LOCUS       NM_006753               4235 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens surfeit 6 (SURF6), transcript variant 1, mRNA.
ACCESSION   NM_006753
VERSION     NM_006753.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Moraleva,A., Deryabin,A., Kordyukova,M., Polzikov,M., Shishova,K.,
            Dobrochaeva,K., Rubtsov,Y., Rubtsova,M., Dontsova,O. and
            Zatsepina,O.
  TITLE     Human nucleolar protein SURF6/RRP14 participates in early steps of
            pre-rRNA processing
  JOURNAL   PLoS One 18 (7), e0285833 (2023)
   PUBMED   37450438
  REMARK    GeneRIF: Human nucleolar protein SURF6/RRP14 participates in early
            steps of pre-rRNA processing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Moraleva,A.A., Malysheva,M.A., Khajdukov,S.V. and Zatsepina,O.V.
  TITLE     A Higher Level of Expression of the Nucleolar Protein SURF6 in
            Human Normal Activated Lymphocytes and in Lymphocytes of Patients
            with Lymphoproliferative Disorders
  JOURNAL   Dokl Biochem Biophys 494 (1), 261-265 (2020)
   PUBMED   33119830
  REMARK    GeneRIF: A Higher Level of Expression of the Nucleolar Protein
            SURF6 in Human Normal Activated Lymphocytes and in Lymphocytes of
            Patients with Lymphoproliferative Disorders.
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Ferrolino,M.C., Mitrea,D.M., Michael,J.R. and Kriwacki,R.W.
  TITLE     Compositional adaptability in NPM1-SURF6 scaffolding networks
            enabled by dynamic switching of phase separation mechanisms
  JOURNAL   Nat Commun 9 (1), 5064 (2018)
   PUBMED   30498217
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Mitrea,D.M., Cika,J.A., Stanley,C.B., Nourse,A., Onuchic,P.L.,
            Banerjee,P.R., Phillips,A.H., Park,C.G., Deniz,A.A. and
            Kriwacki,R.W.
  TITLE     Self-interaction of NPM1 modulates multiple mechanisms of
            liquid-liquid phase separation
  JOURNAL   Nat Commun 9 (1), 842 (2018)
   PUBMED   29483575
  REMARK    GeneRIF: NPM1 and SURF6 form heterotypic liquid-like droplets in
            the nucleolus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Magoulas,C. and Fried,M.
  TITLE     Isolation and genomic analysis of the human surf-6 gene: a member
            of the Surfeit locus
  JOURNAL   Gene 243 (1-2), 115-123 (2000)
   PUBMED   10675619
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Duhig,T., Ruhrberg,C., Mor,O. and Fried,M.
  TITLE     The human Surfeit locus
  JOURNAL   Genomics 52 (1), 72-78 (1998)
   PUBMED   9740673
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   Magoulas,C., Zatsepina,O.V., Jordan,P.W., Jordan,E.G. and Fried,M.
  TITLE     The SURF-6 protein is a component of the nucleolar matrix and has a
            high binding capacity for nucleic acids in vitro
  JOURNAL   Eur J Cell Biol 75 (2), 174-183 (1998)
   PUBMED   9548374
REFERENCE   9  (bases 1 to 4235)
  AUTHORS   Magoulas,C. and Fried,M.
  TITLE     The Surf-6 gene of the mouse surfeit locus encodes a novel
            nucleolar protein
  JOURNAL   DNA Cell Biol 15 (4), 305-316 (1996)
   PUBMED   8639267
REFERENCE   10 (bases 1 to 4235)
  AUTHORS   Yon,J., Jones,T., Garson,K., Sheer,D. and Fried,M.
  TITLE     The organization and conservation of the human Surfeit gene cluster
            and its localization telomeric to the c-abl and can proto-oncogenes
            at chromosome band 9q34.1
  JOURNAL   Hum Mol Genet 2 (3), 237-240 (1993)
   PUBMED   8499913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD104374.1, BC003001.1,
            CB158198.1 and AL772161.10.
            
            On Nov 22, 2018 this sequence version replaced NM_006753.5.
            
            Summary: This gene encodes a conserved protein that is localized to
            the nucleolus. The encoded protein may function as a
            nucleolar-matrix protein with nucleic acid-binding properties.
            There is a pseudogene for this gene on chromosome Y. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.101935.1,
                                           SRR1803614.251090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372022.6/ ENSP00000361092.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CD104374.1         25-75
            52-2295             BC003001.1         1-2244
            2296-2304           CB158198.1         441-449
            2305-4235           AL772161.10        127773-129703       c
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..4235
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="surfeit 6"
                     /db_xref="GeneID:6838"
                     /db_xref="HGNC:HGNC:11478"
                     /db_xref="MIM:185642"
     exon            1..150
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1142
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     surfeit locus protein 6"
                     /codon_start=1
                     /product="surfeit locus protein 6 isoform 1"
                     /protein_id="NP_006744.2"
                     /db_xref="CCDS:CCDS6962.1"
                     /db_xref="GeneID:6838"
                     /db_xref="HGNC:HGNC:11478"
                     /db_xref="MIM:185642"
                     /translation="MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPP
                     KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPAD
                     GLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRK
                     ELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRK
                     EKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYK
                     AEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKA
                     ARAERRLLRARKKGRILPQDLERAGLV"
     exon            151..360
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /inference="alignment:Splign:2.1.0"
     exon            361..449
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /inference="alignment:Splign:2.1.0"
     exon            450..662
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /inference="alignment:Splign:2.1.0"
     exon            663..4235
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="hexamer: AATAAA"
     polyA_site      2001
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="major polyA site"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="hexamer: ATTAAA"
     polyA_site      2295
                     /gene="SURF6"
                     /gene_synonym="RRP14"
     regulatory      2836..2841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="hexamer: GATAAA"
     polyA_site      2859
                     /gene="SURF6"
                     /gene_synonym="RRP14"
     polyA_site      4094
                     /gene="SURF6"
                     /gene_synonym="RRP14"
     regulatory      4213..4218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF6"
                     /gene_synonym="RRP14"
                     /note="hexamer: AATAAA"
     polyA_site      4235
                     /gene="SURF6"
                     /gene_synonym="RRP14"
ORIGIN      
        1 gagagtcgca cgcgcagcgg ggaaggtgtg agtcgtgaac ggcccgggtc tccgccatgg
       61 cctctctact cgccaaggac gcctacctgc agagcctggc caagaagatc tgctcccatt
      121 cggccccgga acagcaggcg cgcacgcggg ctggcaaaac tcaaggctca gaaactgcag
      181 ggcccccaaa aaagaaaagg aagaaaacac aaaagaaatt ccggaagcga gaagagaagg
      241 ctgctgagca caaggccaag tccttggggg agaaatctcc agcagcctct ggggccagga
      301 ggcctgaggc agccaaagag gaagcagctt gggcttccag ctcagcaggg aaccctgcag
      361 atggcctggc cactgagcct gagtctgtct ttgctctgga tgttctgcga cagcgactgc
      421 atgagaagat ccaggaggcc cggggccagg gcagtgccaa ggagctgtcc cctgccgcct
      481 tggagaaaag gcggcggaga aagcaggaac gggaccggaa gaagaggaag cgaaaggagc
      541 tgcgggcgaa agagaaggcc aggaaggctg aggaggccac ggaggcccag gaggtggtgg
      601 aggcaacccc agagggggcc tgcacggagc cgcgggagcc gcccgggctg atcttcaata
      661 aggtggaggt gagcgaagac gagccggcca gcaaggcgca gcgcagaaaa gagaagaggc
      721 agagggtgaa ggggaacctc acgccgctga ccgggaggaa ctaccggcag ctgctggagc
      781 gcctgcaggc acggcagagc cggctggacg agctgcgcgg ccaggatgag gggaaggcgc
      841 aggagctgga ggcgaagatg aagtggacca acctcctcta caaggcggag ggcgtgaaga
      901 tccgtgacga cgaacgcctg ctgcaggagg ccctgaagcg caaggagaag cgcagggcgc
      961 agcggcagcg ccggtgggag aagcgcacgg ccggcgtggt ggagaagatg cagcagcgcc
     1021 aggaccggcg gcggcagaac ctgcgcagga agaaggcggc ccgcgccgag cgccgcctgc
     1081 tcagagcccg caagaagggc cgcatcctgc cgcaggacct ggagcgcgca ggcctggtct
     1141 gagtctttcc cacctggggc cgccgtcttc cgtcctagga gactccagga caccctctga
     1201 gtccttgacg ctggctctgt cccaggatct ccacagacct cggcctctcc atgtgagggg
     1261 gacacagtgg tgctctgctg agttgtgagg gcccagatca cagatcccat gtgagaaaga
     1321 gagagtttca gcgtcatcct tgaacgcagg atccgggacc ttcagaccca gggaaagggt
     1381 gagggagact ggggcctggt ctgctttccc gggcctgaaa gcttccccga ggtttgcagg
     1441 gtcagggagg aggaacggtg ggggtgggca gtcactgcct gttccccact gcctgtgttc
     1501 gcaggagcca cgggacagaa gacggtggcc tctgctgccg ggccacgtta gtccgcagct
     1561 cacccgaaca gaggacaacc ctgaggtgtg gcatatgggc acctggcact gggagtcggg
     1621 ggagcacgtc caggcgtggt gcatcctggg gcagaacgcc atggctcctc cccgctctct
     1681 tggcttctgc ctgttggggt ctcattcctt tctgttcccc agtgccccgg ggcggcattt
     1741 tactgctcag aatttggagg gagggagcag taccttcccg gagtccacgc atgtgagttg
     1801 ggtcaagtgc attggaccta gggaaagaga aagaaagaat aaaagctgga gagagagtga
     1861 agtgaatgca agatacaaag tgggatggaa gaattaaatc cagagttcca ggcaatcaaa
     1921 atgagtgcag gttgaaagaa aacaggtgaa ttttagtggc atatggatga taaagctgta
     1981 aataaaattc ttttgatgaa actctccggt tatgagacaa agactgtaac tgaacaggag
     2041 ctggtgtgac tgttaccaga cagaggcaac tgatgaaaaa gccctgtgaa agataggatg
     2101 tgaggtgagc atgagcttga gctgagagac agacacaaca gtatctgaaa agaatacata
     2161 ctctttccat gcatatatgg aacatggatg gaaactgacc acctactttg tccagaaaag
     2221 aagtcttaag atatttcaag gaatcagtgt cgttatctga ccgtatccca atgtcattaa
     2281 aaaaaatttg agctattttt ttttgttttt tagatagagt cttgctctgt cactcaggct
     2341 ggagtgcagt ggcatttcat atttggaatt tttaaaacac acttataaat tacctatgag
     2401 ttaaagaatt ccgaatggct attagaaata tttgggacta aaggataatg aaaatgctac
     2461 gtattaaaat ttgtggaaca gggcctggca tggtggctca tgctgtcaat cccagctctt
     2521 tgggaggcgg gtggatcact tgagatcagg agttcaaggc tagcctggac aacatgataa
     2581 aaccccatct ctattaaaaa taaaaaatta gctgggtgtg gtggtgcaaa cctgtagtcc
     2641 cagctgcttg ggaggctgag gcgggagaat cacttgaacc caggaggtag aggctgcagt
     2701 gagccaagat cgagccgctg cactccagcc tgggtgacag agcaagactg tctcaaaaag
     2761 aaaaaattta agatttgtgg aacagagcta aagcagcaca aaaaaacata gcccctaaat
     2821 gtatgtgcat ctacagataa atagtgccat ttatacacac atacgctgta tgtctgtatt
     2881 tttaaagcta aagaaaaata agcatgcagc ttaagttgga acaactcaaa gtaaatggaa
     2941 gaaaaatctc caaaactgac taaaagtaat agaaagcctg agttgtaatc actgatgaaa
     3001 ttgagtcagt agttaagaat gttcccctag acggttttac agggaagttc cacgatatag
     3061 agaacaggta attccagacg tagacaaatt ctaacagaat caattgagag aacacttcat
     3121 tcgtgaactt agctttgata ccaaaactag gtaagagaaa gggaagttac caaatacctg
     3181 tgggcggcaa gccacccagg cgccgaggca agagacagag gacacgagct gttccagtat
     3241 aataaaatat aaaacaagaa tagttacagc agatatagat cttagatatg attacatatg
     3301 aatatcatta atcattagtt tgtagcaatt accttttatt ccaatattat aataatcctc
     3361 gctctataat catagcctag gaaaaaccag gccatacaga gataggagct gaggggacat
     3421 aggtgtgacc agaagacaag agtgcgagcc ttctgttatg cccggacagg gccaccagag
     3481 ggctccttgg tctagcggtg acgccagcgt ctgggaagac gcccgttgcc aggtggacca
     3541 tggtctagca gtagcaaaaa gtatcaagga acaacacccg ctacttagca gaccgggaaa
     3601 gggagtgtcc ctttccctgg aggagtttag agaagactct gctcttccac ctcttgtgga
     3661 gggcctgaca tccggcaggc ctgcccgcag ttatctggag gcctaaccgt ctccctgtga
     3721 tgctgtgctt cagtggtcac gctcctagtc cgccttcatg ttccatcctg tacacctggc
     3781 tctgccttct agatagcagt agtaaattag tgaaagtact aaaagtctct gatatgcaga
     3841 agtaatggca taagctgtct ttctctctgt ctcctctctc tctctgcctc ggctgccagg
     3901 cagggaaggg caccctgtcc agtggacacg tgatccacgt gaccttacct atcattggag
     3961 atgactcaca ctctttaccc tgcccctttt gctttgtatc caataaataa caatgcagcc
     4021 agacattcgg ggccactacc ggtctccgag cattggtagt agtggtctcc cgggcccagc
     4081 tgccttttct tttatctctt tgtcttgtgt gtgtatttct acactctctc attgctgcac
     4141 acagggaggg agagacccac ggaccctgtg gggctggtcc ctacaaatac caatgtcaag
     4201 attttagaca ataataaacc aagtttagca aagtg
//
