LOCUS       NM_001367684            4224 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens Sad1 and UNC84 domain containing 1 (SUN1), transcript
            variant 47, mRNA.
ACCESSION   NM_001367684
VERSION     NM_001367684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4224)
  AUTHORS   Fan,T., Zhu,J., Liu,W., Qu,R., Khan,A.U., Shi,Y., Liu,J., Zhou,Z.,
            Xu,C., Dai,J. and Ouyang,J.
  TITLE     SUN1 inhibits osteogenesis and promotes adipogenesis of human
            adipose-derived stem cells by regulating alpha-tubulin and CD36
            expression
  JOURNAL   J Cell Mol Med 28 (19), e70143 (2024)
   PUBMED   39383106
  REMARK    GeneRIF: SUN1 inhibits osteogenesis and promotes adipogenesis of
            human adipose-derived stem cells by regulating alpha-tubulin and
            CD36 expression.
REFERENCE   2  (bases 1 to 4224)
  AUTHORS   Gurusaran,M., Erlandsen,B.S. and Davies,O.R.
  TITLE     The crystal structure of SUN1-KASH6 reveals an asymmetric LINC
            complex architecture compatible with nuclear membrane insertion
  JOURNAL   Commun Biol 7 (1), 138 (2024)
   PUBMED   38291267
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4224)
  AUTHORS   Baskerville,V., Rapuri,S., Mehlhop,E. and Coyne,A.N.
  TITLE     SUN1 facilitates CHMP7 nuclear influx and injury cascades in
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Brain 147 (1), 109-121 (2024)
   PUBMED   37639327
  REMARK    GeneRIF: SUN1 facilitates CHMP7 nuclear influx and injury cascades
            in sporadic amyotrophic lateral sclerosis.
REFERENCE   4  (bases 1 to 4224)
  AUTHORS   Meng,Q., Shao,B., Zhao,D., Fu,X., Wang,J., Li,H., Zhou,Q. and
            Gao,T.
  TITLE     Loss of SUN1 function in spermatocytes disrupts the attachment of
            telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans
  JOURNAL   Hum Genet 142 (4), 531-541 (2023)
   PUBMED   36933034
  REMARK    GeneRIF: Loss of SUN1 function in spermatocytes disrupts the
            attachment of telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans.
REFERENCE   5  (bases 1 to 4224)
  AUTHORS   Wu,H., Zhang,X., Hua,R., Li,Y., Cheng,L., Li,K., Liu,Y., Gao,Y.,
            Shen,Q., Wang,G., Lv,M., Xu,Y., He,X., Cao,Y. and Liu,M.
  TITLE     Homozygous missense mutation in CCDC155 disrupts the transmembrane
            distribution of CCDC155 and SUN1, resulting in non-obstructive
            azoospermia and premature ovarian insufficiency in humans
  JOURNAL   Hum Genet 141 (11), 1795-1809 (2022)
   PUBMED   35587281
  REMARK    GeneRIF: Homozygous missense mutation in CCDC155 disrupts the
            transmembrane distribution of CCDC155 and SUN1, resulting in
            non-obstructive azoospermia and premature ovarian insufficiency in
            humans.
REFERENCE   6  (bases 1 to 4224)
  AUTHORS   Crisp,M., Liu,Q., Roux,K., Rattner,J.B., Shanahan,C., Burke,B.,
            Stahl,P.D. and Hodzic,D.
  TITLE     Coupling of the nucleus and cytoplasm: role of the LINC complex
  JOURNAL   J Cell Biol 172 (1), 41-53 (2006)
   PUBMED   16380439
REFERENCE   7  (bases 1 to 4224)
  AUTHORS   Padmakumar,V.C., Libotte,T., Lu,W., Zaim,H., Abraham,S.,
            Noegel,A.A., Gotzmann,J., Foisner,R. and Karakesisoglou,I.
  TITLE     The inner nuclear membrane protein Sun1 mediates the anchorage of
            Nesprin-2 to the nuclear envelope
  JOURNAL   J Cell Sci 118 (Pt 15), 3419-3430 (2005)
   PUBMED   16079285
  REMARK    GeneRIF: The Sun1 itself does not require functional A-type lamins
            for its localisation at the inner nuclear membrane in mammalian
            cells.
REFERENCE   8  (bases 1 to 4224)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
  REMARK    GeneRIF: Isolation of a cDNA encoding a mouse homolog of the human
            SUN1 (UNC84A) gene.
REFERENCE   9  (bases 1 to 4224)
  AUTHORS   Dreger,M., Bengtsson,L., Schoneberg,T., Otto,H. and Hucho,F.
  TITLE     Nuclear envelope proteomics: novel integral membrane proteins of
            the inner nuclear membrane
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11943-11948 (2001)
   PUBMED   11593002
  REMARK    GeneRIF: KIAA0810 is a novel 100-kDa transmembrane protein with
            similarity to Caenorhabditis elegans Unc-84A and resides in the
            inner nuclear membrane. It is likely to interact with the nuclear
            lamina.
REFERENCE   10 (bases 1 to 4224)
  AUTHORS   Malone,C.J., Fixsen,W.D., Horvitz,H.R. and Han,M.
  TITLE     UNC-84 localizes to the nuclear envelope and is required for
            nuclear migration and anchoring during C. elegans development
  JOURNAL   Development 126 (14), 3171-3181 (1999)
   PUBMED   10375507
  REMARK    GeneRIF: Describes cloning and function of C. elegans unc-84 and
            cloning of human orthologs.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099731.5.
            
            Summary: This gene is a member of the unc-84 homolog family and
            encodes a nuclear envelope protein with an Unc84 (SUN) domain. The
            protein is involved in nuclear anchorage and migration.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jan 2019].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.28964.1,
                                           SRR1803615.226435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC099731.5         151954-151984
            32-220              AC099731.5         174109-174297
            221-405             AC099731.5         177257-177441
            406-432             AC099731.5         178517-178543
            433-612             AC099731.5         178652-178831
            613-810             AC099731.5         183729-183926
            811-921             AC099731.5         185234-185344
            922-1020            AC099731.5         186695-186793
            1021-1114           AC099731.5         187261-187354
            1115-1173           AC099731.5         187920-187978
            1174-1316           AC099731.5         188121-188263
            1317-1526           AC099731.5         188720-188929
            1527-1613           AC099731.5         190231-190317
            1614-1657           AC099731.5         191669-191712
            1658-1787           AC099731.5         193139-193268
            1788-2042           AC099731.5         195439-195693
            2043-2127           AC099731.5         196691-196775
            2128-2243           AC099731.5         201263-201378
            2244-2411           AC099731.5         204660-204827
            2412-2504           AC099731.5         207781-207873
            2505-4224           AC099731.5         208526-210245
FEATURES             Location/Qualifiers
     source          1..4224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..4224
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="Sad1 and UNC84 domain containing 1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
     exon            1..31
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            32..220
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2621
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="isoform uu is encoded by transcript variant 47;
                     Sad1 unc-84 domain protein 1; protein unc-84 homolog A;
                     SUN domain-containing protein 1; sad1/unc-84 protein-like
                     1"
                     /codon_start=1
                     /product="SUN domain-containing protein 1 isoform uu"
                     /protein_id="NP_001354613.1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
                     /translation="MSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQR
                     RSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGL
                     DDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSR
                     VYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHE
                     SKDCESESYKSKSHESKGDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFL
                     LQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFL
                     LTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVF
                     KPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARV
                     DQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKE
                     LEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV
                     REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQ
                     LPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTR
                     CSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIH
                     PAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQ
                     ALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK"
     exon            221..405
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            406..432
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            433..612
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            613..810
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            811..921
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1020
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1114
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1173
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1316
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1526
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1613
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1657
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1787
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..2042
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2127
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2243
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2411
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2504
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..4224
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4166..4171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: AATAAA"
     polyA_site      4192
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="major polyA site"
     regulatory      4200..4205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: TATAAA"
     polyA_site      4224
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
ORIGIN      
        1 agacgaggcc tgaggcggcg gcgcgaggca gttccagcta ttcttcagat gctctggatt
       61 ttgagacgga gcacaaattg gaccctgtat ttgattctcc acggatgtcc cgccgtagtt
      121 tgcgcctggc cacgacagca tgcaccctgg gggatggtga ggctgtgggt gccgacagcg
      181 gcaccagcag cgctgtctcc ctgaagaacc gagcggccag aacaacaaaa cagcgcagaa
      241 gcacaaacaa atcagctttt agtatcaacc acgtgtcaag gcaggtcacg tcctctggcg
      301 tcagccacgg cggcactgtc agcctgcagg atgctgtgac tcgacggcct cctgtattgg
      361 acgagtcttg gattcgtgaa cagaccacag tggaccactt ctggggtctt gatgatgatg
      421 gtgatcttaa aggtggaaat aaagctgcca ttcagggaaa cggggatgtg ggagccgccg
      481 ccgccaccgc gcacaacggc ttctcctgca gcaactgcag catgctgtcc gagcgcaagg
      541 acgtgctcac ggcgcacccc gcggcccccg ggcccgtgtc gagagtttat tctagggaca
      601 ggaatcaaaa atgcggtgcg tctttctacg tgaataggat tttgtggctg gccagataca
      661 ctgcatcatc tttttcatca tttttagttc aactttttca agtggtttta atgaagctca
      721 gttatgaatc agaaaattac aaattgaaaa ctcatgaatc aaaagattgt gaatccgaaa
      781 gctataagtc aaaaagccat gaatcaaaag gcgacgactg taagggcaag aggcacctcg
      841 acgcgcacac agccgcccac tcgcagtcgc cacggctgcc cggtcgggca gggaccctct
      901 ggcacatctg ggcatgtgca ggttacttct tgctgcagat tctgcgcagg atcggagctg
      961 tgggccaggc tgtgtccagg acggcgtggt cggccctttg gctggccgtg gttgctccag
     1021 ggaaggcagc ctctggagtg ttctggtggc tggggattgg atggtaccag tttgttactt
     1081 tgatttcttg gctgaatgtg tttcttctta ccaggtgcct tcgaaacatc tgcaagtttt
     1141 tagtcttgct catcccactc ttccttttac tagcaggtct ctccttacgg ggccagggca
     1201 atttcttttc gttcttgccc gtgttgaact gggcaagcat gcatagaaca cagcgggtgg
     1261 atgaccccca ggacgtgttt aaacccacga cttctcgcct gaagcagcct ctgcagggtg
     1321 acagtgaggc ttttccgtgg cattggatga gtggcgtgga gcagcaggtg gcctctctgt
     1381 ctggacagtg ccaccaccat ggtgagaatc tccgagagct gaccactttg ctacagaagc
     1441 tgcaggctcg ggtggaccag atggaaggcg gcgctgccgg gccgtcagct tcggtcagag
     1501 acgctgtggg acagcccccg agggagactg actttatggc ctttcaccaa gaacatgaag
     1561 tgcgtatgtc acacttggaa gatattctgg gaaaactgag agaaaaatct gaggccatcc
     1621 agaaggaact agaacagacc aagcaaaaaa caatcagtgc ggttggtgag cagctcctgc
     1681 ccacagtcga gcacctccag ctggagctgg atcagctaaa gtcagagctg tccagctggc
     1741 gacacgtgaa gaccggctgt gagacagtgg atgccgtaca agaaagagtg gacgtgcaag
     1801 tcagagaaat ggtgaaactc ctgttttccg aagatcagca aggcggttct ctggaacagc
     1861 tgctgcagag gttctcatca cagtttgtga gcaaaggcga cttgcagacg atgctgcgag
     1921 acctgcagct gcagatcctg cggaacgtca cccaccacgt ttccgtgacc aagcagctcc
     1981 caacctcaga agccgtggtg tctgctgtga gcgaggcggg ggcgtctgga ataacagagg
     2041 cgcaagcacg tgccatcgtg aacagcgcct tgaagctgta ttcccaagat aagaccggga
     2101 tggtggactt tgctctggaa tctggtggtg gcagcatctt gagtactcgc tgttctgaaa
     2161 cttacgaaac caaaacggcg ctgatgagtc tgtttgggat cccgctgtgg tacttctcgc
     2221 agtccccgcg cgtggtcatc cagcctgaca tttaccccgg taactgctgg gcatttaaag
     2281 gctcccaggg gtacctggtg gtgaggctct ccatgatgat ccacccagcc gccttcactc
     2341 tggagcacat ccctaagacg ctgtcgccaa caggcaacat cagcagcgcc cccaaggact
     2401 tcgccgtcta tggattagaa aatgagtatc aggaagaagg gcagcttctg ggacagttca
     2461 cgtatgatca ggatggggag tcgctccaga tgttccaggc cctgaaaaga cccgacgaca
     2521 cagctttcca aatagtggaa cttcggattt tttctaactg gggccatcct gagtatacct
     2581 gtctgtatcg gttcagagtt catggcgaac ctgtcaagtg aagacactac tcattatttt
     2641 tgtacatttt tgtatatact gggacagcgt gaaacactgg aatccttcat ggacgagggc
     2701 atatacaatg atgggacagt gccacactcc ttcaataaac gtggctgctg gccagaggac
     2761 gtgagcgtgt gacgggcgcc ttggcgccac ctgttgggtg ctcactgcct ctgcaggtgc
     2821 agaggggtca gcagcaggag aagcgtgttg aacacgtggc tctcagacac tccttgtttt
     2881 taacgggaag ctctttgcat ttgcatttcc tcaacaaagg agcaaagcag aggaagctga
     2941 gagtctggcg tgttcttgac gctttggtct tcagccttgc actggctctt ctaaaggact
     3001 tttggagggc agataatttc atctgttaaa tccaacacac atttctttca gggaaaaaca
     3061 atgtcaccaa attttcagag ttctaaactc ctttccttca agccggaatt ttcctttttt
     3121 cagcaccagt aggtactaag tctccagatg gggaaataac taaaatgtgt ttttctgctt
     3181 tgttcgctct tacttctgag gaaggtttcc agtcaggact cgctgtacca atatccatgg
     3241 aggaatatgg gagcgtttcg ctctccttgt aggctgaagt cagtctgact tgaaggggcc
     3301 tggtttggat ctaagcaaac acccagatgg ggttctctgg tctcagcaag gcttttcctg
     3361 ttgggagtca cagtaaacag aaacccaaaa atctcatctt gggtgttttc agggcttgtt
     3421 ttgagttttg ctgaataggg agcgcaagac gccctgagcc tccctctcac tggtggtgat
     3481 aagaggagcc gtctggtgtg tcagggtcac gaacccgtta catttcagga cgatcctttt
     3541 tccttcagca gcatttctta ctggctgtgg ctggaatctg ccttttatca cagctgtcac
     3601 cattctcacg tgattcttgt gagactcttt ttggttataa ttactattta atatttagac
     3661 tattttactg agcagacttt ataaatgaga tatctacaag gcacttaaag tgttacagat
     3721 gttttacctt aagaattatt taagttgtgt tgggttaaga cagttttcag tgtaccgtaa
     3781 atgttgtgtt ttcagaaaaa gacaaaacga tggtgctgac tggttttctg tatattgcac
     3841 aacagtcctc aaatacactg atgtatgaaa ctattcatac atcaagcagc atttttttca
     3901 ctctccttag aattggaact atgcagttaa ggcagataaa atgtacagat gtttcatata
     3961 ttacaggtta catatataaa tcaaaatttc ctatataaaa ctgatttggg atttggggtg
     4021 gaaatatttt gaatattaat ttatttttaa agatgcaaga taggactttg tgcaatgtat
     4081 ttttgtaaat gcttttcaaa atatctgtct ttggtagtgc ttctgctgct gccaccaaat
     4141 tgataagatg ctattaagag gtttaaataa agagttttaa tttttaaaag ggcatgggat
     4201 ataaacagtc tatttctttt ctca
//
