LOCUS       NM_017503                833 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens surfeit 2 (SURF2), transcript variant 1, mRNA.
ACCESSION   NM_017503
VERSION     NM_017503.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 833)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 833)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 833)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 833)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   5  (bases 1 to 833)
  AUTHORS   Duhig,T., Ruhrberg,C., Mor,O. and Fried,M.
  TITLE     The human Surfeit locus
  JOURNAL   Genomics 52 (1), 72-78 (1998)
   PUBMED   9740673
REFERENCE   6  (bases 1 to 833)
  AUTHORS   Lennard,A., Gaston,K. and Fried,M.
  TITLE     The Surf-1 and Surf-2 genes and their essential bidirectional
            promoter elements are conserved between mouse and human
  JOURNAL   DNA Cell Biol 13 (11), 1117-1126 (1994)
   PUBMED   7702754
REFERENCE   7  (bases 1 to 833)
  AUTHORS   Yon,J., Jones,T., Garson,K., Sheer,D. and Fried,M.
  TITLE     The organization and conservation of the human Surfeit gene cluster
            and its localization telomeric to the c-abl and can proto-oncogenes
            at chromosome band 9q34.1
  JOURNAL   Hum Mol Genet 2 (3), 237-240 (1993)
   PUBMED   8499913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP244646.1 and BC014411.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017503.4.
            
            Summary: This gene shares a bidirectional promoter with surfeit 1
            (SURF1; GeneID: 6834), which is located on the opposite strand. It
            encodes a conserved protein that is expressed in a variety of
            tissues. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.148954.1,
                                           SRR5189655.18728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371964.5/ ENSP00000361032.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BP244646.1         6-31
            27-833              BC014411.1         1-807
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..833
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /note="surfeit 2"
                     /db_xref="GeneID:6835"
                     /db_xref="HGNC:HGNC:11475"
                     /db_xref="MIM:185630"
     exon            1..121
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..814
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     surfeit locus protein 2"
                     /codon_start=1
                     /product="surfeit locus protein 2 isoform 1"
                     /protein_id="NP_059973.4"
                     /db_xref="CCDS:CCDS6967.1"
                     /db_xref="GeneID:6835"
                     /db_xref="HGNC:HGNC:11475"
                     /db_xref="MIM:185630"
                     /translation="MSELPGDVRAFLREHPSLRLQTDARKVRCILTGHELPCRLPELQ
                     VYTRGKKYQRLVRASPAFDYAEFEPHIVPSTKNPHQLFCKLTLRHINKCPEHVLRHTQ
                     GRRYQRALCKYEECQKQGVEYVPACLVHRRRRREDQMDGDGPRPREAFWEPTSSDEGG
                     AASDDSMTDLYPPELFTRKDLGSTEDGDGTDDFLTDKEDEKAKPPREKATDEGRRETT
                     VYRGLVQKRGKKQLGSLKKKFKSHHRKPKSFSSCKQPG"
     exon            122..276
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..380
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..560
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..730
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..833
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      813..818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /note="hexamer: AATAAA"
     polyA_site      833
                     /gene="SURF2"
                     /gene_synonym="SURF-2"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgagcgg cttccgccgg gctgctccgc gggcgcgtcg gccatgagcg agttgccggg
       61 cgacgtgcgg gcgtttctgc gggagcaccc gagcctgcgg ctccagacgg acgcccgcaa
      121 ggtgaggtgc atcctgacag gtcacgagct gccctgccgc ctgccggagc tccaggtcta
      181 cacccgcggc aaaaagtacc agcggctggt ccgcgcctcc ccggccttcg actatgcaga
      241 gttcgagccg cacatcgtgc ccagcaccaa gaacccgcac cagttgttct gcaaactcac
      301 cctgcggcac atcaacaagt gcccagaaca cgtgctgagg cacacccagg gccggcggta
      361 ccagcgagct ctgtgtaaat atgaagaatg tcagaagcaa ggggtggagt acgtgcctgc
      421 ctgcctggtg caccggagga ggaggaggga ggaccagatg gacggtgacg ggcctcgccc
      481 gcgggaagcc ttctgggagc ccacatccag tgatgagggg ggagctgcaa gtgatgacag
      541 catgacagac ctgtacccac ctgagctatt caccagaaag gaccttggaa gcacggagga
      601 tggggatggc actgatgact ttttgacaga caaagaggat gagaaggcaa agcccccaag
      661 agagaaggcc actgatgagg gcaggagaga gacgaccgtg taccgagggc tggtccagaa
      721 gcgcgggaag aagcagttgg gctcgttgaa aaagaagttc aagagtcatc accgcaaacc
      781 caagagcttc agctcctgta aacagccagg ttaataaaag cacatgccgt gaa
//
