LOCUS       NM_001280790            3080 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens surfeit 4 (SURF4), transcript variant 4, mRNA.
ACCESSION   NM_001280790
VERSION     NM_001280790.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   Shen,Y., Gu,H.M., Qin,S. and Zhang,D.W.
  TITLE     Surf4, cargo trafficking, lipid metabolism, and therapeutic
            implications
  JOURNAL   J Mol Cell Biol 14 (9) (2023)
   PUBMED   36574593
  REMARK    GeneRIF: Surf4, cargo trafficking, lipid metabolism, and
            therapeutic implications.
            Review article
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Tang,X., Wang,T. and Guo,Y.
  TITLE     Export of polybasic motif-containing secretory proteins BMP8A and
            SFRP1 from the endoplasmic reticulum is regulated by surfeit locus
            protein 4
  JOURNAL   J Biol Chem 298 (12), 102687 (2022)
   PUBMED   36370847
  REMARK    GeneRIF: Export of polybasic motif-containing secretory proteins
            BMP8A and SFRP1 from the endoplasmic reticulum is regulated by
            surfeit locus protein 4.
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   Zhai,J., Han,J., Li,C., Guo,F., Ma,F. and Xu,B.
  TITLE     High SURF4 expression is associated with poor prognosis of breast
            cancer
  JOURNAL   Aging (Albany NY) 14 (22), 9317-9337 (2022)
   PUBMED   36446386
  REMARK    GeneRIF: High SURF4 expression is associated with poor prognosis of
            breast cancer.
REFERENCE   4  (bases 1 to 3080)
  AUTHORS   Gomez-Navarro,N., Maldutyte,J., Poljak,K., Peak-Chew,S.Y., Orme,J.,
            Bisnett,B.J., Lamb,C.H., Boyce,M., Gianni,D. and Miller,E.A.
  TITLE     Selective inhibition of protein secretion by abrogating
            receptor-coat interactions during ER export
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2202080119 (2022)
   PUBMED   35901214
  REMARK    GeneRIF: Selective inhibition of protein secretion by abrogating
            receptor-coat interactions during ER export.
REFERENCE   5  (bases 1 to 3080)
  AUTHORS   Tang,X., Chen,R., Mesias,V.S.D., Wang,T., Wang,Y., Poljak,K.,
            Fan,X., Miao,H., Hu,J., Zhang,L., Huang,J., Yao,S., Miller,E.A. and
            Guo,Y.
  TITLE     A SURF4-to-proteoglycan relay mechanism that mediates the sorting
            and secretion of a tagged variant of sonic hedgehog
  JOURNAL   Proc Natl Acad Sci U S A 119 (11), e2113991119 (2022)
   PUBMED   35271396
  REMARK    GeneRIF: A SURF4-to-proteoglycan relay mechanism that mediates the
            sorting and secretion of a tagged variant of sonic hedgehog.
REFERENCE   6  (bases 1 to 3080)
  AUTHORS   Mitrovic,S., Ben-Tekaya,H., Koegler,E., Gruenberg,J. and Hauri,H.P.
  TITLE     The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate
            compartment (ERGIC)-53, and p25 are required to maintain the
            architecture of ERGIC and Golgi
  JOURNAL   Mol Biol Cell 19 (5), 1976-1990 (2008)
   PUBMED   18287528
  REMARK    GeneRIF: Silencing Surf4 together with ERGIC-53 or silencing the
            p24 family member p25 induced an identical phenotype characterized
            by a reduced number of ERGIC clusters and fragmentation of the
            Golgi apparatus without effect on anterograde transport.
REFERENCE   7  (bases 1 to 3080)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   8  (bases 1 to 3080)
  AUTHORS   Duhig,T., Ruhrberg,C., Mor,O. and Fried,M.
  TITLE     The human Surfeit locus
  JOURNAL   Genomics 52 (1), 72-78 (1998)
   PUBMED   9740673
REFERENCE   9  (bases 1 to 3080)
  AUTHORS   Reeves,J.E. and Fried,M.
  TITLE     The surf-4 gene encodes a novel 30 kDa integral membrane protein
  JOURNAL   Mol Membr Biol 12 (2), 201-208 (1995)
   PUBMED   7540914
REFERENCE   10 (bases 1 to 3080)
  AUTHORS   Yon,J., Jones,T., Garson,K., Sheer,D. and Fried,M.
  TITLE     The organization and conservation of the human Surfeit gene cluster
            and its localization telomeric to the c-abl and can proto-oncogenes
            at chromosome band 9q34.1
  JOURNAL   Hum Mol Genet 2 (3), 237-240 (1993)
   PUBMED   8499913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK295435.1 and BX647961.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001280790.1.
            
            Summary: This gene is located in the surfeit gene cluster, which is
            comprised of very tightly linked housekeeping genes that do not
            share sequence similarity. The encoded protein is a conserved
            integral membrane protein that interacts with endoplasmic
            reticulum-Golgi intermediate compartment proteins. Disruption of
            this gene results in reduced numbers of endoplasmic reticulum-Golgi
            intermediate compartment clusters and redistribution of coat
            protein I to the cytosol. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (4) contains an alternate exon in
            its 5' UTR and initiates translation at a downstream start codon,
            compared to variant 1. The encoded isoform (4) has a shorter
            N-terminus, compared to isoform 1. Both variants 4 and 5 encode the
            same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.555817.1,
                                           SRR14038194.1491269.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1314              AK295435.1         4-1317
            1315-3080           BX647961.1         1124-2889
FEATURES             Location/Qualifiers
     source          1..3080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..3080
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="surfeit 4"
                     /db_xref="GeneID:6836"
                     /db_xref="HGNC:HGNC:11476"
                     /db_xref="MIM:185660"
     exon            1..139
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            140..289
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            290..476
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1051
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="isoform 4 is encoded by transcript variant 4;
                     surfeit locus protein 4; surface 4 integral membrane
                     protein"
                     /codon_start=1
                     /product="surfeit locus protein 4 isoform 4"
                     /protein_id="NP_001267719.1"
                     /db_xref="CCDS:CCDS75929.1"
                     /db_xref="GeneID:6836"
                     /db_xref="HGNC:HGNC:11476"
                     /db_xref="MIM:185660"
                     /translation="MWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSR
                     NFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGV
                     PTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKL
                     AALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVS
                     MDEKKKEW"
     exon            477..553
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            554..597
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            598..784
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     exon            785..3080
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="hexamer: GATAAA"
     polyA_site      1679
                     /gene="SURF4"
                     /gene_synonym="ERV29"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="hexamer: AATAAA"
     polyA_site      3080
                     /gene="SURF4"
                     /gene_synonym="ERV29"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgtg gaggccgcag cgggtgcggg cgccgacggg cgagagccag cgagcgagcg
       61 agcgagccga gccgagcctc ccgccgtcgc catgggccag aacgacctga tgggcacggc
      121 cgaggacttc gccgaccaga tgtgctggac tcttggggtc cctttgaccc tgtctgcgtc
      181 tccctccccg tttggactct gccctgggct ggattgagtg gggacctgta cacagcctgg
      241 gaggagggga agcctatctc cctgatagtc tccttccaga agtgtccagt tcctccgtgt
      301 cacaaagcag tacctgcccc acgtggcgcg cctctgtctg atcagcacct tcctggagga
      361 cggcatccgt atgtggttcc agtggagcga gcagcgcgac tacatcgaca ccacctggaa
      421 ctgcggctac ctgctggcct cgtccttcgt cttcctcaac ttgctgggac agctgactgg
      481 ctgcgtcctg gtgttgagca ggaacttcgt gcagtacgcc tgcttcgggc tctttggaat
      541 catagctctg cagacgattg cctacagcat tttatgggac ttgaagtttt tgatgaggaa
      601 cctggccctg ggaggaggcc tgttgctgct cctagcagaa tcccgttctg aagggaagag
      661 catgtttgcg ggcgtcccca ccatgcgtga gagctccccc aaacagtaca tgcagctcgg
      721 aggcagggtc ttgctggttc tgatgttcat gaccctcctt cactttgacg ccagcttctt
      781 ttctattgtc cagaacatcg tgggcacagc tctgatgatt ttagtggcca ttggttttaa
      841 aaccaagctg gctgctttga ctcttgttgt gtggctcttt gccatcaacg tatatttcaa
      901 cgccttctgg accattccag tctacaagcc catgcatgac ttcctgaaat acgacttctt
      961 ccagaccatg tcggtgattg ggggcttgct cctggtggtg gccctgggcc ctgggggtgt
     1021 ctccatggat gagaagaaga aggagtggta acagtcacag atccctacct gcctggctaa
     1081 gacccgtggc cgtcaaggac tggttcgggg tggattcaac aaaactgcca gcttttatgt
     1141 atcctcttcc cttcccctcc cttggtaaag gcacagatgt tttgagaact ttatttgcag
     1201 agacacctga gaatcgatgg ctcagtctgc tctggagcca cagtctggcg tctgaccctt
     1261 cagtgcaggc cagcctggca gctggaagcc tcccccacgc cgaggctttg gagtgaacag
     1321 cccgcttggc tgtggcatct cagtcctatt tttgagtttt tttgtggggg tacaggaggg
     1381 ggccttcaag ctgtactgtg agcagacgca ttggtattat cattcaaagc agtctccctc
     1441 ttatttgtaa gtttacattt ttagcggaaa ctactaaatt attttgggtg gttcagccaa
     1501 acctcaaaac agttaatctc cctggtttaa aatcacacca gtggctttga tgttgtttct
     1561 gccccgcatt gtattttata ggaatagtga aaacatttag ggacacccaa agaatgatgc
     1621 agtattaaag gggtggtaga agctgctgtt tatgataaaa gtcatcggtc agaaaatcag
     1681 cttggattgg tgccaagtgt tttattgggt aacaccctgg gagttttagt agcttgaggc
     1741 aaggtggagg ggcaagaagt ccttggggaa gctgctggtc tgggtgctgc tggcctccaa
     1801 gctggcagtg ggaagggcta gtgagaccac acaggggtag ccccagcagc agcaccctgc
     1861 aagccagcct ggccagctgc tcagaccagc ttgcagagcc gcagccgctg tgggcagggg
     1921 gtgtggcagg agctcccagc actggagacc cacggactca acccagttac ctcacatggg
     1981 gccttttctg agcaaggtct cgaaagcgca ggccgccctg gctgagcagc accgcccttt
     2041 cccagctgca ctcgccctgt ggacagcccc gacacaccac tttcctgagg ctgtcgctca
     2101 ctcagattgt ccgtttgcta tgccgaatgc agccaaaatt cctttttaca atttgtgatg
     2161 ccttaccgat ttgatcttaa tcctgtattt aaagttttct aacactgcct tatactgtgt
     2221 ttctcttttt gggggagctt aactgcttgt tgctccctgt cgtctgcacc atagtaaatg
     2281 ccacaagggt agtcgaacac ctctctggcc cctagaccta tctggggaca ggctggctca
     2341 gcctgtctcc agggctgctg cggcccagcc ccgagcctgc ctccctcttg gcctctcatc
     2401 cattggctct gcagggcagg ggtgaggcag gtttctgctc ataagtgctt ttggaagtca
     2461 cctacctttt taacacagcc gaactagtcc caacgcgttt gcaaatattc ccctggtagc
     2521 ctacttcctt acccccgaat attggtaaga tcgagcaatg gcttcaggac atgggttctc
     2581 ttctcctgtg atcattcaag tgctcactgc atgaagactg gcttgtctca gtgtttcaac
     2641 ctcaccaggg ctgtctcttg gtccacacct cgctccctgt tagtgccgta tgacagcccc
     2701 catcaaatga ccttggccaa gtcacggttt ctctgtggtc aaggttggtt ggctgattgg
     2761 tggaaagtag ggtggaccaa aggaggccac gtgagcagtc agcaccagtt ctgcaccagc
     2821 agcgcctccg tcctagtggg tgttcctgtt tctcctggcc ctgggtgggc tagggcctga
     2881 ttcgggaaga tgcctttgca gggaggggag gataagtggg atctaccaat tgattctggc
     2941 aaaacaattt ctaagatttt tttgctttat gtgggaaaca gatctaaatc tcattttatg
     3001 ctgtatttta tatcttagtt gtgtttgaaa acgttttgat ttttggaaac acatcaaaat
     3061 aaataatggc gtttgttgta
//
