LOCUS       NM_014860               4296 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens SPT7 like, STAGA complex subunit gamma (SUPT7L),
            transcript variant 1, mRNA.
ACCESSION   NM_014860 XM_376044
VERSION     NM_014860.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4296)
  AUTHORS   Hsieh,F.S., Chen,N.T., Yao,Y.L., Wang,S.Y., Chen,J.J., Lai,C.C. and
            Yang,W.M.
  TITLE     The transcriptional repression activity of STAF65gamma is
            facilitated by promoter tethering and nuclear import of class IIa
            histone deacetylases
  JOURNAL   Biochim Biophys Acta 1839 (7), 579-591 (2014)
   PUBMED   24852358
  REMARK    GeneRIF: Our findings reveal a distinct role of STAF65gamma in
            nuclear import, transcriptional repression, and cell cycle
            regulation at high levels of expression, which is associated with
            poor clinical outcomes of lung adenocarcinoma.
REFERENCE   2  (bases 1 to 4296)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   3  (bases 1 to 4296)
  AUTHORS   Gamper,A.M. and Roeder,R.G.
  TITLE     Multivalent binding of p53 to the STAGA complex mediates
            coactivator recruitment after UV damage
  JOURNAL   Mol Cell Biol 28 (8), 2517-2527 (2008)
   PUBMED   18250150
  REMARK    GeneRIF: optimal binding of STAGA to p53 involves interactions of
            STAGA subunits TAF9, GCN5, and ADA2b, respectively
REFERENCE   4  (bases 1 to 4296)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   5  (bases 1 to 4296)
  AUTHORS   Soutoglou,E., Demeny,M.A., Scheer,E., Fienga,G., Sassone-Corsi,P.
            and Tora,L.
  TITLE     The nuclear import of TAF10 is regulated by one of its three
            histone fold domain-containing interaction partners
  JOURNAL   Mol Cell Biol 25 (10), 4092-4104 (2005)
   PUBMED   15870280
REFERENCE   6  (bases 1 to 4296)
  AUTHORS   Wang,H.Y., Peng,G., Guo,Z., Shevach,E.M. and Wang,R.F.
  TITLE     Recognition of a new ARTC1 peptide ligand uniquely expressed in
            tumor cells by antigen-specific CD4+ regulatory T cells
  JOURNAL   J Immunol 174 (5), 2661-2670 (2005)
   PUBMED   15728473
  REMARK    GeneRIF: A novel peptide ligand recognized by tumor-specific CD4+ T
            regulatory (Treg) cells is a dominant peptide derived from the
            mutated ARTC1 gene. ARTC1 peptide-activated CD4+ Treg cells
            suppress proliferation and IL-2 secretion of melanoma-reactive T
            cells.
REFERENCE   7  (bases 1 to 4296)
  AUTHORS   Gocke,C.B., Yu,H. and Kang,J.
  TITLE     Systematic identification and analysis of mammalian small
            ubiquitin-like modifier substrates
  JOURNAL   J Biol Chem 280 (6), 5004-5012 (2005)
   PUBMED   15561718
REFERENCE   8  (bases 1 to 4296)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   9  (bases 1 to 4296)
  AUTHORS   Nishizaka,S., Gomi,S., Harada,K., Oizumi,K., Itoh,K. and
            Shichijo,S.
  TITLE     A new tumor-rejection antigen recognized by cytotoxic T lymphocytes
            infiltrating into a lung adenocarcinoma
  JOURNAL   Cancer Res 60 (17), 4830-4837 (2000)
   PUBMED   10987294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA398215.1, AF197954.1, AB018307.1, AC074091.6 and CF528942.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014860.2.
            
            Summary: SUPT7L is a protein subunit of the human STAGA complex
            (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301)
            acetyltransferase complex), which is a chromatin-modifying
            multiprotein complex (Martinez et al., 2001 [PubMed
            11564863]).[supplied by OMIM, Apr 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Both variants 1 and 2 encode isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.126955.1,
                                           SRR1803611.237525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337768.10/ ENSP00000336750.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA398215.1         229-241
            14-2034             AF197954.1         1-2021
            2035-2929           AB018307.1         2003-2897
            2930-2930           AC074091.6         128058-128058
            2931-3893           AB018307.1         2899-3861
            3894-4296           CF528942.1         16-418              c
FEATURES             Location/Qualifiers
     source          1..4296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..4296
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /note="SPT7 like, STAGA complex subunit gamma"
                     /db_xref="GeneID:9913"
                     /db_xref="HGNC:HGNC:30632"
                     /db_xref="MIM:612762"
     exon            1..286
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /inference="alignment:Splign:2.1.0"
     exon            287..389
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1620
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /note="isoform a is encoded by transcript variant 1;
                     SPTF-associated factor 65 gamma; adenocarcinoma antigen
                     ART1; STAGA complex 65 gamma subunit; STAGA complex 65
                     subunit gamma; STAF65gamma; suppressor of Ty 7-like; SPT7
                     like, STAGA complex gamma subunit"
                     /codon_start=1
                     /product="STAGA complex 65 subunit gamma isoform a"
                     /protein_id="NP_055675.1"
                     /db_xref="CCDS:CCDS42667.1"
                     /db_xref="GeneID:9913"
                     /db_xref="HGNC:HGNC:30632"
                     /db_xref="MIM:612762"
                     /translation="MNLQRYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSA
                     NKPKPPTMLDIPSEPCSLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPL
                     PSCPGSPPLPDDLLPLDCKNPNAPFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQ
                     AVATILAHAGFDCANESVLETLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQ
                     VFHEVGIGSVLSLQKFWQHRIKDYHSYMLQISKQLSEEYERIVNPEKATEDAKPVKIK
                     EEPVSDITFPVSEELEADLASGDQSLPMGVLGAQSERFPSNLEVEASPQASSAEVNAS
                     PLWNLAHVKMEPQESEEGNVSGHGVLGSDVFEEPMSGMSEAGIPQSPDDSDSSYGSHS
                     TDSLMGSSPVFNQRCKKRMRKI"
     exon            390..794
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1119
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1357
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..4296
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2024..2029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /note="hexamer: AATATA"
     polyA_site      2035
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /note="major polyA site"
     regulatory      2823..2828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /note="hexamer: AATGAA"
     polyA_site      2842
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
     regulatory      4264..4269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
                     /note="hexamer: ATTAAA"
     polyA_site      4296
                     /gene="SUPT7L"
                     /gene_synonym="FZPS; SPT7L; STAF65; STAF65(gamma);
                     STAF65G; SUPT7H"
ORIGIN      
        1 agatcactaa tcaacaaacc agctttcggg gtctgacgcg atccttgcct caggcctctc
       61 gaggtccaga cagccgccca gcccgctctg cgacgcagca gtgaatagtg tggtacctcc
      121 ttgtctcggt tcaggtccag acctccccgt cttccggctg ccctgaacgt caggcgacct
      181 caggaccctg tgattggcgc ctgcgccggc ggaccgtgac cgaggaaacc cctggaggga
      241 cttgggcatt ccttgggctc cgtgcctgtt cttcgtgctc ctttcgggca aggatctcac
      301 attatcagtc tttgaccgac acagaatgcc tggcatttga taaatgtttg ttgaacttga
      361 agagacatat ggacaatgaa tctgcaaaga tactggggag agataccaat atcatcaagc
      421 cagaccaaca gaagttcctt cgatttgctc ccacgggagt tccgtctggt ggaagtccat
      481 gacccacccc tgcaccaacc ctcagccaac aagccgaagc cccccactat gctggacatc
      541 ccctcagagc catgtagtct caccatccat acgattcagt tgattcagca caaccgacgt
      601 cttcgcaacc ttattgccac agctcaggcc cagaatcagc agcagacaga aggtgtaaaa
      661 actgaagaga gtgaacctct tccctcgtgc cctgggtcac ctcctctccc tgatgacctc
      721 ctgcctttag attgtaagaa tcccaatgca ccattccaga tccggcacag tgacccagag
      781 agtgactttt atcgtgggaa aggggaacct gtgactgaac tcagctggca ctcctgtcgg
      841 cagctcctct accaggcagt ggccacaatc ctggcccacg cgggctttga ctgtgctaat
      901 gagagtgtcc tggagaccct aactgatgtg gcacatgagt attgccttaa gtttaccaag
      961 ttgctgcgtt ttgctgtgga ccgggaggcc cggctgggac agactccttt tcctgatgtg
     1021 atggagcagg tattccatga agtgggtatt ggcagtgtgc tctccctcca gaagttctgg
     1081 cagcaccgca tcaaggacta tcacagttac atgctacaga ttagtaagca actctctgaa
     1141 gaatatgaaa ggattgtcaa tcctgagaag gccacagagg acgctaaacc tgtgaagatc
     1201 aaggaggaac ctgtgagcga catcactttt cctgtcagtg aggagctgga ggctgacctt
     1261 gcttctggag accagtcact gcctatggga gtgcttgggg ctcagagcga acgcttccca
     1321 tctaacctgg aggttgaagc ttcaccacag gcttcaagtg cagaggtaaa tgcttctcct
     1381 ctttggaatc tggcccatgt gaaaatggag cctcaagaaa gtgaagaagg caatgtctct
     1441 gggcatggtg tgctgggcag tgatgtcttc gaggagccta tgtcaggcat gagtgaagct
     1501 gggattcctc agagccctga tgactcagat agcagctatg gttcccactc cactgacagc
     1561 ctcatggggt cctcccctgt tttcaaccag cgctgcaaga agaggatgag gaaaatataa
     1621 aaggaaaaga gggagatgtt ttgtccagac ctactagacc caacagaaaa ggtttttgta
     1681 ttagaatctg tttccttaaa aattgatttg actcctgttc ttaaacacaa gtggtttttc
     1741 ctaattccag aggaactgga cgtcaccaaa caaggttgca ttttactttt gcatccagtt
     1801 tttatagttt tccacaacca agccaccctt cacagataaa atatgatgct ggcatggcaa
     1861 tcagaccaaa gcactgtccc caattgttgt cttaactatg actagacatg ttatacagcc
     1921 atttatcttg tacaactgag aagaatcata ctttgaccta ccttgtagag atgtgaggat
     1981 ttagatgttt gctaacttca aaactgtgct tgaatagact aataatatat gctcatatca
     2041 gatgtcagtt ttcatttaac ttgattcatt tttggctcag gtcattggga acccattact
     2101 aatacctaac aggaaatagc taaacacaac acaccttatc tattagtcac cttcttaaaa
     2161 ctgtttttgc tacttttgaa gtgtcttatt tataagatca gaggtctgac accttttttg
     2221 cttagacagc tctctatctc atccatttat tttcttctct agacttactc catctctcct
     2281 catccttttg cctttgttat ttctgctcgg actcacatac tttcaccata tacatatttt
     2341 caattgtttc tttccttttc tcctttgtga gcaaagcaaa caagtactgt ccaaggacag
     2401 ccttgtgcat atttcatttg ttgcatttgc ttggtcatca gaggacagca gtccattaag
     2461 cacactttgc tgcttctact gtaaaggcag cctttaaaac atagcaatat gcacctttca
     2521 actttacatc atgtcctgaa caacatcact gtggttactc atccatcaga ctatctgtat
     2581 atataagtac tgaatcagta tttattaagt aaatgatgta gcactgtagt gattaggaat
     2641 cattagcaaa tgtgttgctt catgccttgg tgatggatgc cagcatgtta aactgctgaa
     2701 gtttgatttt ctgatgcaaa atatatcttg taaaatttag accactcctt taatgcagac
     2761 caaaataagg cacagcttta attcattatt gaatgcctta aatgtcccag gtattgagaa
     2821 taaatgaata tgatacaaat gaggttatag tttaacatat aattttaaat ttgccaattg
     2881 taactcttta gcacatttct ctaaaccctt tctgtcacag tctttttttt aatttattta
     2941 tttatttatt tatttttgag atggagtctt gctctgtcac ccaggctgga gtgcaatggt
     3001 gcaatttcga ctcactgcaa cctctgcctc ccaggttcaa gcgattctcc tgcctcagcc
     3061 acctgagtag ctgggattac acgcacatgc caccacaccc agctaatttt tgcattttta
     3121 gtagagatga ggtttcaccg tgttggccag gctggtctca aaactcctga cctcaagtga
     3181 tctgcccgcc tcgggctccc aaagtgctgg gattacaggc gtgagccact gcacctggcc
     3241 tctgttgcag tcttatcttc attttccttt gtttataatg aaagtggcga ttaggcagtt
     3301 agtttccata aagtggccgt atgggaattt agttcattca tccagcaaac attgagtacc
     3361 aattatttgc taggtcctgt gcaaggaata caaaaatgat taagacttct tccttaccct
     3421 tttggagctt gaagcataag gaagacaagt tattctgtaa ggaagataaa gcattcaaaa
     3481 gtactacaga gaaaaaccaa gtatgcttga gttttgcgaa tgttctcctc ttaaagaata
     3541 gcttcaaatt ttgagaccag tggttcccac taagtataga acattaaaat taatacttta
     3601 taataaaaca cttttattgc tgcagaatgt taaactgcat aacaggcacc agatggtcaa
     3661 gacgagggaa atatgagaag gcaaatgatg tgaggattag tatcttgaga ttcacctggt
     3721 ctggaattat gtcataggct actatgcatc agaatcacat ggagggcttt ctaaaacaga
     3781 ctgctcagcc cacccccagg gtttctgagt tcataggtta taagaggtaa gttgaacaat
     3841 tccccagatg atgctgatgc tcctggtcca caatgtgaga accactaagt tggagtactg
     3901 actcatagag ataaaattct ttgaaagaaa tgtactgttt taagatactg taaaatgtgg
     3961 aggcagggca aacgtttata agggctgtta tgtatgaaat gtgcctctga cccaaatcca
     4021 cggactttgc gaaaatcacc aaggagactt tgcattaagt tcagagtaca atacaaactg
     4081 ggcctagctc tgtatttagt cagtatgtgc acgtgggaaa ctttagtaaa atatcacctc
     4141 cttattgaga caagtttgga catctggcct taagcctctg ttgaacagga gaagtgaagc
     4201 tgtttgcaat tatataattt tctaatttga aatcatgaca agcagtctta gaacaaagtt
     4261 aaaattaaaa agtctttatc caagtcacca atgaaa
//
