LOCUS       NM_001030019            1425 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Sad1 and UNC84 domain containing 3 (SUN3), transcript
            variant 1, mRNA.
ACCESSION   NM_001030019
VERSION     NM_001030019.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Chio,A., Schymick,J.C., Restagno,G., Scholz,S.W., Lombardo,F.,
            Lai,S.L., Mora,G., Fung,H.C., Britton,A., Arepalli,S., Gibbs,J.R.,
            Nalls,M., Berger,S., Kwee,L.C., Oddone,E.Z., Ding,J., Crews,C.,
            Rafferty,I., Washecka,N., Hernandez,D., Ferrucci,L., Bandinelli,S.,
            Guralnik,J., Macciardi,F., Torri,F., Lupoli,S., Chanock,S.J.,
            Thomas,G., Hunter,D.J., Gieger,C., Wichmann,H.E., Calvo,A.,
            Mutani,R., Battistini,S., Giannini,F., Caponnetto,C.,
            Mancardi,G.L., La Bella,V., Valentino,F., Monsurro,M.R.,
            Tedeschi,G., Marinou,K., Sabatelli,M., Conte,A., Mandrioli,J.,
            Sola,P., Salvi,F., Bartolomei,I., Siciliano,G., Carlesi,C.,
            Orrell,R.W., Talbot,K., Simmons,Z., Connor,J., Pioro,E.P.,
            Dunkley,T., Stephan,D.A., Kasperaviciute,D., Fisher,E.M.,
            Jabonka,S., Sendtner,M., Beck,M., Bruijn,L., Rothstein,J.,
            Schmidt,S., Singleton,A., Hardy,J. and Traynor,B.J.
  TITLE     A two-stage genome-wide association study of sporadic amyotrophic
            lateral sclerosis
  JOURNAL   Hum Mol Genet 18 (8), 1524-1532 (2009)
   PUBMED   19193627
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Osada,N., Hida,M., Kusuda,J., Tanuma,R., Hirata,M., Suto,Y.,
            Hirai,M., Terao,K., Sugano,S. and Hashimoto,K.
  TITLE     Cynomolgus monkey testicular cDNAs for discovery of novel human
            genes in the human genome sequence
  JOURNAL   BMC Genomics 3 (1), 36 (2002)
   PUBMED   12498619
  REMARK    GeneRIF: cDNA of Macaca fascicularis used to identify a novel human
            gene, SUNC1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF429967.1, BC026189.2 and BU623138.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001030019.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.213369.1,
                                           SRR5189667.342923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297325.9/ ENSP00000297325.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               AF429967.1         13-758
            747-1416            BC026189.2         663-1332
            1417-1425           BU623138.1         16-24               c
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.3"
     gene            1..1425
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /note="Sad1 and UNC84 domain containing 3"
                     /db_xref="GeneID:256979"
                     /db_xref="HGNC:HGNC:22429"
                     /db_xref="MIM:618984"
     exon            1..291
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1243
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /note="isoform 1 is encoded by transcript variant 1; Sad1
                     and UNC84 domain containing 1; sad1/unc-84
                     domain-containing protein 1; SUN domain-containing protein
                     3; hypothetical protein MGC33329"
                     /codon_start=1
                     /product="SUN domain-containing protein 3 isoform 1"
                     /protein_id="NP_001025190.1"
                     /db_xref="CCDS:CCDS34636.1"
                     /db_xref="GeneID:256979"
                     /db_xref="HGNC:HGNC:22429"
                     /db_xref="MIM:618984"
                     /translation="MSGKTKARRAAMFFRRCSEDASGSASGNALLSEDENPDANGVTR
                     SWKIILSTMLTLTFLLVGLLNHQWLKETDVPQKSRQLYAIIAEYGSRLYKYQARLRMP
                     KEQLELLKKESQNLENNFRQILFLIEQIDVLKALLRDMKDGMDNNHNWNTHGDPVEDP
                     DHTEEVSNLVNYVLKKLREDQVEMADYALKSAGASIIEAGTSESYKNNKAKLYWHGIG
                     FLNHEMPPDIILQPDVYPGKCWAFPGSQGHTLIKLATKIIPTAVTMEHISEKVSPSGN
                     ISSAPKEFSVYGITKKCEGEEIFLGQFIYNKTGTTVQTFELQHAVSEYLLCVKLNIFS
                     NWGHPKYTCLYRFRVHGTPGKHI"
     exon            292..353
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..457
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..498
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..661
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..746
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..862
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1030
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1123
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1425
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /note="hexamer: AGTAAA"
     regulatory      1399..1404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /note="hexamer: AATAAA"
     polyA_site      1408
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
     polyA_site      1425
                     /gene="SUN3"
                     /gene_synonym="SUNC1"
                     /note="major polyA site"
ORIGIN      
        1 agaagctttt caaaattccg tcttcaagaa gaaacacccg tggaggaaga agacattata
       61 caaaacaaat ttagaaactg tatgtatagc ttcatgtttt tcataaaata ggaatgagga
      121 caaatgttgc tcttcatcct accagctgtt tgttctttgg taggggatca tgagtggaaa
      181 aacaaaggca agaagggctg ccatgttttt tagacgttgc tctgaagacg ccagcggtag
      241 cgccagtggc aatgctttgt tatcagagga cgaaaatcct gatgcgaatg gggtaactcg
      301 atcatggaag attattctaa gtacaatgct tacactgact tttcttcttg taggactcct
      361 aaatcatcag tggcttaaag aaacagatgt tcctcagaaa tccagacaat tatatgccat
      421 aattgcagaa tatggttcaa ggctttataa atatcaggcc agacttcgta tgcctaaaga
      481 gcaactggaa cttttaaaga aggaaagcca gaatctggaa aacaattttc gtcaaattct
      541 atttttgatc gaacaaatag atgtcctgaa ggcattgcta agagatatga aggatggtat
      601 ggacaataat cacaactgga acacccatgg agaccctgtg gaggacccgg accacacaga
      661 ggaagtgtca aacttggtca attatgtact taaaaagttg agagaagacc aagtcgagat
      721 ggctgattat gccctgaagt cggccggagc ctccatcatt gaagctggga cctcagaaag
      781 ttataaaaat aataaagcaa aattgtactg gcatgggata ggtttcctaa atcatgaaat
      841 gcctccagat attattcttc agccggatgt ctaccctgga aagtgctggg cttttccagg
      901 ttcccagggt cataccctaa tcaagcttgc tacaaagatc ataccaactg ctgttaccat
      961 ggagcacatc tcagagaagg tgtctccgtc aggaaacatc tccagtgcac ccaaggaatt
     1021 ttctgtctat ggcatcacaa aaaaatgtga aggagaagaa attttcctag gtcagtttat
     1081 atataacaaa acaggaacca ccgttcaaac atttgaactc cagcatgcag tttctgaata
     1141 tttattatgt gtgaaactta atatctttag caactgggga cacccgaagt atacttgttt
     1201 atatcgattc agggtccatg gcacaccagg caagcacatc tagaagagtt ggtacagaag
     1261 gccatgccac atgtccagaa tattcaagaa tgcttattct cttagatgat accgcaccca
     1321 taggaattga gaattgggag tgggaagaaa acctcaaagt ggttcatact tgcctgtaaa
     1381 aagtaaatgc attttactaa taaaaaaata tggaagtaaa ttaaa
//
