LOCUS       NM_003171               2477 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens Suv3 like RNA helicase (SUPV3L1), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_003171
VERSION     NM_003171.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2477)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2477)
  AUTHORS   Zhang,J.H., Wu,X., Wang,T.T. and Wang,Z.S.
  TITLE     [SUV3 knockdown inhibits proliferation, migration, and invasion of
            hepatocellular carcinoma cells and induces PD-L1 expression]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 32 (8), 734-743 (2024)
   PUBMED   39267568
  REMARK    GeneRIF: [SUV3 knockdown inhibits proliferation, migration, and
            invasion of hepatocellular carcinoma cells and induces PD-L1
            expression].
REFERENCE   3  (bases 1 to 2477)
  AUTHORS   Jain,M., Golzarroshan,B., Lin,C.L., Agrawal,S., Tang,W.H., Wu,C.J.
            and Yuan,H.S.
  TITLE     Dimeric assembly of human Suv3 helicase promotes its RNA unwinding
            function in mitochondrial RNA degradosome for RNA decay
  JOURNAL   Protein Sci 31 (5), e4312 (2022)
   PUBMED   35481630
  REMARK    GeneRIF: Dimeric assembly of human Suv3 helicase promotes its RNA
            unwinding function in mitochondrial RNA degradosome for RNA decay.
REFERENCE   4  (bases 1 to 2477)
  AUTHORS   van Esveld,S.L., Rodenburg,R.J., Al-Murshedi,F., Al-Ajmi,E.,
            Al-Zuhaibi,S., Huynen,M.A. and Spelbrink,J.N.
  TITLE     Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in
            two siblings with a novel neurodegenerative syndrome
  JOURNAL   J Inherit Metab Dis 45 (2), 292-307 (2022)
   PUBMED   35023579
  REMARK    GeneRIF: Mitochondrial RNA processing defect caused by a SUPV3L1
            mutation in two siblings with a novel neurodegenerative syndrome.
REFERENCE   5  (bases 1 to 2477)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2477)
  AUTHORS   Shu,Z., Vijayakumar,S., Chen,C.F., Chen,P.L. and Lee,W.H.
  TITLE     Purified human SUV3p exhibits multiple-substrate unwinding activity
            upon conformational change
  JOURNAL   Biochemistry 43 (16), 4781-4790 (2004)
   PUBMED   15096047
  REMARK    GeneRIF: Human SUV3 is an ATP-dependent multiple-substrate
            helicase; in addition to dsRNA and dsDNA unwinding activity,
            SUV3-70 and SUV3-83 can unwind heteroduplexes of RNA and DNA.
REFERENCE   7  (bases 1 to 2477)
  AUTHORS   Minczuk,M., Piwowarski,J., Papworth,M.A., Awiszus,K.,
            Schalinski,S., Dziembowski,A., Dmochowska,A., Bartnik,E.,
            Tokatlidis,K., Stepien,P.P. and Borowski,P.
  TITLE     Localisation of the human hSuv3p helicase in the mitochondrial
            matrix and its preferential unwinding of dsDNA
  JOURNAL   Nucleic Acids Res 30 (23), 5074-5086 (2002)
   PUBMED   12466530
  REMARK    GeneRIF: Localisation of hSuv3p helicase in the mitochondrial
            matrix and its preferential unwinding of dsDNA.
REFERENCE   8  (bases 1 to 2477)
  AUTHORS   Glatt,H.
  TITLE     Sulfotransferases in the bioactivation of xenobiotics
  JOURNAL   Chem Biol Interact 129 (1-2), 141-170 (2000)
   PUBMED   11154739
  REMARK    Review article
REFERENCE   9  (bases 1 to 2477)
  AUTHORS   Dmochowska,A., Stankiewicz,P., Golik,P., Stepien,P.P., Bocian,E.,
            Hansmann,I. and Bartnik,E.
  TITLE     Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 84-85 (1998)
   PUBMED   9925937
REFERENCE   10 (bases 1 to 2477)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC398467.1 and BC036112.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003171.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036112.1, AK290416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000359655.9/
                                                  ENSP00000352678.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DC398467.1         31-33
            4-2477              BC036112.1         1-2474
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..2477
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /note="Suv3 like RNA helicase"
                     /db_xref="GeneID:6832"
                     /db_xref="HGNC:HGNC:11471"
                     /db_xref="MIM:605122"
     exon            1..329
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2419
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-dependent RNA helicase SUPV3L1, mitochondrial;
                     suppressor of var1, 3-like 1(SUV3); SUV3-like protein 1;
                     SUV3-like helicase"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase SUPV3L1,
                     mitochondrial isoform 1"
                     /protein_id="NP_003162.2"
                     /db_xref="CCDS:CCDS7287.1"
                     /db_xref="GeneID:6832"
                     /db_xref="HGNC:HGNC:11471"
                     /db_xref="MIM:605122"
                     /translation="MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSV
                     LATASSSASGGSKIPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYK
                     RKEIQKLGADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFP
                     FFLRHAKQIFPVLDCKDDLRKISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAI
                     QKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTV
                     EMCSVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMY
                     TTGEEVEVRDYKRLTPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLES
                     AVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINE
                     KGERELEPITTSQALQIAGRAGRFSSRFKEGEVTTMNHEDLSLLKEILKRPVDPIRAA
                     GLHPTAEQIEMFAYHLPDATLSNLIDIFVDFSQVDGQYFVCNMDDFKFSAELIQHIPL
                     SLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKD
                     LMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHNITKLIKMSET
                     HKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKATEPPSPDAGELSLASRLVQQ
                     GLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKKKEPDSD"
     exon            330..407
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..515
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..630
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            631..799
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            800..911
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..989
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1081
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1262
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1356
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1576
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1657
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1834
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1983
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2477
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /note="hexamer: AATAAA"
     polyA_site      2477
                     /gene="SUPV3L1"
                     /gene_synonym="SUV3"
                     /note="major polyA site"
ORIGIN      
        1 gtcactgtcc gccgccgtgt ccgcggctgc gccagacagt gtagaacctg cggcctcgat
       61 gtccttctcc cgtgccctat tgtgggctcg gctcccggcg gggcgccagg ctggccaccg
      121 ggcagccatc tgctctgccc ttcgtcccca ctttgggccc tttcccgggg ttctggggca
      181 agtttctgtc cttgccaccg cctcctcctc tgcctccggt ggctccaaaa taccaaacac
      241 gtccttgttc gtgcccctga ctgtgaaacc tcagggcccc agcgccgacg gcgacgtcgg
      301 ggccgagcta acccggcctc tggacaagaa tgaagtaaag aaggtcttag acaaatttta
      361 caagaggaaa gaaattcaga aactgggtgc tgattatgga cttgatgctc gtctcttcca
      421 ccaagctttc ataagcttta gaaattatat tatgcagtct cattccctgg atgtggacat
      481 tcacattgtt ttgaatgata tttgcttcgg tgcagctcat gcggatgatt tattcccatt
      541 tttcttgaga catgccaaac aaatatttcc tgtgttggac tgtaaggatg atctacgtaa
      601 aatcagtgac ttaagaatac cacctaactg gtacccagat gctagagcca tgcagcggaa
      661 gataatattt cattcaggcc ccacaaacag tggaaagact tatcacgcaa tccagaaata
      721 cttctcagca aagtctggag tgtattgtgg ccctctaaaa ttactggcac atgagatctt
      781 cgaaaagagt aatgctgctg gtgtgccatg tgacttggtg acaggtgaag agcgtgtgac
      841 agttcagcca aatgggaaac aggcttcaca tgtttcttgt acagttgaga tgtgcagtgt
      901 tacaactcct tatgaagtgg ctgtaattga tgaaattcaa atgattagag atccagccag
      961 aggatgggcc tggaccagag cacttctagg actgtgtgct gaagaggttc atttgtgtgg
     1021 agaacctgct gctattgacc tggtgatgga gcttatgtac acaacggggg aggaagtgga
     1081 ggttcgagac tataagaggc ttacccccat ttctgtgctg gaccatgcac tagaatcttt
     1141 agataacctt cggcctgggg actgcattgt ctgttttagc aagaatgata tttattctgt
     1201 gagtcggcag attgaaattc ggggattaga atcagctgtt atatatggca gtctcccacc
     1261 tgggaccaaa cttgctcaag caaaaaagtt taatgatccc aatgacccat gcaaaatctt
     1321 ggttgctaca gatgcaattg gcatgggact taatttgagc ataaggagaa ttatttttta
     1381 ctcccttata aagcccagta tcaatgaaaa gggagagaga gaactagaac caatcacaac
     1441 ctctcaagcc ctgcagattg ctggcagagc tggcagattc agctcacggt ttaaagaagg
     1501 agaggttaca acaatgaatc atgaagatct cagtttatta aaggaaattt tgaagaggcc
     1561 tgtggatcct ataagggcag ctggtcttca tccaactgct gagcagattg aaatgtttgc
     1621 ctaccatctc cctgatgcaa cactgtccaa tctcattgat atttttgtag acttttcaca
     1681 agttgatggg cagtattttg tctgcaatat ggatgatttt aaattttctg cagagttgat
     1741 ccagcatatt ccactaagtc tgcgagtgag gtatgttttc tgcacagctc ctatcaacaa
     1801 gaagcagcct tttgtgtgtt cttcactgtt acagtttgcc aggcagtata gcaggaatga
     1861 gcccctgacc tttgcatggt tacgccgata catcaaatgg cctttacttc cacctaagaa
     1921 tattaaagac ctcatggatc ttgaagctgt ccacgatgtc ttggatcttt acttgtggct
     1981 aagctaccga tttatggata tgtttccaga tgccagcctt attcgagatc tccagaaaga
     2041 actagatggt attatccaag atggtgtgca caatatcact aaattgatta aaatgtctga
     2101 gacgcataag ctgttgaatt tggagggctt tccatcaggg agccagtcac gattgtcagg
     2161 aaccttaaag agccaagcta gaaggacacg cggcaccaaa gctctaggga gtaaagctac
     2221 tgagccaccc agccccgatg caggagagct gtcccttgct tccagattgg tgcagcaagg
     2281 actcctcact ccagacatgc tgaaacagct agaaaaagag tggatgacac aacaaactga
     2341 acacaacaaa gaaaaaacag agtctgggac tcatccaaaa gggacgagaa gaaagaagaa
     2401 ggaacctgat tcggactagt tttctgttcc tgtttttttt tttttattta attttgcaaa
     2461 taaaaattta ttttgaa
//
