LOCUS       NM_001367696            4090 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens Sad1 and UNC84 domain containing 1 (SUN1), transcript
            variant 59, mRNA.
ACCESSION   NM_001367696
VERSION     NM_001367696.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4090)
  AUTHORS   Fan,T., Zhu,J., Liu,W., Qu,R., Khan,A.U., Shi,Y., Liu,J., Zhou,Z.,
            Xu,C., Dai,J. and Ouyang,J.
  TITLE     SUN1 inhibits osteogenesis and promotes adipogenesis of human
            adipose-derived stem cells by regulating alpha-tubulin and CD36
            expression
  JOURNAL   J Cell Mol Med 28 (19), e70143 (2024)
   PUBMED   39383106
  REMARK    GeneRIF: SUN1 inhibits osteogenesis and promotes adipogenesis of
            human adipose-derived stem cells by regulating alpha-tubulin and
            CD36 expression.
REFERENCE   2  (bases 1 to 4090)
  AUTHORS   Gurusaran,M., Erlandsen,B.S. and Davies,O.R.
  TITLE     The crystal structure of SUN1-KASH6 reveals an asymmetric LINC
            complex architecture compatible with nuclear membrane insertion
  JOURNAL   Commun Biol 7 (1), 138 (2024)
   PUBMED   38291267
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4090)
  AUTHORS   Baskerville,V., Rapuri,S., Mehlhop,E. and Coyne,A.N.
  TITLE     SUN1 facilitates CHMP7 nuclear influx and injury cascades in
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Brain 147 (1), 109-121 (2024)
   PUBMED   37639327
  REMARK    GeneRIF: SUN1 facilitates CHMP7 nuclear influx and injury cascades
            in sporadic amyotrophic lateral sclerosis.
REFERENCE   4  (bases 1 to 4090)
  AUTHORS   Meng,Q., Shao,B., Zhao,D., Fu,X., Wang,J., Li,H., Zhou,Q. and
            Gao,T.
  TITLE     Loss of SUN1 function in spermatocytes disrupts the attachment of
            telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans
  JOURNAL   Hum Genet 142 (4), 531-541 (2023)
   PUBMED   36933034
  REMARK    GeneRIF: Loss of SUN1 function in spermatocytes disrupts the
            attachment of telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans.
REFERENCE   5  (bases 1 to 4090)
  AUTHORS   Wu,H., Zhang,X., Hua,R., Li,Y., Cheng,L., Li,K., Liu,Y., Gao,Y.,
            Shen,Q., Wang,G., Lv,M., Xu,Y., He,X., Cao,Y. and Liu,M.
  TITLE     Homozygous missense mutation in CCDC155 disrupts the transmembrane
            distribution of CCDC155 and SUN1, resulting in non-obstructive
            azoospermia and premature ovarian insufficiency in humans
  JOURNAL   Hum Genet 141 (11), 1795-1809 (2022)
   PUBMED   35587281
  REMARK    GeneRIF: Homozygous missense mutation in CCDC155 disrupts the
            transmembrane distribution of CCDC155 and SUN1, resulting in
            non-obstructive azoospermia and premature ovarian insufficiency in
            humans.
REFERENCE   6  (bases 1 to 4090)
  AUTHORS   Crisp,M., Liu,Q., Roux,K., Rattner,J.B., Shanahan,C., Burke,B.,
            Stahl,P.D. and Hodzic,D.
  TITLE     Coupling of the nucleus and cytoplasm: role of the LINC complex
  JOURNAL   J Cell Biol 172 (1), 41-53 (2006)
   PUBMED   16380439
REFERENCE   7  (bases 1 to 4090)
  AUTHORS   Padmakumar,V.C., Libotte,T., Lu,W., Zaim,H., Abraham,S.,
            Noegel,A.A., Gotzmann,J., Foisner,R. and Karakesisoglou,I.
  TITLE     The inner nuclear membrane protein Sun1 mediates the anchorage of
            Nesprin-2 to the nuclear envelope
  JOURNAL   J Cell Sci 118 (Pt 15), 3419-3430 (2005)
   PUBMED   16079285
  REMARK    GeneRIF: The Sun1 itself does not require functional A-type lamins
            for its localisation at the inner nuclear membrane in mammalian
            cells.
REFERENCE   8  (bases 1 to 4090)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
  REMARK    GeneRIF: Isolation of a cDNA encoding a mouse homolog of the human
            SUN1 (UNC84A) gene.
REFERENCE   9  (bases 1 to 4090)
  AUTHORS   Dreger,M., Bengtsson,L., Schoneberg,T., Otto,H. and Hucho,F.
  TITLE     Nuclear envelope proteomics: novel integral membrane proteins of
            the inner nuclear membrane
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11943-11948 (2001)
   PUBMED   11593002
  REMARK    GeneRIF: KIAA0810 is a novel 100-kDa transmembrane protein with
            similarity to Caenorhabditis elegans Unc-84A and resides in the
            inner nuclear membrane. It is likely to interact with the nuclear
            lamina.
REFERENCE   10 (bases 1 to 4090)
  AUTHORS   Malone,C.J., Fixsen,W.D., Horvitz,H.R. and Han,M.
  TITLE     UNC-84 localizes to the nuclear envelope and is required for
            nuclear migration and anchoring during C. elegans development
  JOURNAL   Development 126 (14), 3171-3181 (1999)
   PUBMED   10375507
  REMARK    GeneRIF: Describes cloning and function of C. elegans unc-84 and
            cloning of human orthologs.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099731.5.
            
            Summary: This gene is a member of the unc-84 homolog family and
            encodes a nuclear envelope protein with an Unc84 (SUN) domain. The
            protein is involved in nuclear anchorage and migration.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jan 2019].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.24400.1,
                                           SRR1660807.163043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC099731.5         151954-151984
            32-128              AC099731.5         167816-167912
            129-317             AC099731.5         174109-174297
            318-502             AC099731.5         177257-177441
            503-529             AC099731.5         178517-178543
            530-709             AC099731.5         178652-178831
            710-820             AC099731.5         185234-185344
            821-919             AC099731.5         186695-186793
            920-1013            AC099731.5         187261-187354
            1014-1072           AC099731.5         187920-187978
            1073-1215           AC099731.5         188121-188263
            1216-1392           AC099731.5         188720-188896
            1393-1479           AC099731.5         190231-190317
            1480-1523           AC099731.5         191669-191712
            1524-1653           AC099731.5         193139-193268
            1654-1908           AC099731.5         195439-195693
            1909-1993           AC099731.5         196691-196775
            1994-2109           AC099731.5         201263-201378
            2110-2277           AC099731.5         204660-204827
            2278-2370           AC099731.5         207781-207873
            2371-4090           AC099731.5         208526-210245
FEATURES             Location/Qualifiers
     source          1..4090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..4090
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="Sad1 and UNC84 domain containing 1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
     exon            1..31
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            32..128
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2487
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="isoform ggg is encoded by transcript variant 59;
                     Sad1 unc-84 domain protein 1; protein unc-84 homolog A;
                     SUN domain-containing protein 1; sad1/unc-84 protein-like
                     1"
                     /codon_start=1
                     /product="SUN domain-containing protein 1 isoform ggg"
                     /protein_id="NP_001354625.1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
                     /translation="MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDP
                     VFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAF
                     SINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKG
                     GNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQ
                     KCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSR
                     TAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLI
                     PLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSE
                     AFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASTDF
                     MAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLEL
                     DQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQ
                     FVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAI
                     VNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPR
                     VVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFA
                     VYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYT
                     CLYRFRVHGEPVK"
     exon            129..317
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            318..502
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            503..529
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            530..709
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            710..820
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            821..919
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1013
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1072
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1215
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1392
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1479
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1523
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1653
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1908
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1993
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2109
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2277
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2370
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..4090
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4032..4037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: AATAAA"
     polyA_site      4058
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="major polyA site"
     regulatory      4066..4071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: TATAAA"
     polyA_site      4090
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
ORIGIN      
        1 agacgaggcc tgaggcggcg gcgcgaggca gtatggtttg aagtggtgaa catggatttt
       61 tctcggcttc acatgtacag tcctccccag tgtgtgccgg agaacacggg ctacacgtat
      121 gcgctcagtt ccagctattc ttcagatgct ctggattttg agacggagca caaattggac
      181 cctgtatttg attctccacg gatgtcccgc cgtagtttgc gcctggccac gacagcatgc
      241 accctggggg atggtgaggc tgtgggtgcc gacagcggca ccagcagcgc tgtctccctg
      301 aagaaccgag cggccagaac aacaaaacag cgcagaagca caaacaaatc agcttttagt
      361 atcaaccacg tgtcaaggca ggtcacgtcc tctggcgtca gccacggcgg cactgtcagc
      421 ctgcaggatg ctgtgactcg acggcctcct gtattggacg agtcttggat tcgtgaacag
      481 accacagtgg accacttctg gggtcttgat gatgatggtg atcttaaagg tggaaataaa
      541 gctgccattc agggaaacgg ggatgtggga gccgccgccg ccaccgcgca caacggcttc
      601 tcctgcagca actgcagcat gctgtccgag cgcaaggacg tgctcacggc gcaccccgcg
      661 gcccccgggc ccgtgtcgag agtttattct agggacagga atcaaaaatg cgacgactgt
      721 aagggcaaga ggcacctcga cgcgcacaca gccgcccact cgcagtcgcc acggctgccc
      781 ggtcgggcag ggaccctctg gcacatctgg gcatgtgcag gttacttctt gctgcagatt
      841 ctgcgcagga tcggagctgt gggccaggct gtgtccagga cggcgtggtc ggccctttgg
      901 ctggccgtgg ttgctccagg gaaggcagcc tctggagtgt tctggtggct ggggattgga
      961 tggtaccagt ttgttacttt gatttcttgg ctgaatgtgt ttcttcttac caggtgcctt
     1021 cgaaacatct gcaagttttt agtcttgctc atcccactct tccttttact agcaggtctc
     1081 tccttacggg gccagggcaa tttcttttcg ttcttgcccg tgttgaactg ggcaagcatg
     1141 catagaacac agcgggtgga tgacccccag gacgtgttta aacccacgac ttctcgcctg
     1201 aagcagcctc tgcagggtga cagtgaggct tttccgtggc attggatgag tggcgtggag
     1261 cagcaggtgg cctctctgtc tggacagtgc caccaccatg gtgagaatct ccgagagctg
     1321 accactttgc tacagaagct gcaggctcgg gtggaccaga tggaaggcgg cgctgccggg
     1381 ccgtcagctt cgactgactt tatggccttt caccaagaac atgaagtgcg tatgtcacac
     1441 ttggaagata ttctgggaaa actgagagaa aaatctgagg ccatccagaa ggaactagaa
     1501 cagaccaagc aaaaaacaat cagtgcggtt ggtgagcagc tcctgcccac agtcgagcac
     1561 ctccagctgg agctggatca gctaaagtca gagctgtcca gctggcgaca cgtgaagacc
     1621 ggctgtgaga cagtggatgc cgtacaagaa agagtggacg tgcaagtcag agaaatggtg
     1681 aaactcctgt tttccgaaga tcagcaaggc ggttctctgg aacagctgct gcagaggttc
     1741 tcatcacagt ttgtgagcaa aggcgacttg cagacgatgc tgcgagacct gcagctgcag
     1801 atcctgcgga acgtcaccca ccacgtttcc gtgaccaagc agctcccaac ctcagaagcc
     1861 gtggtgtctg ctgtgagcga ggcgggggcg tctggaataa cagaggcgca agcacgtgcc
     1921 atcgtgaaca gcgccttgaa gctgtattcc caagataaga ccgggatggt ggactttgct
     1981 ctggaatctg gtggtggcag catcttgagt actcgctgtt ctgaaactta cgaaaccaaa
     2041 acggcgctga tgagtctgtt tgggatcccg ctgtggtact tctcgcagtc cccgcgcgtg
     2101 gtcatccagc ctgacattta ccccggtaac tgctgggcat ttaaaggctc ccaggggtac
     2161 ctggtggtga ggctctccat gatgatccac ccagccgcct tcactctgga gcacatccct
     2221 aagacgctgt cgccaacagg caacatcagc agcgccccca aggacttcgc cgtctatgga
     2281 ttagaaaatg agtatcagga agaagggcag cttctgggac agttcacgta tgatcaggat
     2341 ggggagtcgc tccagatgtt ccaggccctg aaaagacccg acgacacagc tttccaaata
     2401 gtggaacttc ggattttttc taactggggc catcctgagt atacctgtct gtatcggttc
     2461 agagttcatg gcgaacctgt caagtgaaga cactactcat tatttttgta catttttgta
     2521 tatactggga cagcgtgaaa cactggaatc cttcatggac gagggcatat acaatgatgg
     2581 gacagtgcca cactccttca ataaacgtgg ctgctggcca gaggacgtga gcgtgtgacg
     2641 ggcgccttgg cgccacctgt tgggtgctca ctgcctctgc aggtgcagag gggtcagcag
     2701 caggagaagc gtgttgaaca cgtggctctc agacactcct tgtttttaac gggaagctct
     2761 ttgcatttgc atttcctcaa caaaggagca aagcagagga agctgagagt ctggcgtgtt
     2821 cttgacgctt tggtcttcag ccttgcactg gctcttctaa aggacttttg gagggcagat
     2881 aatttcatct gttaaatcca acacacattt ctttcaggga aaaacaatgt caccaaattt
     2941 tcagagttct aaactccttt ccttcaagcc ggaattttcc ttttttcagc accagtaggt
     3001 actaagtctc cagatgggga aataactaaa atgtgttttt ctgctttgtt cgctcttact
     3061 tctgaggaag gtttccagtc aggactcgct gtaccaatat ccatggagga atatgggagc
     3121 gtttcgctct ccttgtaggc tgaagtcagt ctgacttgaa ggggcctggt ttggatctaa
     3181 gcaaacaccc agatggggtt ctctggtctc agcaaggctt ttcctgttgg gagtcacagt
     3241 aaacagaaac ccaaaaatct catcttgggt gttttcaggg cttgttttga gttttgctga
     3301 atagggagcg caagacgccc tgagcctccc tctcactggt ggtgataaga ggagccgtct
     3361 ggtgtgtcag ggtcacgaac ccgttacatt tcaggacgat cctttttcct tcagcagcat
     3421 ttcttactgg ctgtggctgg aatctgcctt ttatcacagc tgtcaccatt ctcacgtgat
     3481 tcttgtgaga ctctttttgg ttataattac tatttaatat ttagactatt ttactgagca
     3541 gactttataa atgagatatc tacaaggcac ttaaagtgtt acagatgttt taccttaaga
     3601 attatttaag ttgtgttggg ttaagacagt tttcagtgta ccgtaaatgt tgtgttttca
     3661 gaaaaagaca aaacgatggt gctgactggt tttctgtata ttgcacaaca gtcctcaaat
     3721 acactgatgt atgaaactat tcatacatca agcagcattt ttttcactct ccttagaatt
     3781 ggaactatgc agttaaggca gataaaatgt acagatgttt catatattac aggttacata
     3841 tataaatcaa aatttcctat ataaaactga tttgggattt ggggtggaaa tattttgaat
     3901 attaatttat ttttaaagat gcaagatagg actttgtgca atgtattttt gtaaatgctt
     3961 ttcaaaatat ctgtctttgg tagtgcttct gctgctgcca ccaaattgat aagatgctat
     4021 taagaggttt aaataaagag ttttaatttt taaaagggca tgggatataa acagtctatt
     4081 tcttttctca
//
