LOCUS       NM_003599               4211 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SPT3 homolog, SAGA and STAGA complex component
            (SUPT3H), transcript variant 1, mRNA.
ACCESSION   NM_003599
VERSION     NM_003599.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4211)
  AUTHORS   Rice,S.J., Aubourg,G., Sorial,A.K., Almarza,D., Tselepi,M.,
            Deehan,D.J., Reynard,L.N. and Loughlin,J.
  TITLE     Identification of a novel, methylation-dependent, RUNX2 regulatory
            region associated with osteoarthritis risk
  JOURNAL   Hum Mol Genet 27 (19), 3464-3474 (2018)
   PUBMED   30010910
  REMARK    GeneRIF: Here, genotype at an Osteoarthritis (OA) risk locus
            correlates with differential DNA methylation, with altered gene
            expression of both a transcriptional regulator (RUNX2), and a
            chromatin remodelling protein (SUPT3H).
REFERENCE   2  (bases 1 to 4211)
  AUTHORS   de Vries,P.S., Boender,J., Sonneveld,M.A., Rivadeneira,F.,
            Ikram,M.A., Rottensteiner,H., Hofman,A., Uitterlinden,A.G.,
            Leebeek,F.W., Franco,O.H., Dehghan,A. and de Maat,M.P.
  TITLE     Genetic variants in the ADAMTS13 and SUPT3H genes are associated
            with ADAMTS13 activity
  JOURNAL   Blood 125 (25), 3949-3955 (2015)
   PUBMED   25934476
  REMARK    GeneRIF: we identified rs41314453 as the main genetic determinant
            of ADAMTS13 activity, and we present preliminary findings for
            further associations at the ADAMTS13 and SUPT3H loci.
REFERENCE   3  (bases 1 to 4211)
  AUTHORS   Nakamura,Y., Kayano,H., Kakegawa,E., Miyazaki,H., Nagai,T.,
            Uchida,Y., Ito,Y., Wakimoto,N., Mori,S. and Bessho,M.
  TITLE     Identification of SUPT3H as a novel 8q24/MYC partner in blastic
            plasmacytoid dendritic cell neoplasm with t(6;8)(p21;q24)
            translocation
  JOURNAL   Blood Cancer J 5 (4), e301 (2015)
   PUBMED   25860292
  REMARK    GeneRIF: significance of the formation PVT1- SUPT3H chimeric gene
            remains unknown and the overexpression of MYC by ectopic promoter
            on chromosome 6 may be essential to tumor genesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4211)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   5  (bases 1 to 4211)
  AUTHORS   Nakajima,M., Takahashi,A., Tsuji,T., Karasugi,T., Baba,H.,
            Uchida,K., Kawabata,S., Okawa,A., Shindo,S., Takeuchi,K.,
            Taniguchi,Y., Maeda,S., Kashii,M., Seichi,A., Nakajima,H.,
            Kawaguchi,Y., Fujibayashi,S., Takahata,M., Tanaka,T., Watanabe,K.,
            Kida,K., Kanchiku,T., Ito,Z., Mori,K., Kaito,T., Kobayashi,S.,
            Yamada,K., Takahashi,M., Chiba,K., Matsumoto,M., Furukawa,K.,
            Kubo,M., Toyama,Y. and Ikegawa,S.
  CONSRTM   Genetic Study Group of Investigation Committee on Ossification of
            the Spinal Ligaments
  TITLE     A genome-wide association study identifies susceptibility loci for
            ossification of the posterior longitudinal ligament of the spine
  JOURNAL   Nat Genet 46 (9), 1012-1016 (2014)
   PUBMED   25064007
REFERENCE   6  (bases 1 to 4211)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   7  (bases 1 to 4211)
  AUTHORS   Yu,J., Madison,J.M., Mundlos,S., Winston,F. and Olsen,B.R.
  TITLE     Characterization of a human homologue of the Saccharomyces
            cerevisiae transcription factor spt3 (SUPT3H)
  JOURNAL   Genomics 53 (1), 90-96 (1998)
   PUBMED   9787080
REFERENCE   8  (bases 1 to 4211)
  AUTHORS   Martinez,E., Kundu,T.K., Fu,J. and Roeder,R.G.
  TITLE     A human SPT3-TAFII31-GCN5-L acetylase complex distinct from
            transcription factor IID
  JOURNAL   J Biol Chem 273 (37), 23781-23785 (1998)
   PUBMED   9726987
  REMARK    Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
REFERENCE   9  (bases 1 to 4211)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
REFERENCE   10 (bases 1 to 4211)
  AUTHORS   Wieczorek,E., Brand,M., Jacq,X. and Tora,L.
  TITLE     Function of TAF(II)-containing complex without TBP in transcription
            by RNA polymerase II
  JOURNAL   Nature 393 (6681), 187-191 (1998)
   PUBMED   9603525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA012115.1, AF073930.1 and AL360272.23.
            
            On Nov 23, 2018 this sequence version replaced NM_003599.3.
            
            Transcript Variant: This variant (1), as well as variant 8, encodes
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1574129.1,
                                           SRR14038196.660585.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371459.6/ ENSP00000360514.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               DA012115.1         118-224
            108-1224            AF073930.1         12-1128
            1225-4211           AL360272.23        24955-27941         c
FEATURES             Location/Qualifiers
     source          1..4211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..4211
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /note="SPT3 homolog, SAGA and STAGA complex component"
                     /db_xref="GeneID:8464"
                     /db_xref="HGNC:HGNC:11466"
                     /db_xref="MIM:602947"
     exon            1..167
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1121
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription initiation protein SPT3 homolog; SPT3-like
                     protein; suppressor of Ty 3 homolog"
                     /codon_start=1
                     /product="transcription initiation protein SPT3 homolog
                     isoform 1"
                     /protein_id="NP_003590.1"
                     /db_xref="CCDS:CCDS34465.1"
                     /db_xref="GeneID:8464"
                     /db_xref="HGNC:HGNC:11466"
                     /db_xref="MIM:602947"
                     /translation="MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPL
                     HETAVLVEDVVHTQLINLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMF
                     IRDYKSKIVKGIDEDDLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEID
                     EVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVVAM
                     EILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEA
                     HSDAIQPCHIREAIRRYSHRIGPLSPFTNAYRRNGMAFLAC"
     exon            168..268
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            269..353
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            354..440
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            441..531
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            532..671
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            672..747
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            748..860
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            861..968
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1079
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..4211
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /note="hexamer: AATAAA"
     polyA_site      1219
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /note="major polyA site"
     regulatory      4175..4180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
                     /note="hexamer: AATAAA"
     polyA_site      4211
                     /gene="SUPT3H"
                     /gene_synonym="SPT3; SPT3L"
ORIGIN      
        1 acacagccga gtcacctttt ccctttctac actccacact ctcagtcccc caccccgccc
       61 ctttccaagc gtgtcccggg ccgcagcagc agaaaccgca ccatctccac ccccacattc
      121 tcctcgcggg aagcgcagca gtgcctccaa gggttcttaa agcagagatg aataatacgg
      181 cagctagtcc aatgtctact gcaacttcaa gtagtggaag gagtacaggg aagtctataa
      241 gctttgcaac agaattacag agtatgatgt attctttagg tgatgctaga aggcctcttc
      301 atgaaacagc agttttggta gaagatgtgg tacacactca gttaattaat ctgttacagc
      361 aagctgctga agtttctcag ctgcggggag caagggtaat cactcctgaa gatcttctgt
      421 ttttgatgcg caaagataag aaaaaactta gaagactgct aaaatacatg tttatccgag
      481 actacaaatc aaagattgtc aaaggcatcg atgaggatga tcttctcgaa gacaaattga
      541 gtggcagcaa taatgcgaac aaaagacaaa agattgctca ggacttcctc aactctattg
      601 accagacagg agaactttta gcaatgtttg aagatgacga aattgatgaa gttaaacaag
      661 aaagaatgga gagagcagaa agacaaactc gaattatgga ttcagctcaa tatgcagaat
      721 tctgtgaaag tcgacaatta agtttctcca aaaaagcttc caaatttcga gactggttgg
      781 actgcagcag tatggagata aaacccaatg ttgtcgcaat ggaaatctta gcatatttag
      841 cgtatgaaac tgtggcacag ttagtggatc tggctcttct tgtgaggcaa gacatggtaa
      901 ccaaggcagg ggaccccttc agccatgcca tttctgcaac cttcattcag tatcacaact
      961 ctgctgagag cactgcagcc tgtggtgttg aggctcacag cgatgccatc cagccctgcc
     1021 acatcagaga ggccattcga cgctacagcc acaggattgg cccactttcc ccattcacaa
     1081 atgcctaccg caggaatggg atggcttttc tagcctgctg atgtgacaac tgtgatgtgc
     1141 ctgcaacaac aggaaaggca atgttatatt aaggtgattt cttgtgaaca aaataaaata
     1201 caaatttacc tttcttttat ctgagggagt gggctggtct gttgtgactt tcaacttgct
     1261 gactcctcct cttttccagc ccctcaacca tcggtcttgt ttactagatg ggctgttcag
     1321 ctaattaatg gcaggatgtt taggatagtc tgtaggtgga caagaatgca gatcacacag
     1381 ttttgaaatt ttaatttgag tagatttact gccctcagct cacatacctt aaaagcagtg
     1441 gttgcccccg tccagcgttt tgtctgcatt ttatttgata tattttataa tccaggtttg
     1501 gaacaaggaa acaaaattaa aaggacagtg agttttcgcc ttcccttaca ccaccaactt
     1561 tactttccaa catttgttga catgtgtttt agtgacagct atccatttta taaacttaca
     1621 gtaatcaaag atctaacaga cctgataaat cacctgttcc cacctccttt ccccttcact
     1681 ccacttatag tatgtgtcat tttcaatgcc tgcttcccaa cttcctgcca tctgcctttc
     1741 atgtgtgttt ttcctcacac agaacctctt cctccatctt catttccctc cttttcctgt
     1801 tcctccaatc cccagatcca ccactcctgc acatgccata cacatttaga agccaagtat
     1861 tcagaatcag tagaagggga gcagagtgat ttcttgcttc ctcccttcaa agcactacca
     1921 cacctagact ggaaatgtgg gctgggtaat ttcttgctgt tagcagccga gctacccttc
     1981 tggcatctat actttctcca gtaaatgagg aaccgtaact ctttggaaca aaccaaaata
     2041 tagcagatgt aattgtacag ttcctgatta aacttcagtt gcaaaaaaga aagttatttc
     2101 tttaattctg tgggagtttt gtataatttt acttttatgg tttttacaca tacttgaaac
     2161 actctttcta aagaattaat aaaaacagaa atgagaaaca tgaaagatct ttttcttgat
     2221 actgctcctt tttcttgata ctgctcaaga gagcaagcct ctcttgatac tgcttcctag
     2281 atttaagggt aaagaaagta gaaatagttc tcccttcacc caaatttgga agtataaaac
     2341 tttctgaaca tgccatttag aggttatgtc attagctttc ctgccttctt atattgtaat
     2401 agttgcgatt caaaaacact gtttcaattt taaattcaag actttttatt tgaaaaccat
     2461 cagactcaaa gaattatgag gctcagttaa tattattatg ccacattatt tacatttgtt
     2521 aactgtcatt tacctgctct atgttaatct ttttagaaaa aatttgcatt tcagaaacaa
     2581 aaagcacgga tagatatata atatcaaaat attcccaaag gattttgatg ttccatctat
     2641 gcttgttaaa atgtatgatt atgattaaac tttttatcat tcttattttc cttggcatcc
     2701 ataatcatgg aaaattacaa gcttgcagta aacatcctaa cttaacttaa cttttaaacg
     2761 atagcattta ttgtatttgg ttttgatctg ccaggcttat agatggtata aaattttcag
     2821 gggataattt ttcacatcaa aattccttct ctcccacatt atacatttta aagtatgcac
     2881 aaggcagaaa atatagggtt tgggtttttt tccttcgttt tattccacct gatctcctta
     2941 tagtcccaga gaaggaagac tcaatgtaca tttctctcag aaatatgaca ggtctgtgtt
     3001 tttgttggtc tggcatatgt ttgtctatct tgaacagtct gacaggtaat tatttataaa
     3061 atctggtttt gcccagtaag ttcatataaa acctttcatt tttcatcata agccagtaag
     3121 ctgaatttag aataaagcaa ggtcatttat gtctgtcctg aaccagccta catgtcccca
     3181 taattgctca atatttttaa ttcccttttc tattttttat acttaggttc tttctctgac
     3241 tctttgcaca atactaaatt tgaagtgaaa taaaacttcc ttcagcagtg actatagaaa
     3301 caaaagaaaa tttacagaag gaatgtttaa gaaaacttca gtaaattatt ttctcaataa
     3361 tcataatgtt agagcagaag atagtcttag agatcattaa gaacagctgc tcatcttgca
     3421 aatgaaaaaa ccatggccta gagagggaaa gtgagtttcc taagatcact caataatgta
     3481 gtgacagacc agagatgaga atcgatggtc cctaattttc agtcggtatt atacagtatt
     3541 ttctaccata ctgggttagc ataagaatat tactaagaca tgttggggtt ttatggcata
     3601 tttatcctag acaacgatgt aaatttattt aaaaactgta ctaattatgg atacatccta
     3661 aagcatacgt gttatatagt aaaatcttca gtgtgactgt ggtattaagt aaacagtctg
     3721 ttatcttaca catcaggctt aactctaagt caaatggaaa tatacaaagc tagtttctat
     3781 tttttgtccc ttgtatttta gagactgaat ttgaaaataa ataagccaat aaataaatag
     3841 cgtctcttga tactgcttcc tagatttaag ggtaaagaaa gtagaaatat ttctcccttc
     3901 acctaaattt ggaagtataa ctttctgaac gtgccattta gagggttatg ccattagctt
     3961 tcctgccttc ttagattgta atcgttgtga ttcaaaaata ctgtttcaat tttaaaacca
     4021 agacttttta tttgaaaacc atcagaagca caaatatttt ttaaatggtg tatataattc
     4081 ctgtatctgg ggagaaccct tcatttattg ctgttctttg tttttataaa ataataaaca
     4141 agccatgtct gatgctttta ccatgtagaa gacaaataaa cataactggt gattcttggt
     4201 ctgaaagaaa a
//
