LOCUS       NM_003170               6404 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens SPT6 homolog, histone chaperone and transcription
            elongation factor (SUPT6H), transcript variant 2, mRNA.
ACCESSION   NM_003170 XM_377464
VERSION     NM_003170.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6404)
  AUTHORS   Miller,C.L.W., Warner,J.L. and Winston,F.
  TITLE     Insights into Spt6: a histone chaperone that functions in
            transcription, DNA replication, and genome stability
  JOURNAL   Trends Genet 39 (11), 858-872 (2023)
   PUBMED   37481442
  REMARK    GeneRIF: Insights into Spt6: a histone chaperone that functions in
            transcription, DNA replication, and genome stability.
            Review article
REFERENCE   2  (bases 1 to 6404)
  AUTHORS   Wang,J., Yang,C., Cao,H., Yang,J., Meng,W., Yu,M., Yu,L. and
            Wang,B.
  TITLE     Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation
            Facilitates Malignant Progression of Laryngeal Squamous Cell
            Carcinoma via Interacting With SPT6
  JOURNAL   Cell Transplant 32, 9636897231154574 (2023)
   PUBMED   36852700
  REMARK    GeneRIF: Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation
            Facilitates Malignant Progression of Laryngeal Squamous Cell
            Carcinoma via Interacting With SPT6.
REFERENCE   3  (bases 1 to 6404)
  AUTHORS   Narain,A., Bhandare,P., Adhikari,B., Backes,S., Eilers,M.,
            Dolken,L., Schlosser,A., Erhard,F., Baluapuri,A. and Wolf,E.
  TITLE     Targeted protein degradation reveals a direct role of SPT6 in
            RNAPII elongation and termination
  JOURNAL   Mol Cell 81 (15), 3110-3127 (2021)
   PUBMED   34233157
  REMARK    GeneRIF: Targeted protein degradation reveals a direct role of SPT6
            in RNAPII elongation and termination.
REFERENCE   4  (bases 1 to 6404)
  AUTHORS   Zumer,K., Maier,K.C., Farnung,L., Jaeger,M.G., Rus,P., Winter,G.
            and Cramer,P.
  TITLE     Two distinct mechanisms of RNA polymerase II elongation stimulation
            in vivo
  JOURNAL   Mol Cell 81 (15), 3096-3109 (2021)
   PUBMED   34146481
  REMARK    GeneRIF: Two distinct mechanisms of RNA polymerase II elongation
            stimulation in vivo.
REFERENCE   5  (bases 1 to 6404)
  AUTHORS   Li,J., Xu,X., Tiwari,M., Chen,Y., Fuller,M., Bansal,V., Tamayo,P.,
            Das,S., Ghosh,P. and Sen,G.L.
  TITLE     SPT6 promotes epidermal differentiation and blockade of an
            intestinal-like phenotype through control of transcriptional
            elongation
  JOURNAL   Nat Commun 12 (1), 784 (2021)
   PUBMED   33542242
  REMARK    GeneRIF: SPT6 promotes epidermal differentiation and blockade of an
            intestinal-like phenotype through control of transcriptional
            elongation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6404)
  AUTHORS   Endoh,M., Zhu,W., Hasegawa,J., Watanabe,H., Kim,D.K., Aida,M.,
            Inukai,N., Narita,T., Yamada,T., Furuya,A., Sato,H., Yamaguchi,Y.,
            Mandal,S.S., Reinberg,D., Wada,T. and Handa,H.
  TITLE     Human Spt6 stimulates transcription elongation by RNA polymerase II
            in vitro
  JOURNAL   Mol Cell Biol 24 (8), 3324-3336 (2004)
   PUBMED   15060154
  REMARK    GeneRIF: Reults establish that human Spt6 (hSpt6) is a classic
            transcription elongation factor that enhances the rate of RNA
            polymerase II elongation.
REFERENCE   7  (bases 1 to 6404)
  AUTHORS   Winkler,M., aus Dem Siepen,T. and Stamminger,T.
  TITLE     Functional interaction between pleiotropic transactivator pUL69 of
            human cytomegalovirus and the human homolog of yeast chromatin
            regulatory protein SPT6
  JOURNAL   J Virol 74 (17), 8053-8064 (2000)
   PUBMED   10933715
REFERENCE   8  (bases 1 to 6404)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     Role of the human homolog of the yeast transcription factor SPT5 in
            HIV-1 Tat-activation
  JOURNAL   J Mol Biol 277 (2), 179-197 (1998)
   PUBMED   9514752
REFERENCE   9  (bases 1 to 6404)
  AUTHORS   Chiang,P.W., Stubbs,L., Zhang,L. and Kurnit,D.M.
  TITLE     Isolation of murine SPT5 homologue: completion of the isolation and
            characterization of human and murine homologues of yeast chromatin
            structural protein complex SPT4, SPT5, and SPT6
  JOURNAL   Genomics 47 (3), 426-428 (1998)
   PUBMED   9480761
REFERENCE   10 (bases 1 to 6404)
  AUTHORS   Chiang,P.W., Wang,S., Smithivas,P., Song,W.J., Ramamoorthy,S.,
            Hillman,J., Puett,S., Van Keuren,M.L., Crombez,E., Kumar,A.,
            Glover,T.W., Miller,D.E., Tsai,C.H., Blackburn,C.C., Chen,X.N.,
            Sun,Z., Cheng,J.F., Korenberg,J.R. and Kurnit,D.M.
  TITLE     Identification and analysis of the human and murine putative
            chromatin structure regulator SUPT6H and Supt6h
  JOURNAL   Genomics 34 (3), 328-333 (1996)
   PUBMED   8786132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833607.1, BC150268.1, BM727811.1 and AW135492.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003170.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.228668.1,
                                           SRR1803612.146735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314616.11/ ENSP00000319104.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AL833607.1         9-87
            80-5956             BC150268.1         1-5877
            5957-6328           BM727811.1         53-424
            6329-6404           AW135492.1         22-97               c
FEATURES             Location/Qualifiers
     source          1..6404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..6404
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /note="SPT6 homolog, histone chaperone and transcription
                     elongation factor"
                     /db_xref="GeneID:6830"
                     /db_xref="HGNC:HGNC:11470"
                     /db_xref="MIM:601333"
     exon            1..138
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            139..278
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..5350
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /note="tat-CT2 protein; tat-cotransactivator 2 protein;
                     histone chaperone suppressor of Ty6; suppressor of Ty 6
                     homolog"
                     /codon_start=1
                     /product="transcription elongation factor SPT6"
                     /protein_id="NP_003161.2"
                     /db_xref="CCDS:CCDS32596.1"
                     /db_xref="GeneID:6830"
                     /db_xref="HGNC:HGNC:11470"
                     /db_xref="MIM:601333"
                     /translation="MSDFVESEAEESEEEYNDEGEVVPRVTKKFVEEEDDDEEEEEEN
                     LDDQDEQGNLKGFINDDDDEDEGEEDEGSDSGDSEDDVGHKKRKRTSFDDRLEDDDFD
                     LIEENLGVKVKRGQKYRRVKKMSDDEDDDEEEYGKEEHEKEAIAEEIFQDGEGEEGQE
                     AMEAPMAPPEEEEEDDEESDIDDFIVDDDGQPLKKPKWRKKLPGYTDAALQEAQEIFG
                     VDFDYDEFEKYNEYDEELEEEYEYEDDEAEGEIRVRPKKTTKKRVSRRSIFEMYEPSE
                     LESSHLTDQDNEIRATDLPERFQLRSIPVKGAEDDELEEEADWIYRNAFATPTISLQE
                     SCDYLDRGQPASSFSRKGPSTIQKIKEALGFMRNQHFEVPFIAFYRKEYVEPELHIND
                     LWRVWQWDEKWTQLRIRKENLTRLFEKMQAYQYEQISADPDKPLADGIRALDTTDMER
                     LKDVQSMDELKDVYNHFLLYYGRDIPKMQNAAKASRKKLKRVREEGDEEGEGDEAEDE
                     EQRGPELKQASRRDMYTICQSAGLDGLAKKFGLTPEQFGENLRDSYQRHETEQFPAEP
                     LELAKDYVCSQFPTPEAVLEGARYMVALQIAREPLVRQVLRQTFQERAKLNITPTKKG
                     RKDVDEAHYAYSFKYLKNKPVKELRDDQFLKICLAEDEGLLTTDISIDLKGVEGYGND
                     QTYFEEIKQFYYRDEFSHQVQEWNRQRTMAIERALQQFLYVQMAKELKNKLLAEAKEY
                     VIKACSRKLYNWLRVAPYRPDQQVEEDDDFMDENQGKGIRVLGIAFSSARDHPVFCAL
                     VNGEGEVTDFLRLPHFTKRRTAWREEEREKKAQDIETLKKFLLNKKPHVVTVAGENRD
                     AQMLIEDVKRIVHELDQGQQLSSIGVELVDNELAILYMNSKKSEAEFRDYPPVLRQAV
                     SLARRIQDPLIEFAQVCSSDEDILCLKFHPLQEHVVKEELLNALYCEFINRVNEVGVD
                     VNRAIAHPYSQALIQYVCGLGPRKGTHLLKILKQNNTRLESRTQLVTMCHMGPKVFMN
                     CAGFLKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDALEYDESAEDANPAGA
                     LEEILENPERLKDLDLDAFAEELERQGYGDKHITLYDIRAELSCRYKDLRTAYRSPNT
                     EEIFNMLTKETPETFYIGKLIICNVTGIAHRRPQGESYDQAIRNDETGLWQCPFCQQD
                     NFPELSEVWNHFDSGSCPGQAIGVKTRLDNGVTGFIPTKFLSDKVVKRPEERVKVGMT
                     VHCRIMKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDAEAADHKQEEDMKRKQ
                     QRTTYIKRVIAHPSFHNINFKQAEKMMETMDQGDVIIRPSSKGENHLTVTWKVSDGIY
                     QHVDVREEGKENAFSLGATLWINSEEFEDLDEIVARYVQPMASFARDLLNHKYYQDCS
                     GGDRKKLEELLIKTKKEKPTFIPYFICACKELPGKFLLGYQPRGKPRIEYVTVTPEGF
                     RYRGQIFPTVNGLFRWFKDHYQDPVPGITPSSSSRTRTPASINATPANINLADLTRAV
                     NALPQNMTSQMFSAIAAVTGQGQNPNATPAQWASSQYGYGGSGGGSSAYHVFPTPAQQ
                     PVATPLMTPSYSYTTPSQPITTPQYHQLQASTTPQSAQAQPQPSSSSRQRQQQPKSNS
                     HAAIDWGKMAEQWLQEKEAERRKQKQRLTPRPSPSPMIESTPMSIAGDATPLLDEMDR
                     "
     exon            279..437
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            438..514
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            515..707
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            708..792
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1066
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1168
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1285
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1375
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1518
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1667
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1766
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1896
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2047
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2202
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2398
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2538
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2656
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2733
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2869
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3007
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3175
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3303
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3511
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3659
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3802
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3943
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4139
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4378
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4492
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4493..4617
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4730
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4731..4808
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..4975
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            4976..5163
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     exon            5164..6404
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5936..5941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /note="hexamer: AATAAA"
     polyA_site      5956
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /note="major polyA site"
     regulatory      6385..6390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
                     /note="hexamer: AGTAAA"
     polyA_site      6404
                     /gene="SUPT6H"
                     /gene_synonym="emb-5; SPT6; SPT6H"
ORIGIN      
        1 gttgacgcag cagcggcggc ggtggcggcg gaggggccgt gcggtgggtc cgtactatct
       61 tttcccagtc tcggttcgac gactccattt tcctcggtgg gggcttagcg cactggagga
      121 gcggcgggct tcagacagtt atcttcaggc agagtgagaa gctgcagcaa tgtctgattt
      181 tgtggaaagc gaggctgagg agtcagagga agaatacaat gatgaaggcg aggtggtacc
      241 ccgagtcacc aagaaatttg tggaagagga ggatgatgat gaggaggagg aggaggagaa
      301 cctagatgat caggatgagc aaggcaactt gaaaggcttt atcaatgacg atgatgatga
      361 agatgaaggg gaggaggatg agggcagtga ctctggtgat tcagaagatg atgttggcca
      421 caagaagaga aaacgcacct cttttgatga ccgcctggag gatgatgatt ttgacctcat
      481 tgaggagaat ttgggtgtca aagtcaaaag aggacaaaag taccggcgtg tcaaaaaaat
      541 gtcagatgac gaggacgatg acgaggagga atatggcaag gaggaacatg aaaaagaagc
      601 tattgcggaa gaaatcttcc aggatgggga aggggaagaa gggcaggagg ccatggaggc
      661 ccccatggct cctccagagg aggaggaaga agatgatgag gagtcagata ttgacgactt
      721 cattgtggat gatgatggac agcctctgaa aaaacctaag tggcggaaaa agcttcctgg
      781 atacacagac gcggccctgc aagaagccca ggaaatcttc ggtgtggact ttgactatga
      841 tgaatttgag aaatacaatg agtatgatga agaactggag gaagagtatg agtatgagga
      901 tgatgaggct gagggtgaaa tccgagtgcg ccccaagaag accaccaaga agcgtgtgag
      961 ccgtaggagc atctttgaaa tgtatgagcc cagtgagcta gaaagcagcc acctcacaga
     1021 tcaggacaat gaaatccgag ccactgacct gcctgagagg ttccagctcc gctccatccc
     1081 agtcaagggg gctgaagatg atgaactaga agaagaagct gactggatct acaggaatgc
     1141 ttttgccaca ccaaccattt ctctccagga aagctgtgat tacctagacc gagggcagcc
     1201 agccagcagc ttcagtcgga aagggcccag cacaattcag aagatcaaag aggccctggg
     1261 cttcatgcga aatcagcatt ttgaggtgcc ttttattgcc ttctatcgaa aggagtatgt
     1321 ggagcctgag ttgcacatca atgacctatg gagagtctgg cagtgggatg aaaagtggac
     1381 ccagctgcgg atccgtaaag agaacctaac acggctgttt gagaagatgc aggcttatca
     1441 gtatgaacag atctctgctg accctgacaa acctcttgct gatggcatcc gggctctgga
     1501 caccactgac atggagaggc tcaaggatgt ccaatcaatg gatgagctga aagatgtcta
     1561 caaccatttt cttctttatt atggccgaga catccctaag atgcagaacg ccgccaaagc
     1621 tagccgcaag aagctgaagc gtgtcaggga agagggagat gaagaaggtg aaggtgacga
     1681 ggcagaagat gaggagcaga gggggcctga gctcaagcaa gcctctcgcc gagacatgta
     1741 caccatctgc cagagtgctg ggctagatgg cctggccaaa aagtttgggc ttactcccga
     1801 gcagtttggg gagaacctgc gggatagcta ccagcggcac gagacagagc agtttcccgc
     1861 ggagcccttg gagctggcca aggattacgt ttgcagccag ttccctactc cagaagctgt
     1921 gctagaaggc gcccgctaca tggtagccct gcagattgcc cgtgagcccc ttgtccggca
     1981 ggtgctgagg caaaccttcc aagagagagc caagttaaat ataaccccca ccaagaaagg
     2041 tagaaaggat gtggatgagg cccactatgc ctattccttc aagtatttaa agaacaagcc
     2101 tgttaaggaa ctgagagatg accagtttct caagatatgc ctggctgaag acgaagggct
     2161 cctcaccact gacatcagca tagatttgaa gggagtggaa ggctatggca acgaccagac
     2221 atattttgag gagataaaac agttttacta ccgagatgag ttcagccacc aggtgcagga
     2281 gtggaaccgg cagcgcacca tggccatcga acgggcttta cagcagttcc tctatgtgca
     2341 gatggccaaa gaactcaaga acaagctgct ggctgaagcc aaggaatatg tcataaaggc
     2401 ctgtagtcga aagctctaca attggttgag agtggcaccc taccgaccag atcagcaggt
     2461 ggaagaagat gacgacttta tggacgagaa ccaagggaag ggcattcgag tcctcggcat
     2521 tgctttctcc tctgccagag atcaccctgt gttctgcgcc ctggtcaatg gtgaaggaga
     2581 agtgacagac ttccttcgac tgccccattt taccaaacgg cgaactgcat ggagagagga
     2641 agagcgggaa aagaaggctc aagacattga aacgctaaag aaatttctcc tgaataagaa
     2701 gcctcatgta gtgacagttg caggagagaa cagggacgcc cagatgttga ttgaagatgt
     2761 gaagcgcatt gtacatgagc tggaccaggg ccagcagctg tcatctattg gggtagagct
     2821 ggttgacaac gagttggcca ttctctatat gaacagcaag aagtcagagg cagagttccg
     2881 ggattatcct ccagtgctga gacaggccgt ctccctggcc cggcgcatcc aggaccctct
     2941 gattgaattt gcccaggtgt gcagttccga tgaagacatc ctgtgtctca agtttcaccc
     3001 cttgcaggag catgtggtga aagaggagct gctcaacgcc ttgtactgtg aatttatcaa
     3061 ccgagtcaat gaggtcgggg tcgatgtcaa ccgtgccatt gcccaccctt acagccaggc
     3121 cttgatccag tatgtttgtg gcctgggacc tcggaaaggg acccacctcc tgaagatcct
     3181 gaagcagaac aacacccggc tcgagagccg gacccagctg gtcaccatgt gccacatggg
     3241 tcccaaagtc ttcatgaatt gtgctggctt cctcaagatc gacacggcct ccctggggga
     3301 cagcactgac tcatatattg aagtccttga tggttcccgt gtccaccctg agacttatga
     3361 gtgggctagg aagatggcag tggatgccct ggaatacgat gaatcagccg aggatgccaa
     3421 tcctgcagga gcccttgaag aaatcttgga aaacccagag cgactgaaag acctggacct
     3481 tgatgccttt gcagaagagc tggagaggca gggctatggt gacaaacaca tcacactcta
     3541 tgacatccgg gcagagctga gctgtcgata taaggacctc cggacagcct accgctctcc
     3601 caacacagag gagatcttca atatgttaac caaagaaaca ccagagacct tctacattgg
     3661 aaagctcatc atctgcaatg tcactggcat tgcccacagg cgtccccagg gtgagagcta
     3721 tgaccaggcg atccgcaatg atgagacagg gctgtggcag tgccccttct gtcagcagga
     3781 caatttccct gaactaagcg aggtgtggaa ccactttgac agcggttcgt gcccaggcca
     3841 ggccatcggt gtcaaaacac ggctagacaa tggtgtcacc ggcttcatcc ccaccaaatt
     3901 cctcagtgac aaagtggtaa agcggccaga agaacgagtg aaggtgggaa tgactgttca
     3961 ctgccgcatc atgaagattg acattgagaa gttcagtgca gacctgacct gccgcacctc
     4021 agacctcatg gacaggaaca atgagtggaa gctgcccaaa gacacctact atgactttga
     4081 tgctgaagct gcagaccaca agcaggagga ggacatgaag cggaagcagc agcggaccac
     4141 atacatcaag agagtgatcg cacacccatc cttccataat atcaatttca agcaagcaga
     4201 aaagatgatg gagaccatgg accagggtga tgtgattatc cgaccaagca gcaagggcga
     4261 gaaccacctg acagtgacct ggaaagtcag tgatggcatc taccagcatg tggatgtgcg
     4321 ggaggagggc aaggaaaatg ccttcagcct gggagccact ctgtggatca acagtgagga
     4381 attcgaagat ttggatgaga ttgttgctcg ctatgtccag cccatggcat cctttgcccg
     4441 ggaccttctg aatcacaagt attatcagga ctgcagcggt ggggaccgca agaaattaga
     4501 ggagctgctc atcaaaacta agaaggagaa gcccaccttc atcccttatt tcatctgtgc
     4561 ctgcaaggaa ctgcccggca agttcctact gggataccag ccccggggta aacccaggat
     4621 agaatatgta acggtgactc cagagggatt ccggtaccgg ggccagatct tcccaaccgt
     4681 gaatggactg tttagatggt ttaaggatca ctaccaggat cctgtaccag gcatcacccc
     4741 tagcagcagc agcaggaccc ggacacctgc ctctatcaat gctaccccag ccaacatcaa
     4801 ccttgcagat ctgacacggg ctgtgaatgc cctgcctcag aacatgactt cacagatgtt
     4861 cagtgccatt gctgcggtga caggccaagg acagaaccct aatgccaccc cagcccagtg
     4921 ggcctccagc cagtacggct atggcggcag tggaggcggc agcagtgctt accacgtatt
     4981 cccaacgcca gcccagcagc cagtggccac accactaatg acccctagct actcctacac
     5041 gaccccaagc cagcccatca ccacccctca gtaccaccag ctccaggcca gcaccacccc
     5101 acagtcggcc caggcccagc cccagccctc ttccagctcc cggcaacggc agcagcagcc
     5161 aaagtccaac agccatgcag ccatcgactg gggaaaaatg gcggagcagt ggctgcagga
     5221 aaaggaggca gaacggcgga aacagaagca gcggctgaca cctcggccct cccccagccc
     5281 catgatcgaa agcaccccca tgtccattgc tggcgatgcc accccactcc tggacgagat
     5341 ggatcggtag ggggcctgct cctcggactc tggttacctc tgaggctggg aaaggcctgg
     5401 ctgcccactg cctccctccc tgcccctcct tttatgtcca taaagtggcg tgaagtgaga
     5461 cgttctcttt ggtggtcaac ccggatgggt gacaggctgg atggccttgt gaacttgagc
     5521 tcagtgtatg ctaggcaaca attctcccgc tccagaccct caccgaccac ctgtcctggg
     5581 accaggctgg gaggggagtg tggcagggag gaggaagagg aaggtgagaa tgagtagaac
     5641 agttttgtat tctactccct acaagccatt ttgaacttct gccctcaccg gactctgggc
     5701 tgtgactggg gcaccaaact cagcacatga gtctccccta gctctcgtgg ggagagggat
     5761 gctatttatt cagtttgggg caggagggag aggagggaaa gtatttctga ccctgatgcc
     5821 aacagccggg tggctgtcca agcaggattg caggggacac agggaagcac tgcccagccc
     5881 ctgcctggct gccctttccc ccctgctgct gccaccgctt cctgcctgtc atttgaataa
     5941 acagtgtttc tattgagctc ttgccaaagc ctctctctcc aactctccag ctctttgagg
     6001 ggtggctttc aaagcagtgt ttggagctcc aaggactccc ctgactccct cttctgatcc
     6061 atcagaggca aagattcata gactagaggc agcttctaca tcagactgcc tggggcacat
     6121 ccctgctcta cttcccagcc gggtgaccct gtgccagttc ctgctgcctt tcagctggct
     6181 ttcttacctg taacatggag atagtgatac ctgcctcatc agctgctgtg aggaccaagg
     6241 cagcgtgtgc aagctccttg gcccaacgcc tggtacgtcg caaatgttac ccggtattat
     6301 tacacccact cactcaccca cagcacagct gccccatccg cccatgcctg ctggtcttct
     6361 ctggcaccct ggagaaaggc cacaagtaaa tctggatttc tcaa
//
