LOCUS       NM_015374               3960 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens Sad1 and UNC84 domain containing 2 (SUN2), transcript
            variant 2, mRNA.
ACCESSION   NM_015374
VERSION     NM_015374.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3960)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 3960)
  AUTHORS   Zhang,Y., Kong,Y., Guo,H., Liu,Y., Zang,Y. and Li,J.
  TITLE     Inner nuclear membrane protein TMEM201 maintains endothelial cell
            migration and angiogenesis by interacting with the LINC complex
  JOURNAL   J Mol Cell Biol 14 (3) (2022)
   PUBMED   35311970
REFERENCE   3  (bases 1 to 3960)
  AUTHORS   Cruz-Palomar,K., Hawkins,J., Vandal,C., Quenneville,J., Gagnon,E.
            and Lippe,R.
  TITLE     SUN2 Modulates the Propagation of HSV-1
  JOURNAL   J Virol 96 (9), e0045322 (2022)
   PUBMED   35435724
  REMARK    GeneRIF: SUN2 Modulates the Propagation of HSV-1.
REFERENCE   4  (bases 1 to 3960)
  AUTHORS   Ji,J., Shen,J., Xu,Y., Xie,M., Qian,Q., Qiu,T., Shi,W., Ren,D.,
            Ma,J., Liu,W. and Liu,B.
  TITLE     FBXO2 targets glycosylated SUN2 for ubiquitination and degradation
            to promote ovarian cancer development
  JOURNAL   Cell Death Dis 13 (5), 442 (2022)
   PUBMED   35525855
  REMARK    GeneRIF: FBXO2 targets glycosylated SUN2 for ubiquitination and
            degradation to promote ovarian cancer development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3960)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3960)
  AUTHORS   Gronborg,M., Kristiansen,T.Z., Stensballe,A., Andersen,J.S.,
            Ohara,O., Mann,M., Jensen,O.N. and Pandey,A.
  TITLE     A mass spectrometry-based proteomic approach for identification of
            serine/threonine-phosphorylated proteins by enrichment with
            phospho-specific antibodies: identification of a novel protein,
            Frigg, as a protein kinase A substrate
  JOURNAL   Mol Cell Proteomics 1 (7), 517-527 (2002)
   PUBMED   12239280
REFERENCE   7  (bases 1 to 3960)
  AUTHORS   Hoffenberg,S., Liu,X., Nikolova,L., Hall,H.S., Dai,W., Baughn,R.E.,
            Dickey,B.F., Barbieri,M.A., Aballay,A., Stahl,P.D. and Knoll,B.J.
  TITLE     A novel membrane-anchored Rab5 interacting protein required for
            homotypic endosome fusion
  JOURNAL   J Biol Chem 275 (32), 24661-24669 (2000)
   PUBMED   10818110
REFERENCE   8  (bases 1 to 3960)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 3960)
  AUTHORS   Raff,J.W.
  TITLE     The missing (L) UNC?
  JOURNAL   Curr Biol 9 (18), R708-R710 (1999)
   PUBMED   10508607
  REMARK    Review article
REFERENCE   10 (bases 1 to 3960)
  AUTHORS   Malone,C.J., Fixsen,W.D., Horvitz,H.R. and Han,M.
  TITLE     UNC-84 localizes to the nuclear envelope and is required for
            nuclear migration and anchoring during C. elegans development
  JOURNAL   Development 126 (14), 3171-3181 (1999)
   PUBMED   10375507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB988569.1, CN299688.1, BC094797.1, AK304188.1, BX537962.1 and
            CD365855.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015374.2.
            
            Summary: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane
            (INM) proteins that play a major role in nuclear-cytoplasmic
            connection by formation of a 'bridge' across the nuclear envelope,
            known as the LINC complex, via interaction with the conserved
            luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located
            in the outer nuclear membrane (ONM). The LINC complex provides a
            direct connection between the nuclear lamina and the cytoskeleton,
            which contributes to nuclear positioning and cellular rigidity
            (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by
            OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2179618.1,
                                           SRR14038196.2611445.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000689035.1/ ENSP00000508608.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                CB988569.1         59-129
            72-726              CN299688.1         3-657
            727-2096            BC094797.1         768-2137
            2097-2546           AK304188.1         1977-2426
            2547-3537           BX537962.1         2559-3549
            3538-3960           CD365855.1         21-443              c
FEATURES             Location/Qualifiers
     source          1..3960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..3960
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /note="Sad1 and UNC84 domain containing 2"
                     /db_xref="GeneID:25777"
                     /db_xref="HGNC:HGNC:14210"
                     /db_xref="MIM:613569"
     exon            1..236
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            237..395
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2427
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /note="isoform 2 is encoded by transcript variant 2; Sad1
                     unc-84 domain protein 2; protein unc-84 homolog B; SUN
                     domain-containing protein 2; nuclear envelope protein;
                     rab5-interacting protein; sad1/unc-84 protein-like 2"
                     /codon_start=1
                     /product="SUN domain-containing protein 2 isoform 2"
                     /protein_id="NP_056189.1"
                     /db_xref="CCDS:CCDS13978.1"
                     /db_xref="GeneID:25777"
                     /db_xref="HGNC:HGNC:14210"
                     /db_xref="MIM:613569"
                     /translation="MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLK
                     RKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVR
                     RRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVS
                     RAGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLL
                     PLLLLTCLTYGAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRV
                     MSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEG
                     LVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLK
                     SEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVR
                     DDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAA
                     ASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSET
                     YETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAV
                     TLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAP
                     TMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH"
     exon            396..559
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            560..697
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            698..793
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            794..887
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            888..958
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1086
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1341
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1419
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1463
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1629
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1851
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1936
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2052
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2220
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2313
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..3960
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3943..3948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /note="hexamer: AATAAA"
     polyA_site      3960
                     /gene="SUN2"
                     /gene_synonym="rab5IP; UNC84B"
                     /note="major polyA site"
ORIGIN      
        1 acacgcgcgc cgcccggccc cactcgcgca gcgcgggcct ccgccggccg cattgtccgc
       61 ccgcccgcct tgtcccgcgt cgccgctctt cgcgtgcccg cgcgccccgg gcccggccgc
      121 tgtgtcgccc tgagcggagc gccgcccgcg ggatccccac gcggaaaggg ggcgcgcccc
      181 ggcggcggcc tggcctcgga cgcccccggc cgggctagaa gccgccgcgg cagcagattc
      241 tcttcagggg aagagtccac atcccacctc atcatgtccc gaagaagcca gcgcctcacg
      301 cgctactccc agggtgacga tgacggcagc agcagcagcg gagggagctc ggtggctggg
      361 agtcagagca ccctgtttaa agacagtcct ctcaggacct tgaagaggaa atccagcaac
      421 atgaagcgcc tgtccccagc gccacagctg ggcccgtcct ctgatgcaca cacctcctac
      481 tacagtgagt cgctggtcca cgagtcctgg ttcccaccca ggagctccct ggaggaactg
      541 catggtgacg ccaactgggg tgaggacctg cgggtgcgga ggaggagagg cacgggtggc
      601 tcagagagca gcagggccag cgggcttgtg gggcgcaagg ccaccgagga cttcctgggc
      661 tcttcctcgg gctactcctc tgaggacgac tacgtgggct actcggatgt ggaccagcag
      721 agttccagct cgcggctccg aagcgccgtc tcacgggcgg gctccttact ctggatggtg
      781 gccacttcgc caggccggct cttcagactt ctctactggt gggctggcac cacctggtac
      841 cgcctgacca cagctgcctc cctccttgac gtcttcgttt taaccaggcg cttctcgtcc
      901 ctgaagacgt tcctctggtt cctgctgccg ctgctcttgc tgacgtgcct gacgtatggt
      961 gcttggtatt tctaccccta tgggctgcag acattccacc ctgctttggt ttcctggtgg
     1021 gcagcgaagg acagcaggag gccggatgag ggctgggaag ccagagactc atcgccacat
     1081 ttccaggctg agcagcgtgt tatgtcccgg gtacactctc tggagcggcg tctggaagct
     1141 cttgctgctg aattttcctc caactggcag aaggaggcca tgcggctgga acgtctggag
     1201 ctgcggcaag gggctcctgg ccagggaggt ggtggtggcc tgagccacga ggacaccctg
     1261 gcgctgctgg aggggctagt gagccgccgt gaagctgccc tgaaggagga tttccgcagg
     1321 gaaactgctg ctcgcatcca ggaagaactg tctgccctga gagcagagca tcagcaagac
     1381 tcagaagacc tcttcaagaa gatcgtccgg gcctcccagg agtccgaggc tcgcatccag
     1441 cagctgaagt cagagtggca aagcatgacc caggagtcct tccaggagag ctctgtgaag
     1501 gagctgaggc ggctggagga ccagctggcc ggcctgcagc aggagctggc ggctctggca
     1561 ctgaagcaga gctcggtggc ggaagaagtg ggcctgctgc cccagcagat ccaggccgtg
     1621 cgggacgacg tggaatctca gttcccggcc tggatcagtc agttccttgc ccgaggtgga
     1681 gggggccgcg tggggctcct tcagagagag gagatgcaag ctcagctgcg agagctggag
     1741 agcaagatcc tcacccatgt ggcagagatg cagggcaagt cggccaggga agccgcggcc
     1801 tccctgagcc tgacgctgca gaaagaaggt gtgattggag tgacagagga gcaggtgcac
     1861 cacatcgtga agcaggccct gcagcgctac agtgaggacc gcatcgggct ggcagactac
     1921 gccctggagt caggaggggc cagcgtcatc agcacccgat gttctgagac ctacgagacc
     1981 aagacggccc tcctcagcct cttcggcatc cccctgtggt accactccca gtcaccccga
     2041 gtcatcctcc agccagatgt gcacccaggc aactgctggg ccttccaggg gccacaaggc
     2101 ttcgccgtgg tccgcctctc tgcccgcatc cgccccacag ccgttacctt agagcatgtg
     2161 cccaaggcct tgtcacccaa cagcactatc tccagtgccc ccaaggactt cgccatcttt
     2221 gggtttgacg aagacctgca gcaggagggg acactccttg gcaagttcac ttacgatcag
     2281 gacggcgagc ctattcagac gtttcacttt caggccccta cgatggccac gtaccaggtg
     2341 gtggagctgc ggatcctgac taactggggc caccccgagt acacctgcat ctaccgcttc
     2401 agagtgcatg gggagcccgc ccactagccc tgcttactgg tgcctgctgc cagccatctg
     2461 ggagtgggtg aacagcaccc cgccgcttcc cccacacgct tgctcggcgc tctgacttct
     2521 aggagcacaa gagaggagcc tgtggcccca tgcagatgaa aaggacgggc agggtctcct
     2581 gagcagcagg tggctcgagg cggttagcag gctccagcag ctcccttctt ccttccctct
     2641 gtgcccgtgg cgtctgcttc ccatcctggg agtgtgtata tatgtagcat atcatggggg
     2701 actgggaagt tgggagaggt aggacctgac tggtcttggc tggggtcagg ggctggtgcc
     2761 tgggagctga tgaagcaggt gccagggctg tgggaggggc aagctacggc ctgggctagg
     2821 tgagctgcct ctgcccctgg gcaaggaagc gaggccctct gggaggaggg tgcttagctc
     2881 cagagcagga tgggacttcc ccaggcagga agcacttgat ggagagctgc ccagctctcc
     2941 tacaaggtta gtgccctcca cctagggaag catgaaccac agggtccctg agggccttcg
     3001 acaaaagtgt gtatttgtcc cggggagggt agcagtgggc catggggctt cttgtgccct
     3061 aaaggggact ggctgctgtg atcttctaag gggcccaggg ccaaccctgt aggcttcccc
     3121 tctgctgggg acggtagttg cttttctctc tcctgatgct aggttggggc ccaccctgct
     3181 ccctgttcct gctagggcct gccagtgccc ctgagcttgc tttccacatt ctcccagggt
     3241 atggagacct agacctgtct ttggggccat tagcatctgg ggttatagca agaagagtgg
     3301 ggagcatgga actcctgggc tcttgtgggg acgttcaggg tatcggggtg cgaggtctgt
     3361 ctgcaccggc ccccacatct aaccaggccc tgatgtaggg gtcgtccgct caggctgccc
     3421 ccttgggctc ttgcagctct tgttcaggta gtcgcccttc tggtttgttc tctgtggggc
     3481 agttggtggg ggctggggga agaggctggc agaagttacc ctggataggg aagggggagg
     3541 aggggacttt tagagccagc aggccccact gtattatgta tatatttttc aaggtctgtt
     3601 tttctaactg aaaagctaag ggcttgattc ctagccccgt tctgtggggc actgggtgat
     3661 actcagtttc ttgttcctgg ccgtggagag gggcctgggg cactggttcc ggctgtgtct
     3721 ggtggtctgg ctgcggggaa ggggcaagaa ggcgggcagg ccttcactgc agcactgagc
     3781 ctcaaatccg ctctggagca tgaggctgga tgcagtggtg gtgaggccgc cccgctccat
     3841 cccgaggcag ccagggtttg ttttgcgctc tcctgtcaca aatgctgcac tattggttct
     3901 taagtttttt atctccagat cctaatttat gcctatgcaa aaaataaatg acgcccaaga
//
