LOCUS       NM_001111020            3678 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SPT5 homolog, DSIF elongation factor subunit (SUPT5H),
            transcript variant 2, mRNA.
ACCESSION   NM_001111020
VERSION     NM_001111020.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3678)
  AUTHORS   Harteveld,C.L., Achour,A., Fairuz Mohd Hasan,N.F., Legebeke,J.,
            Arkesteijn,S.J.G., Huurne,J.T., Verschuren,M.,
            Bhagwandien-Bisoen,S., Schaap,R., Vijfhuizen,L., Idrissi,H.E.,
            Babbs,C., Higgs,D.R., Koopmann,T.T., Vrettou,C.,
            Traeger-Synodinos,J. and Baas,F.
  CONSRTM   International Hemoglobinopathy Research Network (INHERENT)
  TITLE     Loss-of-Function Variants in SUPT5H as Modifying Factors in
            Beta-Thalassemia
  JOURNAL   Int J Mol Sci 25 (16), 8928 (2024)
   PUBMED   39201615
  REMARK    GeneRIF: Loss-of-Function Variants in SUPT5H as Modifying Factors
            in Beta-Thalassemia.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3678)
  AUTHORS   Du,X., Qin,W., Yang,C., Dai,L., San,M., Xia,Y., Zhou,S., Wang,M.,
            Wu,S., Zhang,S., Zhou,H., Li,F., He,F., Tang,J., Chen,J.Y., Zhou,Y.
            and Xiao,R.
  TITLE     RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and
            termination by coordinating 7SK-P-TEFb complex and SPT5
  JOURNAL   Genome Biol 25 (1), 102 (2024)
   PUBMED   38641822
  REMARK    GeneRIF: RBM22 regulates RNA polymerase II 5' pausing, elongation
            rate, and termination by coordinating 7SK-P-TEFb complex and SPT5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3678)
  AUTHORS   Lou,J., Ye,Y., Sun,M., Zhao,Y., Fu,Y. and Liu,Y.
  TITLE     A stepwise haematological screening and whole-exome sequencing
            reveal multiple mutations from SUPT5H causing an elevation of Hb A2
            from a cohort of 47336 individuals
  JOURNAL   Int J Lab Hematol 45 (1), 90-95 (2023)
   PUBMED   36054783
  REMARK    GeneRIF: A stepwise haematological screening and whole-exome
            sequencing reveal multiple mutations from SUPT5H causing an
            elevation of Hb A2 from a cohort of 47336 individuals.
            Review article
REFERENCE   4  (bases 1 to 3678)
  AUTHORS   Park,K., Zhong,J., Jang,J.S., Kim,J., Kim,H.J., Lee,J.H. and Kim,J.
  TITLE     ZWC complex-mediated SPT5 phosphorylation suppresses divergent
            antisense RNA transcription at active gene promoters
  JOURNAL   Nucleic Acids Res 50 (7), 3835-3851 (2022)
   PUBMED   35325203
  REMARK    GeneRIF: ZWC complex-mediated SPT5 phosphorylation suppresses
            divergent antisense RNA transcription at active gene promoters.
REFERENCE   5  (bases 1 to 3678)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3678)
  AUTHORS   Yamada-Okabe,T., Doi,R., Shimmi,O., Arisawa,M. and Yamada-Okabe,H.
  TITLE     Isolation and characterization of a human cDNA for mRNA 5'-capping
            enzyme
  JOURNAL   Nucleic Acids Res 26 (7), 1700-1706 (1998)
   PUBMED   9512541
REFERENCE   7  (bases 1 to 3678)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     Role of the human homolog of the yeast transcription factor SPT5 in
            HIV-1 Tat-activation
  JOURNAL   J Mol Biol 277 (2), 179-197 (1998)
   PUBMED   9514752
REFERENCE   8  (bases 1 to 3678)
  AUTHORS   Wada,T., Takagi,T., Yamaguchi,Y., Ferdous,A., Imai,T., Hirose,S.,
            Sugimoto,S., Yano,K., Hartzog,G.A., Winston,F., Buratowski,S. and
            Handa,H.
  TITLE     DSIF, a novel transcription elongation factor that regulates RNA
            polymerase II processivity, is composed of human Spt4 and Spt5
            homologs
  JOURNAL   Genes Dev 12 (3), 343-356 (1998)
   PUBMED   9450929
REFERENCE   9  (bases 1 to 3678)
  AUTHORS   Stachora,A.A., Schafer,R.E., Pohlmeier,M., Maier,G. and
            Ponstingl,H.
  TITLE     Human Supt5h protein, a putative modulator of chromatin structure,
            is reversibly phosphorylated in mitosis
  JOURNAL   FEBS Lett 409 (1), 74-78 (1997)
   PUBMED   9199507
REFERENCE   10 (bases 1 to 3678)
  AUTHORS   Chiang,P.W., Fogel,E., Jackson,C.L., Lieuallen,K., Lennon,G.,
            Qu,X., Wang,S.Q. and Kurnit,D.M.
  TITLE     Isolation, sequencing, and mapping of the human homologue of the
            yeast transcription factor, SPT5
  JOURNAL   Genomics 38 (3), 421-424 (1996)
   PUBMED   8975720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB097498.1 and AF040253.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001111020.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, and 5 all encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12790.1, AB000516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432763.7/ ENSP00000404029.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               DB097498.1         37-573
            538-3678            AF040253.1         602-3742
FEATURES             Location/Qualifiers
     source          1..3678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3678
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /note="SPT5 homolog, DSIF elongation factor subunit"
                     /db_xref="GeneID:6829"
                     /db_xref="HGNC:HGNC:11469"
                     /db_xref="MIM:602102"
     exon            1..56
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..218
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3407
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /note="isoform a is encoded by transcript variant 2;
                     transcription elongation factor SPT5; DRB
                     sensitivity-inducing factor large subunit;
                     Tat-cotransactivator 1 protein; DSIF large subunit; DSIF
                     p160; hSPT5; DRB sensitivity-inducing factor 160 kDa
                     subunit; suppressor of Ty 5 homolog"
                     /codon_start=1
                     /product="transcription elongation factor SPT5 isoform a"
                     /protein_id="NP_001104490.1"
                     /db_xref="CCDS:CCDS12536.1"
                     /db_xref="GeneID:6829"
                     /db_xref="HGNC:HGNC:11469"
                     /db_xref="MIM:602102"
                     /translation="MSDSEDSNFSEEEDSERSSDGEEAEVDEERRSAAGSEKEEEPED
                     EEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEK
                     EEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDE
                     LSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAP
                     EHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPK
                     SWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKR
                     PPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSE
                     LEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITI
                     MPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTM
                     HELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGK
                     VVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLFRSFAFL
                     HCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRG
                     GFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTC
                     QTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSR
                     TPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPN
                     PQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQV
                     APSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGI
                     EQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHL
                     EPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKLLEA"
     exon            219..384
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..450
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..462
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..532
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..601
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..667
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..698
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..767
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1019
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1109
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1180
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1286
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1380
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1517
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1673
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1820
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1967
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2093
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2178
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2298
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2401
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2529
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2635
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2794
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2963
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3167
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3263
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3678
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3652..3657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /note="hexamer: AATAAA"
     polyA_site      3678
                     /gene="SUPT5H"
                     /gene_synonym="SPT5; SPT5H; Tat-CT1"
                     /note="major polyA site"
ORIGIN      
        1 agtcaggcgt cgtgcgaaca gcagctggta ccgaaggcgg aggtggagcc cgagagggaa
       61 ccagcgggga aactgaggct cggggtggag cgcaggattg tgggacgcgc caaggctgct
      121 gtctttccca gcagcagcgg aagatgtcgg acagcgagga cagcaacttt tccgaggagg
      181 aggacagcga gcgcagcagt gacggcgagg aggccgaggt agacgaagag cggcggagtg
      241 cagcgggcag tgagaaagaa gaagagcctg aggacgaaga ggaggaggaa gaggaggagg
      301 aatacgatga ggaagaggag gaagaagatg atgaccgacc ccccaagaaa ccccgccatg
      361 gaggcttcat tctggacgag gctgatgttg acgatgagta tgaggacgag gaccagtggg
      421 aggatggagc agaggacatt ctagagaaag aagagattga agcctccaat atcgataatg
      481 ttgtcctgga tgaagatcgt tctggggctc gccgcctgca aaacctctgg agggaccagc
      541 gagaagaaga actgggcgag tattacatga agaaatacgc caagtcatct gtgggagaga
      601 cggtgtatgg aggatctgat gagctctcag acgacatcac ccagcagcag ctgctcccag
      661 gagtcaagga tcccaatctg tggactgtca aatgtaagat tggggaggaa cgggccacgg
      721 ccatttcctt gatgcgcaag ttcattgcct accagttcac agacacgccc ctgcagatca
      781 agtcagtagt ggcaccagag catgtgaagg gctacatcta cgtggaggcc tacaagcaga
      841 cccacgtgaa gcaggccatt gagggggtgg gcaacctgcg gcttggctac tggaaccagc
      901 agatggtgcc catcaaggag atgacagacg tgctcaaagt ggtgaaggag gtggccaacc
      961 tgaaaccaaa gtcctgggtc cgcctcaagc ggggcatcta caaggatgac attgctcagg
     1021 tggactacgt ggagcccagc cagaacacca tctccctgaa gatgatccca cgcatcgact
     1081 acgatcgcat caaggcccgc atgagcttga aagactggtt tgccaaaagg aagaagttta
     1141 agcggcctcc acagaggctg tttgatgctg agaagatcag gtccctgggg ggtgatgttg
     1201 cctctgatgg tgacttcctc atctttgagg ggaaccgtta cagccggaag ggctttctgt
     1261 tcaagagctt cgccatgtct gctgtgatca cggagggtgt gaagccaaca ctctctgagc
     1321 tggaaaagtt tgaggaccag ccagagggca ttgacctgga ggtggtgact gagagcacag
     1381 ggaaggagcg ggagcacaac ttccaacctg gggacaacgt ggaggtctgt gagggtgagc
     1441 tcatcaacct gcagggcaag atcctcagcg tggatggcaa caagatcacc atcatgccca
     1501 agcatgagga cctcaaggac atgttggagt tcccagccca ggaacttaga aaatacttca
     1561 agatggggga ccacgtgaag gtgattgctg gccgattcga gggcgacaca ggcctcattg
     1621 tgcgggtgga ggagaatttc gttatcctgt tctctgacct caccatgcat gagctgaagg
     1681 tgctcccccg ggacctgcag ctctgctcag agacagcatc aggtgtggat gttgggggcc
     1741 agcatgaatg gggcgagctg gtgcagctgg atccccagac tgtgggtgtc atcgtgcgac
     1801 tagaacggga gaccttccag gtgctgaaca tgtacgggaa ggtggtgact gtcagacatc
     1861 aggctgtgac ccggaagaag gacaaccgct ttgctgtggc cttggactca gagcagaaca
     1921 acatccatgt gaaagacatc gttaaggtca ttgatggccc ccactcaggc cgagaagggg
     1981 agattcgcca tctcttccga agcttcgcct tcctacattg caagaaactg gtggagaacg
     2041 ggggcatgtt tgtctgcaag acccgccacc tggtgctggc tgggggctca aagccccgtg
     2101 atgtgaccaa cttcaccgtg ggtggctttg cgcctatgag tccccggatc agcagcccca
     2161 tgcaccccag tgctggaggt cagcgtggcg gctttggtag cccaggtggc ggcagtggtg
     2221 gcatgagcag gggccggggc cggagggaca acgaactcat cggccagacc gtgcgcatct
     2281 cccaggggcc ctacaaaggc tacatcggtg tggtgaaaga tgccacagag tccacggccc
     2341 gtgtggagct gcactccacc tgccagacca tctctgtgga ccgtcagcgg ctcaccacgg
     2401 tgggctcacg gcgcccgggc ggcatgacct cgacctatgg gaggacgccc atgtatggct
     2461 cccagacgcc catgtatggc tctggctccc gaacacccat gtacggctca cagacacccc
     2521 tccaggatgg tagccgcacc ccacactacg gctcacagac gcccctgcat gatggcagcc
     2581 gcactcctgc ccagagtggg gcctgggacc ccaacaaccc caacacgccg tcacgggctg
     2641 aggaagaata tgagtatgct ttcgatgatg agcccacccc gtccccgcag gcctatgggg
     2701 gaacccccaa tccccaaaca cctggctacc cagacccctc gtccccacag gtcaacccac
     2761 aatacaaccc gcagacgcca gggacgccgg ccatgtacaa cacagaccag ttctctccct
     2821 atgctgcccc ctccccacaa ggttcctacc agcccagccc cagcccccag agctaccacc
     2881 aggtggcgcc aagcccagca ggctaccaga atacccactc cccagccagc taccacccta
     2941 caccgtcgcc catggcctat caggctagcc ccagcccgag ccccgttggc tacagtccta
     3001 tgacacctgg agctccctcc cctggtggct acaacccaca cacgccaggc tcaggcatcg
     3061 agcagaactc cagcgactgg gtaaccactg acattcaggt gaaggtgcgg gacacctacc
     3121 tggatacaca ggtggtggga cagacaggtg tcatccgcag tgtcacgggg ggcatgtgct
     3181 ctgtgtacct gaaggacagt gagaaggttg tcagcatttc cagtgagcac ctggagccta
     3241 tcacccccac caagaacaac aaggtgaaag tgatcctggg cgaggatcgg gaagccacgg
     3301 gcgtcctact gagcattgat ggtgaggatg gcattgtccg tatggacctt gatgagcagc
     3361 tcaagatcct caacctccgc ttcctgggga agctcctgga agcctgaagc aggcagggcc
     3421 ggtggacttc gtcggatgaa gagtgatcct ccttccttcc ctggcccttg gctgtgacac
     3481 aagatcctcc tgcagggcta ggcggattgt tctggatttc cttttgtttt tccttttagt
     3541 tttccatctt ttccctccct ggtgctcatt ggaatctgag tagagtctgg gggagggtcc
     3601 ccaccttcct gtacctcctc cccacagctt gcttttgttg taccgtcttt caataaaaag
     3661 aagctgtttg gtctaaaa
//
