LOCUS       NM_007192               4433 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens SPT16 homolog, facilitates chromatin remodeling
            subunit (SUPT16H), mRNA.
ACCESSION   NM_007192
VERSION     NM_007192.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4433)
  AUTHORS   Li,Y. and Huang,H.
  TITLE     Structural basis for H2A-H2B recognitions by human Spt16
  JOURNAL   Biochem Biophys Res Commun 651, 85-91 (2023)
   PUBMED   36801613
  REMARK    GeneRIF: Structural basis for H2A-H2B recognitions by human Spt16.
REFERENCE   2  (bases 1 to 4433)
  AUTHORS   Ma,M., Zhang,X., Zheng,Y., Lu,S., Pan,X., Mao,X., Pan,H.,
            Chung,H.L., Wang,H., Guo,H. and Bellen,H.J.
  TITLE     The fly homolog of SUPT16H, a gene associated with
            neurodevelopmental disorders, is required in a cell-autonomous
            fashion for cell survival
  JOURNAL   Hum Mol Genet 32 (6), 984-997 (2023)
   PUBMED   36255738
  REMARK    GeneRIF: The fly homolog of SUPT16H, a gene associated with
            neurodevelopmental disorders, is required in a cell-autonomous
            fashion for cell survival.
REFERENCE   3  (bases 1 to 4433)
  AUTHORS   Wang,J., Wang,Z., Dai,L., Zhu,X., Guan,X., Wang,J., Li,J.,
            Zhang,M., Bai,Y. and Guo,H.
  TITLE     Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway
            in Human Pluripotent Stem Cells Derived Neural Stem Cells
  JOURNAL   Int J Mol Sci 24 (3), 3035 (2023)
   PUBMED   36769360
  REMARK    GeneRIF: Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy
            Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4433)
  AUTHORS   McCauley,M.J., Morse,M., Becker,N., Hu,Q., Botuyan,M.V.,
            Navarrete,E., Huo,R., Muthurajan,U.M., Rouzina,I., Luger,K.,
            Mer,G., Maher,L.J. 3rd and Williams,M.C.
  TITLE     Human FACT subunits coordinate to catalyze both disassembly and
            reassembly of nucleosomes
  JOURNAL   Cell Rep 41 (13), 111858 (2022)
   PUBMED   36577379
  REMARK    GeneRIF: Human FACT subunits coordinate to catalyze both
            disassembly and reassembly of nucleosomes.
REFERENCE   5  (bases 1 to 4433)
  AUTHORS   Zhou,D., Wu,Z., Park,J.G., Fiches,G.N., Li,T.W., Ma,Q., Huang,H.,
            Biswas,A., Martinez-Sobrido,L., Santoso,N.G. and Zhu,J.
  TITLE     FACT subunit SUPT16H associates with BRD4 and contributes to
            silencing of interferon signaling
  JOURNAL   Nucleic Acids Res 50 (15), 8700-8718 (2022)
   PUBMED   35904816
  REMARK    GeneRIF: FACT subunit SUPT16H associates with BRD4 and contributes
            to silencing of interferon signaling.
REFERENCE   6  (bases 1 to 4433)
  AUTHORS   Wada,T., Orphanides,G., Hasegawa,J., Kim,D.K., Shima,D.,
            Yamaguchi,Y., Fukuda,A., Hisatake,K., Oh,S., Reinberg,D. and
            Handa,H.
  TITLE     FACT relieves DSIF/NELF-mediated inhibition of transcriptional
            elongation and reveals functional differences between P-TEFb and
            TFIIH
  JOURNAL   Mol Cell 5 (6), 1067-1072 (2000)
   PUBMED   10912001
REFERENCE   7  (bases 1 to 4433)
  AUTHORS   Kang,S.W., Kuzuhara,T. and Horikoshi,M.
  TITLE     Functional interaction of general transcription initiation factor
            TFIIE with general chromatin factor SPT16/CDC68
  JOURNAL   Genes Cells 5 (4), 251-263 (2000)
   PUBMED   10792464
REFERENCE   8  (bases 1 to 4433)
  AUTHORS   Orphanides,G., Wu,W.H., Lane,W.S., Hampsey,M. and Reinberg,D.
  TITLE     The chromatin-specific transcription elongation factor FACT
            comprises human SPT16 and SSRP1 proteins
  JOURNAL   Nature 400 (6741), 284-288 (1999)
   PUBMED   10421373
REFERENCE   9  (bases 1 to 4433)
  AUTHORS   LeRoy,G., Orphanides,G., Lane,W.S. and Reinberg,D.
  TITLE     Requirement of RSF and FACT for transcription of chromatin
            templates in vitro
  JOURNAL   Science 282 (5395), 1900-1904 (1998)
   PUBMED   9836642
REFERENCE   10 (bases 1 to 4433)
  AUTHORS   Orphanides,G., LeRoy,G., Chang,C.H., Luse,D.S. and Reinberg,D.
  TITLE     FACT, a factor that facilitates transcript elongation through
            nucleosomes
  JOURNAL   Cell 92 (1), 105-116 (1998)
   PUBMED   9489704
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024072.1, AK001719.1,
            BC014046.2, BP872403.1 and AL135744.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007192.3.
            
            Summary: Transcription of protein-coding genes can be reconstituted
            on naked DNA with only the general transcription factors and RNA
            polymerase II. However, this minimal system cannot transcribe DNA
            packaged into chromatin, indicating that accessory factors may
            facilitate access to DNA. One such factor, FACT (facilitates
            chromatin transcription), interacts specifically with histones
            H2A/H2B to effect nucleosome disassembly and transcription
            elongation. FACT is composed of an 80 kDa subunit and a 140 kDa
            subunit; this gene encodes the 140 kDa subunit. [provided by
            RefSeq, Feb 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.7420079.1,
                                           SRR11853567.8739.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216297.7/ ENSP00000216297.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK024072.1         250-266
            18-488              AK001719.1         1-471
            489-1653            BC014046.2         473-1637
            1654-1691           BP872403.1         5-42
            1692-2022           AK001719.1         1675-2005
            2023-2027           AL135744.4         161907-161911       c
            2028-3218           AK001719.1         2011-3201
            3219-4433           AL135744.4         152416-153630       c
FEATURES             Location/Qualifiers
     source          1..4433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..4433
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /note="SPT16 homolog, facilitates chromatin remodeling
                     subunit"
                     /db_xref="GeneID:11198"
                     /db_xref="HGNC:HGNC:11465"
                     /db_xref="MIM:605012"
     exon            1..158
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3236
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /note="facilitates chromatin remodeling 140 kDa subunit;
                     hSPT16; FACT 140 kDa subunit; facilitates chromatin
                     transcription complex subunit SPT16; chromatin-specific
                     transcription elongation factor 140 kDa subunit;
                     suppressor of Ty 16 homolog"
                     /codon_start=1
                     /product="FACT complex subunit SPT16"
                     /protein_id="NP_009123.1"
                     /db_xref="CCDS:CCDS9569.1"
                     /db_xref="GeneID:11198"
                     /db_xref="HGNC:HGNC:11465"
                     /db_xref="MIM:605012"
                     /translation="MAVTLDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVGVDEEI
                     VYAKSTALQTWLFGYELTDTIMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPA
                     ITLLIREKNESNKSSFDKMIEAIKESKNGKKIGVFSKDKFPGEFMKSWNDCLNKEGFD
                     KIDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLA
                     ESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMG
                     IRFKSYCSNLVRTLMVDPSQEVQENYNFLLQLQEELLKELRHGVKICDVYNAVMDVVK
                     KQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGK
                     KPEEKTYALFIGDTVLVDEDGPATVLTSVKKKVKNVGIFLKNEDEEEEEEEKDEAEDL
                     LGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKS
                     NVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYT
                     YLRINFYCPGSALGRNEGNIFPNPEATFVKEITYRASNIKAPGEQTVPALNLQNAFRI
                     IKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEA
                     HVNGFRFTSVRGDKVDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQF
                     YTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFE
                     VPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVELIHFERVQFHLKNFD
                     MVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPE
                     GFFEQGGWSFLEPEGEGSDAEEGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEE
                     SDYSKESLGSEEESGKDWDELEEEARKADRESRYEEEEEQSRSMSRKRKASVHSSGRG
                     SNRGSRHSSAPPKKKRK"
     exon            159..251
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            252..422
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            423..575
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            576..722
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            723..874
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1047
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1138
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1212
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1325
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1391
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1487
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1603
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1757
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1885
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2021
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2148
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2267
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2393
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2506
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2582
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2752
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2882
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3012
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3090
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..4433
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4397..4402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /note="hexamer: AATAAA"
     polyA_site      4433
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /note="major polyA site"
ORIGIN      
        1 gggagagtgc gggattcctg ggccgagagc gggtggctga gccgggacct cgcgtgattc
       61 tcggaacccg aggagaagcg gcgtccgggg ctatggctgt gactctggac aaagacgctt
      121 attatcggcg agtgaagaga ctgtacagca attggcggaa aggagaagat gagtatgcca
      181 acgttgatgc cattgttgta tcagtgggtg ttgatgaaga aattgtttat gccaaatcaa
      241 ctgccttaca gacatggctc tttggttatg aactaactga tactatcatg gtcttttgtg
      301 atgacaaaat catctttatg gccagcaaga aaaaagtgga gttcttgaaa cagattgcca
      361 acactaaggg caatgagaat gctaatggag cccctgccat cacactgcta atacgagaaa
      421 agaatgaaag taataagagt agctttgaca aaatgattga agccattaaa gaaagcaaga
      481 atggcaagaa gattggagtg ttcagcaaag acaaattccc tggagagttc atgaagagct
      541 ggaatgactg cctcaacaaa gaaggctttg acaaaataga tatcagtgca gttgtggcat
      601 ataccatcgc tgtaaaggag gatggggagc tcaacctaat gaagaaagca gccagcatca
      661 cttctgaagt cttcaacaaa ttcttcaagg aaagagtcat ggaaatagtt gatgcagatg
      721 agaaagttcg acacagcaaa ctggctgagt ctgtggaaaa ggccattgaa gagaaaaaat
      781 accttgctgg ggcagaccct tctactgtgg aaatgtgtta ccctcctatc attcagagtg
      841 gtggcaacta taatctcaag ttcagtgtgg tgagtgacaa gaatcatatg cactttgggg
      901 ctatcacttg tgccatgggt attcgcttca agtcttactg ctccaacctt gttcgcactt
      961 tgatggttga tccttctcaa gaagttcaag aaaattataa ctttttgctc cagcttcaag
     1021 aggagctgct gaaggaatta agacatggtg tgaagatatg tgacgtgtat aacgctgtca
     1081 tggacgtggt taaaaagcag aagccagaac tgctgaacaa aattaccaaa aacctagggt
     1141 ttgggatggg aattgaattc cgtgaaggct ccctagtaat caatagcaaa aatcaataca
     1201 aactgaagaa aggaatggtt ttcagcatca atttaggatt ctcagacctg actaacaagg
     1261 aggggaaaaa gccagaagag aaaacctatg ccctgttcat tggtgacaca gtgcttgtgg
     1321 atgaggatgg cccagctact gttctcactt ctgtgaagaa gaaagtgaag aatgtgggga
     1381 ttttcctaaa gaatgaagat gaggaagaag aggaggagga gaaagatgag gcagaggacc
     1441 ttttgggaag aggttctcgg gcagcattac ttacagaaag aacaagaaat gaaatgactg
     1501 cagaagagaa gcgaagagca catcagaaag aactagcggc tcaactcaat gaagaagcaa
     1561 agaggcgatt gactgaacaa aagggagaac agcagattca gaaagctcgc aagtctaatg
     1621 tgtcctataa aaacccatct ctgatgccta aggaaccaca tattcgggaa atgaagatct
     1681 acatcgataa gaaatatgag actgtaataa tgcccgtgtt tggcattgca acaccgtttc
     1741 acattgccac aatcaagaat ataagtatgt ccgtggaagg agattatact tacttgcgaa
     1801 tcaactttta ttgcccaggc agtgctctgg gcaggaatga aggcaacatc tttcctaacc
     1861 ctgaagcgac ttttgtcaag gaaattacat accgagcatc aaatattaag gcacccggag
     1921 aacagacagt accagccttg aaccttcaga atgctttccg aattattaaa gaagtacaga
     1981 aacgttataa aactcgagaa gctgaagaga aagagaagga ggggattgta aaacaagact
     2041 cactggtgat caatctaaac cggagtaatc cgaaactgaa agatctatac attcgcccaa
     2101 atattgccca aaagaggatg caaggctcac tggaggccca tgtcaatggc ttccgcttca
     2161 catctgttcg aggagacaaa gtggatattt tgtacaataa tattaagcat gctttgttcc
     2221 agccctgtga tggagaaatg attattgtct tgcactttca cctcaagaat gccatcatgt
     2281 ttgggaagaa gcggcacacg gatgtgcagt tctacacaga agtgggagag ataaccacgg
     2341 acttggggaa acatcagcat atgcatgacc gagatgacct ctatgctgag cagatggaac
     2401 gagaaatgag gcacaaactg aaaacagcct ttaaaaattt cattgagaaa gtagaggctc
     2461 taactaagga ggaactggaa tttgaagtgc cttttaggga cttgggattt aacggagctc
     2521 cctataggag tacctgcctc cttcagccca ctagtagtgc gctggtaaat gctacggaat
     2581 ggccaccttt tgtggtgaca ttggatgagg tagagctgat ccactttgag cgggtccagt
     2641 ttcacctgaa gaactttgat atggtaatcg tctacaagga ctacagcaag aaagtgacca
     2701 tgatcaacgc cattcctgta gcctctcttg accccatcaa ggaatggttg aattcctgcg
     2761 acctgaaata cacagaagga gtacagtccc tcaactggac taaaatcatg aagaccattg
     2821 ttgatgaccc tgagggcttc ttcgaacaag gtggctggtc tttcctggag cctgagggtg
     2881 aggggagtga tgctgaagaa ggggattcag agtctgaaat tgaagatgag acttttaatc
     2941 cttcagaaga tgactatgaa gaggaagagg aggacagtga tgaagattat tcatcagaag
     3001 cagaagagtc agactattct aaggagtcat tgggtagtga agaagagagt ggaaaggatt
     3061 gggatgaact ggaggaagaa gcccgaaaag cggaccgaga aagtcgttac gaggaagaag
     3121 aagaacaaag tcgaagtatg agccggaaga ggaaggcatc tgtgcacagt tcgggccgtg
     3181 gctctaaccg tggttccaga cacagctctg caccccccaa gaaaaagagg aagtaacttc
     3241 tgaactttgg ccctgagctc cattcttcct ccagccaacc cctgaaaatt ttacatgaca
     3301 tagaaactgt atttttcctt tcgttttcat ttgaagtttt gccatttgtg tttatgggtt
     3361 tagggggcca tttgtgtgga ccaatctact cggggaattc caggcccacc aggacacgtg
     3421 ccaatggccc cattcagatg gcaagggagg aggtgttctt gaagacagga ggaggctccc
     3481 gctgttaata aatattgttt cattcttctc tcttcctgtc accttctgcc aagacattga
     3541 tggcttctga catcttattt ggtgtctcaa agctgtattt ccaagacagt ggtacaaggt
     3601 gacccttaat tacccgtatc atggttcttg accagcacat tcaatcctcc aacctaccct
     3661 actgccatga ccttccgcac atctctaagt tttatctttg caatactcaa ggttctcgga
     3721 aatttgctaa tggttgtgat aaaccataca gcttgagcca gtgaggcaga ttgggctggt
     3781 gccttcgtct gagttttcct gctttcctgc ctcgtgcaga ttctgaggta tatctgctgc
     3841 cttggaagac ataagaagca gtgatactcc ctggctcggt tattttctcc atacaatgca
     3901 cacatggtac aatgatagaa ggcaaaattg ccactgtctt cttttttttc tcatatatct
     3961 aaggaagata tatcaggttg tgcctcatgt accgcttcta gtgaaatgta gaggaaggct
     4021 caaaggagtc aacatttata tctggaaggg acaagtcatg ccttgggcct agaataccct
     4081 gatgagaaaa gagaagagga agggaggcca tatctacaac acagcctctc ggcactgctg
     4141 ctccttattt taactttgtc ttgcattgtc ctgtatttat cacagtttct gttgaacagc
     4201 ttttcaagta tttggggagt ttatcttgcc atcctcccct tctggttctc tgcacccacc
     4261 tgtcccactg cagttccttc cgtgctctgt gactttaaga gaagaagggg ggaggggtcc
     4321 cggattttat gtttgtttgt tttttctcct tagcagtagg acttgatatt ttcaattttg
     4381 gaagaactaa aagatgaata aactgggttt tttttgttgt ttgtttttgt aaa
//
