LOCUS       NM_033161               2930 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens surfeit 4 (SURF4), transcript variant 1, mRNA.
ACCESSION   NM_033161
VERSION     NM_033161.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Shen,Y., Gu,H.M., Qin,S. and Zhang,D.W.
  TITLE     Surf4, cargo trafficking, lipid metabolism, and therapeutic
            implications
  JOURNAL   J Mol Cell Biol 14 (9) (2023)
   PUBMED   36574593
  REMARK    GeneRIF: Surf4, cargo trafficking, lipid metabolism, and
            therapeutic implications.
            Review article
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Tang,X., Wang,T. and Guo,Y.
  TITLE     Export of polybasic motif-containing secretory proteins BMP8A and
            SFRP1 from the endoplasmic reticulum is regulated by surfeit locus
            protein 4
  JOURNAL   J Biol Chem 298 (12), 102687 (2022)
   PUBMED   36370847
  REMARK    GeneRIF: Export of polybasic motif-containing secretory proteins
            BMP8A and SFRP1 from the endoplasmic reticulum is regulated by
            surfeit locus protein 4.
REFERENCE   3  (bases 1 to 2930)
  AUTHORS   Zhai,J., Han,J., Li,C., Guo,F., Ma,F. and Xu,B.
  TITLE     High SURF4 expression is associated with poor prognosis of breast
            cancer
  JOURNAL   Aging (Albany NY) 14 (22), 9317-9337 (2022)
   PUBMED   36446386
  REMARK    GeneRIF: High SURF4 expression is associated with poor prognosis of
            breast cancer.
REFERENCE   4  (bases 1 to 2930)
  AUTHORS   Gomez-Navarro,N., Maldutyte,J., Poljak,K., Peak-Chew,S.Y., Orme,J.,
            Bisnett,B.J., Lamb,C.H., Boyce,M., Gianni,D. and Miller,E.A.
  TITLE     Selective inhibition of protein secretion by abrogating
            receptor-coat interactions during ER export
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2202080119 (2022)
   PUBMED   35901214
  REMARK    GeneRIF: Selective inhibition of protein secretion by abrogating
            receptor-coat interactions during ER export.
REFERENCE   5  (bases 1 to 2930)
  AUTHORS   Tang,X., Chen,R., Mesias,V.S.D., Wang,T., Wang,Y., Poljak,K.,
            Fan,X., Miao,H., Hu,J., Zhang,L., Huang,J., Yao,S., Miller,E.A. and
            Guo,Y.
  TITLE     A SURF4-to-proteoglycan relay mechanism that mediates the sorting
            and secretion of a tagged variant of sonic hedgehog
  JOURNAL   Proc Natl Acad Sci U S A 119 (11), e2113991119 (2022)
   PUBMED   35271396
  REMARK    GeneRIF: A SURF4-to-proteoglycan relay mechanism that mediates the
            sorting and secretion of a tagged variant of sonic hedgehog.
REFERENCE   6  (bases 1 to 2930)
  AUTHORS   Mitrovic,S., Ben-Tekaya,H., Koegler,E., Gruenberg,J. and Hauri,H.P.
  TITLE     The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate
            compartment (ERGIC)-53, and p25 are required to maintain the
            architecture of ERGIC and Golgi
  JOURNAL   Mol Biol Cell 19 (5), 1976-1990 (2008)
   PUBMED   18287528
  REMARK    GeneRIF: Silencing Surf4 together with ERGIC-53 or silencing the
            p24 family member p25 induced an identical phenotype characterized
            by a reduced number of ERGIC clusters and fragmentation of the
            Golgi apparatus without effect on anterograde transport.
REFERENCE   7  (bases 1 to 2930)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   8  (bases 1 to 2930)
  AUTHORS   Duhig,T., Ruhrberg,C., Mor,O. and Fried,M.
  TITLE     The human Surfeit locus
  JOURNAL   Genomics 52 (1), 72-78 (1998)
   PUBMED   9740673
REFERENCE   9  (bases 1 to 2930)
  AUTHORS   Reeves,J.E. and Fried,M.
  TITLE     The surf-4 gene encodes a novel 30 kDa integral membrane protein
  JOURNAL   Mol Membr Biol 12 (2), 201-208 (1995)
   PUBMED   7540914
REFERENCE   10 (bases 1 to 2930)
  AUTHORS   Yon,J., Jones,T., Garson,K., Sheer,D. and Fried,M.
  TITLE     The organization and conservation of the human Surfeit gene cluster
            and its localization telomeric to the c-abl and can proto-oncogenes
            at chromosome band 9q34.1
  JOURNAL   Hum Mol Genet 2 (3), 237-240 (1993)
   PUBMED   8499913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC424374.1, BC018741.1 and
            BX647961.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033161.3.
            
            Summary: This gene is located in the surfeit gene cluster, which is
            comprised of very tightly linked housekeeping genes that do not
            share sequence similarity. The encoded protein is a conserved
            integral membrane protein that interacts with endoplasmic
            reticulum-Golgi intermediate compartment proteins. Disruption of
            this gene results in reduced numbers of endoplasmic reticulum-Golgi
            intermediate compartment clusters and redistribution of coat
            protein I to the cytosol. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.83563.1,
                                           SRR1660809.165117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371989.8/ ENSP00000361057.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                DC424374.1         109-179
            72-1529             BC018741.1         1-1458
            1530-2930           BX647961.1         1489-2889
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..2930
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="surfeit 4"
                     /db_xref="GeneID:6836"
                     /db_xref="HGNC:HGNC:11476"
                     /db_xref="MIM:185660"
     exon            1..139
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..901
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     surfeit locus protein 4; surface 4 integral membrane
                     protein"
                     /codon_start=1
                     /product="surfeit locus protein 4 isoform 1"
                     /protein_id="NP_149351.1"
                     /db_xref="CCDS:CCDS6968.1"
                     /db_xref="GeneID:6836"
                     /db_xref="HGNC:HGNC:11476"
                     /db_xref="MIM:185660"
                     /translation="MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRM
                     WFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIA
                     LQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLG
                     GRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVY
                     FNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW"
     exon            140..326
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            327..403
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            404..447
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            448..634
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            635..2930
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1504..1509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="hexamer: GATAAA"
     polyA_site      1529
                     /gene="SURF4"
                     /gene_synonym="ERV29"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgtg gaggccgcag cgggtgcggg cgccgacggg cgagagccag cgagcgagcg
       61 agcgagccga gccgagcctc ccgccgtcgc catgggccag aacgacctga tgggcacggc
      121 cgaggacttc gccgaccagt tcctccgtgt cacaaagcag tacctgcccc acgtggcgcg
      181 cctctgtctg atcagcacct tcctggagga cggcatccgt atgtggttcc agtggagcga
      241 gcagcgcgac tacatcgaca ccacctggaa ctgcggctac ctgctggcct cgtccttcgt
      301 cttcctcaac ttgctgggac agctgactgg ctgcgtcctg gtgttgagca ggaacttcgt
      361 gcagtacgcc tgcttcgggc tctttggaat catagctctg cagacgattg cctacagcat
      421 tttatgggac ttgaagtttt tgatgaggaa cctggccctg ggaggaggcc tgttgctgct
      481 cctagcagaa tcccgttctg aagggaagag catgtttgcg ggcgtcccca ccatgcgtga
      541 gagctccccc aaacagtaca tgcagctcgg aggcagggtc ttgctggttc tgatgttcat
      601 gaccctcctt cactttgacg ccagcttctt ttctattgtc cagaacatcg tgggcacagc
      661 tctgatgatt ttagtggcca ttggttttaa aaccaagctg gctgctttga ctcttgttgt
      721 gtggctcttt gccatcaacg tatatttcaa cgccttctgg accattccag tctacaagcc
      781 catgcatgac ttcctgaaat acgacttctt ccagaccatg tcggtgattg ggggcttgct
      841 cctggtggtg gccctgggcc ctgggggtgt ctccatggat gagaagaaga aggagtggta
      901 acagtcacag atccctacct gcctggctaa gacccgtggc cgtcaaggac tggttcgggg
      961 tggattcaac aaaactgcca gcttttatgt atcctcttcc cttcccctcc cttggtaaag
     1021 gcacagatgt tttgagaact ttatttgcag agacacctga gaatcgatgg ctcagtctgc
     1081 tctggagcca cagtctggcg tctgaccctt cagtgcaggc cagcctggca gctggaagcc
     1141 tcccccacgc cgaggctttg gagtgaacag cccgcttggc tgtggcatct cagtcctatt
     1201 tttgagtttt tttgtggggg tacaggaggg ggccttcaag ctgtactgtg agcagacgca
     1261 ttggtattat cattcaaagc agtctccctc ttatttgtaa gtttacattt ttagcggaaa
     1321 ctactaaatt attttgggtg gttcagccaa acctcaaaac agttaatctc cctggtttaa
     1381 aatcacacca gtggctttga tgttgtttct gccccgcatt gtattttata ggaatagtga
     1441 aaacatttag ggacacccaa agaatgatgc agtattaaag gggtggtaga agctgctgtt
     1501 tatgataaaa gtcatcggtc agaaaatcag cttggattgg tgccaagtgt tttattgggt
     1561 aacaccctgg gagttttagt agcttgaggc aaggtggagg ggcaagaagt ccttggggaa
     1621 gctgctggtc tgggtgctgc tggcctccaa gctggcagtg ggaagggcta gtgagaccac
     1681 acaggggtag ccccagcagc agcaccctgc aagccagcct ggccagctgc tcagaccagc
     1741 ttgcagagcc gcagccgctg tgggcagggg gtgtggcagg agctcccagc actggagacc
     1801 cacggactca acccagttac ctcacatggg gccttttctg agcaaggtct cgaaagcgca
     1861 ggccgccctg gctgagcagc accgcccttt cccagctgca ctcgccctgt ggacagcccc
     1921 gacacaccac tttcctgagg ctgtcgctca ctcagattgt ccgtttgcta tgccgaatgc
     1981 agccaaaatt cctttttaca atttgtgatg ccttaccgat ttgatcttaa tcctgtattt
     2041 aaagttttct aacactgcct tatactgtgt ttctcttttt gggggagctt aactgcttgt
     2101 tgctccctgt cgtctgcacc atagtaaatg ccacaagggt agtcgaacac ctctctggcc
     2161 cctagaccta tctggggaca ggctggctca gcctgtctcc agggctgctg cggcccagcc
     2221 ccgagcctgc ctccctcttg gcctctcatc cattggctct gcagggcagg ggtgaggcag
     2281 gtttctgctc ataagtgctt ttggaagtca cctacctttt taacacagcc gaactagtcc
     2341 caacgcgttt gcaaatattc ccctggtagc ctacttcctt acccccgaat attggtaaga
     2401 tcgagcaatg gcttcaggac atgggttctc ttctcctgtg atcattcaag tgctcactgc
     2461 atgaagactg gcttgtctca gtgtttcaac ctcaccaggg ctgtctcttg gtccacacct
     2521 cgctccctgt tagtgccgta tgacagcccc catcaaatga ccttggccaa gtcacggttt
     2581 ctctgtggtc aaggttggtt ggctgattgg tggaaagtag ggtggaccaa aggaggccac
     2641 gtgagcagtc agcaccagtt ctgcaccagc agcgcctccg tcctagtggg tgttcctgtt
     2701 tctcctggcc ctgggtgggc tagggcctga ttcgggaaga tgcctttgca gggaggggag
     2761 gataagtggg atctaccaat tgattctggc aaaacaattt ctaagatttt tttgctttat
     2821 gtgggaaaca gatctaaatc tcattttatg ctgtatttta tatcttagtt gtgtttgaaa
     2881 acgttttgat ttttggaaac acatcaaaat aaataatggc gtttgttgta
//
