaggatat cgagccacaa acaacaacaa gacattcatt cccaacgatg
      421 gcaccttttg tacagacata gatgagtgtg aagtttctgg cctgtgcagg catggagggc
      481 gatgcgtgaa cactcatggg agctttgaat gctactgtat ggatggatac ttgccaagga
      541 atggacctga acctttccac ccgaccaccg atgccacatc atgcacagaa atagactgtg
      601 gtacccctcc tgaggttcca gatggctata tcataggaaa ttatacgtct agtctgggca
      661 gccaggttcg ttatgcttgc agagaaggat tcttcagtgt tccagaagat acagtttcaa
      721 gctgcacagg cctgggcaca tgggagtccc caaaattaca ttgccaagag atcaactgtg
      781 gcaaccctcc agaaatgcgg cacgccatct tggtaggaaa tcacagctcc aggctgggcg
      841 gtgtggctcg ctatgtctgt caagagggct ttgagagccc tggaggaaag atcacttctg
      901 tttgcacaga gaaaggcacc tggagagaaa gtactttaac atgcacagaa attctgacaa
      961 agattaatga tgtatcactg tttaatgata cctgtgtgag atggcaaata aactcaagaa
     1021 gaataaaccc caagatctca tatgtgatat ccataaaagg acaacggttg gaccctatgg
     1081 aatcagttcg tgaggagaca gtcaacttga ccacagacag caggacccca gaagtgtgcc
     1141 tagccctgta cccaggcacc aactacaccg tgaacatctc cacagcacct cccaggcgct
     1201 cgatgccagc cgtcatcggt ttccagacag ctgaagttga tctcttagaa gatgatggaa
     1261 gtttcaatat ttcaatattt aatgaaactt gtttgaaatt gaacaggcgt tctaggaaag
     1321 ttggatcaga acacatgtac caatttaccg ttctgggtca gaggtggtat ctggctaact
     1381 tttctcatgc aacatcgttt aacttcacaa cgagggaaca agtgcctgta gtgtgtttgg
     1441 atctgtaccc tacgactgat tatacggtga atgtgaccct gctgagatct cctaagcggc
     1501 actcagtgca aataacaata gcaactcccc cagcagtaaa acagaccatc agtaacattt
     1561 caggatttaa tgaaacctgc ttgagatgga gaagcatcaa gacagctgat atggaggaga
     1621 tgtatttatt ccacatttgg ggccagagat ggtatcagaa ggaatttgcc caggaaatga
     1681 cctttaatat cagtagcagc agccgagatc ccgaggtgtg cttggaccta cgtccgggta
     1741 ccaactacaa tgtcagtctc cgggctctgt cttcggaact tcctgtggtc atctccctga
     1801 caacccagat aacagagcct cccctcccgg aagtagaatt ttttacggtg cacagaggac
     1861 ctctaccacg cctcagactg aggaaagcca aggagaaaaa tggaccaatc agttcatatc
     1921 aggtgttagt gcttcccctg gccctccaaa gcacattttc ttgtgattct gaaggcgctt
     1981 cctccttctt tagcaacgcc tctgatgctg atggatacgt ggctgcagaa ctactggcca
     2041 aagatgttcc agatgatgcc atggagatac ctataggaga caggctgtac tatggggaat
     2101 attataatgc acccttgaaa agagggagtg attactgcat tatattacga atcacaagtg
     2161 aatggaataa ggtgagaaga cactcctgtg cagtttgggc tcaggtgaaa gattcgtcac
     2221 tcatgctgct gcagatggcg ggtgttggac tgggttccct ggctgttgtg atcattctca
     2281 cattcctctc cttctcagcg gtgtgatggc agatggacac tgagtgggga ggatgcactg
     2341 ctgctgggca ggtgttctgg cagcttctca ggtgcccgca cagaggctcc gtgtgacttc
     2401 cgtccaggga gcatgtgggc ctgcaacttt ctccattccc agctgggccc cattcctgga
     2461 tttaagatgg tggctatccc tgaggagtca ccataaggag aaaactcagg aattctgagt
     2521 cttccctgct acaggaccag ttctgtgcaa tgaacttgag actcctgatg tacactgtga
     2581 tattgaccga aggctacata cagatctgtg aatcttggct gggacttcct ctgagtgatg
     2641 cctgagggtc agctcctcta gacattgact gcaagagaat ctctgcaacc tcctatataa
     2701 aagcatttct gttaattcat tcagaatcca ttctttacaa tatgcagtga gatgggctta
     2761 agtttgggct agagtttgac tttatgaagg aggtcattga aaaagagaac agtgacgtag
     2821 gcaaatgttt caagcacttt agaaacagta cttttcctat aattagttga tatactaatg
     2881 agaaaatata ctagcctggc catgccaata agtttcctgc tgtgtctgtt aggcagcatt
     2941 gctttgatgc aatttctatt gtcctatata ttcaaaagta atgtctacat tccagtaaaa
     3001 atatcccgta attaa
//
